Typing tool
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Typing tool
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Complete norovirus genomes
| OR536444 | GII.14 | |
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| GII.P7 |
ORF1: 1..5076
ORF2: 5057..6667
ORF3: 6667..7457
LOCUS OR536444 7457 bp RNA linear VRL 04-MAR-2024
DEFINITION Norovirus GII isolate Hu/NL/2017/GII.14/Rotterdam/I89S17_P18-d83
nonstructural polyprotein (ORF1) gene, partial cds; VP1 (ORF2)
gene, complete cds; and VP2 (ORF3) gene, partial cds.
ACCESSION OR536444
VERSION OR536444.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7457)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Intra-host multi-lineage evolution of human Norovirus in
immunocompromised individuals: Implications for treatment
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7457)
AUTHORS Izquierdo Lara,R.W., Villabruna,N., Hesselink,D.A.,
Schapendonk,C.M.E., Ribo Pons,S., Meier,J.I.J., Goodfellow,I.,
Dalm,V.A.S.H., Fraaij,P.L.A., van Kampen,J.A., Koopmans,M.P.G. and
de Graaf,M.
TITLE Direct Submission
JOURNAL Submitted (11-SEP-2023) Viroscience, Erasmus Medical Center, Dr.
Molewaterplein 40, Rotterdam, Zuid-Holland 3015 GD, Netherlands
COMMENT ##Assembly-Data-START##
Assembly Method :: Spades v. 3.15.4; BWA-MEM v. 0.7.17
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7457
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/NL/2017/GII.14/Rotterdam/I89S17_P18-d83"
/isolation_source="feaces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Netherlands: Rotterdam"
/collection_date="28-Feb-2017"
/note="genotype: GII.14"
gene <1..5076
/gene="ORF1"
CDS <1..5076
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="WMX17710.1"
/translation="DATTAFGSQNSVNDSTNTAPSNREEVGAFSNIKVGFKKMLGAVP
KSTKAPSSDQQCPTVKIGPRTLVVPPEPPNGEDVVQFDVKSETVSGLPDLTTVQNEHE
NTPYTVPPLSEREHRPAAEPLPGTILEMWDGEFYHYSIYVSGGKALGVHKPPAAISLA
TIELTPISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWL
CRRSISRTSGFFKPYQTWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLK
PLNLLHLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPEDLA
VELVPVVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKK
EEKAEMETLRAIEDAVLDMEAIGNNHLTTLLKDKDSLAAFMKTLDLEEEKARKLSTKS
SSPDIVGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAK
SIANTMSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGSPVKDALTLQELADTCPV
TLNCDRIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVK
RDFPGQPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAG
LVHERRDEFQLQGSDLQIYNFDTNRVSAFRKLAADNKYGIMETMKVGAALKNVKTLED
LKVALRDVKFNECEIIYRSSKYRVSSNGKGSVSVDKVEDHASQTANEVSSALLRLRQA
RARYYISCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQETVESEKETAQSR
WEIEPKDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYL
QDRDRYYEEVAVARATEEDFCEEEEAKIRQRIFRPTRKQRKEERGVLGLVTGSDIRKR
KPDDFQPKGNLWADDTRGVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTH
VLPKGLKELFGVEVKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVK
RPTGEMIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYK
RGNDIVVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAPKLS
TKTKFWRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPA
ILEEAKKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGP
LADQASKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMVRCAR
AFGGLMDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSVL
SAAMEVMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAH
WILTLSAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPAKLTQKLREYGLVPTR
PDKTEGPLVITENLAGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYES
MVPHSQRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRF
SDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide <1..984
/gene="ORF1"
/product="p48"
mat_peptide 985..2082
/gene="ORF1"
/product="NTPase"
mat_peptide 2083..2601
/gene="ORF1"
/product="p22"
mat_peptide 2602..3000
/gene="ORF1"
/product="VPg"
mat_peptide 3001..3543
/gene="ORF1"
/product="Pro"
mat_peptide 3544..5073
/gene="ORF1"
/product="RdRp"
gene 5057..6667
/gene="ORF2"
CDS 5057..6667
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="WMX17711.1"
/translation="MKMASNDATPSDDGAAGLVPEINNEVMALEPVAGASIAAPVVGQ
QNIIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLAHLSRMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPVVLDQMYTSRNENIIVQPQNGRCTTDGELLGTT
TLQSVSICNFRGTMQAKLNEQPRYQLQITNLDGSPIDPTDDMPAPLGTPDFQAVLYGV
ASQRSPSDNATRAHDAQIDTAGDTFAPKIGQVRFKSSSDDFDLHDPTKFTPIGVNVDD
QHPFRQWSLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSHIPSAGGFTDGAMDCLLP
QEWIEHFYQEAAPSQSDIALVRFINPDTGRVLLEAKLHKQGFLTVAASGDHPIVMPAN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6667..>7457
/gene="ORF3"
CDS 6667..>7457
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="WMX17712.1"
/translation="MAGALLAGLAGDVAASSLGSLVGAGANAINQKVEYDFNRQLQEA
SFKHDKDMLRAQVAATAGLQQAMIDIKREALTAGGFSPADAARGSVRAPMTKILDWNG
SRHWAPNSMKTTGYSGTFASQGIKSSPHLSNQTPSAVKPTKTLPSISSSSSVYSSPST
APSQSTQSTALSAGTGSSRLNTVSTKTSTLSRTSDWVRGQNEILGPFMSGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQT"
ORIGIN
1 gacgctacca ctgcctttgg cagccaaaac tctgtcaatg acagtactaa caccgcccct
61 tccaatagag aagaggttgg tgcattctcc aacattaaag ttggatttaa gaaaatgctg
121 ggtgccgtgc ccaagagcac caaagcgccc agcagtgacc aacaatgccc cacagtcaag
181 attggaccca gaacattagt ggtcccgcct gaaccaccaa atggagaaga tgtcgtgcag
241 tttgatgtaa agtcagaaac tgtgagtggg ctaccagatc tgacaacggt gcaaaatgaa
301 catgaaaaca ccccatatac agtcccccca ctgagtgaga gggaacacag accagccgct
361 gagccactcc ctggtacaat actagagatg tgggacggtg agttctacca ctactccatc
