Typing tool
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Typing tool
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Complete norovirus genomes
| OR536463 | GII.14 | |
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| GII.P7 |
ORF1: 4..5097
ORF2: 5078..6688
ORF3: 6688..7482
LOCUS OR536463 7515 bp RNA linear VRL 04-MAR-2024
DEFINITION Norovirus GII isolate Hu/NL/2021/GII.14/Rotterdam/I129S33_P18-d1765
nonstructural polyprotein (ORF1), VP1 (ORF2), and VP2 (ORF3) genes,
complete cds.
ACCESSION OR536463
VERSION OR536463.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7515)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Intra-host multi-lineage evolution of human Norovirus in
immunocompromised individuals: Implications for treatment
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7515)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Direct Submission
JOURNAL Submitted (11-SEP-2023) Viroscience, Erasmus Medical Center, Dr.
Molewaterplein 40, Rotterdam, Zuid-Holland 3015 GD, Netherlands
COMMENT ##Assembly-Data-START##
Assembly Method :: Spades v. 3.15.4; BWA-MEM v. 0.7.17
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7515
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/NL/2021/GII.14/Rotterdam/I129S33_P18-d1765"
/isolation_source="feaces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Netherlands: Rotterdam"
/collection_date="07-Oct-2021"
/note="genotype: GII.14"
gene 4..5097
/gene="ORF1"
CDS 4..5097
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="WMX17767.1"
/translation="MKMASNDATTAFGSQNSVNDSTNTAPSNKEEVGAFSNFKVGFKK
MLGAVPKSTKAPSSDQQCPTVKIGPRTLVVPPEPPNGEDIVQFDAKSETVSGLPDLTT
VQNEHENTPYTVPPLSEREHRPAAEPLPGTILEMWDGEFYHYSIYVGGGKTLGVHKPP
AAISLATIELTPISLYWRPVYTPNYLICPDTLKGLAGERFPYTAFSNNCYNFCCWVLE
LNDTWLSRKSISRTTGFFKPYQTWNRKPLPTFDDGKIKKVANAILCALGSLFSKPIKD
LLGKLKPLNLLHLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQ
GPEDLAVELVPVVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMK
WFFPKKEEKAEMETLRAIEDAILDMEAIGNNHLTALLKDKDSLAAFMKTLDLEEEKAR
KLSTKSSSPDIVGTINAILARIAAARSLLHRAKEEMFSRVRPVVVMISGRPGIGKTHM
ARHLAKSIAGTMSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMASPVKDALTLQEL
ADTCPVTLNCDRIENKGKMFDSDVIIITTNLANPAPLDYVNFEACSRRVDFLVYAESP
EIEKVKRDFPGQPDMWKDHFKPDHSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSL
TARVAGLVHERRDEFQLQGNDLQVYNFDTNKVSAFRKLAADNKYGIIETMKVGAALKN
VKTLEDLKAALRDVKFNECEIIYRSSKYRVSSNGKGSVSVDKVEDHASQTANEVCSAL
LRLRQARAKYYLSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQETFESEK
ETAQSRWEIEPKDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKY
SIEEYLQDRDRYYEEVAVARATEEDFCEEEEAKIRQRVFRPTRRQRKEERGVLGLVTG
SDIRKRKPDDFQPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNL
LITTTHVLPRGLKELFGVEVKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTV
