Typing tool
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Typing tool
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Complete norovirus genomes
| OR536464 | GII.14 | |
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| GII.P7 |
ORF1: 1..5026
ORF2: 5007..6617
ORF3: 6617..7411
LOCUS OR536464 7431 bp RNA linear VRL 04-MAR-2024
DEFINITION Norovirus GII isolate Hu/NL/2021/GII.14/Rotterdam/I129S34_P18-d1815
nonstructural polyprotein (ORF1) gene, partial cds; and VP1 (ORF2)
and VP2 (ORF3) genes, complete cds.
ACCESSION OR536464
VERSION OR536464.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7431)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Intra-host multi-lineage evolution of human Norovirus in
immunocompromised individuals: Implications for treatment
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7431)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Direct Submission
JOURNAL Submitted (11-SEP-2023) Viroscience, Erasmus Medical Center, Dr.
Molewaterplein 40, Rotterdam, Zuid-Holland 3015 GD, Netherlands
COMMENT ##Assembly-Data-START##
Assembly Method :: Spades v. 3.15.4; BWA-MEM v. 0.7.17
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7431
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/NL/2021/GII.14/Rotterdam/I129S34_P18-d1815"
/isolation_source="feaces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Netherlands: Rotterdam"
/collection_date="26-Nov-2021"
/note="genotype: GII.14"
gene <1..5026
/gene="ORF1"
CDS <1..5026
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="WMX17770.1"
/translation="AAPSNKEEVGAFSNFKVGFKKMLGAVPKSTKAPSNDQQCPTVKI
GPRTLVVPPEPPNGEDIVQFDAKSETVSGLPDLTTVQNEHENTPYTVPPLSEREHRPA
AEPLPGTILEMWDGEFYHYSIYVGGGKTLGVHKPPAAISLATIELTPISLYWRPVYTP
NYLICPDTLKGLAGERFPYTAFSNNCYNFCCWVLELNDTWLSRKSISRTTGFFKPYQT
WNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLLHLLASCDWTFAG
IVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPEDLAVELVPVVMGGIGMVLGF
TAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAEMETLRAIEDAVL
DMEAIGNNHLTTLLKDKDSLAAFMKTLDLEEEKARKLSTKSSSPDIVGTINAILARIA
AARSLLHRAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIAGTMSGDQRVGLVPR
NGVDHWDAYRGERVVLWDDYGMASPVKDALTLQELADTCPVTLNCDRIENKGKMFDSD
VIIITTNLANPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPGQPDMWKDHFKPD
HSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHERRDEFQLQGNDLQ
VYNFDTNKVSAFRKLAADNKYGIMETMKVGAALKNVKTLEDLKAALRDVKFNECEIIY
RSSKYRVSSNGKGSVSVDKVEDHASQTANEVCSALLRLRQARARYYISCFQDLVYTLI
QVAGASFVVNRISKRFCWERWVKPTEAQETFEPEKETAQSRWEIEPKDAEPEGKKGKN
KKGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDRYYEEVAVARATE
EDFCEEEEAKIRQRVFRPTRKQRKEERGVLGLVTGSDIRKRKPDDFQPKGNLWADDTR
GVDYNERIDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPRGLKELFGVEVKQI
QIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGEMIPLAVRMGTHA
SMRIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDIIVAGVHTAAARG
GNTVICATQGQDGEAVLEGNESLGTYCGAPILGPGKAPKLSTKTKFWRSSPDALPPGT
YEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAILEEAKKTVMNVLEQTI
DPAKPWTYSQACASLDKTTSSGSPHHVRKNDYWNGESFTGPLADQASKANLMYEQAKH
VQPMYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGLMDSMKASCIALP
CRVGMNMNEDGPIIFDKHSKYRFHYDADYSRWDSTQQRSILTAAMEVMVRFSAEPELA
QVVAEDLLAPSQLDVGDFVVSVQEGLPSGVPCTSQWNSIAHWILTLSAMAEVSGLSPD
VVQAHSCFSFYGDDEIVSTDINIDPAKLTQKLREYGLVPTRPDKTEGPLVITENLAGL
TFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHSQRATQLMALLGE
ASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLSTWEGDRNLAPEGV
NEDGVE"
mat_peptide <1..934
/gene="ORF1"
/product="p48"
mat_peptide 935..2032
/gene="ORF1"
/product="NTPase"
mat_peptide 2033..2551
/gene="ORF1"
/product="p22"
mat_peptide 2552..2950
/gene="ORF1"
/product="VPg"
mat_peptide 2951..3493
/gene="ORF1"
/product="Pro"
mat_peptide 3494..5023
/gene="ORF1"
/product="RdRp"
gene 5007..6617
/gene="ORF2"
CDS 5007..6617
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="WMX17771.1"
/translation="MKMASNDATPSDDGAAGLVPEINNEVMALEPVAGASIAAPVVGQ
QNVIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLSHLSRMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPAVLDQMYTSRSENIIVQPQNGRCTLDGELLGTT
TLQSVSICSFRGTMQAKLNGQPRYQLQITNLDGSPIDPTDDMPAPLGTPDFRAMLYGV
ASQRSPADNATRAHEAQIDTAGDTFAPKIGQVRFESGSDDFDLRDPTKFTPIGIKVDD
QHPFRQWSLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSHIPSAGGFTDGAMDCLLP
QEWIEHFYQEAAPAQSDIALVRFINPDTGRVLLEAKLHKQGFLTVAASGDHPIVMPAN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6617..7411
/gene="ORF3"
CDS 6617..7411
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="WMX17772.1"
/translation="MAGAFLAGLAGDVAASSLSSLVGAGANAINQKVEYDFNRQLQEA
SFKHDKDMLRAQVAATTGLQQAMIDIKREALTAGGFSPADAARGSVKAPMTTLLDWNG
SRHWAPNSMRTTGYSGTFTSQGIRSSPHLSNQTPGAVKPTKTLPSISSSSSVYSSPST
APSQSTQSTTLSAGTGSSRPNTVSTKTSTLSRTSDWVRDQNQMIGPFMNGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHMRRRGESQT"
ORIGIN
1 cgccgcccct tccaataaag aagaggttgg tgcattctcc aactttaaag ttggatttaa
61 gaaaatgctg ggtgccgtgc ccaagagcac caaagcgccc agcaatgacc aacaatgccc
121 cacagtcaag attggaccta gaacattagt ggtcccgcct gaaccaccaa atggagaaga
181 tatcgtgcag tttgatgcaa agtcagaaac tgtgagtggg ctaccagacc tgacaacggt
241 gcaaaatgaa catgaaaaca ccccatatac ggtccctcca ctgagtgaga gggaacacag
301 accagccgct gagccactcc ctggcacaat attagagatg tgggacggtg agttctacca
361 ctactccatc tatgtcggtg gtggtaagac cctgggggtc cacaaacccc ctgcggctat
421 aagccttgca acaatcgagc taacccccat atctctgtac tggcggcctg tctacacccc
481 taattacttg atttgtccag acacattgaa gggtcttgct ggtgagagat tcccctacac
