Typing tool
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Typing tool
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Complete norovirus genomes
| OR536445 | GII.14 | |
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| GII.P7 |
ORF1: 4..5097
ORF2: 5078..6688
ORF3: 6688..7482
LOCUS OR536445 7501 bp RNA linear VRL 04-MAR-2024
DEFINITION Norovirus GII isolate Hu/NL/2017/GII.14/Rotterdam/I89S16_P18-d167
nonstructural polyprotein (ORF1), VP1 (ORF2), and VP2 (ORF3) genes,
complete cds.
ACCESSION OR536445
VERSION OR536445.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7501)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Intra-host multi-lineage evolution of human Norovirus in
immunocompromised individuals: Implications for treatment
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7501)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Direct Submission
JOURNAL Submitted (11-SEP-2023) Viroscience, Erasmus Medical Center, Dr.
Molewaterplein 40, Rotterdam, Zuid-Holland 3015 GD, Netherlands
COMMENT ##Assembly-Data-START##
Assembly Method :: Spades v. 3.15.4; BWA-MEM v. 0.7.17
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7501
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/NL/2017/GII.14/Rotterdam/I89S16_P18-d167"
/isolation_source="feaces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Netherlands: Rotterdam"
/collection_date="23-May-2017"
/note="genotype: GII.14"
gene 4..5097
/gene="ORF1"
CDS 4..5097
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="WMX17713.1"
/translation="MKMASNDATTAFGSQNSVNDSTNTAPSNREEVGAFSNIKVGLKK
MLGAVPKSTKAPSSDQQCPTVKIGPRTLVVPPEPPNGEDVVQFDVKSETVSGLPDLTT
VQNEHENTPYTVPPLSEREHRPAAEPLPGTILEMWDGEFYHYSIYVSGGKALGVHKPP
AAISLATIELTPISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLE
LNDTWLCRRSISRTSGFFKPYQTWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKD
LLGKLKPLNLLHLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQ
GPEDLAVELVPVVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMK
WFFPKKEEKAEMETLRAIEDAVLDMEAIGNNHLTTLLKDKDSLAAFMKTLDLEEEKAR
KLSTKSSSPDIVGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHM
ARHLAKSIANTMSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGSPVKDALTLQEL
ADTCPVTLNCDRIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESP
EIEKVKRDFPGQPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSL
TARVAGLVHERRDEFQLQGSDLQIYNFDTNRVSAFRKLAADNKYGIMETMKVGAALKN
VKTLEDLKVALRDVKFNECEIIYRSSKYRVSSNGKGSVSVDKVEDHASQTANEVSSAL
LRLRQARARYYISCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQETVESEK
ETAQSRWEIEPKDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKY
SIEEYLQDRDRYYEEVAVARATEEDFCEEEEAKIRQRIFRPTRKQRKEERGVLGLVTG
SDIRKRKPDDFQPKGNLWADDTRGVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNL
LITTTHVLPKGLKELFGVEVKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTV
CSILVKRPTGEMIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCG
CPYIYKRGNDIVVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPG
KAPKLSTKTKFWRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRG
KPPRPAILEEAKKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNG
ESFTGPLADQASKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGT
MVRCARAFGGLMDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDST
QQRSVLSAAMEVMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQ
WNSIAHWILTLSAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPAKLTQKLREY
GLVPTRPDKTEGPLVITENLAGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNH
ENPYESMVPHSQRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAM
FRWMRFSDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide 4..1005
/gene="ORF1"
/product="p48"
mat_peptide 1006..2103
/gene="ORF1"
/product="NTPase"
mat_peptide 2104..2622
/gene="ORF1"
/product="p22"
mat_peptide 2623..3021
/gene="ORF1"
/product="VPg"
mat_peptide 3022..3564
/gene="ORF1"
/product="Pro"
mat_peptide 3565..5094
/gene="ORF1"
/product="RdRp"
gene 5078..6688
/gene="ORF2"
CDS 5078..6688
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="WMX17714.1"
/translation="MKMASNDATPSDDGAAGLVPEINNEVMALEPVAGASIAAPVVGQ
QNIIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLAHLSRMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPVVLDQMYTSRNENIIVQPQNGRCTTDGELLGTT
TLQSVSICNFRGTMQAKLNEQPRYQLQITNLDGSPIDPTDDMPAPLGTPDFQAMLYGV
ASQRSPRDNATRAHEAQIDTAGDTFAPKIGQVRFKSSSDDFDLHDPTKFTPIGVNVDD
QHPFRQWSLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSHIPSAGGFTDGAMDCLLP
QEWIEHFYQEAAPAQSDIALVRFINPDTGRVLLEAKLHKQGFLTVAASGDHPIVMPAN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6688..7482
/gene="ORF3"
CDS 6688..7482
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="WMX17715.1"
/translation="MAGALLAGLAGDVAASSLGSLVGAGANAINQKVEYDFNRQLQEA
SFKHDKDMLRAQVAATAGLQQAMIDIKREALTAGGFSPADAARGSVRAPMTKILDWNG
SRHWAPNSMKTTGYSGTFTSQGIKSSPHLSNQTPSAVKPTKTLPSISSSSSVYSSPST
APSQSTQSTALSAGTGSSRPNTVSTKTSTLSRTSDWVRGQNEILGPFMSGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 tgaatgaaga tggcgtctaa cgacgctacc actgcctttg gcagccaaaa ctctgtcaat
61 gacagtacta acaccgcccc ttccaataga gaagaggttg gtgcattctc caacattaaa
121 gttggactta agaaaatgct gggtgccgtg cccaagagca ccaaagcgcc cagcagtgac
181 caacaatgcc ccacagtcaa gattggaccc agaacattag tggtcccgcc tgaaccacca
241 aatggagaag atgtcgtgca gtttgatgta aagtcagaaa ctgtgagtgg gctaccagat
301 ctgacaacgg tgcaaaatga acatgaaaac accccatata cagtcccccc actgagcgag
361 agggaacaca gaccagccgc tgagccactc cctggtacaa tactagagat gtgggacggt
421 gagttctacc actactccat ctatgtcagt ggtggtaagg ccctgggggt ccacaaaccc
481 cctgcggcta taagtcttgc aacaatcgag ttaaccccca tatctctgta ctggcggcct
541 gtctacaccc ctaactactt ggtttgtcca gacacattga agggtcttgc tggtgagaag
601 ttcccctaca cggctttcag caacaactgt tacaacttct gctgctgggt gctggagctc
661 aacgacacgt ggctttgcag aaggtccata tctagaacct ctggcttctt taaaccgtac
721 cagacctgga acagaaagcc tctcccaact gtcgacgatg gaaagattaa gaaggtggcc
781 aatgcaattc tctgtgcgct tggttcacta ttttcaaaac caatcaaaga cctattaggc
841 aagctcaaac cactgaatct gctgcacctg ctcgcttcat gtgattggac gtttgcgggt
901 atagtggaga cggtcatctt aatggcggaa ctctttaacg tcttctggac cccgcctgac
961 gtctccaatt tcatagcctc cctgataggt gactttgagt tacaggggcc tgaggacttg
1021 gctgtggaac tagtccctgt ggttatgggt ggcataggca tggttcttgg cttcacggct
1081 gagaagatag gccgcatgtt gtcatctgct gcatcaactc tccgggcgtg caaagatctg
1141 ggaaactacg ccctcgacat acttaaactg gtcatgaaat ggttcttccc taagaaagaa
1201 gaaaaagctg agatggaaac cttaagggcg attgaggatg ctgtcttgga catggaggct
1261 ataggaaaca atcacctcac aactcttctt aaagacaagg atagcctcgc agccttcatg
1321 aagaccctag atctagaaga ggaaaaagcg aggaagctgt cgaccaaatc atcgtcacct
1381 gacatcgtcg gcaccatcaa cgccatactg gctagaattg ccgctgccag gtccctccta
1441 cacaaggcca aagaagagat gttcagcaga atcagaccag tggttgttat gatctcaggc
1501 aggcctggca ttggcaagac ccacatggca agacacctgg ctaagagcat cgctaacacc
1561 atgagtggtg accagagagt cggactcgtt ccgcggaacg gagtagacca ctgggatgca
1621 tacagagggg agagagtggt cttgtgggat gactatggca tgggcagccc tgtcaaagat