CSILVKRPTGEMIPLAVRMGTHASMRIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCG
CPYIYKRGNDIVVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPG
KAPKLSTKTKFWRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRG
KPPRPAILEEAKKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNG
ESFTGPLADQASKANLMYEQAKHVQPMYTAALKDELVKTDKIYKKIKKRLLWGSDLGT
MIRCARAFGGLMDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRFHYDADYSRWDST
QQRSILTAAMEVMVRFSAEPELAQVVAEDLLAPSQLDVGDFVVSVQEGLPSGVPCTSQ
WNSIAHWILTLSAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINIDPAKLTQKLREY
GLVPTRPDKTEGPLVITENLAGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNH
ENPYESMVPHSQRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAM
FRWMRFSDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide 4..1005
/gene="ORF1"
/product="p48"
mat_peptide 1006..2103
/gene="ORF1"
/product="NTPase"
mat_peptide 2104..2622
/gene="ORF1"
/product="p22"
mat_peptide 2623..3021
/gene="ORF1"
/product="VPg"
mat_peptide 3022..3564
/gene="ORF1"
/product="Pro"
mat_peptide 3565..5094
/gene="ORF1"
/product="RdRp"
gene 5078..6688
/gene="ORF2"
CDS 5078..6688
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="WMX17768.1"
/translation="MKMASNDATPSDDGAAGLVPEINNEVMALEPVAGASIAAPVVGQ
QNVIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLSHLSRMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPAVLDQMYTSRSENIIVQPQNGRCTLDGELLGTT
TLQSVSICNFRGTMQAKLNGQPRYQLQITNLDGSPIDPTDDMPAPLGTPDFQAMLYGV
ASQRSPADNATRAHEAQIDTAGDTFAPKIGQVRFESGSDDFDLHDPTKFTPIGIKVDD
QHPFRQWSLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSHIPSAGGFTDGAMDCLLP
QEWIEHFYQEAAPAQSDIALVRFINPDTGRVLLEAKLHKQGFLTVAASGDHPIVMPAN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6688..7482
/gene="ORF3"
CDS 6688..7482
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="WMX17769.1"
/translation="MAGAFLAGLAGDVAASSLSSLVGAGANAINQKVEYDFNRQLQEA
SFKHDKDMLRAQVAATTGLQQAMIDIKREALTAGGFSPADAARGSVKAPMTTLLDWNG
SRHWAPNSMRTTGYSGTFTSQGIRSSPHLSNQTPSAVKPTKTLPSISSSSSVYSSPST
APSQSTQSTTLSAGTGSSRPNTVSTKTSTLSRTSDWVRDQNQMIGPFMNGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHMRRRGESQT"
ORIGIN
1 tgaatgaaga tggcgtctaa cgacgctacc actgcctttg gcagccaaaa ctctgtcaat
61 gacagtacta acaccgctcc ttccaataag gaagaggtcg gtgcattttc caactttaaa
121 gttggattta agaaaatgct gggtgccgtg cccaagagca ccaaagcgcc cagcagtgac
181 caacaatgcc ccacagtcaa gattggaccc agaacattag tggtcccgcc tgaaccacca
241 aatggagaag atatcgtgca gtttgatgca aagtcagaaa ctgtgagtgg gctaccagac
301 ctgacaacgg tgcaaaatga acatgaaaac accccatata cggtccctcc actgagtgag
361 agggaacaca gaccagccgc tgagccactc cctggcacaa tattagagat gtgggacggt
421 gagttctacc actactccat ctacgtcggt ggtggtaaga ccctgggggt ccacaaaccc
481 cctgcggcta taagccttgc aacaatcgag ttaaccccca tatctctgta ctggcggcct