541 ggctttcagt aacaactgtt acaacttctg ctgctgggtg ctggagctca atgacacgtg
601 gcttagcaga aagtccatat ctagaaccac tggcttcttt aaaccgtacc agacttggaa
661 cagaaagcct ctcccaactg tcgatgatgg aaagattaag aaggtggcca atgcaatcct
721 ctgtgcgctt ggttcgctgt tttcaaaacc aatcaaagac ttattaggta agctcaaacc
781 actgaatctg ctgcacttgc tcgcttcgtg tgattggacg tttgcgggta tagtggagac
841 ggtcatctta atggcggagc tcttcaacgt cttttggacc ccgcctgacg tctccaattt
901 catagcctcc ctgataggtg actttgagtt acaagggcct gaggatttgg ctgtggaact
961 agtccctgtg gttatgggtg gcataggcat ggttcttggc ttcacggctg agaagatagg
1021 ccgcatgttg tcatctgctg catcaactct ccgggcgtgc aaagatctgg gaaactacgc
1081 ccttgacata ctcaaactgg tcatgaaatg gttcttcccc aagaaagagg aaaaagctga
1141 gatggaaacc ttaagagcga ttgaggatgc tgtcttggac atggaggcta taggaaacaa
1201 tcacctcaca actcttctta aagataagga tagcctcgca gccttcatga agactctgga
1261 tctagaagag gaaaaagcga ggaagctgtc gaccaaatca tcgtcacctg acatcgtcgg
1321 caccatcaac gccatactgg ctagaatcgc cgctgccagg tccctcctac acagggccaa
1381 agaggagatg ttcagcagaa tcagaccagt ggttgttatg atctcaggca ggcctggcat
1441 tggcaagacc cacatggcaa gacacctggc caagagcatc gctggcacca tgagtggtga
1501 ccagagagtc ggactcgttc cgcggaacgg agtggaccac tgggacgcat acagagggga
1561 gagagtggtc ttgtgggacg actatggcat ggccagtcct gtcaaagatg ctttaaccct
1621 gcaagaattg gccgacactt gcccagtcac cttaaattgt gacaggattg aaaacaaagg
1681 aaaaatgttt gacagtgatg tcatcataat cacaaccaac ttggccaacc ccgcacccct
1741 cgactatgtg aactttgagg cgtgctccag aagagttgat ttcctggtct atgcagaatc
1801 accagaaatt gaaaaggtca agagggattt ccctggacaa cctgacatgt ggaaagacca
1861 cttcaagcca gaccactccc atataaaact gaccctagcc ccccagggtg ggtttgataa
1921 aaatggtaac actccgcatg gcaagggcac catgcgatct ctaacccaag gttctttaac
1981 tgcaagggtt gcagggttag tccatgagag gagagatgag ttccagctcc aaggaaatga
2041 cctccaagta tacaattttg acaccaacaa ggtctctgcg tttaggaaac tggctgcaga
2101 caacaagtat ggaatcatgg agacaatgaa ggtgggcgct gcgctcaaga atgtcaagac
2161 cttggaagat ctaaaggctg ctttgaggga tgtgaaattc aatgagtgtg agatcattta
2221 caggagctct aaatacagag tctcttccaa tggcaagggc tcagtttctg ttgataaggt
2281 tgaggaccac gcatcccaga ccgcaaatga agtgtgctca gcactcctga ggctcaggca
2341 agcgagggcc agatattata tcagctgctt ccaggacctt gtctacacgc tcatacaagt
2401 cgccggggca tcatttgttg tcaacagaat ctccaagagg ttttgctggg aaagatgggt
2461 taaaccaacc gaggctcagg agacatttga gcccgagaag gagaccgcgc aaagcaggtg
2521 ggagattgaa cccaaagatg cagaaccaga aggcaagaag ggtaaaaaca agaagggaag
2581 aggcaagaag cacacagcct tctccagcaa gggtctgagt gatgaagaat atgatgagta
2641 caagagaatc agggaggaaa ggaatggaaa gtactctatt gaggagtacc tacaagaccg
2701 ggaccgatac tacgaagaag tggcagttgc ccgagcaaca gaggaagact tctgtgaaga
2761 ggaggaggcc aagatcagac agagggtttt ccgcccaaca aggaaacaaa ggaaagagga
