Typing tool
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Typing tool
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Complete norovirus genomes
| MW305734 | GII.17 | |
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| GII.P3 |
ORF1: 1..5076
ORF2: 5057..6682
ORF3: 6682..7461
LOCUS MW305734 7499 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate DS284 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305734
VERSION MW305734.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7499)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REFERENCE 2 (bases 1 to 7499)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7499
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="DS284"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Saudi Arabia"
/collection_date="1990"
/note="genotype: GII.17[GII.P3]"
gene <1..5076
/gene="ORF1"
CDS <1..5076
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QPJ59538.1"
/translation="VAGKNINNDKEKSSSDSLFSNMTVTFKKALGARPKQPPPGETKQ
TQKPPRPPTPELVKRIPPPPPNGEDEPKVVYRVGEGVSGLPDLTTVAQPDAQNTAYSV
PPLSQREAGEAKEPLPGSILEMWDGEIYHYGLYVERGHILGVHKPPAAISLAKIELTP
LSLYWRVVYTPQYLIAPDTLKNLSGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQ
RTTGFFRPYQDWNRKPLPTMDEPKIKKVANAVLCALSSLFTRPIKDIIGKLKPMNILN
ILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYEMQGPEDLAVELVPV
VMGGVGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANEL
AMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIV
GTINALLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLARELAKKVASTL
SGDQRIGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCPLTLNCDR
IENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEKAKRDFPGQ
PDMWKDHYRPDFTHIKLQLAPQGGFDKNGNTPHGKGVVKSLTIGSLIARASGLLHERM
DEFELQGPNLPTFNFDRNKIAAFRQLAAENKYGMVDTLRVGNQLKSVKTMDELKQAIK
SITIKKCQIVYNGCTYTMESDGRGRVSVDKVQNTTVQTNNELSGALHHLRSARIRYYV
KCFQEVVYSLLQIAGAAFVTSRIVRRMNISSLWSKPPVEESDEPEDKEGCPKPRDEDD
LTIDSKDIKVEGKKGKNKSGRGKKHTAFSAKGLSDEEYDEYKRIREERNGKYSIEEYL
QDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLVTGSEIRKR
NPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWVSPSLFITSTH
VIPKGITEAFGVPMNQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAPEGTVASILIK
RTTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYK
RGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGNAPKLS
TKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPNPS
VLESAKKTIINVLEQVIDPPQKWSYAQACASLDKSTSSGHPHHVRKNDYWSGESFTGK
LADQASKANLMYEEGKHMPPVYTAALKDELVKTDKIYGKIKKRLLWGSDLATMIRCAR
AFGGLMDELKANCITLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRAVL
AAALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCTSQWNSIAH
WLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTR
PDKTEGPLVVSEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQLYWTRGPNHEDPSET
MIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQESMFRWMRF
SDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..966
/gene="ORF1"
/product="p48"
mat_peptide 967..2064
/gene="ORF1"
/product="NTPase"
mat_peptide 2065..2601
/gene="ORF1"
/product="p22"
mat_peptide 2602..3000
/gene="ORF1"
/product="VPg"
mat_peptide 3001..3543
/gene="ORF1"
/product="Pro"
mat_peptide 3544..5073
/gene="ORF1"
/product="RdRp"
gene 5057..6682
/gene="ORF2"
CDS 5057..6682
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59539.1"
