Typing tool
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Typing tool
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Complete norovirus genomes
| MW305736 | GII.6 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6696
ORF3: 6696..7475
LOCUS MW305736 7525 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Bethesda20181111 nonstructural polyprotein
(ORF1) gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes,
complete cds.
ACCESSION MW305736
VERSION MW305736.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7525)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7525)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7525
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Bethesda20181111"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="11-Nov-2018"
/note="genotype: GII.6[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59544.1"
/translation="LGSQNSVNDSINTTPSNKEEAGAFSNIKVGFKKMLGAVPKGTKV
PSSDQHRPTVKIGPKTLTVPPEPPNGEDTVQFDAKSETIIGLPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSGGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLSRRSI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKNIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRIDFLVYAESPEIEKVKRDFPG
QPDMWKDYFKQDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
KDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKNVKTLEDLKVAL
RDVKFNECEIIYRSSKYRVSSNGKGSVSVDKVEDHTSQTANEVGSALLRLRQARARYY
VSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQEVSEPEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTRKQRKEERGVLGLVTGSDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
VKELFGVEIKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMVRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKRVSKMVISEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6696
/gene="ORF2"
CDS 5044..6696
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59545.1"
/translation="MKMASNDAAPSNDGAANLVPEANSEVMALEPVVGASIAAPVVGQ
QNIIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVDNISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQENTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAAIDMLYTDPNESIVVQPQNGRCTLDGTLQGTTQ
LVPTQICAFRGTLISQNARAADSVDSPQRVRDHPLHVQVKNLDGTQYDPTDDIPAVLG
AIDFKGTVFGVASQRDVSGTQEQGHYATRAHEAHIDTTDPKYAPKLGTILIKSESTDF
TTNQPIRFTPVGMGDNNWRQWELPDYSGRLTLNMNLAPAVSPSFPGERILFFRSIVPS
AGGFGSGYIDCLIPQEWVQHFYQEAAPSQSAVALVRYVNPDTGRNIFEAKLHREGFLT
VANSGNNPIVVPPNGYFRFEAWVNQFYTLAPMGSGQGRRRAQ"
gene 6696..7475
/gene="ORF3"
CDS 6696..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59546.1"
/translation="MAGAFFAGLAGDVVSNGIGSLINAGANAVNQKVEYDFNKQLQMA
SFKHDKEMLQSQVLATKQLQQEMMNIKQGVLTAGGFSPADAARGAVNAPMTKILDWNG
TRYWAPNSMKTTSYSGQFSSSPVHRSPAPLQHTAPPKSKLQSDSASVYSSPSTVSSQS
THSTVLSAGTGLSRSTPTSTATSTLSRTSDWVRGQNERLSPFMDGALQTTFVTPPSSK
ASSNGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 cccttggcag tcaaaactct gtcaatgaca gtatcaacac caccccttca aacaaagaag