1681 gctctaaccc tgcaagaatt ggccgacact tgcccagtca ccctaaattg tgacaggatt
1741 gaaaacaaag ggaagatgtt tgacagtgat gtcattataa tcacaactaa cttggtcaac
1801 cccgcacccc tcgactatgt gaactttgag gcgtgctcca gaagagttga tttcctggtc
1861 tatgcagagt caccagaaat tgaaaaggtc aagagggatt tccctggtca acctgacatg
1921 tggaaagacc acttcaagcc agacttctcc catataaaac tgaccctagc cccccagggt
1981 gggtttgata agaatggtaa cactccgcat ggcaagggca ccatgcgatc tctaacccaa
2041 ggttctttaa ctgcaagagt tgcagggtta gtccatgaga ggagagatga gttccagctc
2101 caaggaagtg acctccaaat atacaatttt gacaccaata gggtctctgc gtttaggaaa
2161 ctggctgcag acaacaagta tggaatcatg gagacaatga aagtgggcgc tgcactcaag
2221 aatgtcaaga ccttggaaga tctaaaagtt gctttgaggg atgtgaaatt caatgagtgt
2281 gagatcattt acaggagctc taaatataga gtctcttcca atggcaaggg ttcagtttct
2341 gttgacaagg ttgaggacca cgcatcccag accgcaaatg aagtgagttc agcactcctg
2401 aggctcaggc aagcaagggc cagatattat atcagctgct tccaggatct tgtctacacg
2461 ctcatacaag tcgccggggc gtcatttgtt gtcaacagaa tctccaagag gttttgctgg
2521 gaaagatggg ttaaaccaac cgagactcag gagacagttg agtccgagaa ggagaccgct
2581 caaagcaggt gggaaattga acccaaagat acagaaccag aaggcaagaa gggtaaaaac
2641 aagaagggaa gaggcaagaa gcacacagcc ttctccagca agggtctgag tgatgaagaa
2701 tatgatgagt tcaagagaat cagggaggaa agaaatggaa agtactccat tgaggagtac
2761 ctacaagacc gggaccgata ctacgaagaa gtggcagtcg cccgagcaac agaggaagat
2821 ttctgtgaag aggaggaggc caagatcaga cagagaattt tccgcccaac gaggaaacaa
2881 aggaaagagg agaggggagt gctcggcctg gtcaccggct cagacattag aaagagaaaa
2941 ccagatgact ttcaaccaaa aggcaacttg tgggcagatg acaccagagg tgtagactat
3001 aatgagagac ttgactttga ggctccccca agtgtttggt ctaggatagt cccattggga
3061 actggttggg gtttctgggt ctcatccaat cttctgatca ctacaacaca tgtcctgccc
3121 aagggactca aagaactctt cggagttgag gttaaacaaa ttcagatcca caaatctggc
3181 gagttttgta gattcagatt cccaagacca atcaggccag atgtcacagg gttggtgcta
3241 gaagagggtg ctccagaagg cactgtttgc tccatacttg tgaagagacc cacaggtgag
3301 atgatcccct tggcggtgag gatgggcact catgcatcca tgaaaatcca gggcaggacc
3361 gtcggcggcc aaatgggaat gcttctcaca ggagcgaatg ccaagaacat ggaccttggc
3421 accggccctg gtgattgcgg ttgtccctac atctataaac gcggcaatga catagttgtt
3481 gcaggcgttc ataccgcagc agcccgggga ggtaacactg tcatctgtgc tacccaagga
3541 caagatgggg aggcagtgct tgaagggaac gaaaatcttg gcacttactg tggtgccccg
3601 atcctaggtc ctggcaaggc acccaagctc agcacaaaaa ccaaattctg gcgctcatcg
3661 ccagacgcct taccacctgg cacatatgaa cctgcttacc taggaggcaa ggaccctaga
3721 gtagagaaag ggccctccct gcagcaggtc atgagagacc agctaaaacc cttcacagag
3781 cctaggggta aaccaccgag acctgcgatc ctagaagagg ctaagaagac agtgatgaat
3841 gttttggaac agaccatcga ccctgctaaa ccttggacct actctcaagc atgtgcatca
3901 ctggataaaa ccacctccag tggcagcccc caccatgtca ggaagaatga ccactggaat
3961 ggagagtctt tcacaggtcc ccttgcagac caagcatcta aagctaacct catgtatgaa
4021 caggccaaac atgtgcagcc cgtgtacacg gccgcactca aggatgaact tgttaagact
4081 gataaaatct acaaaaagat aaagaagaga ctcctgtggg gatcagacct tggcacgatg
4141 gtcaggtgcg ccagggcttt tggtggcctc atggatagca tgaaggcgag ctgcatagcc
4201 cttccttgta gggtgggaat gaacatgaat gaggatggtc caatcatctt tgacaagcac
4261 tccaagtaca gataccatta tgatgctgac tattcaaggt gggactcaac ccaacaaagg
4321 agtgtcctat ctgccgctat ggaggtgatg gttcggttct ctgcagaacc agagctagca
4381 caagtagtag cagaggatct cttggcacct agtcaactgg atgttggtga ttttgtcatc
4441 tcagtccagg agggtctacc atcgggggtt ccatgcacat cacaatggaa ctcgatagcg
4501 cactggatcc taaccttgag tgcaatggca gaagtgtcag gcctttcacc agatgttgtc
4561 caggctcatt cctgtttctc cttctatggc gatgatgaga ttgtcagcac tgatatcaac
