Typing tool
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Typing tool
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Complete norovirus genomes
| MW305731 | GII.3 | |
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| GII.P3 |
ORF1: 1..5077
ORF2: 5058..6704
ORF3: 6704..7468
LOCUS MW305731 7505 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate DS332 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305731
VERSION MW305731.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7505)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7505)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7505
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="DS332"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Saudi Arabia"
/collection_date="1990"
/note="genotype: GII.3[GII.P3]"
gene <1..5077
/gene="ORF1"
CDS <1..5077
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ59529.1"
/translation="VAGKNNNNDKEKSSGDSLFSNMTVSFKKALGARPKQPPPGETKQ
TQKPPRPPTPELVKRIPPPPPNGDDEPKVVYRVGEGVSGLPDLTTVAQPDAQNTAYSV
PPLSQREVGEAKEPLPGSILEMWDGEIYHYGLYVERGHILGVHKPPAAISLAKIELTP
LSLYWRVVYTPQYLIAPDTLKSLNGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQ
RTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDIIGKLKPMNILN
ILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYEMQGPEDLAVELVPV
VMGGIGLVLGFTKEKIGKMLSSAASTLKACKDLGAYGLEILKLVMKWFFPKKEEANEL
ALVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIV
GTINALLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLARELAKKVASTL
SGDQRIGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCPLTLNCDR
IENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEKAKRDFPGQ
PDMWKDHYRPDFTHIKLQLAPQGGFDKNGNTPHGKGVVKSLTLGSLIARASGLLHERM
DEFELQGPNLPTFNFDCNKIAAFRQLAAENKYGMVDTLRVGNQLKSVKTMDELKQAIK
NITIKKCQIVYNGCTYTMESDGRGKVSVDKVQNATVQTNNELSGALHHLRSARIRYYV
KCFQEAVYSLLQIAGAAFVTSRIVRRMNISSLWSKPPVEESDESEDKEGCPKPRDEDD
LTIDSKDIKVEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYL
QDRDRYYEELAIAKATEENFCEEEEIKIRQRIFRPTKKQRKEERATLGLVTGSEIRKR
NPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWVSPSLFITSTH
VIPKGITEAFGVPMNQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAPEGTVASILIK
RTTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYK
RGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILGPGNAPKLS
TKTKFWRSSNAPLPPGTYEPAYLGGKDPRVRGGPSLQQVMRDQLKPFTEPRGKPPNPS
VLESAKKTIINVLEQVIDPPQKWSYAQACASLDKTTSSGHPHHVRKNDYWSGESFTGK
LADQASKANLMYEEGKHMPPVYTAALKDELVKTDKIYGKIKKRLLWGSDLSTMIRCAR
AFGGLMDELKANCITLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRAVL
AAALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCTSQWNSIAH
WLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTR
PDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQLYWTRGPNHEDPSET
MIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQESMFRWMRF
SDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..967
/gene="ORF1"
/product="p48"
mat_peptide 968..2065
/gene="ORF1"
/product="NTPase"
mat_peptide 2066..2602
/gene="ORF1"
/product="p22"
mat_peptide 2603..3001
/gene="ORF1"
/product="VPg"
mat_peptide 3002..3544
/gene="ORF1"
/product="Pro"
mat_peptide 3545..5074
/gene="ORF1"
/product="RdRp"
gene 5058..6704
/gene="ORF2"
CDS 5058..6704
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59530.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNEAMALEPVAGAAIAAPLTGQ
QNIIDPWIMNNFVQAPGGEFTVSPRNSPGEVLLNLELGPEINPYLAHLARMYNGYAGG
FEVQVVLAGNAFTAGKVIFAAIPPNFPIDNLSSAQITMCPHVIVDVRQLEPINLPMPD
VRNNFFHYNQGSDSRLRLIAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFSFNFLVPP
TVESKTKPFTLPILTISEMSNSRFPVPIDSLHTSPTENIVVQCQNGRVTLDGELMGTT
QLLPSQICAFRGTLTRSTSRASDQADTSTPRLFNYYWHIQLDNLNGTPYDPAEDIPAP
LGTPDFQGKVFGVASQRNPDSTTRAHEAKVDTTSGRFTPKLGSLEIITESDDFDTNQP
TKFTPVGIGVDNEAEFQQWSLPNYSGQFTHNMNLAPAVAPNFPGEQLLFFRSQLPSSG
GRSNGTLDCLVPQEWVQHFYQESAPAQTQVALVRYVNPDTGRVLFEAKLHKLGFMTIA
KNGDSPITVPPNGYFRFESWVNPFYTLAPMGTGNGRRRIQ"
gene 6704..7468
/gene="ORF3"
CDS 6704..7468
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59531.1"
/translation="MAGAFIAGLAGDMLTNTVGSLVNAGANAINQKVDFENNKYLQNA
SFNHDKEMLNAQIEATKRLQTDMIAIKQGVLTAGGFSPTDAARGAINAPMTKVLDWSG
TRYWAPNATSTTSMSGGFTSQVVHRTTPNFKTSQAPKFTPSSGSSVRSSSTQLTNLSS
HSSGSSRSSGSTVVSSLPSSSRTRDWVNQQNLNLEPYMPGSLRTAFVTPPSSTASSSG
TVSTVPKNVLDSWTSAFNTRRQPLFAHLRRRGESNV"
ORIGIN
1 cgttgctggc aaaaacaaca acaacgacaa ggaaaaatct tcaggtgaca gcttgttttc
61 taacatgact gtctccttta agaaagccct cggggcgcgg cctaaacaac cgcccccggg
121 agaaacaaaa caaacacaaa aaccaccaag accaccaaca ccggaattgg tgaaaagaat
181 acccccacca ccacccaacg gcgatgatga accaaaggtg gtatacaggg tgggagaagg
241 tgtgtccggg ctgcccgact taacaaccgt ggcgcagcct gacgcacaaa acacagctta
301 tagtgtgccc ccacttagcc aaagagaggt cggcgaagct aaggaaccgc tacctggatc
361 cattctggaa atgtgggatg gtgagatcta ccactatggg ctgtacgttg agcgggggca
421 catacttggg gtgcataaac cacctgctgc aataagcctc gccaaaattg aactaacacc
481 actgtctctc tactggagag tggtttacac tccccagtac ttgatagccc cagacactct
541 gaagagcttg aatggagaat cattcccata cacagccttt gacaacaact gttacgcctt
601 ctgttgttgg gtcttagatc tcaatgactc ttggcttagc aggagaatga ttcaaaggac
661 aaccggcttc ttcaggccgt accaagattg gaatagaaaa cccctgccaa ccatggatga
721 gccaaaaatc aagaaggccg cgaatgctgt tctgtgcgct ctctcctcac tcttcactag
781 acccattaag gacattattg gaaagctcaa accaatgaac atcctcaata tattagcaac
