Typing tool
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Typing tool
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Complete norovirus genomes
| OR536460 | GII.14 | |
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| GII.P7 |
ORF1: 1..5089
ORF2: 5070..6680
ORF3: 6680..7474
LOCUS OR536460 7507 bp RNA linear VRL 04-MAR-2024
DEFINITION Norovirus GII isolate Hu/NL/2021/GII.14/Rotterdam/I129S26_P18-d1611
nonstructural polyprotein (ORF1) gene, partial cds; and VP1 (ORF2)
and VP2 (ORF3) genes, complete cds.
ACCESSION OR536460
VERSION OR536460.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7507)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Intra-host multi-lineage evolution of human Norovirus in
immunocompromised individuals: Implications for treatment
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7507)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Direct Submission
JOURNAL Submitted (11-SEP-2023) Viroscience, Erasmus Medical Center, Dr.
Molewaterplein 40, Rotterdam, Zuid-Holland 3015 GD, Netherlands
COMMENT ##Assembly-Data-START##
Assembly Method :: Spades v. 3.15.4; BWA-MEM v. 0.7.17
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7507
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/NL/2021/GII.14/Rotterdam/I129S26_P18-d1611"
/isolation_source="feaces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Netherlands: Rotterdam"
/collection_date="06-May-2021"
/note="genotype: GII.14"
gene <1..5089
/gene="ORF1"
CDS <1..5089
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="WMX17758.1"
/translation="MASNDATTAFGSQNSVNDSTNAAPSNKEEVGAFSNFKVGFKKML
GAVPKSTKAPSSDQQCPTVKIGPRTLVVPPEPPNGEDIVQFDVKSETVSGLPDLTTVQ
NEHENTPYTVPPLSEREHRPAAEPLPGTILEMWDGEFYHYSIYVGGGKTLGVHKPPAA
ISLATIELTPISLYWRPVYTPNYLICPDTLKGLAGERFPYTAFSNNCYNFCCWVLELN
DTWLSRKSISRTTGFFKPYQTWNRKPLPTFDDGKIKKVANAILCALGSLFSKPIKDLL
GKLKPLNLLHLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGP
EDLAVELVPVVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWF
FPKKEEKAEMETLRAIEDAILDMEAIGNNHLTALLKDKDSLAAFMKTLDLEEEKARKL
STKSSSPDIVGTINAILARIAAARSLLHRAKEEMYSRVRPVVVMISGRPGIGKTHMAR
HLAKSIANTMSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMASPVKDALTLQELAD
TCPVTLNCDRIENKGKMFDSDVIIITTNLANPAPLDYVNFEACSRRVDFLVYAESPEI
EKVKRDFPGQPDMWKDHFKPDHSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTA
RVAGLVHERRDEFQLQGNDLQVYNFDTNKVSAFRKLAADNKYGIMETMKVGAALKNVK
TLEDLKAALRDVKFNECEIIYRSSKYRVSSNGKGSVSVDKVEDHASQTANEVCSALLR
LRQARAKYYLSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQETFESEKET
AQSRWEIEPKDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEYKRIREERDGKYSI
EEYLQDRDRYYEEVAVARATEENFCEEEEAKIRQRVFRPTRRQRKEERGVLGLVTGSD
IRKRKPDDFQPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLI
TTTHVLPRGLKELFGVEVKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCS
ILVKRPTGEMIPLAVRMGTHASMRIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCP
YIYKRGNDIVVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKA
PKLSTKTKFWRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKP
PRPAILEEAKKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGES
FTGPLADQASKANLMYEQAKHVQPMYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMI
RCARAFGGLMDSMKASCIALPCRVGMNMNEDGPIIFDKHAKFKYHYDADYSRWDSTQQ
RSVLTAAMEVMVRFSAEPELAQVVAEDLLAPSQLDVGDFVVSVQEGLPSGVPCTSQWN
SIAHWILTLSAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINIDPAKLTQKLREYGL
VPTRPDKTEGPLVITENLAGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHEN
PYESMVPHSQRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFR
WMRFSDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide <1..997
/gene="ORF1"
/product="p48"
mat_peptide 998..2095
/gene="ORF1"
/product="NTPase"
mat_peptide 2096..2614
/gene="ORF1"
/product="p22"
mat_peptide 2615..3013
/gene="ORF1"
/product="VPg"
mat_peptide 3014..3556
/gene="ORF1"
/product="Pro"
mat_peptide 3557..5086
/gene="ORF1"
/product="RdRp"
gene 5070..6680
/gene="ORF2"
CDS 5070..6680
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="WMX17759.1"
/translation="MKMASNDATPSDDGAAGLVPEINNEVMALEPVAGASIAAPVVGQ
QNVIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLSHLSRMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLKLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPAVLDQMYTSRSENIIVQPQNGRCTLDGELLGTT
TLQSVSICNFRGTMQAKLNGQPRYQLQITNLDGSPIDPTDDMPAPLGTPDFQAMLYGV
ASQRSPADNATRAHEAQIDTAGDTFAPKIGQVRFESGSDDFDLHDPTKFTPIGIKVDD
QHPFRQWSLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSHIPSAGGFADGAMDCLLP
QEWIEHFYQEAAPAQSDIALVRFINPDTGRVLLEGKLHKQGFLTVAASGDHPIVMPAN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6680..7474
/gene="ORF3"
CDS 6680..7474
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="WMX17760.1"
/translation="MAGAFLAGLAGDVAASSLSSLVGAGANAINQKVEYDFNRQLQEA
SFKHDKDMLRAQVAATAGLQQAMIDIKRETLTAGGFSPADAARGSVKAPMTKLLDWNG
SRHWAPNSMRTTGYSGTFTSQGIKSSPHLSNQIPSAVKPTKTLPSISSSSSVYSSPST
APSQSTQSTTLSAGTGSSRPNTVSTKTSTLSRTSDWVRDQNQMIGPFMNGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRQGESQI"
ORIGIN
1 gatggcgtct aacgacgcta ccactgcctt tggcagccaa aactctgtca atgacagtac
61 taacgccgcc ccttccaata aagaagaggt cggtgcattc tccaacttta aagttggatt
121 taagaaaatg ctgggtgccg tgcccaagag caccaaagcg cccagcagtg accaacaatg
181 ccccacagtc aagattggac ccagaacatt agtggtcccg cctgaaccac caaatggaga
241 agatatcgtg cagtttgatg taaagtcaga aactgtgagt gggctaccag acctgacaac
301 ggtgcaaaat gaacatgaaa acaccccata tacagtccct ccactgagtg agagggaaca
361 cagaccagcc gctgagccac tccctggcac aatattagag atgtgggacg gtgagttcta
421 ccactactcc atctatgtcg gtggtggtaa gaccctgggg gtccacaaac cccctgcggc