421 tatgtcagtg gtggtaaggc cctgggggtc cacaaacccc ctgcggctat aagtcttgca
481 acaatcgagt taacccccat atctctgtac tggcggcctg tctacacccc taactacttg
541 gtttgtccag acacattgaa gggtcttgct ggtgagaagt tcccctacac ggctttcagc
601 aacaactgtt acaacttctg ctgctgggtg ctggagctca acgacacgtg gctttgcaga
661 aggtccatat ctagaacctc tggcttcttt aaaccgtacc agacctggaa cagaaagcct
721 ctcccaactg tcgacgatgg aaagattaag aaggtggcca atgcaattct ctgtgcgctt
781 ggttcactat tttcaaaacc aatcaaagac ctattaggca agctcaaacc actgaatctg
841 ctgcacctgc tcgcttcatg tgattggacg tttgcgggta tagtggagac ggtcatctta
901 atggcggaac tctttaacgt cttctggacc ccgcctgacg tctccaattt catagcctcc
961 ctgataggtg actttgagtt acaggggcct gaggacttgg ctgtggaact agtccctgtg
1021 gttatgggtg gcataggcat ggttcttggc ttcacggctg agaagatagg ccgcatgttg
1081 tcatctgctg catcaactct ccgggcgtgc aaagatctgg gaaactacgc cctcgacata
1141 cttaaactgg tcatgaaatg gttcttccct aagaaagaag aaaaagctga gatggaaacc
1201 ttaagggcga ttgaggatgc tgtcttggac atggaggcta taggaaacaa tcacctcaca
1261 actcttctta aagacaagga tagcctcgca gccttcatga agaccctaga tctagaagag
1321 gaaaaagcga ggaagctgtc gaccaaatca tcgtcacctg acatcgtcgg caccatcaac
1381 gccatactgg ctagaattgc cgctgccagg tccctcctac acaaggccaa agaagagatg
1441 ttcagcagaa tcagaccagt ggttgttatg atctcaggca ggcctggcat tggcaagacc
1501 cacatggcaa gacacctggc taagagcatc gctaacacca tgagtggtga ccagagagtc
1561 ggactcgttc cgcggaacgg agtagaccac tgggatgcat acagagggga gagagtggtc
1621 ttgtgggatg actatggcat gggcagccct gtcaaagatg ctctaaccct gcaagaattg
1681 gccgacactt gcccagtcac cctaaattgt gacaggattg aaaacaaagg gaagatgttt
1741 gacagtgatg tcattataat cacaactaac ttggtcaacc ccgcacccct cgactatgtg
1801 aactttgagg cgtgctccag aagagttgat ttcctggtct atgcagagtc accagaaatt
1861 gaaaaggtca agagggattt ccctggtcaa cctgacatgt ggaaagacca cttcaagcca
1921 gacttctccc atataaaact gaccctagcc ccccagggtg ggtttgataa gaatggtaac
1981 actccgcatg gcaagggcac catgcgatct ctaacccaag gttctttaac tgcaagagtt
2041 gcagggttag tccatgagag gagagatgag ttccagctcc aaggaagtga cctccaaata
2101 tacaattttg acaccaatag ggtctctgcg tttaggaaac tggctgcaga caacaagtat
2161 ggaatcatgg agacaatgaa agtgggcgct gcactcaaga atgtcaagac cttggaagat
2221 ctaaaagttg ctttgaggga tgtgaaattc aatgagtgtg agatcattta caggagctct
2281 aaatatagag tctcttccaa tggcaagggt tcagtttctg ttgacaaggt tgaggaccac
2341 gcatcccaga ccgcaaatga agtgagttca gcactcctga ggctcaggca agcaagggcc
2401 agatattata tcagctgctt ccaggatctt gtctacacgc tcatacaagt cgccggggcg
2461 tcatttgttg tcaacagaat ctccaagagg ttttgctggg aaagatgggt taaaccaacc
2521 gagactcagg agacagttga gtccgagaag gagaccgctc aaagcaggtg ggaaattgaa
2581 cccaaagata cagaaccaga aggcaagaag ggtaaaaaca agaagggaag aggcaagaag
2641 cacacagcct tctccagcaa gggtctgagt gatgaagaat atgatgagtt caagagaatc
2701 agggaggaaa gaaatggaaa gtactccatt gaggagtacc tacaagaccg ggaccgatac
2761 tacgaagaag tggcagtcgc ccgagcaaca gaggaagatt tctgtgaaga ggaggaggcc