541 gtctacaccc ctaattactt gatctgtcca gacacattga agggtcttgc tggtgagagg
601 ttcccctaca cggctttcag caacaactgt tacaacttct gctgctgggt gttggaactc
661 aacgacacgt ggcttagcag gaagtccata tctagaacaa ctggcttctt taaaccgtac
721 cagacttgga acagaaagcc tctcccaact ttcgatgatg gaaagattaa gaaagtggcc
781 aatgcaatcc tctgtgcgct tggttcgctg ttttcaaaac caatcaaaga cttattaggt
841 aagctcaaac cactgaatct gctgcacttg ctcgcttcgt gtgattggac gtttgcgggt
901 atagtggaga cggtcatctt aatggcggag ctcttcaacg tcttttggac cccgcctgac
961 gtctccaatt tcatagcctc cctgataggt gactttgagt tacaagggcc tgaggatttg
1021 gctgtggaac tagtccctgt ggttatgggt ggcataggca tggttcttgg cttcacggct
1081 gagaagatag gccgcatgtt gtcatctgct gcatcaactc tccgggcgtg caaagatctg
1141 ggaaactacg cccttgacat acttaaactg gtcatgaaat ggttcttccc caagaaagag
1201 gaaaaagctg agatggaaac cttaagggcg attgaggatg ctatcttgga catggaggct
1261 atagggaaca atcacctcac agctcttctt aaagacaagg atagcctcgc agccttcatg
1321 aagaccctag atctagaaga ggaaaaggcg aggaagctgt cgaccaaatc atcgtcacct
1381 gacatcgtcg gtaccatcaa cgccatactg gctagaattg ccgctgccag gtccctccta
1441 cacagggcca aagaggagat gttcagcaga gtcagaccag tggttgttat gatctcaggc
1501 aggcctggca ttggcaagac ccacatggca agacacctgg ccaagagcat cgctggcacc
1561 atgagtggtg accagagagt cggactcgtt ccgcggaacg gagtggacca ctgggacgca
1621 tacagagggg agagagtggt cttgtgggac gactatggca tggccagtcc tgtcaaagat
1681 gctttaaccc tgcaagaatt ggccgacact tgcccagtca ccttaaattg tgacaggatt
1741 gaaaacaaag gaaaaatgtt tgacagtgat gtcatcataa tcacaaccaa cttggccaac
1801 cccgcacccc tcgactatgt gaactttgag gcgtgctcca gaagagttga tttcctggtc
1861 tatgcagaat caccagaaat tgaaaaagtc aagagggatt tccctggcca acctgacatg
1921 tggaaagacc acttcaagcc agaccactcc cacataaaac tgaccctagc cccccagggc
1981 gggtttgaca agaatggtaa cactccgcat ggcaagggca ccatgcgatc tctaacccaa
2041 ggttctttga ctgcaagggt tgcagggtta gtccatgaga ggagagatga gttccagctc
2101 caaggaaatg acctccaagt atacaatttt gacaccaaca aggtttctgc gtttaggaaa
2161 ctggctgcag acaacaaata tgggatcatt gagacaatga aggtgggcgc tgcactcaag
2221 aatgtcaaaa ccttggagga tctgaaggct gctttgaggg atgtgaaatt caatgagtgt
2281 gagatcattt acaggagttc taaatataga gtctcttcca atggtaaggg ttcagtttct
2341 gttgacaagg tcgaggacca cgcatcccag actgcaaatg aagtgtgttc agcactcctg
2401 aggctcaggc aagcaagggc caaatattat ctcagctgct tccaggacct tgtctacacg
2461 ctcatacaag tcgccggggc gtcatttgtt gtcaacagaa tctccaagag gttttgctgg
2521 gaaagatggg tcaaaccaac cgagactcag gagacatttg agtccgagaa ggagaccgct
2581 caaagcaggt gggagattga acccaaagac acagaaccag aaggcaagaa gggtaaaaac
2641 aagaagggaa gaggcaagaa gcacacagcc ttctccagca agggtctgag tgatgaagag
2701 tatgatgagt acaagagaat cagggaggaa aggaatggaa agtactctat tgaggagtac
2761 ctacaagacc gggaccgata ctacgaagaa gtggcagttg cccgagcaac agaggaagac
2821 ttctgtgaag aggaggaggc caagatcaga cagagggttt tccgcccaac aaggagacaa