/translation="MKMASNDAAPSNDGATGLVPEINNETLPLEPVAGAAIAAAVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
VRNTFFHYNNRPSERMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTISELTNSRFPAPIDSLFTAQNNVLNVQCQNGRCTLDGELQGTT
QLLPTGICSFRGKITANVEGSHDDKWHMSLTNLNGTPFDPTEDVPAPLGTPDFTGLLF
GVASQRNVGGTANNTTRAHEAVISTTSTQFVPKLGSVNFGSESPDFQIGQPTRFTPVG
IKIEDGHPFEQWKLPNYAGALTLNMNLAPPIAPNFPGEQLLFFRSNVPCAGGISDGVI
DCLLPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRTGYITVAHTGDYPL
VVPSNGYFRFDSWVNQFYSLAPMGTGNGRRRIQ"
gene 6682..7461
/gene="ORF3"
CDS 6682..7461
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59540.1"
/translation="MAGAFIAGLAGDMLTNAVGSLANAGANAITQKIDFENNKQLQTA
SFQHDKDMLRAQVDATKQLQSEMIAIRQGVLTAGGFSPTDAARGAVGAPMTKVLDWSG
TRYWAPNSTKTTSYSGQFTSTPVHTPNLSSKPKPTNVKTQPLSSSSGSVYSLSTQSTT
LSGPSSGSSVSSASTQSTKLSSVSSMNRTADWVNQQRSLSPYMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 gttgctggca aaaacatcaa caacgacaag gaaaaatctt caagtgacag cttgttttca
61 aacatgactg ttacttttaa gaaagccctc ggggcgcggc ctaaacagcc gcccccgggg
121 gaaacaaaac aaacacaaaa accaccaaga ccaccaacac cggaattggt gaaaagaata
181 cccccacccc cacccaacgg cgaggatgaa cctaaggtgg tgtacagggt gggagagggt
241 gtgtccgggc tgcccgactt aacaaccgtg gcgcagcctg acgcacaaaa cacagcttat
301 agtgttcccc cacttagcca gagagaggca ggcgaagcta aagagccgct acctggatcc
361 attctggaaa tgtgggatgg tgagatctac cactatgggc tatacgttga gcggggacac
421 atacttggag tgcataaacc acctgctgca ataagcctcg ccaaaatcga attaacacca
481 ctgtctctct actggagagt ggtttacact ccccagtact tgatagcccc agacactctg
541 aagaacttga gtggagaatc attcccatat acggcctttg acaacaattg ttacgccttc
601 tgttgttggg tcttagatct caatgactct tggcttagca ggagaatgat tcaaaggaca
661 accggcttct tcaggccgta tcaagattgg aatagaaaac ccttgccaac catggatgag
721 ccaaaaatca agaaggtcgc gaatgctgtt ctgtgcgctc tctcctcact cttcactaga
781 cccattaagg acattattgg aaaactcaaa ccaatgaaca tcctcaatat attagcaact
841 tgtgactgga cttttgcagg catagtggaa tccctaattc ttcttgctga actctttggg
901 gtgttctgga cacccccaga tgtgtctgcg atgattgctc ccttactcgg tgactacgag
961 atgcaaggcc ccgaagacct ggccgtggaa ctcgtacctg tggtgatggg aggggtaggt
1021 ttggtgttgg gattcaccaa ggagaagatc ggcaagatgc tttcatcagc tgcatccacg
1081 cttagggcct gcaaagatct aggggcctat ggattggaga tactcaaatt agtcatgaag
1141 tggttcttcc ccaagaaaga agaggctaat gagttagcca tggtaagggc catcgaggat
1201 gcagtcttgg acttggaggc aatagaaaac aaccacatga ccactcttct caaggacaaa
1261 gacagtctgg ccacatacat gaggactctt gacttggagg aagagaaagc aaggaaactg
1321 tccaccaaat ctgcatcacc tgacattgta ggcacaataa atgcattatt ggcaaggatt
1381 gcagccgcta ggtcactagt ccataaggct aaggaggagc tttcaagcag acagaggcct
1441 gttgtcgtga tgatatcagg tagaccaggc ataggaaaga cccatctcgc cagagagcta
1501 gccaagaaag ttgcatcaac actgtcgggc gaccaaagaa ttggactggt gcctagaaac
1561 ggtgtagacc actgggatgc ctacaagggg gaaagagtag tgctatggga cgactatggc
1621 atgagcaacc ccatacagga tgcactgaga cttcaagagt tggccgatac ctgtcctcta
1681 actctaaact gtgatagaat tgaaaacaag ggaaaagtgt ttgacagtga tgccataatc
1741 ataacaacca accttgcaaa cccagcacca ctggattatg tcaattttga ggcttgctcc
1801 agacgcatag acttcttagt gtatgcagat gcacctgaca ttgagaaggc caagcgcgac
1861 ttccctggcc aaccagatat gtggaaagat cattacagac cagacttcac acacatcaaa
1921 cttcagctag caccacaggg aggttttgat aagaatggta acaccccaca tggtaaaggt