481 tataagcctt gcaacaatcg agttaacccc catatctctg tactggcggc ctgtctacac
541 ccctaattac ttgatctgtc cagacacatt gaagggtctt gctggtgaga ggttccccta
601 cacggctttc agcaacaact gttacaactt ctgctgctgg gtgttggaac tcaacgacac
661 gtggcttagc aggaagtcca tatctagaac aactggcttc tttaaaccgt accagacttg
721 gaacagaaag cctctcccaa ctttcgatga tggaaagatt aagaaagtgg ccaatgcaat
781 tctctgtgcg cttggttcgc tattctcaaa accaatcaaa gacctattag gcaagctcaa
841 accactgaac ctgctgcacc tgctcgcttc gtgtgattgg acgtttgcgg gtatagtgga
901 gacggtcatc ttaatggcgg aactctttaa cgtcttctgg accccgcctg acgtctccaa
961 tttcatagcc tccctgatag gtgactttga gttgcaaggg cctgaggact tagctgtgga
1021 actagtccct gtggttatgg gtggcatagg catggttctt ggcttcacgg ctgagaagat
1081 aggccgcatg ttgtcatctg ctgcatcaac tctccgggcg tgcaaagatc tgggaaacta
1141 cgcccttgac atactcaaac tggtcatgaa atggttcttc cccaagaaag aggaaaaagc
1201 tgagatggaa accttaaggg cgattgagga tgctatcttg gacatggagg ctatagggaa
1261 caatcacctc acagctcttc ttaaagacaa ggatagcctc gcagccttca tgaagaccct
1321 agatctagaa gaggaaaaag cgaggaagct gtcgaccaaa tcatcgtcac ctgacatcgt
1381 cggtaccatc aacgccatac tggctagaat tgccgctgcc aggtccctcc tacacagggc
1441 caaagaggag atgtacagca gagtcagacc agtggttgtt atgatttcag gcaggcccgg
1501 cattggcaag acccacatgg caagacacct ggccaagagc atcgctaaca ccatgagtgg
1561 tgaccagaga gtcggactcg ttccgcggaa cggagtagac cactgggatg catacagagg
1621 ggagagagtg gtcttgtggg atgactatgg catggccagt cctgtcaaag acgctttaac
1681 cctgcaagaa ttggccgaca cttgcccagt caccttaaat tgtgacagga ttgaaaacaa
1741 agggaaaatg tttgacagtg atgttatcat aatcacaacc aacttggcca atcccgcacc
1801 cctcgactat gtgaactttg aggcgtgctc cagaagagtt gatttcctgg tctatgcaga
1861 atcaccagaa attgaaaaag tcaagaggga tttccctggc caacctgaca tgtggaaaga
1921 ccacttcaag ccagaccact cccacataaa actgacccta gccccccagg gcgggtttga
1981 caagaatggt aacactccgc atggcaaggg caccatgcga tctctaaccc aaggttcttt
2041 gactgcaagg gttgcagggt tagtccatga gaggagagat gagttccagc tccaaggaaa
2101 tgacctccaa gtatacaatt ttgacaccaa caaggtttct gcgtttagga aactggctgc
2161 agacaacaaa tatgggatca tggagacaat gaaggtgggc gctgcgctca agaatgtcaa
2221 aaccttggaa gatctgaagg ctgctttgag ggatgtgaaa ttcaatgagt gtgagatcat
2281 ttacaggagt tctaaatata gagtctcttc caatggtaag ggttcagttt ctgttgacaa
2341 ggtcgaggac cacgcatccc agactgcaaa tgaagtgtgt tcagcactcc tgaggctcag
2401 gcaagcaagg gccaaatatt atctcagctg cttccaggac cttgtctaca cgctcataca
2461 agtcgccggg gcgtcatttg ttgtcaacag aatctccaag aggttttgct gggaaagatg
2521 ggttaaacca accgagactc aggagacatt tgagtccgag aaggagaccg ctcaaagcag
2581 gtgggagatt gaacccaaag acacagaacc agaaggcaag aagggtaaaa acaagaaggg
2641 aagaggcaag aagcacacag ccttctccag caagggtctg agtgatgaag agtatgatga
2701 gtacaagaga atcagggagg aaagagatgg aaagtactcc attgaggagt acctacaaga
2761 ccgggaccga tactacgaag aagtggcagt cgcccgagca acagaggaaa acttctgtga