61 aggctggtgc attctccaac atcaaagttg gatttaagaa aatgctgggt gccgtaccta
121 agggcactaa agtacccagc agtgatcagc accgtccaac agttaagatt ggacccaaaa
181 cactaacagt cccccctgaa cccccaaatg gtgaagacac tgtacagttt gatgcaaaat
241 cggaaactat aattgggcta ccggacttga caacagtgca aaatgaacat gaaaacaccc
301 catacactgt ccctccactg agtgagaggg aacacaggcc agccactgag ccgcttcctg
361 gcacaatact ggagatgtgg gatggtgagt tctaccatta ctccgtgtac gtcagcggcg
421 gcaaagctct gggggttcat aaacctccgg cggctataag cctcgcgacg atagagctca
481 cccccatatc cctatactgg aggcctgttt acacccccaa ctacctggtc tgcccagaca
541 cactgaaagg actcgctggc gaaaagttcc cctacacggc cttcagcaac aattgctaca
601 acttctgctg ctgggtgctt gaactcaatg acacgtggct tagcagaaga agcatttcca
661 gaaccaccgg cttcttcaaa ccgtaccagt cttggaacag gaaacctctt ccaaccgttg
721 atgatggaaa gatcaaaaag gtggccaatg cgatcctttg tgcgctcggt tcgctgttct
781 caaaaccaat caaggacctg ctaggcaagc tcaaaccatt gaacctacta catctgcttg
841 cgtcgtgtga ttggacgttt gcgggtatag tggagacagt catcttaatg gcagaacttt
901 tcaatgtctt ttggaccccg ccagacgtct ctaatttcat agcctccctg ataggtgatt
961 ttgaattgca ggggcctgag gacttggcag tagagctcgt tcctgtggtt atgggtggta
1021 taggaatggt tctcggcttc acagctgaga agataggccg catgctgtca tccgctgcat
1081 caacactgcg ggcgtgcaaa gacttaggaa attatgccct tgacatactc aaattggtca
1141 tgaaatggtt cttcccaaag aaagaggaga aagccgagat ggaaaccttg agggcgattg
1201 aggatgccgt cctagacatg gaggccatag gtaacaacca cctcacgact ctactcaagg
1261 ataaagatag tctcacggcc ttcatgaaga ccttggatct ggaagaagag aaagcaagga
1321 agctatccac caaatcatcc tcgccggata tcgtcggcac catcaatgcc atactggcta
1381 ggatagctgc tgctagatcc ctcctgcaca aagccaaaga agagatgttc agcaggatca
1441 gaccagtggt tgttatgatc tcaggcagac ctggcatcgg caaaacccat atggctagac
1501 acttggctaa gaacatcgcc aacaccatga gtggtgacca gagagttggg cttgttccgc
1561 gcaatggggt tgaccactgg gacgcttaca ggggagagag ggtggtcttg tgggatgatt
1621 atggaatggg gaaccctgtc aaggatgctt taacactgca agagctagct gacacatgcc
1681 cagtcaccct aaactgtgac aggatcgaga acaagggaaa aatgttcgac agtgatgtca
1741 tcataatcac aaccaaccta gtcaaccctg cacctctcga ctatgtgaac ttcgaggcgt
1801 gctctagaag aatcgatttc ttggtctatg cagagtcacc agaaattgag aaagttaaaa
1861 gagatttccc cggccaacct gacatgtgga aagactattt caaacaagac ttttcccaca
1921 taaagctaac tctagccccc caaggcggat ttgacaagaa tggtaacacc ccgcatggca
1981 agggcaccat gcgatccctc acccaggggt ccctgaccgc aagggttgca ggtctcgttc
2041 atgaaaggaa ggatgagttc caactacaag ggaatgacct ccagacatac aactttgaca
2101 ccaacagggt ctctgcgttc aggaaactgg ctgcagacaa caagtatgga atcatggaaa
2161 caatgagagt gggtgcggcg ctcaaaaatg tcaaaacttt ggaagatctg aaagtcgcct
2221 tgagagatgt aaagttcaat gagtgtgaaa taatttacag gagctctaag taccgggtct
2281 cttccaacgg caagggctct gtttctgttg acaaagttga ggaccacacg tcccagaccg
2341 caaatgaagt gggctcagca ctcctcagac tcaggcaagc aagggctaga tattatgtca
2401 gctgcttcca agaccttgtc tacactctca tacaggttgc tggggcgtca ttcgttgtca
2461 acaggatctc caaaagattc tgttgggaaa gatgggttaa accaaccgaa acccaagaag
2521 tgagtgaacc cgaaaaggaa gtggctcaag gtagatggga gatagagccc aaggacacgg