841 ttgtgactgg acttttgcag gcatagtgga gtcccttatt cttcttgctg aactttttgg
901 ggtgttctgg acacccccag atgtgtctgc gatgattgct cccttactcg gtgactacga
961 gatgcaaggc cccgaagacc tggccgtgga acttgtaccc gtggtaatgg gagggatagg
1021 tttggtgttg ggattcacca aggagaagat cggcaagatg ctttcgtcag ctgcatccac
1081 gcttaaggcc tgcaaagatc taggagccta tggattggag atacttaaat tggtcatgaa
1141 gtggttcttc cctaagaagg aagaggctaa cgagttagcc ttggtaaggg ccatcgagga
1201 tgcagtcctg gatttagagg caatagaaaa caaccacatg accactctcc tcaaggacaa
1261 agacagtctg gccacataca tgaggactct tgacctggag gaagagaaag caaggaaact
1321 gtccaccaaa tccgcatcac ctgacattgt gggcacaata aatgcattat tggcaaggat
1381 tgcagccgct aggtcactag tccacaaggc taaggaggag ctttcaagca gacagaggcc
1441 tgtcgtcgtg atgatatctg gcagaccagg catagggaag acccatctcg ccagagagct
1501 agccaagaaa gttgcatcaa ccctgtcggg cgaccaaagg attggactgg tgcctagaaa
1561 cggtgtagac cactgggacg cctacaaggg ggaaagagtg gttctatggg atgactatgg
1621 catgagtaac cccatacagg atgcactgag gcttcaagag ttggctgata cctgtcctct
1681 aactctaaac tgtgacagaa ttgaaaacaa gggaaaagtg tttgacagtg atgccataat
1741 cataacaacc aaccttgcaa acccagcacc gctggattat gtcaactttg aggcttgctc
1801 cagacgcata gactttttag tgtatgcaga tgcacctgac attgagaaag ccaagcgtga
1861 cttccctggc caaccagata tgtggaaaga tcactacaga ccagacttta cacacatcaa
1921 acttcagcta gcaccacagg gaggttttga taagaatggc aacaccccac atggtaaagg
1981 tgtagtgaag tctctgacgc ttgggtcatt gatcgccagg gcttctggct tgcttcacga
2041 gagaatggat gaattcgagc tccaaggccc taacctacca accttcaatt ttgactgcaa
2101 caagatcgcc gcctttaggc aattggcagc tgaaaacaaa tatggtatgg tggacacact
2161 gagggtcggt aatcaactga agagtgtcaa gaccatggat gagctcaaac aggctataaa
2221 gaatatcacc attaagaagt gccaaatagt gtacaatggg tgtacctaca caatggagtc
2281 tgatggaaga ggcaaggttt cagttgacaa ggtgcaaaat gcaacagtcc aaactaacaa
2341 tgagctttca ggagcgctgc accacttaag atctgcaaga ataagatatt atgttaaatg
2401 tttccaggaa gctgtctatt ctttgctaca aattgctggt gcggcttttg tcacctcacg
2461 cattgtgagg cgcatgaaca tctcaagcct ctggtcgaag ccacctgttg aagagagtga
2521 tgaatctgaa gacaaagaag ggtgcccgaa gcccagagat gaagatgacc tcactatcga
2581 ttccaaggac attaaagtgg aaggaaagaa aggcaagaac aagtccggcc gaggtaagaa
2641 acacacagcc ttctcatcta agggcctcag tgatgaagag tacgatgagt acaagagaat
2701 cagagaagaa aggaatggca aatactcaat agaggagtac ctccaagaca gggacagata
2761 ctatgaagag cttgccattg ctaaggccac tgaagagaac ttctgtgaag aggaggagat
2821 caagatccgt cagagaatct tccgccccac caaaaagcag cggaaagagg aaagggctac
2881 acttgggctc gtcacagggt cggagatcag aaagaggaat ccagatgact tcaagccaaa
2941 agggaaactg tgggctgatg ataacaggag tgtggactac aatgagagaa tagattttga
3001 agcaccccct agcgtttggt caaggatagt caactttggc acaggctggg gattctgggt