4621 cttgaccctg caaaactgac acagaaactc agggaatacg gccttgtccc cacccggcct
4681 gacaagactg agggtcccct tgtcataact gagaacctag ccggtctgac tttcctccgc
4741 aggtcgatag cacgagatcc agctgggtgg tttggaaaac tggaccaaga ctcaattctc
4801 agacaattgt actggacaag agggcctaac catgaaaacc catacgaaag catggtcccc
4861 cactcccaac gagctacaca gcttatggcc ctccttggtg aggcctcact acatgggccc
4921 cagttttaca agaaggttag caaaatggtc attaatgaga tcaaaagtgg tggtctggaa
4981 ttttacgtgc ccagacaaga ggccatgttc aggtggatga gattctctga cctcagcacg
5041 tgggagggcg atcgcaatct tgctcccgag ggtgtgaatg aagatggcgt cgaatgacgc
5101 tactccatct gatgatggtg cagccggcct cgtaccagag atcaacaatg aggtcatggc
5161 tcttgaaccc gtcgctgggg cctccattgc agcccctgta gtcgggcaac agaatataat
5221 agatccctgg attagaaata actttgtaca agcccctgct ggtgaattta cagtctcccc
5281 tagaaactct cctggagaac tcctacttga tttagaattg ggccctgaac tgaatcccta
5341 tcttgcacac ctgtccagga tgtacaatgg gcacgcaggg ggaatggaag tgcagatagt
5401 actggctggg aatgcgttca cagctggtaa gatcctattt gccgccatcc cacctagctt
5461 cccctatgaa aatttgtcac ctgctcaatt gactatgtgt ccccatgtga tagtggatgt
5521 gagacaacta gaaccagtgc ttctgccaat gccagatata agaaatgttt tctatcacta
5581 taaccaaaac aatagtccca aactcaggct tgtagctatg ctttacactc ctttgagagc
5641 taacaactca ggtgatgacg tgttcacggt gtcttgccgc gttttgacac gtccttctcc
5701 agacttccag ttcacctttc tggtcccacc cacagttgaa tctaaaacta agaacttcac
5761 ccttcctgtc cttagggtct cagagatgac aaactcaagg ttccccgttg ttttggacca
5821 aatgtacaca agcaggaatg aaaacatcat tgtccaaccc caaaacggca ggtgcacgac
5881 tgacggtgag ctgctcggca ccaccacctt gcagtctgtg tctatatgca attttagagg
5941 aacaatgcag gcaaagctga atgaacaacc acgataccaa ttacaaatca ccaatttgga
6001 tggctcaccc atagacccaa cagatgacat gcctgccccc ctcggcacac cagacttcca
6061 ggccatgttg tatggcgttg caagtcaacg ctcccccaga gacaacgcca ctagggcaca
6121 tgaagcacag attgacactg cgggtgatac tttcgccccg aaaatcggcc aggtccgctt
6181 caaatcaagc tctgatgatt ttgacctaca tgaccctaca aagttcacac ccattggtgt
6241 caacgtggat gatcagcacc cctttagaca gtggtccctg ccaaactatg gtggtcacct
6301 tgccctgaat aatcatttag cccccgctgt gacaccactc ttccctggcg agcagatttt
6361 gttcttcaga tcacacattc caagcgccgg aggttttaca gacggtgcta tggactgctt
6421 gctgccccaa gagtggatag agcacttcta ccaggaggca gctcctgccc agtctgacat
6481 cgcactggtg aggttcatca accccgatac aggaagagtg ctccttgaag ctaagttgca
6541 caaacagggc ttccttacag ttgcagcatc tggagaccac cccattgtga tgcccgctaa
6601 tggttatttt aggtttgaag cttgggtcaa ccccttctac actctcgccc ccgtgggaac
6661 tgggtctggg cgcagaagga ttcaataatg gcaggagctc tccttgcagg cttggcaggt
6721 gacgttgcgg cttccagctt gggctcactt gtgggcgccg gagccaacgc catcaatcag
6781 aaagtggagt atgacttcaa cagacaactc caggaggcat ccttcaaaca tgacaaggat
6841 atgctcagag cccaggttgc agcaacagca ggccttcaac aggccatgat agacattaag
6901 cgggaggcat tgaccgcagg cggcttttcc cccgctgatg ctgcaagagg ttcagtcagg
6961 gcgcctatga caaaaatcct tgattggaat ggctctaggc attgggcacc caactccatg
7021 aagacaactg gctattcagg cacatttact tcccagggca tcaaaagttc cccccacctg
7081 tctaaccaaa ctccaagtgc tgttaaaccc actaaaacct tgccatctat atctagttct
7141 tctagtgtat atagctctcc ttctactgcc ccctcgcaat caacacaatc aacagcgctg
7201 tctgcaggaa cagggtcgtc caggcctaac accgtgtcca caaagacctc cacactgtcg
7261 aggacaagtg actgggtcag aggtcaaaat gagatacttg gcccgttcat gagtggtgca
7321 cttcaaactg cttatgttac tccaccatcg agcagggcct catcacaagg gacggtctcg
7381 accgtaccca aggctgtttt ggactcctgg actcctatgt tcaacaccca caggcagcct
7441 ctcttcgccc acttgcgtag gcgaggggag tcacagattt agtgaaaagg atgattaggg
7501 c
//