2581 aaccagaggg taagaagggc aagaacaaga aagggagagg caagaaacac acagccttct
2641 ccagcaaggg cctaagtgat gaagaatatg atgagttcaa gagaatcaga gaagagagga
2701 acggaaagta ctccattgag gaatacctgc aagaccggga ccgctactac gaagaagtag
2761 cagttgcccg agcaacagaa gaggacttct gtgaagaaga agaagccaag ataagacaaa
2821 ggatcttccg cccaacgagg aagcaaagaa aggaggaaag gggggttctt ggcttagtca
2881 ctggttcaga catcaggaaa aggagaccag atgatttcca gccaaaagga aacctatggg
2941 cagatgacac taggagtgtg gactacaatg agagacttga ctttgaggct ccaccaagcg
3001 tctggtcaag aatagtccca ttgggcaccg gttggggctt ctgggtctca tcaaacctcc
3061 tgatcacaac aacacatgtc ctgcccaagg gggtcaaaga actctttggg gtcgaaatca
3121 aacaaattca aatccacaag tctggagagt tctgcaggtt taggttccca agaccaatca
3181 ggccagatgt cacaggactc gtgctggagg aaggtgctcc tgagggtact gtctgttcca
3241 tactcgttaa gaggcctaca ggtgagatga tccccctagc agtgaggatg ggcacgcatg
3301 catccatgaa aatacagggc aggaccgtcg gcggtcagat gggaatgctc ctcacagggg
3361 caaatgcaaa gaacatggat cttgggaccg gtcctggtga ctgcggttgt ccttacatct
3421 acaagcgtgg caacgatata gttgtcgcgg gtgtccacac cgcagcagcc cgagggggca
3481 atactgtcat ctgtgccact caaggacaag atggagaggc agtccttgag ggaaacgaga
3541 accttggcac ctactgtggt gctccaattc tgggccctgg caaagcgcct aaactcagca
3601 cgaagaccaa attttggcgc tcatcaccag atgccctacc tcctggcacg tatgaacctg
3661 cttatctggg aggtaaggat cccagagttg aaaaggggcc ctccttacag caagttatga
3721 gagaccagct gaaaccattc acagagccca ggggcaaacc acctagacca gcagttttag
3781 aagaggctaa gaaaacagta atgaacgtcc tggaacagac cattgaccct gctaaaccat
3841 ggacttactc acaagcatgt gcttcgctgg acaagaccac ttctagtgga agcccccacc
3901 atgtcaggaa gaatgatcac tggaatgggg agtcttttac cggtccccta gcggaccaag
3961 catccaaagc caacctcatg tatgaacagg caaaacatgt gcagcccgtg tatacggccg
4021 cactcaaaga tgagcttgtt aagactgata agatctacaa gaaaataaag aagagacttc
4081 tgtgggggtc agaccttggt acgatggtca ggtgtgccag ggcttttggc ggccttatgg
4141 acagtatgaa ggcaagttgt atagcccttc catgcagggt ggggatgaac atgaatgagg
4201 atggccccat catatttgac aaacactcca agtataggta ccactatgat gctgactact
4261 ctaggtggga ctcaacccag caaaggagca ttctttccgc cgccatggag gtgatggtaa
4321 ggttctctgc tgaaccagaa ttggcacaag tggtcgcaga ggacctttta gcgcctagcc
4381 agctagatgt tggcgatttt gtcatctcag tccaggaggg cctgccatca ggagtcccat
4441 gtacgtcaca atggaattca atagcgcact ggattctaac tctgagcgca atggcagaag
4501 tgtcaggtct ctcaccagac gttgtccaag cccactcctg tttttcattt tatggcgacg
4561 atgagatcgt cagcactgac atcaaccttg accccatgaa attgacacaa aaactcaggg
4621 agtatggtct ggtccccacc cggcctgata agaccgaagg ccccctcgtt ataactgaag
4681 acctaaccgg cctgactttc ctgcgcagat cgattgcacg ggatccagct ggatggtttg
4741 gaaaattgga ccaagactca atcctcaggc aattgtactg gacaaggggg cccaatcatg
4801 aaaacccata cgagagcatg gttccccact cccagcgagc tactcagctc atggcccttc
4861 ttggtgaggc ctcactgcat ggtccacagt tttacaagag agtcagcaag atggtcatta
4921 gtgagattaa gagtggtggt ctggagtttt atgtgcccag acaagaggcc atgtttaggt
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgagggtg
5041 tgaatgaaga tggcgtcgaa tgacgccgct ccatcgaatg atggtgctgc caacctcgta
5101 ccagaggcca acagtgaggt tatggcactt gaaccggtag tgggagcgtc aattgcagct
5161 cctgttgtcg gccagcagaa tataattgac ccctggatta gagaaaattt tgttcaagca
5221 ccacagggcg agtttactgt ttcaccaagg aactcgcccg gtgagatgct cctgaatctt
5281 gaattgggcc cagaacttaa cccctattta agtcatttgt cccgcatgta caatgggtat
5341 gctggtggca tgcaggttca ggtggtccta gctgggaatg cgttcacagc tgggaagatc
5401 atctttgccg ctgtgccacc acatttccct gtggataata ttagtgcagc ccagataact
5461 atgtgccccc atgtgattgt tgatgtgaga cagcttgaac cagtgcttct acccctccct
5521 gacataagga acaggttctt ccattacaat caggaaaaca caccccgaat gagactcgtg
5581 gccatgctct acacgcctct aagggctaat tccggagagg atgtgttcac tgtgtcctgc
5641 agagttctaa ctcgccccgc tccagatttt gaatttacat ttttagttcc accaactgtt
5701 gaatcaaaaa caaaaccctt taccctacca attctaaccc ttggtgagct gtcaaattcc
5761 cgttttcctg ctgctataga catgctttac actgatccca atgaatcaat agttgtacag
5821 ccccaaaatg gtaggtgcac ccttgatggt acgttgcagg gcacaacaca attagtccca
5881 acacagattt gtgcttttag aggcactctg atcagccaga atgcgagagc agccgattca
5941 gtagactccc cccagagagt ccgtgaccac ccgttgcatg tccaggtcaa gaacctagat
6001 ggcacacagt atgacccaac agatgacatc cctgcagtcc tgggggccat tgacttcaaa
6061 ggtacagtgt tcggagtggc aagtcagagg gacgtctctg ggacacaaga acagggccat
6121 tatgccaccc gggctcatga agcacacatt gacacaactg acccaaagta tgctcctaaa
6181 ttaggcacaa ttctcatcaa atctgaatct actgatttca ccacaaatca gcccatcagg
6241 tttactccgg tgggtatggg tgacaacaat tggagacagt gggagttgcc tgactactct
6301 ggcagattga ctctgaatat gaaccttgcc cctgctgttt ctccatcctt ccctggtgag
6361 cgaatccttt tctttaggtc tatagtacca tcagccggag gcttcgggtc tggctatata
6421 gactgtctca taccccagga atgggtgcaa cacttctacc aggaggcagc accttcacag
6481 tctgctgttg cactggttag gtatgtcaac cctgacactg ggcgcaacat ctttgaggct
6541 aagttgcaca gagaagggtt cctcaccgtg gccaattctg gaaacaatcc tattgtggtt
6601 ccccctaatg gttatttcag atttgaggct tgggttaatc aattctatac acttgccccc
6661 atgggatctg gacaggggcg tagaagagct cagtaatggc tggagccttc ttcgcagggt
6721 tagcaggtga tgtcgtatcg aacggcatcg gttccctcat caatgcaggt gctaatgcag
6781 tcaatcaaaa ggttgagtat gattttaata agcaacttca gatggcatca tttaaacatg
6841 ataaggagat gttacaatca caggtgttgg caaccaaaca actgcagcag gaaatgatga
6901 acataaagca gggggtgttg accgctggcg gcttttcccc cgcggacgct gctagagggg
6961 ctgttaacgc tccaatgaca aaaatactag actggaatgg cacaagatac tgggcaccta
7021 atagcatgaa gaccacaagc tattcaggac agttctctag tagccccgtc cacaggtctc
7081 ctgctcccct ccagcacact gccccaccaa aaagtaaatt gcaaagtgat tctgctagtg
7141 tgtatagctc cccttctact gtttcttcac aatcaactca ttcaacagtg ttgtctgcag
7201 gaactgggtt gtccagatcc acccccacgt ccacagcaac ctccaccctg tctaggacca
7261 gcgactgggt tagaggacag aatgaaagac ttagcccgtt tatggatggt gctctccaaa
7321 ctacttttgt cacaccacca tcgagcaaag cttcatcaaa tgggacagtc tcgaccgtgc
7381 ccaaagctgt tttggactcc tggactccta tgttcaacac acataggcag cctctcttcg
7441 cccatctacg taggcgaggg gagtcacaaa tttagtgaaa agagtgatta ggttttcttt
7501 ccttcctccc ccttttctct ctttt
//