Typing tool
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Typing tool
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Complete norovirus genomes
| OR536462 | GII.14 | |
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| GII.P7 |
ORF1: 1..5085
ORF2: 5066..6676
ORF3: 6676..7426
LOCUS OR536462 7426 bp RNA linear VRL 04-MAR-2024
DEFINITION Norovirus GII isolate Hu/NL/2021/GII.14/Rotterdam/I129S32_P18-d1744
nonstructural polyprotein (ORF1) gene, partial cds; VP1 (ORF2)
gene, complete cds; and VP2 (ORF3) gene, partial cds.
ACCESSION OR536462
VERSION OR536462.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7426)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Intra-host multi-lineage evolution of human Norovirus in
immunocompromised individuals: Implications for treatment
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7426)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Direct Submission
JOURNAL Submitted (11-SEP-2023) Viroscience, Erasmus Medical Center, Dr.
Molewaterplein 40, Rotterdam, Zuid-Holland 3015 GD, Netherlands
COMMENT ##Assembly-Data-START##
Assembly Method :: Spades v. 3.15.4; BWA-MEM v. 0.7.17
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7426
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/NL/2021/GII.14/Rotterdam/I129S32_P18-d1744"
/isolation_source="feaces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Netherlands: Rotterdam"
/collection_date="16-Sep-2021"
/note="genotype: GII.14"
gene <1..5085
/gene="ORF1"
CDS <1..5085
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="WMX17764.1"
/translation="ASNDATTAFGSQNSVNDSTNTAPSNKEEVGAFSNFKVGFKKMLG
AVPKSTKAPSSDQQCPTVKIGPRTLVVPPEPPNGEDIVQFDVKSETVSGLPDLTTVQN
EHENTPYTVPPLSEREHRPAAEPLPGTILEMWDGEFYHYSIYVGGGKTLGVHKPPAAI
SLATIELTPISLYWRPVYTPNYLICPDTLKGLAGERFPYTAFSNNCYNFCCWVLELND
TWLSRKSISRTTGFFKPYQTWNRKPLPTFDDGKIKKVANAILCALGSLFSKPIKDLLG
KLKPLNLLHLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPE
DLAVELVPVVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFF
PKKEEKAEMETLRAIEDAILDMEAIGNNHLTALLKDKDSLAAFMKTLDLEEEKARKLS
TKSSSPDIVGTINAILARIAAARSLLHRAKEEMYSRVRPVVVMISGRPGIGKTHMARH
LAKSIANTMSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMASPVKDALTLQELADT
CPVTLNCDRIENKGKMFDSDVIIITTNLANPAPLDYVNFEACSRRVDFLVYAESPEIE
KVKRDFPGQPDMWKDHFKPDHSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTAR
VAGLVHERRDEFQLQGNDLQVYNFDTNKVSAFRKLAADNKYGIIETMKVGAALKNVKT
LEDLKAALRDVKFNECEIIYRSSKYRVSSNGKGSVSVDKVEDHASQTANEVCSALLRL
RQARAKYYLSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQETFESEKETA
QSRWEIEPKDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEYKRIREERDGKYSIE
EYLQDRDRYYEEVAVARATEENFCEEEEAKIRQRVFRPTRRQRKEERGVLGLVTGSDI
RKRKPDDFQPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLIT
TTHVLPRGLKELFGVEVKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSI
LVKRPTGEMIPLAVRMGTHASMRIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPY
IYKRGNDIVVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAP
KLSTKTKFWRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPP
RPAILEEAKKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESF
TGPLADQASKANLMYEQAKHVQPMYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIR
CARAFGGLMDSMKASCIALPCRVGMNMNEDGPIIFDKHAKFKYHYDADYSRWDSTQQR
SILTAAMEVMVRFSAEPELAQVVAEDLLAPSQLDVGDFVVSVQEGLPSGVPCTSQWNS
IAHWILTLSAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINIDPAKLTQKLREYGLV
PTRPDKTEGPLVITENLAGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENP
YESMVPHSQRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRW
MRFSDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide <1..993
/gene="ORF1"
/product="p48"
mat_peptide 994..2091
/gene="ORF1"
/product="NTPase"
mat_peptide 2092..2610
/gene="ORF1"
/product="p22"
mat_peptide 2611..3009
/gene="ORF1"
/product="VPg"
mat_peptide 3010..3552
/gene="ORF1"
/product="Pro"
mat_peptide 3553..5082
/gene="ORF1"
/product="RdRp"
gene 5066..6676
/gene="ORF2"
CDS 5066..6676
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="WMX17765.1"
/translation="MKMASNDATPSDDGAAGLVPEINNEVMALEPVAGASIAAPVVGQ
QNVIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLSHLSRMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPAVLDQMYTSRSENIIVQPQNGRCTLDGELLGTT
TLQSVSICNFRGTMQAKLNGQPRYQLQITNLDGSPIDPTDDMPAPLGTPDFQAMLYGV
ASQRSPADNATRAHEAQIDTAGDTFAPKIGQVRFESGSDDFDLHDPTKFTPIGIKVDD
QHPFRQWSLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSHIPSAGGFTDGAMDCLLP
QEWIEHFYQEAAPAQSDIALVRFINPDTGRVLLEAKLHKQGFLTVAASGDHPIVMPAN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6676..>7426
/gene="ORF3"
CDS 6676..>7426
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="WMX17766.1"
/translation="MAGAFLAGLAGDVAASSLSSLVGAGANAINQKVEYDFNRQLQEA
SFKHDKDMLRAQVAATTGLQQAMIDIKREALTAGGFSPADAARGSVKAPMTTLLDWNG
SRHWAPNSMRTTGYSGTFTSQGIRSSPHLSNQTPSAVKPTKTLPSISSSSSVYSSPST
APSQSTQSTTLSAGTGSSRPNTVSTKTSTLSRTSDWVRDQNQMIGPFMNGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQ"
ORIGIN
1 gcgtctaacg acgctaccac tgcctttggc agccaaaact ctgtcaatga cagtactaac
61 accgctcctt ccaataagga agaggtcggt gcattttcca actttaaagt tggatttaag
121 aaaatgctgg gtgccgtgcc caagagcacc aaagcgccca gcagtgacca acaatgcccc
181 acagtcaaga ttggacccag aacattagtg gtcccgcctg aaccaccgaa tggagaagat
241 atcgtgcagt ttgatgtaaa gtcagaaact gtgagtgggc taccagacct gacaacggtg
301 caaaatgaac atgaaaacac cccatataca gtccctccac tgagtgagag ggaacacaga
361 ccagccgctg agccactccc tggcacaata ttagagatgt gggacggtga gttctaccac
421 tactccatct acgtcggtgg tggtaagacc ctgggggtcc acaaaccccc tgcggctata