1981 gtagtgaagt ctctgacgat tgggtcattg atcgccaggg cttctggctt gctccacgag
2041 agaatggatg aattcgagct ccaaggccct aacctaccaa ctttcaattt cgaccgcaac
2101 aagatcgccg ccttcaggca attggcagct gaaaacaaat atggtatggt agacacactg
2161 agggtcggta atcaactgaa aagtgtcaag accatggatg agcttaaaca ggctataaag
2221 agtatcacta tcaagaagtg ccaaatagtg tacaatgggt gtacctacac catggagtcc
2281 gatggaagag gcagggtctc agttgacaag gtgcaaaata caacagtcca aaccaataat
2341 gagctttcag gagcgctgca ccacttaaga tctgcaagaa taaggtatta tgtcaaatgt
2401 ttccaggaag ttgtctattc tttgctacaa attgctggtg cagcctttgt cacctcacgc
2461 atcgtgaggc gcatgaacat ctcaagcctc tggtcgaagc cacctgttga agagagtgat
2521 gaacctgaag acaaagaagg gtgccccaaa cccagagatg aagatgatct caccatcgat
2581 tccaaggaca ttaaagtgga aggaaagaag ggcaagaaca aatccggccg aggtaagaaa
2641 cacacagcct tctcagctaa gggcctcagt gatgaagagt acgatgagta taagagaatc
2701 agagaagaaa ggaatggcaa atactcaata gaagagtacc tccaagacag ggacaggtac
2761 tatgaagaac ttgccatcgc taaggccact gaagaggact tctgtgaaga agaggagatc
2821 aaaatccgtc agagaatctt ccgccccacc aggaagcagc ggaaagagga aagggctaca
2881 cttgggctcg tcacagggtc agagatcaga aagaggaatc cagatgactt caaaccaaaa
2941 gggaaattgt gggctgatga taacaggagt gtggactaca acgaaaggat agattttgaa
3001 gcacccccca gcgtttggtc aagaatagtc aactttggca caggttgggg attctgggtt
3061 tctcctagcc tcttcataac ctcaacacac gtgataccaa aaggaatcac ggaggccttt
3121 ggagtaccca tgaaccaaat ccaaattcat aaatcagggg aattctgccg cttaaggttt
3181 ccaaaaccaa tcaggccaga cgtgagtggg atgatcttgg aagagggtgc ccccgaagga
3241 actgttgcgt ccatcctcat caaaagaaca acaggggaac tgatgccact tgcagccaga
3301 atgggaaccc acgccacaat gaaaatccaa ggaagaacgg tgggtggtca gatgggcatg
3361 ttgctcaccg gttcaaatgc caaaagcatg gacctaggca caacaccagg tgactgtggg
3421 tgcccctaca tatacaagag gggcaatgac ttcgtggtca ttggcgtgca cactgcagca
3481 gcacgtggag ggaacacagt catatgtgcc acacaaggaa gcgagggtga agccactctt
3541 gaaggaggtg acaacaaagg cacctattgt ggagccccca ttttgggacc aggcaatgca
3601 ccaaaattga gcacaaaaac gaaattctgg agatcttcca atgcaccgct accgccaggc
3661 acctatgaac cagcgtacct gggtgggaaa gacccacgtg tgaagggtgg cccatcccta
3721 caacaggtca tgagggatca acttaaacct tttacagaac ccagggggaa accgccaaac
3781 ccaagtgtcc tagaatcagc aaagaaaact atcatcaatg ttctagaaca ggtcatcgac
3841 cccccccaga agtggtctta tgcccaagct tgtgcatctc ttgacaaatc aacctccagt
3901 ggacacccac accacgttcg gaagaatgac tactggagcg gtgaatcctt cacaggaaaa
3961 cttgcagacc aggcatcaaa agcaaacctc atgtacgagg aaggcaaaca catgccgcca
4021 gtttacaccg cagcgctcaa ggacgagctg gtgaagactg acaaaattta tggtaaaatc
4081 aagaagaggc tcctgtgggg ttctgacctc gccaccatga ttcgatgcgc cagagcattt
4141 ggtggtctca tggatgaact caaagcaaat tgtatcacac ttcctatcag agttggcatg
4201 aacatgaatg aagatggtcc cataatattt gagaaacatt ccagatacag ataccactat
4261 gatgcagatt actcccgctg ggattccacg cagcagcggg cagtgttggc agcagcacta
4321 gaaatcatgg tgaggttctc tgctgaacca cagttagcac aaatagttgc tgaagatctg
4381 ctggcaccaa gcgtggttga tgtgggtgac ttcaaaatca ccattaatga aggcctacct
4441 tctggtgtgc cttgcacctc acaatggaac tccattgccc actggttgct tactctatgt
4501 gccctttctg aagtgacagg actaggccct gacatcatac aagccaattc catgtactct
4561 ttttatggtg atgatgagat tgtaagcact gacataaaat tggacccaga gaaactgact
4621 gcaaaactca aagagtatgg cctcaaaccc actcgccccg acaaaactga agggccgctg
4681 gtggtcagtg aagacctgaa tgggttgacg ttcctccgcc gaacagtcac ccgtgaccca
