Typing tool
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Typing tool
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Complete norovirus genomes
| OR536465 | GII.14 | |
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| GII.P7 |
ORF1: 1..5037
ORF2: 5018..6628
ORF3: 6628..7422
LOCUS OR536465 7455 bp RNA linear VRL 04-MAR-2024
DEFINITION Norovirus GII isolate Hu/NL/2022/GII.14/Rotterdam/I129S36_P18-d1868
nonstructural polyprotein (ORF1) gene, partial cds; and VP1 (ORF2)
and VP2 (ORF3) genes, complete cds.
ACCESSION OR536465
VERSION OR536465.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7455)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Intra-host multi-lineage evolution of human Norovirus in
immunocompromised individuals: Implications for treatment
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7455)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Direct Submission
JOURNAL Submitted (11-SEP-2023) Viroscience, Erasmus Medical Center, Dr.
Molewaterplein 40, Rotterdam, Zuid-Holland 3015 GD, Netherlands
COMMENT ##Assembly-Data-START##
Assembly Method :: Spades v. 3.15.4; BWA-MEM v. 0.7.17
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7455
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/NL/2022/GII.14/Rotterdam/I129S36_P18-d1868"
/isolation_source="feaces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Netherlands: Rotterdam"
/collection_date="18-Jan-2022"
/note="genotype: GII.14"
gene <1..5037
/gene="ORF1"
CDS <1..5037
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="WMX17773.1"
/translation="DSTNTAPSNKEEVGAFSNFKVGFKKMLGAVPKSTKAPSSDQQCP
TVKIGPRTLVVPPEPPNGEDIVQFDVKSETVSGLPDLTTVQNEHENTPYTVPPLSERE
HRPAAEPLPGTILEMWDGEFYHYSIYVGGGKTLGVHKPPAAISLATIELTPISLYWRP
VYTPNYLICPDTLKGLAGERFPYTAFSNNCYNFCCWVLELNDTWLSRKSISRTTGFFK
PYQTWNRKPLPTFDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLLHLLASCDW
TFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPEDLAVELVPVVMGGIGM
VLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAEMETLRAIE
DAILDMEAIGNNHLTALLKDKDSLAAFMKTLDLEEEKARKLSTKSSSPDIVGTINAIL
ARIAAARSLLHRAKEEMYSRVRPVVVMISGRPGIGKTHMARHLAKSIANTMSGDQRVG
LVPRNGVDHWDAYRGERVVLWDDYGMASPVKDALTLQELADTCPVTLNCDRIENKGKM
FDSDVIIITTNLANPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPGQPDMWKDH
FKPDHSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHERRDEFQLQG
NDLQVYNFDTNKVSAFRKLAADNKYGIIETMKVGAALKNVKTLEDLKAALRDVKFNEC
EIIYRSSKYRVSSNGKGSVSVDKVEDHASQTANEVCSALLRLRQARAKYYLSCFQDLV
YTLIQVAGASFVVNRISKRFCWERWVKPTETQETFEPEKETAQSRWEIEPKDTEPEGK
KGKNKKGRGKKHTAFSSKGLSDEEYDEYKRIREERDGKYSIEEYLQDRDRYYEEVAVA
RATEENFCEEEEAKIRQRVFRPTRRQRKEERGVLGLVTGSDIRKRKPDDFQPKGNLWA
DDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPRGLKELFGVE
VKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGEMIPLAVRM
GTHASMRIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDIVVAGVHTA
AARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAPKLSTKTKFWRSSPDAL
PPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAILEEAKKTVMNVL
EQTIDPAKPWTYTQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQASKANLMYE
QAKHMQPMYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGLMDSMKASC
IALPCRVGMNMNEDGPIIFDKHAKFKYHYDADYSRWDSTQQRSILTAAMEVMVRFSAE
PELAQVVAEDLLAPSQLDVGDFVVSVQEGLPSGVPCTSQWNSIAHWILTLSAMAEVSG
LSPDVVQAHSCFSFYGDDEIVSTDINIDPAKLTQKLREYGLVPTRPDKTEGPLVISEN
LAGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHSQRATQLMA
LLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLSTWEGDRNLA
PEGVNEDGVE"
mat_peptide <1..945
/gene="ORF1"
/product="p48"
mat_peptide 946..2043
/gene="ORF1"
/product="NTPase"
mat_peptide 2044..2562
/gene="ORF1"
/product="p22"
mat_peptide 2563..2961
/gene="ORF1"
/product="VPg"
mat_peptide 2962..3504
/gene="ORF1"
/product="Pro"
mat_peptide 3505..5034
/gene="ORF1"
/product="RdRp"
gene 5018..6628
/gene="ORF2"
CDS 5018..6628
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="WMX17774.1"
/translation="MKMASNDATPSDDGAAGLVPEINNEVMALEPVAGASIAAPVVGQ
QNVIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLSHLSRMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPAVLDQMYTSRSENIIVQPQNGRCTLDGELLGTT
TLQSVSICNFRGTMQAKLNGQPRYQLQITNLDGSPIDPTDDMPAPLGTPDFQAMLYGV
ASQRSSADNATRAHEAQIDTAGDTFAPKIGQVRFESGSDDFDLHDPTKFTPIGIKVDD
QHPFRQWSLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSHIPSAGGFTDGAMDCLLP
QEWIEHFYQEAAPAQSDIALVRFINPDTGRVLLEAKLHKQGFLTVAASGDHPIVMPAN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6628..7422
/gene="ORF3"
CDS 6628..7422
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="WMX17775.1"
/translation="MAGAFLAGLAGDVAASSLSSLVGAGANAINQKVEYDFNRQLQEA
SFKHDKDMLRAQVAATTGLQQAMIDIKREALTAGGFSPADAARGSVKAPMTTLLDWNG
SRHWAPNSMRTTGYSGTFTSQGIRSSPHLSNQIPSAVKPTKTLPSISSSSSVYSSPST
APSQSTQSTTLSAGTGSSRPNTVSTKTSTLSRTSDWVRDQNQMIGPFMNGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHMRRRGESQT"
ORIGIN
1 gacagtacta acaccgctcc ttccaataag gaagaggtcg gtgcattttc caactttaaa
61 gttggattta agaaaatgct gggtgccgtg cccaagagca ccaaagcgcc cagcagtgac
121 caacaatgcc ccacagtcaa gattggaccc agaacattag tggtcccgcc tgaaccaccg
181 aatggagaag atatcgtgca gtttgatgta aagtcagaaa ctgtgagtgg gctaccagac
241 ctgacaacgg tgcaaaatga acatgaaaac accccatata cagtccctcc actgagtgag
301 agggaacaca gaccagccgc tgagccactc cctggcacaa tattagagat gtgggacggt
361 gagttctacc actactccat ctacgtcggt ggtggtaaga ccctgggggt ccacaaaccc
421 cctgcggcta taagccttgc aacaatcgag ttaaccccca tatctctgta ctggcggcct
481 gtctacaccc ctaattactt gatctgtcca gacacattga agggtcttgc tggtgagagg