3061 ttctccaagt ctcttcataa cctcgacaca cgtgatacca aaaggaatca cggaggcatt
3121 tggggtgccc atgaaccaaa tccaaattca taaatcaggg gaattctgcc gcttacggtt
3181 tccaaaacca atcaggccag acgtgagtgg gatgattttg gaagagggtg cccctgaagg
3241 aactgttgcg tccatcctca tcaaaagaac aacaggggag ttgatgcccc ttgcagccag
3301 aatgggaacc cacgccacaa tgaaaatcca aggaagaacg gtgggtggcc agatgggcat
3361 gttactcaca ggttcaaatg ccaaaagcat ggacctaggc acaacaccag gtgactgtgg
3421 gtgcccctac atatacaaga ggggcaatga cttcgtggtc attggcgtgc acactgcagc
3481 agcacgtgga ggaaacacag tcatatgtgc cacgcaagga agcgaaggtg aagccactct
3541 tgagggaggt gacgacaagg gcacctattg tggagccccc attttaggac ctggtaatgc
3601 accaaaattg agcacaaaaa caaaattctg gagatcttcc aacgcaccgc tcccgccagg
3661 cacctatgaa ccagcatacc taggtgggaa agatccacgt gtgaggggtg gtccgtctct
3721 gcaacaggtc atgagagacc aacttaaacc tttcacagag cccagaggga aaccaccaaa
3781 cccgagtgtc ctagaatcag caaagaaaac tatcatcaat gttctagagc aggtcattga
3841 ccccccccag aagtggtcct atgcccaagc ttgtgcatcc cttgacaaaa caacctccag
3901 tggacacccg caccacgttc ggaagaatga ttactggagt ggtgaatcct tcacaggaaa
3961 acttgcagac caggcttcaa aagcaaatct catgtatgaa gaaggcaaac acatgccacc
4021 ggtttacacc gcagcgctca aggacgagct ggtgaaaact gacaaaatct atggtaaaat
4081 taagaaaagg ctcctgtggg gttctgacct ctctaccatg attcggtgcg ccagagcatt
4141 tggtggcctc atggatgaac tcaaagcaaa ttgtatcaca cttcctgtca gagttggcat
4201 gaacatgaat gaagatggtc ccataatatt tgagaaacat tccagataca gataccacta
4261 tgatgcagat tactcccgct gggactccac gcagcagcgg gcagtgttgg cagcagcact
4321 tgaaatcatg gtgaggttct ctgctgaacc acagctagca caaatagtag ctgaagatct
4381 gctagcacca agtgtggttg atgtgggtga cttcaagatc accattaatg aaggcctacc
4441 ttctggtgtg ccttgcacct cacagtggaa ctccattgcc cactggttgc ttactctgtg
4501 tgccctttct gaagtgacag gactaggccc cgacatcata caagctaatt ccatgtactc
4561 tttctatggt gatgatgaga ttgtgagcac tgacataaaa ttggacccag agaaactgac
4621 tgcaaaactc aaagagtacg gcctcaaacc cactcggccc gacaaaaccg aagggccgct
4681 ggtgatcagt gaagacttga atggtttaac gttcctccgc cgaacggtca cccgtgaccc
4741 agcaggttgg tttggaaagc tggagcaaag ttccatcctc aggcagctat actggacaag
4801 aggacctaac catgaagacc ccagtgaaac catgatacca catgcgcaga gacccgtgca
4861 gctcatggca ctactgggag aatcctccct acatggaccc tcattttaca gcaaggtcag
4921 caagctggtt atatctgaac ttaaggaggg aggaatggat ttttatgtgc ccagacaaga
4981 gtcaatgttc aggtggatga ggttctcaga tctaagcaca tgggagggcg atcgcaatct
5041 ggctcccagt tttgtgaatg aagatggcgt cgaatgacgc tgctccatct aatgatggtg
5101 ccgccggcct cgtcccagag atcaacaatg aggcaatggc gctagagcca gtggcgggtg
5161 cagcgatagc agcgcccctc actggtcagc aaaatataat tgatccctgg attatgaata
5221 attttgtgca agcacctggt ggtgagttta cagtgtcacc taggaattcc cctggtgaag