481 agccttgcaa caatcgagtt aacccccata tctctgtact ggcggcctgt ctacacccct
541 aattacttga tctgtccaga cacattgaag ggtcttgctg gtgagaggtt cccctacacg
601 gctttcagca acaactgtta caacttctgc tgctgggtgt tggaactcaa cgacacgtgg
661 cttagcagga agtccatatc tagaacaact ggcttcttta aaccgtacca gacttggaac
721 agaaagcctc tcccaacttt cgatgatgga aagattaaga aagtggccaa tgcaattctc
781 tgtgcgcttg gttcgctatt ctcaaaacca atcaaagacc tattaggcaa gctcaaacca
841 ctgaacctgc tgcacctgct cgcttcgtgt gattggacgt ttgcgggtat agtggagacg
901 gtcatcttaa tggcggaact ctttaacgtc ttctggaccc cgcctgacgt ctccaatttc
961 atagcctccc tgataggtga ctttgagttg caagggcctg aggacttagc tgtggaacta
1021 gtccctgtgg ttatgggtgg cataggcatg gttcttggct tcacggctga gaagataggc
1081 cgcatgttgt catctgctgc atcaactctc cgggcgtgca aagatctggg aaactacgcc
1141 cttgacatac tcaaactggt catgaaatgg ttcttcccca agaaagagga aaaagctgag
1201 atggaaacct taagggcgat tgaggatgct atcttggaca tggaggctat agggaacaat
1261 cacctcacag ctcttcttaa agacaaggat agcctcgcag ccttcatgaa gaccctagat
1321 ctagaagagg aaaaggcgag gaagctgtcg accaaatcat cgtcacctga catcgtcggt
1381 accatcaacg ccatactggc tagaattgcc gctgccaggt ccctcctaca cagggccaaa
1441 gaggagatgt acagcagagt cagaccagtg gttgttatga tttcaggcag gcccggcatt
1501 ggcaagaccc acatggcgag acacctggcc aagagcatcg ctaacaccat gagtggtgac
1561 cagagagtcg gactcgttcc gcggaacgga gtggaccact gggatgcata cagaggggag
1621 agagtggtct tgtgggatga ctatggcatg gccagtcctg tcaaagacgc tttaaccctg
1681 caagaattgg ccgacacttg cccagtcacc ttaaattgtg acaggattga aaacaaaggg
1741 aaaatgtttg acagtgatgt tatcataatc acaaccaact tggccaatcc cgcacccctc
1801 gactatgtga actttgaggc gtgctccaga agagttgatt tcctggtcta tgcagaatca
1861 ccagaaattg aaaaagtcaa gagggatttc cctggccaac ctgacatgtg gaaagaccac
1921 ttcaagccag accactccca cataaaactg accctagccc cccagggcgg gtttgacaag
1981 aatggtaaca ctccgcatgg caagggcacc atgcgatctc taacccaagg ttctttgact
2041 gcaagggttg cagggttagt ccatgagagg agagatgagt tccagctcca aggaaatgac
2101 ctccaagtat acaattttga caccaacaag gtttctgcgt ttaggaaact ggctgcagac
2161 aacaaatatg ggatcattga gacaatgaag gtgggcgctg cactcaagaa tgtcaaaacc
2221 ttggaagatc tgaaggctgc tttgagggat gtgaaattca atgagtgtga gatcatttac
2281 aggagttcta aatatagagt ctcttccaat ggtaagggtt cagtttctgt tgacaaggtc
2341 gaggaccacg catcccagac tgcaaatgaa gtgtgttcag cactcctgag gctcaggcaa
2401 gcaagggcca aatattatct cagctgcttc caggaccttg tctacacgct catacaagtc
2461 gccggggcgt catttgttgt caacagaatc tccaagaggt tttgctggga aagatgggtc
2521 aaaccaaccg agactcagga gacatttgag tccgagaagg agaccgctca aagcaggtgg
2581 gagattgaac ccaaagacac agaaccagaa ggcaagaagg gtaaaaacaa gaagggaaga
2641 ggcaagaagc acacagcctt ctccagcaag ggtctgagtg atgaagagta tgatgagtac
2701 aagagaatca gggaggaaag agatggaaag tactccattg aggagtacct acaagaccgg
2761 gaccgatact acgaagaagt ggcagtcgcc cgagcaacag aggaaaactt ctgtgaagag
