Typing tool
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Typing tool
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Complete norovirus genomes
| MW305737 | GII.6 | |
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| GII.P7 |
ORF1: 5..5098
ORF2: 5079..6722
ORF3: 6722..7501
LOCUS MW305737 7556 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate HenrytonSP24, complete genome.
ACCESSION MW305737
VERSION MW305737.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7556)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7556)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7556
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="HenrytonSP24"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="1972"
/note="genotype: GII.6[GII.P6]"
gene 5..5098
/gene="ORF1"
CDS 5..5098
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QPJ59547.1"
/translation="MKMASNDATTAFGSQNSVNDSTNTTPSNKEEVGAFSNIKVGLKK
MLGAVPKSTKAPSGDQHCPTVKIGSKTLAIPPEPPNGEDVVQFDAKSETVRGLPDLTT
VQNEHENTPYTVPPLSEREHRPATEPLPGTILEMWDGEFYHYSIYVSGGKALGVHKPP
AAISLATIELTPISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLE
LNDTWLCRRSISRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKD
LLGKLKPLNLLHLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQ
GPEDLAVELVPVVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMK
WFFPKKEEKAEMETLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKAR
KLSTKSSSPDIVGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHM
ARHLAKNIANTMSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQEL
ADTCPVTLNCDRIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRIDFLVYAESP
EIEKVKRDFPGQPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSL
TARVAGLVHERRDEFQLQGDNLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKN
VKTLEDLKVALRDVKFNECEIIYRNSKYRVSSNGKGTVSVHKVEDLTSQTANEVSSAL
LRLRQARARYYVSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQEASEPEK
ETAQGEWEIEPKDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKY
SIEEYLQDRDRYYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTG
SDIRKRRPDDFQPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNL
LITTTHVLPKGIKELFGVDVKQIQIHKSGEFCRFRFPRPIRPDVSGLVLEEGAPEGTV
CSILVKRPTGEMIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCG
CPYIYKRGNDIIVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPG
KAPKLSTKTKFWRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFAEPRG
KPPRPAVLEEAKKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHIKKNDHWNG
ESFTGPLADQASKANLMYEQAKHMQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGT
MVRCARAFGGLMDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDST
QQRSILSAAMEVMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQ
WNSIAHWILTLSAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPSKLTQKLREY
GLVPTRPDKTEGPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNH
ENPYESMVPHSQRATQLMALLGEASLHGPQFYKKVSKMVISEIKSGGLEFYVPRQEAM
FRWMRFSDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide 5..1006
/gene="ORF1"
/product="p48"
mat_peptide 1007..2104
/gene="ORF1"
/product="NTPase"
mat_peptide 2105..2623
/gene="ORF1"
/product="p22"
mat_peptide 2624..3022
/gene="ORF1"
/product="VPg"
mat_peptide 3023..3565
/gene="ORF1"
/product="Pro"
mat_peptide 3566..5095
/gene="ORF1"
/product="RdRp"
gene 5079..6722
/gene="ORF2"
CDS 5079..6722