541 ttcccctaca cggctttcag caacaactgt tacaacttct gctgctgggt gttggaactc
601 aacgacacgt ggcttagcag gaagtccata tctagaacaa ctggcttctt taaaccgtac
661 cagacttgga acagaaaacc tctcccaact ttcgatgatg gaaagattaa gaaagtggcc
721 aatgcaattc tctgtgcgct tggttcgcta ttctcaaaac caatcaaaga cctattaggc
781 aagctcaaac cactgaacct gctgcacctg ctcgcttcgt gtgattggac gtttgcgggt
841 atagtggaga cggtcatctt aatggcggaa ctctttaacg tcttctggac cccgcctgac
901 gtctccaatt tcatagcctc cctgataggt gactttgagt tgcaagggcc tgaggactta
961 gctgtggaac tagtccctgt ggttatgggt ggcataggca tggttcttgg cttcacggct
1021 gagaagatag gccgcatgtt gtcatctgct gcatcaactc tccgggcgtg caaagatctg
1081 ggaaactacg cccttgacat actcaaactg gtcatgaaat ggttcttccc caagaaagag
1141 gaaaaagctg agatggaaac cttgagggcg attgaggatg ctatcttgga catggaggct
1201 atagggaaca atcacctcac agctcttctt aaagacaagg atagcctcgc agccttcatg
1261 aagaccctag atctagaaga ggaaaaggcg aggaagctgt cgaccaaatc atcgtcacct
1321 gacatcgtcg gtaccatcaa cgccatactg gctagaattg ccgctgccag gtccctccta
1381 cacagggcca aagaggagat gtacagcaga gtcagaccag tggttgttat gatttcaggc
1441 aggcccggca ttggcaagac ccacatggcg agacacctgg ccaagagcat cgctaacacc
1501 atgagtggtg accagagagt cggactcgtt ccgcggaacg gagtagacca ctgggatgca
1561 tacagagggg agagagtggt cttgtgggat gactatggca tggccagtcc tgtcaaagac
1621 gctttaaccc tgcaagaatt ggccgacact tgcccagtca ccttaaattg tgacaggatt
1681 gaaaacaaag ggaaaatgtt tgacagtgat gttatcataa tcacaaccaa cttggccaat
1741 cccgcacccc tcgactatgt gaactttgag gcgtgctcca gaagagttga tttcctggtc
1801 tatgcagaat caccagaaat tgaaaaagtc aagagggatt tccctggcca acctgacatg
1861 tggaaagacc acttcaagcc agaccactcc cacataaaac tgaccctagc cccccagggc
1921 gggtttgaca agaatggtaa cactccgcat ggcaagggca ccatgcgatc tctaacccaa
1981 ggttctttga ctgcaagggt tgcagggtta gtccatgaga ggagagatga gttccagctc
2041 caaggaaatg acctccaagt atacaatttt gacaccaaca aggtttctgc gtttaggaaa
2101 ctggctgcag acaacaaata tgggatcatt gagacaatga aggtgggtgc tgcactcaag
2161 aatgtcaaaa ccttggaaga tctgaaggct gctttgaggg atgtgaaatt caatgagtgt
2221 gagatcattt acaggagttc taaatataga gtctcttcca atggtaaggg ttcagtttct
2281 gttgacaagg tcgaggacca cgcatcccag actgcaaatg aagtgtgttc agcactcctg
2341 aggctcaggc aagcaagggc caaatattat ctcagctgct tccaggacct tgtctacacg
2401 ctcatacaag tcgccggggc gtcatttgtt gtcaacagaa tctccaagag gttttgctgg
2461 gaaagatggg tcaaaccaac cgagactcag gagacatttg agcccgagaa ggagaccgct
2521 caaagcaggt gggagattga acccaaagac acagaaccag aaggcaagaa gggtaaaaac
2581 aagaagggaa gaggcaagaa gcacacagcc ttctccagca agggtctgag tgatgaagag
2641 tatgatgagt acaagagaat cagggaggaa agagatggaa agtactccat tgaggagtac
2701 ctacaagacc gggaccggta ctacgaagaa gtggcagtcg cccgagcaac agaggaaaac
2761 ttctgtgaag aggaggaggc caagatcagg cagagggttt tccgcccaac gaggagacaa
2821 aggaaagagg agagaggagt gctcggcctg gtcaccggct cagacattag aaagagaaaa