2821 gaggaggcca agatcaggca gagggttttc cgcccaacga ggagacaaag gaaagaggag
2881 agaggagtgc tcggcctggt caccggctca gacattagaa agagaaaacc agatgacttc
2941 caaccaaaag gcaacttgtg ggcagatgac accagaagtg tggactacaa tgagagactt
3001 gattttgaag ctcccccgag tgtttggtcc aggatagtcc cattgggaac tggttggggg
3061 ttctgggtct cgtccaatct cctgatcact acaacacatg tcctgcccag gggactcaaa
3121 gaactcttcg gagttgaggt taaacaaatc cagatccaca agtctggcga gttttgtaga
3181 ttcagattcc caagaccaat caggccagat gtcacagggt tggtgctaga agagggtgct
3241 ccagaaggca ctgtttgctc catacttgtg aagagaccca caggagagat gattcccttg
3301 gcggtgagga tgggcactca tgcatccatg agaatccagg gcaggaccgt cggcggccaa
3361 atgggaatgc ttctcacagg agcaaatgcc aagaacatgg accttggcac cggccctggt
3421 gattgcggtt gtccctacat ctataaacgc ggcaacgaca tagttgttgc aggtgttcat
3481 accgcagcag cccggggagg taacactgtc atctgtgcta cccaaggaca agatggggag
3541 gcagtgcttg aagggaacga aaatcttggc acttactgtg gtgccccgat cctaggtcct
3601 ggcaaggcac ccaagctcag cacaaaaacc aaattctggc gctcatcgcc agatgcccta
3661 ccacctggca catatgagcc tgcttaccta ggaggcaagg accctagagt ggagaaaggg
3721 ccctccctgc agcaggtcat gagagaccag ctaaaaccct tcacagagcc tagaggtaaa
3781 ccaccgagac ctgcgatcct agaagaggct aagaagacag tgatgaatgt tttggaacag
3841 accatcgacc ctgctaaacc ttggacctac tctcaagcat gtgcatcact agataaaacc
3901 acctccagtg gtagccccca ccatgtcagg aagaatgacc actggaatgg agagtctttc
3961 acaggtcccc ttgcagacca agcatctaaa gctaacctca tgtatgaaca ggccaaacat
4021 gtgcagccca tgtacacggc cgcactcaag gatgaacttg ttaagactga taaaatctac
4081 aaaaagataa agaaaagact cctgtgggga tcagaccttg gcacgatgat caggtgcgcc
4141 agggcttttg gtggcctcat ggatagcatg aaggcgagct gcatagcact tccttgtagg
4201 gtggggatga acatgaatga ggatggccca atcatctttg acaagcacgc caagttcaaa
4261 tatcactatg atgctgacta ttcaaggtgg gactcaaccc aacaaaggag tatcctaact
4321 gccgctatgg aggtgatggt tcggttctct gcagaaccag agttagcaca agtagtagca
4381 gaggatctct tggcacctag tcaactggat gttggtgatt ttgttgtctc agtccaggag
4441 ggtttgccat cgggtgttcc atgcacatca caatggaact cgatagcgca ctggattcta
4501 accttaagtg caatggcaga agtgtcaggc ctttcaccag atgttgtcca ggctcattcc
4561 tgtttctcct tctatggtga tgatgagatt gtcagcaccg atatcaacat tgaccctgca
4621 aaattgacac agaaactcag ggaatatggc cttgtcccca cccggcctga caagactgag
4681 ggtcccctcg tcataactga gaacctagct ggcctgactt tcctccgcag gtcgatagcg
4741 cgggatccag ctgggtggtt tggaaaactg gaccaagact caattctcag acaactgtac
4801 tggacaagag ggcctaacca tgaaaaccca tacgaaagca tggtccccca ttcccaacga
4861 gctacacagc tcatggccct ccttggtgag gcctcactac atgggcccca gttttacaag
4921 aaggttagca aaatggtcat caatgagatc aaaagtggtg gtctggaatt ttacgtgccc
4981 agacaagagg ccatgttcag gtggatgaga ttctctgacc tcagcacgtg ggagggcgat
5041 cgcaatcttg ctcccgaggg tgtgaatgaa gatggcgtcg aatgacgcta ctccatctga