2821 aagatcagac agagaatttt ccgcccaacg aggaaacaaa ggaaagagga gaggggagtg
2881 ctcggcctgg tcaccggctc agacattaga aagagaaaac cagatgactt tcaaccaaaa
2941 ggcaacttgt gggcagatga caccagaggt gtagactata atgagagact tgactttgag
3001 gctcccccaa gtgtttggtc taggatagtc ccattgggaa ctggttgggg tttctgggtc
3061 tcatccaatc ttctgatcac tacaacacat gtcctgccca agggactcaa agaactcttc
3121 ggagttgagg ttaaacaaat tcagatccac aaatctggcg agttttgtag attcagattc
3181 ccaagaccaa tcaggccaga tgtcacaggg ttggtgttag aagagggtgc tccagaaggc
3241 actgtttgct ccatacttgt gaagagaccc acaggtgaga tgatcccctt ggcggtgagg
3301 atgggcactc atgcatccat gaaaatccag ggcaggaccg tcggcggcca aatgggaatg
3361 cttctcacag gagcgaatgc caagaacatg gaccttggca ccggccctgg tgattgcggt
3421 tgtccctaca tctataaacg cggcaatgac atagttgttg caggcgttca taccgcagca
3481 gcccggggag gtaacactgt catctgtgct acccaaggac aagatgggga ggcagtgctt
3541 gaagggaacg aaaatcttgg cacttactgt ggtgccccga tcctaggtcc tggcaaggca
3601 cccaagctca gcacaaaaac caaattctgg cgctcatcgc cagacgcctt accacctggc
3661 acatatgaac ctgcttacct aggaggcaag gaccctagag tagagaaagg gccctccctg
3721 cagcaggtca tgagagacca gctaaaaccc ttcacagagc ctaggggtaa accaccgaga
3781 cctgcgatcc tagaagaggc taagaagaca gtgatgaatg ttttggagca gaccatcgac
3841 cctgctaaac cttggaccta ctctcaagca tgtgcatcac tggataaaac cacctccagt
3901 ggcagccccc accatgtcag gaagaatgac cactggaatg gagagtcttt cacaggtccc
3961 cttgcagacc aagcatctaa agctaacctc atgtatgaac aggccaaaca tgtgcagccc
4021 gtgtacacgg ccgcactcaa ggatgaactt gttaagactg ataaaatcta caaaaagata
4081 aagaagagac tcctgtgggg atcagacctt ggcacgatgg tcaggtgcgc cagggctttt
4141 ggtggcctca tggatagcat gaaggcgagc tgcatagccc ttccttgtag ggtgggaatg
4201 aacatgaatg aggatggtcc aatcatcttt gacaagcact ccaagtacag gtaccattat
4261 gatgctgact attcaaggtg ggactcaacc caacaaagga gtgtcctatc tgccgctatg
4321 gaggtgatgg ttcggttctc tgcagaacca gagctagcac aagtagtagc agaggatctc
4381 ttggcaccta gtcaactgga tgttggtgat tttgtcatct cagtccagga gggtctacca
4441 tcgggggttc catgcacatc acaatggaac tcgatagcgc actggatcct aaccttgagt
4501 gcaatggcag aagtgtcagg cctttcacca gatgttgtcc aggctcattc ctgtttctcc
4561 ttctatggcg atgatgagat tgtcagcact gatatcaacc ttgaccctgc aaaactgaca
4621 cagaaactca gggaatacgg ccttgtcccc acccggcctg acaagactga gggtcccctt
4681 gtcataactg agaacctagc cggtctgact ttcctccgca ggtcgatagc acgagatcca
4741 gctgggtggt ttggaaaact ggaccaagac tcaattctca gacaattgta ctggacaaga
4801 gggcctaacc atgaaaaccc atacgaaagc atggtccccc actcccaacg agctacacag
4861 cttatggccc tccttggtga ggcctcacta catgggcccc agttttacaa gaaggttagc
4921 aaaatggtca ttaatgagat caaaagtggt ggtctggaat tttacgtgcc cagacaagag
4981 gccatgttca ggtggatgag attctctgac ctcagcacgt gggagggcga tcgcaatctt
5041 gctcccgagg gtgtgaatga agatggcgtc gaatgacgct actccatctg atgatggtgc