2821 agaggaggag gccaagatca ggcagagggt tttccgccca acgaggagac aaaggaaaga
2881 ggagagagga gtgctcggcc tggtcaccgg ctcagacatt agaaagagaa aaccagatga
2941 cttccaacca aaaggcaact tgtgggcaga tgacaccaga agtgtggact acaatgagag
3001 acttgatttt gaagctcccc cgagtgtttg gtccaggata gtcccattgg gaactggttg
3061 ggggttctgg gtctcgtcca atctcctgat cactacaaca catgtcctgc ccaggggact
3121 caaagaactc ttcggagttg aggttaaaca aattcagatc cacaagtctg gcgagttttg
3181 tagattcaga ttcccaagac caatcaggcc agatgtcaca gggttggtgc tagaagaggg
3241 tgctccagaa ggcactgttt gctccatact tgtgaagaga cccacaggag agatgattcc
3301 cttggcggtg aggatgggca ctcatgcatc catgagaatc cagggcagga ccgtcggcgg
3361 ccaaatggga atgcttctca caggagcaaa tgccaagaac atggaccttg gcaccggccc
3421 tggtgattgc ggttgtccct acatctataa acgcggcaat gacatagttg ttgcaggtgt
3481 tcataccgca gcagcccggg gaggtaacac tgtcatctgt gctacccaag gacaagatgg
3541 ggaggcagtg cttgaaggga acgaaaatct tggcacttac tgtggtgccc cgatcctagg
3601 tcctggcaag gcacccaagc tcagcacaaa aaccaaattc tggcgctcat cgccagatgc
3661 cctaccacct ggcacatatg agcctgctta cctaggaggc aaggacccta gagtggagaa
3721 agggccctcc ctgcagcagg tcatgagaga ccagctaaaa cccttcacag agcctagagg
3781 taaaccaccg agacctgcga tcctagaaga ggctaagaag acagtgatga atgttttgga
3841 acagaccatc gaccctgcta aaccttggac ctactctcaa gcatgtgcat cactagataa
3901 aaccacctcc agtggtagcc cccaccatgt caggaagaat gaccactgga atggagagtc
3961 tttcacaggt ccccttgcag accaagcatc taaagctaac ctcatgtatg aacaggccaa
4021 acatgtgcag cccatgtaca cggccgcact caaggatgaa cttgttaaga ctgataaaat
4081 ctacaaaaag ataaagaaaa gactcctgtg gggatcagac cttggcacga tgatcaggtg
4141 cgccagggct tttggtggcc tcatggatag catgaaggcg agctgcatag cacttccttg
4201 tagggtgggg atgaacatga atgaggatgg cccaatcatc tttgacaagc acgccaagtt
4261 caaatatcac tatgatgctg actattcaag gtgggactca acccaacaaa ggagtgtcct
4321 aactgccgct atggaggtga tggttcggtt ctctgcagaa ccagagctag cacaagtagt
4381 agcagaggat ctcttggcac ctagtcaact ggatgttggt gattttgttg tctcagtcca
4441 ggagggtctg ccatcgggtg ttccatgcac atcacaatgg aactcgatag cgcactggat
4501 tctaacctta agtgcaatgg cagaagtgtc aggcctttca ccagatgttg tccaggctca
4561 ttcctgtttc tccttctatg gcgatgatga gattgtcagc accgatatca acattgaccc
4621 tgcaaaattg acacagaaac tcagggaata tggccttgtc cccacccggc ctgacaagac
4681 tgagggtccc ctcgtcataa ctgagaacct agccggcctg actttcctcc gcaggtcgat
4741 agcgcgggat ccagctgggt ggtttggaaa actggaccaa gactcaattc tcagacaact
4801 gtactggaca agagggccta accatgaaaa cccatacgaa agcatggtcc cccattccca
4861 acgagctaca cagctcatgg ccctccttgg tgaggcctca ctacatgggc cccagtttta
4921 caagaaggtt agcaaaatgg tcatcaatga gatcaaaagt ggtggtctgg aattttacgt
4981 gcccagacaa gaggccatgt tcaggtggat gagattctct gacctcagca cgtgggaggg
5041 cgatcgcaat cttgctcccg agggtgtgaa tgaagatggc gtcgaatgac gctactccat
5101 ctgatgatgg tgcagccggc ctcgtaccag agatcaacaa tgaggttatg gctcttgaac