5101 tgatggtgca gccggcctcg taccagagat caacaatgag gttatggctc ttgaacccgt
5161 tgctggggcc tccattgcag cccccgtggt cgggcaacag aatgtaatag atccctggat
5221 tagaaataac tttgtacaag cccctgctgg tgaattcaca gtttccccta gaaactctcc
5281 tggagaactc ttacttgatt tagaattggg ccctgaactg aatccctatc tttcacacct
5341 gtccaggatg tacaatgggc acgcaggtgg aatggaagtg cagatagtac tggctgggaa
5401 tgcgttcaca gctggtaaga tcctatttgc tgccatccca cctagcttcc cctatgaaaa
5461 tttgtcacct gctcaattga ctatgtgccc ccatgtaata gtggatgtga gacaactaga
5521 accagtgctt ctgccaatgc cagacataag aaatgttttc tatcactata accaaaacaa
5581 tagtcccaaa ctcaggcttg tagctatgct ttacactcct ttgagagcta acaactcagg
5641 tgatgacgtg ttcacggtgt cttgccgcgt tttgacacgc ccctctccag acttccagtt
5701 cacctttctg gtcccaccca cagttgaatc taaaactaag aactttaccc ttcctgtcct
5761 tagggtctca gagatgacaa actcaaggtt ccccgctgtt ttggaccaaa tgtacacaag
5821 taggagtgaa aacatcattg tccaacccca aaacggcagg tgcacgcttg acggtgagct
5881 gctcggtacc accaccttgc aatctgtgtc tatatgcaat tttagaggaa caatgcaggc
5941 aaagctgaat ggacaaccac gataccaatt acaaatcacc aatttggatg gctcacccat
6001 agacccaaca gatgacatgc ctgcccccct tggcacacca gatttccagg ccatgttgta
6061 tggcgttgca agtcaacgct cccccgcaga caacgccact agggcacatg aagcacagat
6121 tgacactgcg ggtgacactt tcgccccgaa aattggccag gtccgtttcg aatcaggctc
6181 tgatgatttt gacctacatg accctacaaa gttcacaccc attggtatca aagtggatga
6241 tcagcacccc tttagacagt ggtccctgcc aaactatggt ggtcaccttg ccctgaacaa
6301 tcatttagcc cccgctgtga caccactctt ccccggcgag cagattttgt tcttcaggtc
6361 acacattcca agcgccggag gctttacaga cggtgctatg gactgcttgc tgccccaaga
6421 gtggatagag cacttctacc aggaggcagc tcctgcccag tctgacatcg cactggtgag
6481 gttcattaac cccgatacag gaagagtgct ccttgaagcc aagttgcaca aacagggctt
6541 ccttacagtt gcagcatctg gagaccaccc cattgtgatg cccgctaatg gttattttag
6601 gtttgaagct tgggtcaacc ccttctacac tctcgccccc gtgggaactg ggtctgggcg
6661 cagaaggatt cagtaatggc aggagctttc cttgcaggtc tagcaggtga cgttgcggct
6721 tctagtttga gctcactcgt gggcgctgga gccaacgcca tcaatcagaa ggtggagtac
6781 gacttcaaca gacaactcca ggaggcttcc ttcaaacatg acaaggatat gctcagagcc
6841 caggttgcag caacaacagg cctccaacag gccatgatag atatcaagcg ggaggcattg
6901 accgcaggcg gcttttcccc cgctgatgct gcaagaggtt cagtcaaggc gcccatgaca
6961 acactccttg attggaatgg ctctaggcat tgggcaccca actccatgag gacaactggc
7021 tattcaggca catttacttc ccagggcatt agaagctccc cccacctgtc taatcaaact
7081 ccaagtgctg tcaaacccac taaaaccttg ccatctatat ctagttcttc tagtgtgtat
7141 agctctcctt ctactgcccc ctcgcaatca acacaatcaa ctacgctgtc tgcaggaaca
7201 gggtcgtcca ggcctaacac cgtgtccaca aagacctcca cactgtcgag gacaagtgac
7261 tgggtcagag atcaaaatca gatgattggc ccgttcatga atggtgcact tcaaactgct
7321 tatgtcactc caccatcgag cagggcctca tcacaaggga cggtctcgac cgtacccaag
7381 gctgttttgg actcctggac tcctatgttc aacacccaca ggcagc
//