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59548.1"
/translation="MKMASNDAAPSNDGAANLVPEANNEVMALEPVVGASIAAPVVGQ
QNIIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVENISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQENTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAPIDMLYTDPNEGIVVQPQNGRCTLDGTLQGTTQ
LVPTQICAFRGTLIGQTSRSSDSTDSAPRRRDHPLHVQLKNLDGTQYDPTDEVPAVLG
AIDFKGAVFGVASQRDVSGTQVGATRAHEVHINTTDPRYTPKLGSILMHSESDDFVTG
QPIQFTPVGMGDNDWHQWELPDYSGHLTLNMNLAPAVAPAFPGERILFFRSIVPSAGG
YGSGQIDCLIPQEWVQHFYQEAAPSQSAVALIRYVNPDTGRNIFEAKLHREGFITVAN
SGNNPIVVPPNGYFRFEAWVNQFYTLTPMGTGQGRRRNQ"
gene 6722..7501
/gene="ORF3"
CDS 6722..7501
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59549.1"
/translation="MASAFLAGLAGDVITNGVGSLINAGANAVNQKVEYDFNKQLQMA
SFKHDKEMLQSQVLATKQLQQEMMNIRQGVLTAGGFSPADAARGAVNAPLTKILDWNG
TRYWAPNSMKTTSYSGQFSSSPVHKSPAPSQHTALSKGKLQSDSASVYSSPSTISSQS
THSTALSPGTGSSRSTSTSTATSTLSRTSDWVRGQNERLSPFMDGALQTTFVTPPSSR
ASSNGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 gtgaatgaag atggcgtcta acgacgctac cactgccttt ggcagccaaa actctgtcaa
61 tgacagtacc aacaccaccc cttctaacaa agaagaggtt ggtgcgttct ccaacatcaa
121 agttggactt aagaaaatgc tgggtgccgt gcccaaaagc accaaggcac ccagcggtga
181 ccagcactgc cccactgtta agattgggtc taaaacacta gcgatcccac cagagccccc
241 aaacggtgag gacgttgtgc agtttgatgc aaaatcggaa actgtacgtg ggctacccga
301 cctgacgaca gtgcaaaatg aacatgaaaa caccccatac acagtccctc cactgagtga
361 aagggagcat agaccagcca ctgagccact ccctggcaca atactggaga tgtgggatgg
421 tgaattctat cactactcca tttatgtcag cggaggcaaa gccctgggag tacacaaacc
481 cccagcagct ataagcctcg cgacaataga actcaccccc atatcccttt actggcggcc
541 tgtctacact ccaaactacc tggtctgccc agacacattg aagggtcttg ctggtgagaa
601 gtttccttat acggccttca gtaacaactg ctacaacttc tgttgttggg tgcttgagct
661 taatgacacg tggctttgca ggagaagtat ttccagaacc actggcttct tcaaaccata
721 ccagtcttgg aacaggaagc ctctcccaac cgttgacgat ggaaaaatca aaaaggtggc
781 caatgcaatt ctctgtgcac ttggctcact gttttcaaaa ccaatcaaag atctattggg
841 caaactcaag ccactgaatc tactacatct gctcgcgtcg tgtgactgga catttgcagg
901 tatagtagag acggtcatct taatggcgga actcttcaac gtcttttgga ccccgccaga
961 tgtctccaac tttatagcct ccctgatagg tgattttgag ctacaagggc ctgaggactt
1021 agctgtggag cttgtccccg tggttatggg aggcatagga atggtcctcg gtttcactgc
1081 tgagaagatt ggccgcatgt tgtcatctgc cgcatcaact ctacgggcat gcaaagatct
1141 ggggaactac gccctcgaca tactaaaact agtcatgaag tggttcttcc caaagaagga
1201 agagaaggcc gagatggaga ccttaagggc gatcgaggac gccgttttag acatggaggc
1261 aatagggaac aaccatctca cgacactcct caaggataag gatagcctca ctgcattcat
1321 gaagacttta gacctagaag aggagaaagc aagaaaactg tcaacaaagt catcctcgcc
1381 agacatcgtc ggcaccatta atgccatact ggctagaata gcagctgcta gatcccttct
1441 acacaaggcc aaggaagaga tgtttagcag aattagacca gtagttgtca tgatctcagg
1501 caggcctggc attggtaaaa cccatatggc gaggcatctg gctaagaata tagccaacac
1561 catgagtgga gaccagagag ttgggcttgt cccgcgcaac ggggttgacc attgggatgc
1621 ctacagggga gagagggtag tcctatggga cgactacggt atggggaacc ctgtcaaaga
1681 tgccttaaca ttacaagagc tggccgacac ctgcccagtt accctgaatt gtgataggat
1741 tgagaacaag ggaaagatgt ttgacagtga tgtcatcata attacaacta atttggtcaa
1801 ccctgcaccc ctcgattatg taaacttcga ggcttgctcc agaagaatcg atttcctcgt
1861 ttatgcagag tcaccagaaa tagaaaaggt caagagagac ttccctggtc agcctgacat
1921 gtggaaagac cacttcaaac cggacttctc ccacataaaa ctgactttag ccccccaggg