2881 ccagatgact tccaaccaaa aggcaacttg tgggcagatg acaccagaag tgtggactac
2941 aatgagagac ttgatttcga agctcccccg agtgtttggt ccaggatagt cccattggga
3001 actggttggg ggttctgggt ctcgtccaat ctcctgatca ctacaacaca tgtcctgccc
3061 aggggactca aagaactctt cggagttgag gttaaacaaa tccagatcca caagtctggc
3121 gagttttgta gattcagatt cccaagacca atcaggccag atgtcacagg gttggtgcta
3181 gaagagggtg ctccagaagg cactgtttgc tccatacttg tgaagagacc cacaggagag
3241 atgattccct tggcggtgag gatgggcact catgcatcca tgagaatcca gggcaggacc
3301 gtcggcggcc aaatgggaat gcttctcaca ggagcaaatg ccaagaacat ggaccttggc
3361 accggccctg gtgattgcgg ttgtccctac atctataaac gcggcaacga catagttgtt
3421 gcaggtgttc ataccgcagc agcccgggga ggtaacactg tcatctgtgc tacccaagga
3481 caagatgggg aggcagtgct tgaagggaac gaaaatcttg gcacttactg tggtgccccg
3541 atcctaggtc ctggcaaggc acccaagctc agcacaaaaa ccaaattctg gcgctcatcg
3601 ccagatgccc taccacctgg cacatatgag cctgcttacc taggaggcaa ggaccctaga
3661 gtggagaaag ggccctccct gcagcaggtc atgagagatc agctaaaacc cttcacagag
3721 cctagaggta aaccaccgag acctgcgatc ctagaagagg ctaagaagac agtgatgaat
3781 gttttggaac agaccatcga ccctgctaaa ccttggacct acactcaagc atgtgcatca
3841 ctagataaaa ccacctccag tggtagcccc caccatgtca ggaagaatga ccactggaat
3901 ggagagtctt tcacaggtcc ccttgcagac caagcatcta aagctaacct catgtatgaa
3961 caggccaaac atatgcagcc catgtacacg gccgcactca aggatgaact tgttaagact
4021 gataaaatct acaaaaagat aaagaaaaga ctcctgtggg gatcagacct tggcacgatg
4081 atcaggtgcg ccagggcttt tggtggcctc atggatagca tgaaggcgag ctgcatagca
4141 cttccttgta gggtggggat gaacatgaat gaggatggcc caatcatctt tgacaagcac
4201 gccaagttca aatatcacta tgatgctgac tattcaaggt gggactcaac ccaacaaagg
4261 agtatcttaa ctgccgctat ggaggtgatg gttcggttct ctgcagaacc agagttagca
4321 caagtagtag cagaggatct tttggcacct agtcaactgg atgttggtga ttttgttgtc
4381 tcagtccagg agggtttgcc atcaggtgtt ccatgcacat cacaatggaa ctcgatagcg
4441 cactggattc taaccttaag tgcaatggca gaagtgtcag gcctttcacc agatgttgtc
4501 caggctcatt cctgtttctc cttctatggt gatgatgaga ttgtcagcac cgatatcaac
4561 attgaccctg caaaattgac acagaaactc agggaatatg gccttgtccc cacccggcct
4621 gacaagactg agggtcccct cgtcataagt gagaacctag ccggcctgac tttcctccgc
4681 aggtcgatag cgcgggatcc agctgggtgg tttggaaaac tggaccaaga ctcaattctc
4741 agacaactgt actggacaag agggcctaac catgaaaacc catacgaaag catggtcccc
4801 cactcccaac gagctacaca gctcatggcc ctccttggtg aggcctcact acatgggccc
4861 cagttttaca agaaggttag caaaatggtc atcaatgaga tcaaaagtgg tggtctggaa
4921 ttttacgtgc ccagacaaga ggccatgttc aggtggatga gattctctga cctcagcacg
4981 tgggagggcg atcgcaatct tgctcccgag ggtgtgaatg aagatggcgt cgaatgacgc
5041 tactccatct gatgatggtg cagccggcct cgtaccagag atcaacaatg aggttatggc
5101 tcttgaaccc gttgctgggg cctccattgc agcccccgtg gtcgggcaac agaatgtaat