4741 gcaggttggt tcggaaagct ggatcaaagt tccatcctca ggcagctata ctggacaaga
4801 ggacctaacc atgaagaccc cagtgaaacc atgataccac atgcgcaaag acccgtgcag
4861 ctcatggcac tgctgggaga gtcctcccta catggaccct cattttacag caaggttagc
4921 aagctagtca tatctgaact taaggaggga ggaatggatt tttatgtgcc cagacaagag
4981 tcaatgttca gatggatgag gttctcagat ctaagcacat gggagggcga tcgcaatctg
5041 gctcccagtt ttgtgaatga agatggcgtc gaatgacgcc gctccatcta atgatggtgc
5101 tacgggcctc gtcccagaga tcaacaacga gacccttccc ctagaaccag tggctggtgc
5161 ggctattgct gcagctgtca ctggtcaaaa taatataatt gatccctgga ttagaacaaa
5221 ttttgtacaa gcacctaacg gggaattcac cgtttcacct aggaattccc caggagagat
5281 tcttctaaat ttggaattag gtcctgatct aaatccttat ttggcacacc tatccagaat
5341 gtacaatggc tatgctggtg gagtggaagt tcaggttctc ctggcgggga acgcgttcac
5401 tgctggaaag atcctcttcg ctgctgtgcc accaaatttc ccagttgaat ttctgagtcc
5461 tgctcaaatt actatgctcc cacacttgat agttgatgtt agaactcttg aaccaatcat
5521 gatacccctc cccgatgtga gaaacacctt cttccactac aacaaccggc cttctgagcg
5581 catgcgcttg gtagccatgc tgtacacacc tctgaggtcc aatggttcag gtgatgatgt
5641 tttcacagtt tcatgtagag tgctgactag acctacccca gattttgagt ttacttattt
5701 agttccacct tcagtagaat ctaaaacaaa acctttctct ctccctatac tgactatttc
5761 tgaattaact aactcaagat tcccagcacc tattgattca ttgttcactg ctcaaaacaa
5821 tgtcctcaat gtccaatgtc agaatggccg atgcacactg gatggtgaac tacaggggac
5881 cactcaactg ctcccaactg gcatatgctc ctttagagga aagataacag caaatgtgga
5941 gggcagccac gatgacaagt ggcatatgag tttgacaaac ctcaatggaa ccccatttga
6001 cccaacggag gatgtcccag ccccactagg tacccctgac ttcacaggtc tcctctttgg
6061 agtcgcaagc caaaggaacg tcggtgggac agccaacaac accaccaggg cacatgaggc
6121 tgtgatatca acaaccagca cacaatttgt gccaaaatta ggttctgtca actttgggag
6181 tgagagtccg gatttccaga ttggccagcc aaccagattt acaccagttg gaatcaaaat
6241 tgaagatggg catccttttg aacaatggaa gttaccaaac tatgctggag cactgaccct
6301 caacatgaac cttgccccac ccattgctcc caatttccca ggtgagcagt tgcttttctt
6361 cagatcaaat gttccttgtg ctggtggtat cagtgacggt gtcattgact gtctgctacc
6421 tcaggagtgg atacagcatt tctaccaaga atctgccccg tcccaatcag acgtggcgct
6481 gatcagatat gtcaaccctg acacgggccg cactctcttt gaggcgaagc ttcacaggac
6541 tggctacatc actgttgccc acactggtga ttatcccctt gttgtcccct ccaatggcta
6601 cttcagattt gattcttggg taaatcaatt ttactcactt gcccccatgg gaactgggaa
6661 tgggcgcaga aggattcagt aatggcagga gccttcatag caggtcttgc aggtgacatg
6721 ctcaccaacg ctgttggctc tctggcgaac gccggagcaa atgccataac tcaaaagata
6781 gattttgaaa acaacaaaca actgcagaca gcctccttcc aacatgacaa ggacatgctc
6841 cgcgcgcaag tggatgcaac caaacaactg caatcagaga tgatcgccat caggcagggg
6901 gttttgaccg cgggcggctt ttcccctact gatgcagcga gaggggctgt gggagcaccc
6961 atgactaaag ttcttgattg gtctggcacc cgttactggg caccaaattc taccaaaaca
7021 acaagctatt cggggcaatt cacatcaaca cctgtgcaca caccaaattt gagtagcaaa
7081 cccaaaccca caaacgttaa aacccaaccc ctttcttctt cttctggtag tgtttatagt
7141 ctttcaactc agtcaactac actgtccgga ccttcttcag gttcatctgt ttcctctgct
7201 tcaacacaat caacaaaatt aagttcagtt tcttctatga atagaacagc tgattgggtc
7261 aatcaacaaa gaagccttag cccttacatg agtggagctc tcaacatctc tcatgtaaca
7321 cctccatcaa gcagggcttc tagttcggga acagtctcga ctgtacccaa agaagttttg
7381 gactcctgga catctgcatt taacacacgc agacagccgc tcttcgcaca cctcagagtg
7441 aggggggagt cacgtgttta gtgaaaagaa ataattgatt tttaattagg cttaaaatt
//