1981 cgggtttgat aagaatggta acaccccaca tggtaagggc accatgcggt ccctgaccca
2041 ggggtccctg actgcaagag ttgcaggact tgttcatgag aggagagatg agttccagct
2101 gcaaggggac aacctacaaa catacaactt tgacaccaac agggtctctg cgtttaggaa
2161 actggccgca gataataagt atggaatcat ggagacaatg agagtaggtg cggcactcaa
2221 gaatgtcaag actttggaag acctcaaagt tgccttgaga gatgtgaaat tcaatgaatg
2281 tgagatcatc tacaggaact ccaagtaccg agtctcatcc aatggcaaag gcacagtctc
2341 tgttcacaaa gtcgaggacc tcacttctca aaccgcaaac gaggtgagct cagccctcct
2401 caggctcaga caagcgaggg ccagatacta cgtcagctgt ttccaggacc ttgtctacac
2461 tctcatacag gttgctgggg cttcattcgt cgtcaacagg atctctaaga ggttctgctg
2521 ggaaaggtgg gttaaaccaa ccgagaccca ggaggcgagt gagcccgaaa aggagactgc
2581 ccagggtgaa tgggagattg aacccaagga cacagaacca gaaggtaaga agggcaaaaa
2641 caagaaagga aggggcaaga agcacacagc cttctccagt aaaggtctga gtgacgaaga
2701 gtatgatgaa ttcaaaagga ttagagaaga aagaaacgga aagtactcca ttgaggaata
2761 cctgcaagac cgggaccgct actacgaaga agtggcagtt gcccgggcaa cagaggagga
2821 cttctgtgaa gaggaagagg ccaagataag gcaaagaatc ttccgcccaa caaagaagca
2881 gagaaaagag gaaagggggg tgcttggcct ggtcactggt tcggacatca gaaagaggag
2941 gccagatgac ttccaaccaa agggcaattt atgggcagat gacactagaa gtgtggacta
3001 caatgagaga cttgacttcg aggcccctcc aagtgtgtgg tcaaggatag tcccactggg
3061 caccggttgg ggcttctggg tctcatccaa cctcctgatt acaacaacac atgtcctgcc
3121 taagggtatt aaggaactct ttggagtcga tgtcaagcaa attcaaatcc acaaatctgg
3181 agaattttgc aggttcagat tcccaaggcc aatcaggcca gacgtctcag ggctcgtgtt
3241 agaagaaggt gcaccagagg gcactgtctg ctccatactc gtgaagagac caacaggtga
3301 gatgatccct ctggcggtga ggatgggcac gcatgcatct atgaaaattc agggtaggac
3361 tgttggcggc caaatgggaa tgcttctcac aggagcgaac gcaaagaaca tggaccttgg
3421 caccggccca ggcgattgcg gttgtccata catctacaaa cgcggtaatg atataattgt
3481 ggcaggtgtt cacaccgcag cagcccgagg aggcaacact gtcatctgtg ccacccaagg
3541 gcaggatgga gaagcagtcc ttgagggaaa tgagaatctt ggtacgtact gcggtgcccc
3601 aattttaggt cctggcaagg cgcccaagct aagcactaag accaaatttt ggcgttcatc
3661 gccagatgcc ctgccacccg gcacatatga acctgcttac ctaggaggca aggaccccag
3721 agtggagaaa ggaccttccc tgcagcaagt catgagagac caactgaaac ccttcgcgga
3781 acccaggggt aaaccaccaa gacccgcagt cctagaagag gctaaaaaga cagtgatgaa
3841 cgtcctggaa caaaccattg accctgctaa accatggacc tactcacaag catgcgcctc
3901 cttggataag accacttcca gtggtagtcc ccaccacatt aagaaaaatg accattggaa
3961 tggagagtct ttcactggcc cccttgcaga ccaagcttct aaagccaatc ttatgtatga
4021 gcaggccaaa cacatgcagc ccgtgtacac ggctgcactt aaagatgagc tcgtcaagac
4081 tgacaaaatc tataaaaaga taaagaagag gctcctttgg gggtcagacc ttggcacaat
4141 ggttagatgt gccagggcct ttggtggtct catggacagc atgaaagcaa gttgcatagc
4201 cctcccgtgc agggtgggaa tgaacatgaa tgaggacgga cccatcatct ttgacaagca
4261 ctccaaatac aggtaccatt atgatgctga ctattctagg tgggattcaa ctcaacaaag
4321 aagcatcttg tctgccgcta tggaagtgat ggtgcggttc tctgcagaac cagaattggc
4381 acaagtggtt gcagaggacc ttctggcacc tagccaacta gatgttggcg actttgtcat
4441 ctctgttcag gaaggcttac cgtcaggggt cccatgcacg tcacaatgga attcaatagc
4501 acactggatt ttaactttga gtgcaatggc agaagtgtca ggcctctcgc cagacgttgt
4561 ccaagcccac tcctgtttct ccttctatgg tgatgatgag attgtgagca ctgacatcaa
4621 ccttgaccct tcaaaattga cacagaaact cagggagtat ggtttggtcc ccacccggcc
4681 tgacaaaact gaaggtcccc tcgtcataac tgaagacctc accggcctaa cgttcctgcg