2881 aggaaagagg agagaggagt gctcggcctg gtcaccggct cagacattag aaagagaaaa
2941 ccagatgact tccaaccaaa aggcaacttg tgggcagatg acaccagaag tgtggactac
3001 aatgagagac ttgatttcga agctcccccg agtgtttggt ccaggatagt cccattggga
3061 actggttggg ggttctgggt ctcgtccaat ctcctgatca ctacaacaca tgtcctgccc
3121 aggggactca aagaactctt cggagttgag gttaaacaaa tccagatcca caagtctggc
3181 gagttttgta gattcagatt cccaagacca atcaggccag atgtcacagg gttggtgcta
3241 gaagagggtg ctccagaagg cactgtttgc tccatacttg tgaagagacc cacaggagag
3301 atgattccct tggcggtgag gatgggcact catgcatcca tgagaatcca gggcaggacc
3361 gtcggcggcc aaatgggaat gcttctcaca ggagcaaacg ccaagaacat ggaccttggc
3421 accggccctg gtgattgcgg ttgtccctac atctataaac gcggcaacga catagttgtt
3481 gcaggtgttc ataccgcagc agcccgggga ggtaacactg tcatctgtgc tacccaagga
3541 caagatgggg aggcagtgct tgaagggaac gaaaatcttg gcacttactg tggtgccccg
3601 atcctaggtc ctggcaaggc acccaagctc agcacaaaaa ccaaattctg gcgctcatcg
3661 ccagatgccc taccacctgg cacatatgag cctgcttacc taggaggcaa ggaccctaga
3721 gtggagaaag ggccctccct gcagcaggtc atgagagatc agctaaaacc cttcacagag
3781 cctagaggta aaccaccgag acctgcgatc ctagaagagg ctaagaagac agtgatgaat
3841 gttttggaac agaccatcga ccctgctaaa ccttggacct actctcaagc atgtgcatca
3901 ctagataaaa ccacctccag tggtagcccc caccatgtca ggaagaatga ccactggaat
3961 ggagagtctt tcacaggtcc ccttgcagac caagcatcta aagctaacct catgtatgag
4021 caggccaaac atgtgcagcc catgtacacg gccgccctca aggatgaact tgttaagact
4081 gataaaatct acaaaaagat aaagaagaga ctcctgtggg gatcagacct tggcacgatg
4141 atcaggtgcg ccagggcttt tggtggcctc atggacagca tgaaggcgag ctgcatagct
4201 cttccttgta gggtggggat gaacatgaat gaggatggtc caatcatctt tgacaagcac
4261 tccaagtaca gattccatta tgatgctgac tattcaaggt gggactcaac ccaacaaagg
4321 agtatcctaa ctgccgctat ggaggtgatg gttcggttct ctgcagaacc agagttagca
4381 caagtagtag cagaggatct cttggcacct agtcaactgg atgttggtga ttttgttgtc
4441 tcagtccagg agggtttgcc atcgggtgtt ccatgcacat cacaatggaa ctcgatagcg
4501 cactggattc taaccttaag tgcaatggca gaagtgtcag gcctttcacc agatgttgtc
4561 caggctcatt cctgtttctc cttctatggt gatgatgaga ttgtcagcac cgatatcaac
4621 attgaccctg caaaattgac acagaaactc agggaatatg gccttgtccc cacccggcct
4681 gacaagactg agggtcccct cgtcataact gagaacctag ctggcctgac tttcctccgc
4741 aggtcgatag cgcgggatcc agctgggtgg tttggaaaac tggaccaaga ctcaattctc
4801 agacaactgt actggacaag agggcctaac catgaaaacc catacgaaag catggtcccc
4861 cattcccaac gagctacaca gctcatggcc ctccttggtg aggcctcact acatgggccc
4921 cagttttaca agaaggttag caaaatggtc atcaatgaga tcaaaagtgg tggtctggaa
4981 ttttacgtgc ccagacaaga ggccatgttc aggtggatga gattctctga cctcagcacg
5041 tgggagggcg atcgcaatct tgctcccgag ggtgtgaatg aagatggcgt cgaatgacgc
5101 tactccatct gatgatggtg cagccggcct cgtaccagag atcaacaatg aggttatggc
5161 tcttgaaccc gttgctgggg cctccattgc agcccccgtg gtcgggcaac agaatgtaat