5101 agccggcctc gtaccagaga tcaacaatga ggtcatggct cttgaacccg tcgctggggc
5161 ctccattgca gcccctgtag tcgggcaaca gaatataata gatccctgga ttagaaataa
5221 ctttgtacaa gcccctgctg gtgaatttac agtctcccct agaaactctc ctggagaact
5281 cctacttgat ttagaattgg gccctgaact gaatccctat cttgcacacc tgtccaggat
5341 gtacaatggg cacgcagggg gaatggaagt gcagatagta ctggctggga atgcgttcac
5401 agctggtaag atcctatttg ctgccatccc acctagcttc ccctatgaaa atttgtcacc
5461 tgctcaattg actatgtgtc cccatgtgat agtggatgtg agacaactag aaccagtgct
5521 tctgccaatg ccagatataa gaaatgtttt ctatcactat aaccaaaaca atagtcccaa
5581 actcaggctt gtagctatgc tttacactcc tttgagagct aacaactcag gtgatgacgt
5641 gttcacggtg tcttgccgcg ttttgacacg tccttctcca gacttccagt tcacctttct
5701 ggtcccaccc acagttgaat ctaaaactaa gaacttcacc cttcctgtcc ttagggtctc
5761 agagatgaca aactcaaggt tccccgttgt tttggaccaa atgtatacaa gcaggaatga
5821 aaacatcatt gtccaacccc aaaatggcag gtgtacgact gacggtgagc tgctcggcac
5881 taccaccttg cagtctgtgt ctatatgcaa ttttagagga acaatgcagg caaagctgaa
5941 tgaacaacca cgataccaat tacaaatcac caacttggat ggctcaccca tagacccaac
6001 agatgacatg cccgcccccc tcggcacacc agacttccag gccgtgttgt atggcgttgc
6061 aagtcaacgc tcccccagtg acaacgccac tagggcacat gatgcacaga ttgacactgc
6121 gggtgatact ttcgccccga aaatcggcca ggtccgcttc aaatcaagct ctgatgattt
6181 tgacctacat gaccctacaa agttcacacc cattggtgtc aacgtggatg atcagcaccc
6241 ctttagacag tggtccctgc caaactatgg tggtcacctt gccctgaata atcatttagc
6301 ccccgctgtg acaccactct tccctggcga gcagattttg ttcttcagat cacacattcc
6361 aagcgccgga ggttttacag acggtgctat ggactgcttg ctgccccaag agtggataga
6421 gcacttctac caggaggcag ctccttccca gtctgacatc gcactggtga ggttcatcaa
6481 ccccgataca ggaagagtgc tccttgaagc taagttgcac aaacagggct tccttacagt
6541 tgcagcatct ggagaccacc ccattgtgat gcccgctaat ggttatttta ggtttgaagc
6601 ttgggtcaac cccttctaca ctctcgcccc cgtgggaact gggtctgggc gcagaaggat
6661 tcaataatgg caggagctct ccttgcaggc ttggcaggtg acgttgcggc ttccagcttg
6721 ggctcacttg tgggcgccgg agccaacgcc atcaaccaga aggtggagta tgacttcaac
6781 agacaactcc aggaggcatc cttcaaacat gataaggata tgctcagagc ccaggttgca
6841 gcaacagcag gccttcaaca ggccatgata gacattaagc gggaggcatt gaccgcaggc
6901 ggcttttccc ccgctgatgc tgcaagaggt tcagtcaggg cgcctatgac aaaaatcctt
6961 gattggaatg gctctaggca ttgggcaccc aactccatga agacaactgg ctattcaggc
7021 acatttgctt cccagggcat caaaagttcc ccccacctgt ctaaccaaac tccaagtgct
7081 gttaaaccta ctaaaacctt gccatctata tctagttctt ctagtgtata tagttctcct
7141 tctactgccc cctcgcaatc aacacaatca acagcgctgt ctgcaggaac agggtcgtcc
7201 aggcttaaca ccgtgtccac aaagacctcc acactgtcga ggacaagtga ctgggtcaga
7261 ggtcaaaatg agatacttgg cccgttcatg agtggtgcac ttcaaactgc ttatgttact
7321 ccaccatcga gcagggcctc atcacagggg acggtctcga ccgtacccaa ggctgttttg
7381 gactcctgga ctcctatgtt caacacccac aggcagcctc tcttcgccca cttgcgtagg
7441 cgaggggagt cacagac
//