5161 ccgttgctgg ggcctccatt gcagcccccg tggtcgggca acagaatgta atagatccct
5221 ggattagaaa taactttgta caagcccctg ctggtgaatt cacagtttcc cctagaaact
5281 ctcctggaga actcttactt gatttagaat tgggccctga actgaatccc tatctttcac
5341 acctgtccag gatgtacaat gggcacgcag gtggaatgga agtgcagata gtactggctg
5401 ggaatgcgtt cacagctggt aagatcctat ttgctgccat cccacctagc ttcccctatg
5461 aaaatttgtc acctgctcaa ttgactatgt gcccccatgt aatagtggat gtgagacaat
5521 tagaaccagt gcttctgcca atgccagaca taagaaatgt tttctatcac tataaccaaa
5581 acaatagtcc caaactcaag cttgtagcta tgctttacac tcctttgaga gctaacaact
5641 caggtgatga cgtgttcacg gtgtcttgcc gcgttttgac acgtccctct ccagacttcc
5701 agttcacctt tctggtccca cccacagttg aatctaaaac taagaacttt acccttcctg
5761 tccttagggt ctcagagatg acaaactcaa ggttccccgc tgttttggac caaatgtaca
5821 caagcaggag tgaaaacatc attgtccaac cccaaaacgg caggtgcacg cttgacggtg
5881 agctgctcgg caccaccacc ttgcaatctg tgtctatatg caattttaga ggaacaatgc
5941 aggcaaagct gaatggacaa ccacgatacc aattacaaat caccaatttg gatggctcac
6001 ccatagaccc aacagatgac atgcctgccc cccttggcac accagatttc caggccatgt
6061 tgtatggcgt tgcaagtcaa cgctcccccg cagacaacgc cactagggca catgaagcac
6121 agattgacac tgcgggtgac actttcgccc cgaaaattgg ccaggtccgt ttcgaatcag
6181 gctctgatga ttttgaccta catgacccta caaagttcac acccattggt atcaaagtgg
6241 atgatcagca cccctttaga cagtggtccc tgccaaacta tggtggtcac cttgccctga
6301 ataatcattt agcccccgct gtgacaccac tcttccccgg cgagcagatt ttgttcttca
6361 ggtcacacat tccaagcgcc ggaggctttg cagacggtgc tatggactgc ttgctgcccc
6421 aagagtggat agagcacttc taccaggagg cagctcctgc ccagtctgac atcgcactgg
6481 tgaggttcat taaccccgat acaggaagag tgctccttga aggtaagttg cacaaacagg
6541 gcttcctcac agttgcagca tctggagacc accccattgt gatgcccgct aatggttatt
6601 ttaggtttga agcttgggtc aaccccttct acactctcgc ccccgtggga actgggtctg
6661 ggcgcagaag gattcaataa tggcaggagc tttccttgcg ggcctggcag gtgacgttgc
6721 ggcttctagt ttgagctcac ttgtgggcgc tggagccaac gccatcaatc agaaggtgga
6781 gtatgacttc aacagacaac tccaggaggc ttccttcaaa catgataagg acatgctcag
6841 agcccaggtt gcagcaacag caggcctcca acaggccatg atagacatca aacgggagac
6901 attgaccgca ggcggctttt cccccgctga tgctgcaaga ggttcagtca aggcgcccat
6961 gacaaaactc cttgattgga atggctctag gcattgggca cccaactcca tgaggacaac
7021 tggctattca ggcacattta cttcccaggg catcaaaagt tccccccacc tgtctaatca
7081 aattccaagt gctgttaaac ccactaaaac cttgccatct atatctagtt cttctagtgt
7141 gtatagctct ccttctactg ccccctcgca atcaacacaa tcaactacgc tgtctgcagg
7201 aacagggtcg tccaggccta acaccgtgtc cacaaagacc tccacactgt cgaggacaag
7261 tgactgggtc agagatcaaa atcagatgat tggcccgttc atgaatggtg cacttcaaac
7321 tgcttatgtc actccaccat cgagcagggc ctcatcacaa gggacggtct cgaccgtacc
7381 caaggctgtt ttggactcct ggactcctat gttcaacacc cacaggcagc ctctcttcgc
7441 ccacttgcgt aggcaagggg agtcacagat ttagtgaaaa ggatgattag ggcttttctt
7501 cccattc
//