5221 agatccctgg attagaaata actttgtaca agcccctgct ggtgaattca cagtttcccc
5281 tagaaactct cctggagaac tcttacttga tttagaattg ggccctgaac tgaatcccta
5341 tctttcacac ctgtccagga tgtacaatgg gcacgcaggt ggaatggaag tgcagatagt
5401 actggctggg aatgcgttca cagctggtaa gatcctattt gctgccatcc cacctagctt
5461 cccctatgaa aatttgtcac ctgctcaatt gactatgtgc ccccatgtaa tagtggatgt
5521 gagacaacta gaaccagtgc ttctgccaat gccagacata agaaatgttt tctatcacta
5581 taaccaaaac aatagtccca aactcaggct tgtagctatg ctttatactc ctttgagagc
5641 taacaactca ggtgatgacg tgttcacggt gtcttgccgc gttttgacac gcccctctcc
5701 agacttccag ttcacctttc tggtcccacc cacagttgaa tctaaaacta agaactttac
5761 ccttcctgtc cttagggtct cagagatgac aaactcaagg ttccccgctg ttttggacca
5821 aatgtacaca agcaggagtg aaaacatcat tgtccaaccc caaaacggca ggtgcacgct
5881 tgacggtgag ctgctcggta ccaccacctt gcaatctgtg tctatatgca attttagagg
5941 aacaatgcag gcaaagctga atggacaacc acgataccaa ttacaaatca ccaatttgga
6001 tggctcaccc atagacccaa cagatgacat gcctgccccc cttggcacac cagatttcca
6061 ggccatgttg tatggcgttg caagtcaacg ctcccccgca gacaacgcca ctagggcaca
6121 tgaagcacag attgacactg cgggtgacac tttcgccccg aaaattggcc aggtccgttt
6181 cgaatcaggc tctgatgatt ttgacctaca tgaccctaca aagttcacac ccattggtat
6241 caaagtggat gatcagcacc cctttagaca gtggtccctg ccaaactatg gtggtcacct
6301 tgccctgaac aatcatttag cccccgctgt gacaccactc ttccccggcg agcagatttt
6361 gttcttcagg tcacacattc caagcgccgg aggctttaca gacggtgcta tggactgctt
6421 gctgccccaa gagtggatag agcacttcta ccaggaggca gctcctgccc agtctgacat
6481 cgcactggtg aggttcatta accccgatac aggaagagtg ctccttgaag ccaagttgca
6541 caaacagggc ttccttacag ttgcagcatc tggagaccac cccattgtga tgcccgctaa
6601 tggttatttt aggtttgaag cttgggtcaa ccccttctac actctcgccc ccgtgggaac
6661 tgggtctggg cgcagaagga ttcagtaatg gcaggagctt tccttgcagg tctagcaggt
6721 gacgttgcgg cttctagttt gagctcactc gtgggcgctg gagccaacgc catcaatcag
6781 aaggtggagt acgacttcaa cagacaactc caggaggctt ccttcaaaca tgacaaggat
6841 atgctcagag cccaggttgc agcaacaaca ggcctccaac aggccatgat agatatcaag
6901 cgggaggcat tgaccgcagg cggcttttcc cccgctgatg ctgcaagagg ttcagtcaag
6961 gcgcccatga caacgctcct tgattggaat ggctctaggc attgggcacc caactccatg
7021 aggacaactg gctattcagg cacatttact tcccagggca ttagaagctc cccccacctg
7081 tctaatcaaa ctccaagtgc tgtcaaaccc actaaaacct tgccatctat atctagttct
7141 tctagtgtgt atagctctcc ttctactgcc ccctcgcaat caacacaatc aactacgctg
7201 tctgcaggaa cagggtcgtc caggcctaac accgtgtcca caaagacctc cacactgtcg
7261 aggacaagtg actgggtcag agatcaaaat cagatgattg gcccgttcat gaatggtgca
7321 cttcaaactg cttatgtcac tccaccatcg agcagggcct catcacaagg gacggtctcg
7381 accgtaccca aggctgtttt ggactcctgg actcctatgt tcaacaccca caggcagcct
7441 ctcttcgccc acatgcgtag gcgaggggag tcacagactt agtgaaaagg atgattaggg
7501 cttttctttc ctttc
//