5161 agatccctgg attagaaata actttgtaca agcccctgct ggtgaattca cagtttcccc
5221 tagaaactct cctggagaac tcttacttga tttagaattg ggccctgaac tgaatcccta
5281 tctttcacac ctgtccagga tgtacaatgg gcacgcaggt ggaatggaag tgcagatagt
5341 actggctggg aatgcgttca cagctggtaa gatcctattt gctgccatcc cacctagctt
5401 cccctatgaa aatttgtcac ctgctcaatt gactatgtgc ccccatgtaa tagtggatgt
5461 gagacaacta gaaccagtgc ttctgccaat gccagacata agaaatgttt tctatcacta
5521 taaccagaac aatagtccca aactcaggct tgtagctatg ctttatactc ctttgagagc
5581 taacaactca ggtgatgacg tgttcacggt gtcttgccgc gttttgacac gcccctctcc
5641 agacttccag ttcacctttc tggtcccacc cacagttgaa tctaaaacta agaactttac
5701 ccttcctgtc cttagggtct cagagatgac aaactcaagg ttccccgctg ttttggacca
5761 aatgtacaca agcaggagtg aaaacatcat tgtccaaccc caaaacggca ggtgcacgct
5821 tgacggtgag ctgctcggta ccaccacctt gcaatctgtg tctatatgca attttagagg
5881 aacaatgcag gcaaagctga atggacaacc acgataccaa ttacaaatca ccaatttgga
5941 tggctcaccc atagacccaa cagatgacat gcctgccccc cttggcacac cagatttcca
6001 ggccatgttg tatggcgttg caagtcaacg ctcctccgca gacaacgcca ctagggcaca
6061 tgaagcacag attgacactg cgggtgacac tttcgccccg aaaattggcc aggtccgttt
6121 cgaatcaggc tctgatgatt ttgacctaca tgaccctaca aagttcacac ccattggtat
6181 caaagtggat gatcagcacc cctttagaca gtggtccctg ccaaactatg gtggtcacct
6241 tgccctgaac aatcatttag cccccgctgt gacaccactc ttccccggcg agcagatttt
6301 gttcttcagg tcacacattc caagcgccgg aggctttaca gacggtgcta tggactgctt
6361 gctgccccaa gagtggatag agcacttcta ccaggaggca gctcctgccc agtctgacat
6421 cgcactggtg aggttcatta accccgatac aggaagagtg ctccttgaag ccaagttgca
6481 caaacagggc ttccttacag ttgcagcatc tggagaccac cccattgtga tgcccgctaa
6541 tggttatttt aggtttgaag cttgggtcaa ccccttctac actctcgccc ccgtgggaac
6601 tgggtctggg cgcagaagga ttcagtaatg gcaggagctt tccttgcagg tctagcaggt
6661 gacgttgcgg cttctagttt gagctcactc gtgggcgctg gagccaacgc catcaatcag
6721 aaggtggagt acgacttcaa cagacaactc caggaggctt ccttcaaaca tgacaaggat
6781 atgctcagag cccaggttgc agcaacaaca ggcctccaac aggccatgat agatatcaag
6841 cgggaggcat tgaccgcagg cggcttttcc cccgctgatg ctgcaagagg ttcagtcaag
6901 gcgcccatga caacgctcct tgactggaat ggctctaggc attgggcacc caactccatg
6961 aggacaactg gctattcagg cacatttact tcccagggca ttagaagctc cccccacctg
7021 tctaatcaaa ttccaagtgc tgtcaaaccc actaaaacct tgccatctat atctagttct
7081 tctagtgtgt atagctctcc ttctactgcc ccctcgcaat caacacaatc aactacgctg
7141 tctgcaggaa cagggtcgtc caggcctaac accgtgtcca caaagacctc cacactgtcg
7201 aggacaagtg actgggtcag agatcaaaat cagatgattg gcccgttcat gaatggtgca
7261 cttcaaactg cttatgtcac tccaccatcg agcagggcct catcacaagg gacggtctcg
7321 accgtaccca aggctgtttt ggactcctgg actcctatgt tcaacaccca caggcagcct
7381 ctcttcgccc acatgcgtag gcgaggggag tcacagactt agtgaaaagg atgattaggg
7441 cttttctttc ctttc
//