5281 tgcttcttaa tttggaatta ggtccagaaa taaatcccta tttggctcat cttgctagaa
5341 tgtacaatgg ttatgcaggt ggatttgaag tgcaagtggt cctagctgga aatgcgttta
5401 cagcaggaaa ggttatcttt gcagctatac cccctaattt ccctattgac aatctgagct
5461 cggcacagat cacaatgtgc ccgcacgtga ttgtggatgt caggcagttg gaaccaatca
5521 atctcccgat gcctgatgtc cgcaacaatt tctttcatta taatcaaggt tctgattcaa
5581 gattacgttt gattgcaatg ctgtatacac ctcttagggc aaataattct ggagatgatg
5641 ttttcactgt gtcttgtagg gtgttaacta ggcctagccc tgatttctca ttcaattttc
5701 ttgtcccacc cactgtggaa tcaaagacaa aaccttttac cctccccatt ttaaccatct
5761 ctgaaatgtc taattccagg tttccggtgc caattgactc tctgcacacc agcccaactg
5821 agaatatagt tgtccagtgc caaaatgggc gcgtcactct tgacggtgag ttaatgggca
5881 ccacccaact cttaccgagc caaatatgtg ctttcagggg cacactcact agatcaacaa
5941 gcagggccag tgaccaagcc gacacatcaa cccctaggct attcaactat tattggcaca
6001 tacaattgga taatctaaat ggaactccct acgaccctgc agaggacata ccagctcctt
6061 tgggcacacc agacttccag ggcaaggtct ttggcgtagc cagccagaga aaccccgaca
6121 gcacaacaag ggcacatgaa gcaaaagtgg acacaacatc tggccgcttc accccaaaat
6181 tgggctcctt agaaataatc actgaatctg atgactttga cacaaatcag ccaacaaaat
6241 tcaccccagt tggcattgga gttgacaatg aggcagaatt tcagcaatgg tccttaccca
6301 actattctgg tcagtttact cataatatga acttagcccc agctgtcgcc cccaattttc
6361 ctggtgaaca gctacttttc ttccgatcac agctgccatc ctctggtggg cggtctaacg
6421 ggactctaga ctgcctggtc ccccaggaat gggttcaaca cttttaccaa gaatcagccc
6481 ccgcccaaac acaggtggcc ctggtcaggt atgtcaaccc tgacactggt agagtgctat
6541 ttgaggccaa gctacacaaa ttgggtttta tgactatagc aaagaatggt gactccccaa
6601 taactgtccc tccaaatgga tattttagat ttgaatcttg ggttaacccc ttttacacac
6661 ttgcccccat gggaactgga aacgggcgta gaaggattca ataatggctg gagcttttat
6721 agcaggattg gctggtgaca tgctcacaaa cactgtgggg tctttggtta atgcaggggc
6781 taatgctatc aatcaaaaag ttgattttga aaataataaa tatttgcaaa atgcttcttt
6841 taatcatgat aaggagatgc taaatgcaca aattgaggca acaaagaggc tgcagactga
6901 catgattgca atcaaacaag gggtcttgac cgctggcggc ttttccccca ctgatgcagc
6961 acgtggggca attaatgccc caatgacaaa agttttagat tggagtggaa caaggtactg
7021 ggcaccaaac gccacctcca caacttcaat gtcaggtggc ttcacaagcc aagttgtgca
7081 cagaaccaca ccaaatttca aaacgagcca ggcccccaaa ttcacaccca gcagtgggtc
7141 ttcagtgaga tcaagctcaa cccaactcac caacttgagc tcacactcat ccgggtcgtc
7201 ccgatctagc gggtctacgg ttgtcagctc gctgccgtcc tccagtagga ctagggactg
7261 ggtcaatcaa caaaatctca atttggaacc atacatgcct ggatctctca ggacagcttt
7321 tgtcactcca ccatctagca cagcctctag ttcaggcaca gtctcaaccg tgcccaaaaa
7381 tgttttggac tcctggacat ctgcgtttaa tacgcgcaga cagccgctgt ttgcacacct
7441 tcgtagaagg ggggagtcaa atgtttagtg aaaagattat tcctaaattt gatttagaat
7501 ctttt
//