2821 gagaggagtg ctcggcctgg tcaccggctc agacattaga aagaggaaac cagatgactt
2881 tcaaccaaaa ggcaacttgt gggcagatga caccagaggt gtggactata atgagagaat
2941 tgactttgaa gctcccccaa gtgtttggtc tagaatagtc ccattgggaa ctggttgggg
3001 attctgggtc tcatccaatc ttctgatcac tacaacacat gtcctgccta ggggactcaa
3061 agaactcttc ggagttgagg ttaaacaaat tcagatccac aaatctggcg agttttgtag
3121 gttcagattc ccaagaccaa tcaggccaga tgtcacaggg ttggtgctag aagagggtgc
3181 tccagaaggc actgtttgct ccatacttgt aaagagacct acaggagaga tgatccccct
3241 ggcggtgagg atgggcactc atgcatccat gagaatccag ggcaggaccg tcggcggcca
3301 aatgggaatg cttctcacag gagcgaacgc caagaacatg gaccttggca ccggccctgg
3361 tgactgcggt tgcccctaca tctacaaacg cggcaatgac ataatcgttg caggcgtcca
3421 taccgcagca gcccggggag gtaacactgt catctgtgct acccaaggac aagatgggga
3481 ggcagtgctt gaagggaacg aaagtcttgg cacttactgt ggtgccccaa tcttaggccc
3541 tggcaaggca cccaagctca gcacaaagac caaattctgg cgctcatcgc cagacgcctt
3601 accacctggc acatatgaac ctgcttacct aggaggcaag gaccctagag tggagaaagg
3661 gccctccctg cagcaggtca tgagagacca gctaaaaccc ttcacggagc ctaggggcaa
3721 accaccgaga cctgcaatcc tagaagaggc taagaagaca gtgatgaatg tcctggagca
3781 gaccatcgac cctgctaaac cttggaccta ctctcaagca tgtgcatcac tagataaaac
3841 cacctccagt ggcagccctc accatgtcag gaagaatgac tactggaatg gagagtcttt
3901 cacaggtccc cttgcagacc aagcatctaa agctaacctc atgtatgagc aggccaaaca
3961 tgtgcagccc atgtacacgg ccgccctcaa ggatgaactt gttaagactg ataaaatcta
4021 caaaaagata aagaagagac tcctgtgggg atcagacctt ggcacgatga tcaggtgcgc
4081 cagggctttt ggtggcctca tggacagcat gaaggcgagc tgcatagctc ttccttgtag
4141 ggtggggatg aacatgaatg aggatggtcc aatcatcttt gacaagcact ccaagtacag
4201 attccattat gatgctgact attcaaggtg ggactcaacc caacaaagga gtatcctaac
4261 tgccgctatg gaggtgatgg ttcggttctc tgcagaacca gagttagcac aagtagtagc
4321 agaggatctc ttggcaccta gtcaactgga tgttggtgat tttgttgtct cagtccagga
4381 gggtttgcca tcgggtgttc catgcacatc acaatggaac tcgatagcgc actggattct
4441 aaccttaagt gcaatggcag aggtgtcagg cctttcacca gatgttgtcc aggctcattc
4501 ctgtttctcc ttctatggcg atgatgagat tgtcagcacc gatatcaaca ttgaccctgc
4561 aaaattgaca cagaaactca gggaatatgg ccttgtcccc acccggcctg acaagactga
4621 gggtcccctc gtcataactg agaacctggc tggcctgact ttcctccgca ggtcgatagc
4681 gcgggatcca gctgggtggt ttggaaaact ggaccaagac tcaattctca gacaactgta
4741 ctggacaaga gggcctaacc atgaaaaccc atacgaaagc atggtccccc attcccaacg
4801 agctacacag ctcatggccc tccttggtga ggcctcacta catgggcccc agttttacaa
4861 gaaggttagc aaaatggtca tcaatgagat caaaagtggt ggtctggaat tttacgtgcc
4921 cagacaagag gccatgttca ggtggatgag attctctgac ctcagcacgt gggagggcga
4981 tcgcaatctt gctcccgagg gtgtgaatga agatggcgtc gaatgacgct actccatctg
5041 atgatggtgc agccggcctc gtaccagaga tcaacaatga ggttatggct cttgaacccg
5101 ttgctggggc ctccattgca gcccccgtgg tcgggcaaca aaatgtaata gatccctgga