4741 caggtcaatt gcacgggacc ctgctgggtg gtttggaaag ctggatcaag actcaattct
4801 cagacagttg tactggacaa gagggcccaa tcatgaaaac ccatatgaaa gtatggtccc
4861 ccactctcag cgggccacac agctcatggc cctccttggt gaagcttcat tgcacgggcc
4921 ccagttttac aagaaggtca gcaagatggt tatcagtgag atcaagagtg gtggtctgga
4981 gttttatgtg cccagacaag aggccatgtt caggtggatg agattctctg acctcagcac
5041 atgggagggc gatcgcaatc ttgctcccga gggtgtgaat gaagatggcg tcgaatgacg
5101 ctgctccatc gaatgatggt gctgccaacc tcgtaccaga ggccaacaat gaggttatgg
5161 cacttgaacc ggtggtggga gcttcaatcg cagctcctgt tgtcggtcag caaaatataa
5221 ttgacccctg gattagagaa aattttgtcc aagcaccaca gggcgagttc actgtttcac
5281 caaggaactc gcctggtgag atgctcttaa accttgagtt gggcccagag cttaacccct
5341 atctaagtca tttgtcccgc atgtataacg ggtatgctgg tggcatgcag gttcaggtgg
5401 tcctggctgg gaatgcgttc acagctggga aaatcatctt tgccgccgta ccaccacatt
5461 tccccgtaga aaatatcagt gcagcccaga taactatgtg cccccatgta attgttgatg
5521 tgagacaact tgaaccagtg cttctgcccc tccctgacat aaggaacaga ttcttccatt
5581 acaatcagga gaacaccccc cggatgagac ttgtagctat gctttacaca cctctgagag
5641 ccaactctgg tgaggatgtg tttactgtat cttgcagggt tttgactcgt cctgctccag
5701 attttgagtt cactttcttg gtgccaccaa ctgttgaatc aaagactaag ccttttacac
5761 tgcctatatt aactcttggt gaattgtcca attctaggtt cccagcccca atagatatgt
5821 tatacactga cccaaatgag gggattgtag tccaaccaca aaatggtagg tgcactcttg
5881 atggcactct gcagggtacc acacaattag tccccaccca gatatgtgct ttcaggggca
5941 cgctaattgg ccaaacctca agatcttcag actcaactga ttcagctccc cgaagaaggg
6001 atcacccact ccacgtgcaa ttaaagaatc ttgatggcac gcagtatgac ccaactgatg
6061 aggtgccagc ggtccttggt gccattgatt tcaagggggc cgtctttgga gtagccagcc
6121 agagggatgt ttcagggact caagtggggg caactcgtgc tcatgaagtg cacatcaaca
6181 caacagatcc caggtataca ccaaaactgg gatccattct catgcactcg gagtcggacg
6241 actttgtgac tgggcagcca atccaattca cacccgtggg aatgggtgat aacgactggc
6301 accagtggga gttgcccgat tactctggac acctaaccct gaatatgaat cttgccccag
6361 cagtcgcgcc tgccttccca ggtgagagga tccttttctt tagatcaata gtcccatctg
6421 ccggcggcta tgggtctgga caaatagatt gtctcatacc acaggagtgg gtccagcatt
6481 tctatcagga agctgcacca tcccagtctg ctgtggctct catcaggtat gtcaaccctg
6541 acacgggcag aaacatcttt gaggcaaaat tgcacaggga aggcttcatc actgtggcaa
6601 attctggtaa caaccccatt gttgtccccc ctaatgggta ctttaggttt gaagcttggg
6661 tgaatcaatt ttacactttg acccccatgg gaactggtca ggggcgcagg agaaaccaat
6721 aatggctagt gcttttcttg caggtcttgc tggcgacgtc ataacaaatg gcgttggatc
6781 tcttattaat gctggagcta atgcagttaa tcagaaagtt gaatatgatt ttaataagca
6841 gcttcaaatg gcatcattta agcatgataa ggagatgttg caatcacaag tgttggcaac
6901 caaacaattg cagcaggaga tgatgaacat aaggcaaggg gtgttgaccg ctggcggctt
6961 ctcccccgcg gacgctgcta gaggggccgt caacgctcca ttgacaaaga ttctggactg
7021 gaatggcact agatattggg caccaaatag tatgaaaacc acaagctact caggacagtt
7081 ctctagcagc cctgttcata agtcccctgc tccttctcag cacactgctc tatcaaaggg
7141 taaattgcaa agtgattctg ctagtgtata tagctctcct tctactattt cttcacaatc
7201 aacccattca acagcgctgt ctccaggaac tgggtcttcc aggtccacct ccacgtccac
7261 agcaacctcc accttgtcta ggaccagtga ctgggttagg ggacagaatg agaggctcag
7321 cccgtttatg gatggtgctc tccaaaccac ctttgtcaca ccaccatcga gcagggcctc
7381 atcaaatggc acggtctcga ccgttcccaa agctgttttg gactcctgga ctcctatgtt
7441 caacacgcat aggcagcctc tcttcgccca cctgcgtagg cgaggggagt cacaaattta
7501 gtgaaaagag tgattaggtt ttcttttctt ttctctttcc ttttctctct tttaaa
//