5161 ttagaaataa ctttgtacaa gcccctgctg gtgaattcac agtttcccct agaaactctc
5221 ctggagaact cttacttgat ttagaattgg gccctgaact gaatccctat ctttcacacc
5281 tgtccaggat gtacaatggg cacgcaggtg gaatggaagt gcagatagta ctggctggga
5341 atgcgttcac agctggtaag atcctatttg ctgccatccc acctagcttc ccctatgaaa
5401 atttgtcacc tgctcaattg actatgtgcc cccatgtaat agtggatgtg agacaactag
5461 aaccagtgct tctgccaatg ccagacataa gaaatgtttt ctatcactat aaccaaaaca
5521 atagtcccaa actcaggctt gtagctatgc tttacactcc tttgagagct aacaactcag
5581 gtgatgacgt gttcacggtg tcttgccgcg ttttgacacg cccctctcca gacttccagt
5641 tcacctttct ggtcccaccc acagttgaat ctaaaactaa gaactttacc cttcctgtcc
5701 ttagggtctc agagatgaca aactcaaggt tccccgctgt tttggaccaa atgtacacaa
5761 gcaggagtga aaacatcatt gtccaacccc aaaatggcag gtgcacgctt gacggtgagc
5821 tgctcggcac caccaccttg caatctgtgt ctatatgcag ttttagagga acaatgcagg
5881 caaagctgaa tggacaacca cgataccaat tacaaatcac caatttggat ggctcaccca
5941 tagacccaac agatgacatg cctgcccccc ttggcacacc agatttccgg gccatgttgt
6001 atggcgttgc aagtcaacgc tcccccgcag acaacgccac tagggcacat gaggcacaga
6061 ttgacactgc gggtgacact ttcgccccga aaattggcca ggtccgtttc gaatcaggct
6121 ctgatgattt tgacctacgt gaccctacaa agttcacacc cattggtatc aaagtggatg
6181 atcagcaccc ctttagacag tggtccctgc caaactatgg tggtcacctt gccctgaaca
6241 atcatttagc ccccgctgtg acaccactct tccccggcga gcagatcttg ttcttcaggt
6301 cacacattcc aagcgccgga ggttttacag acggtgctat ggactgcttg ctgccccaag
6361 agtggataga gcacttctac caggaggcag ctcctgccca gtctgacatc gcactggtga
6421 ggttcattaa ccccgataca ggaagagtgc tccttgaagc caagttgcac aaacagggct
6481 tccttacagt tgcagcatct ggagaccacc ccattgtgat gcccgctaat ggttacttta
6541 ggtttgaagc ttgggtcaac cccttctaca ctctcgcccc cgtgggaact gggtctgggc
6601 gcagaaggat tcagtaatgg caggagcttt ccttgcaggt ctagcaggtg acgttgcggc
6661 ttctagtttg agctcactcg tgggcgctgg agccaacgcc atcaatcaga aggtggagta
6721 cgacttcaac agacaactcc aggaggcttc cttcaaacat gacaaggata tgctcagagc
6781 ccaggttgca gcaacaacag gcctccaaca ggccatgata gatatcaagc gggaggcatt
6841 gaccgcaggc ggcttttccc ccgctgatgc tgcaagaggt tcagtcaagg cgcccatgac
6901 aacactcctt gattggaatg gctctaggca ttgggcaccc aactccatga ggacaactgg
6961 ttattcaggc acatttactt cccagggcat tagaagctct ccccacctgt ctaatcaaac
7021 tccaggtgct gtcaaaccca ctaaaacctt gccatctata tctagttctt ctagtgtgta
7081 tagctctcct tctactgccc cctcgcaatc aacacaatca actacgctgt ctgcaggaac
7141 agggtcgtcc aggcctaaca ccgtgtccac aaagacctcc acactgtcga ggacaagtga
7201 ctgggtcaga gatcaaaatc agatgattgg cccgttcatg aatggtgcac ttcaaactgc
7261 ttatgtcact ccaccatcga gcagggcctc atcacaaggg acggtctcga ccgtacccaa
7321 ggctgttttg gactcctgga ctcctatgtt caacacccac aggcagcctc tcttcgccca
7381 catgcgtagg cgaggggagt cacagactta gtgaaaagga tgattaggac t
//