Typing tool
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Typing tool
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Complete norovirus genomes
| MW305709 | GII.7 | |
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| GII.P7 |
ORF1: 1..5031
ORF2: 5012..6634
ORF3: 6634..7407
LOCUS MW305709 7463 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate CMH-N093-13 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305709
VERSION MW305709.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7463)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7463)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7463
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="CMH-N093-13"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Thailand"
/collection_date="08-Jul-2013"
/note="genotype: GII.7[GII.P7]"
gene <1..5031
/gene="ORF1"
CDS <1..5031
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QPJ59463.1"
/translation="NNATPSNKEEVGAFSNIKVGFKKMLGAVPKGTKAPSSVQHCPTV
KIGPKTLTIPPEPPNGEDTVQFDAKSETIIGLPDLTTVQNEHENTPYTVPPLSEREHR
PATEPLPGTILEMWDGEFYHYSVYVSNGKALGVHKPPAAISLATIELTPISLYWRPVY
TPNYLVSPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLNRRCISRTTGFFKPY
QSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLLHLLASCDWTF
AGIVETVILMAELFNVFWTPPDVSNFVASLIGDFELQGPQDLAVELVPVVMGGIGMVL
GFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAEMETLRAIEDA
VLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDIVGTINAILAR
IAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANTMSGDQRVGLV
PRNGVDHWDAYRGERVVLWDDYGMGSPVKDALTLQELADTCPVTLNCDRIENKGKMFD
SDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPGQPDMWKDHFK
PDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHERRDEFQLQGND
LQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKNVKTLEDLKIALRDVKFNECEI
IYKNSKYRVSSNGKGSVSVGKVEDNASQTVNEVQSALLRLRQARARYYISCFQDLVYT
LIQVAGASFVVNRISRRFCWERWVKPTETQEVNESEKEVAQGRWEIEPKDTEPEGKKG
KNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDRYYEEVAVARA
TEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGSDIRKRRPDDFQPKGNLWADD
TRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKGVKELFGVEIK
QIQVHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILIKRPTGEMIPLAVRMGT
HASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDIVVAGVHTAAA
RGGNTVICATQGQDGEAVLEGNEDLGTYCGAPILGPGKAPKLSTKTKFWRSSPDALPP
GTYEPAYLGGKDPRVEKGPSLQQVMRDQLRPFTEPRGKPPRPAVLEEAKKTVMNVLEQ
TIDPAKPWSYSQACASLDKTTSSGSPHHVKKNDHWNGESFTGPLADQASKANLMYEQA
KHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGLMDSMKASCIA
LPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAMEVMVRFSAEPE
LAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTLSAMAEVSGLS
PDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTEGPLVITEDLT
GLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHSQRATQLMALL
GEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLSTWEGDRNLAPE
GVNEDGVE"
mat_peptide <1..939
/gene="ORF1"
/product="p48"
mat_peptide 940..2037
/gene="ORF1"
/product="NTPase"
mat_peptide 2038..2556
/gene="ORF1"
/product="p22"
mat_peptide 2557..2955
/gene="ORF1"
/product="VPg"
mat_peptide 2956..3498
/gene="ORF1"
/product="Pro"
mat_peptide 3499..5028
/gene="ORF1"
/product="RdRp"
gene 5012..6634
/gene="ORF2"
CDS 5012..6634
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59464.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNEVMPLEPVAGASLATPVVGQ
QNIIDPWIRNNFVQAPAGEFTVSPRNSPGEILLDLELGPELNPYLAHLARMYNGHAGG
MEVQIVLAGNAFTAGKIIFAAIPPGFPYENLSPSQITMCPHVIIDVRQLEPVLLPMPD
IRNNFFHYNQGNDPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTKPSPDFEFTFLVPP
TVESKTKQFTLPILKISEMTNSRFPVPVEMMYTARNENQVVQPQNGRVTLDGELLGTT
PLLAVNICKFKGEVIAKNGDVRSYRMDMEITNTDGTPIDPTEDTPGPIGSPDFQGILF
GVASQRNKNEQNPATRAHEANINTGGDQYAPKLAQVKFFSESQDFEVHQPTVFTPVGV
AGDTSHPFRQWVLPRYGGHLTNNTHLAPAVAPLFPGEQILFFRSQIPSSGGHELGYMD
CLVPQEWVQHFYQEAATAQSEVALIRFINPDTGRVLFEAKLHKQGFITVAHTGDNPIV
MPPNGYFRFEAWVNQFYSLAPVGTGNGRRRIQ"
gene 6634..7407
/gene="ORF3"
CDS 6634..7407
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59465.1"
/translation="MASAFLVNLAGGVASNGISSLINAGANAINQKVEFDYNKQLQNA
SFSHDKEMLQAQIEATKRLQQEMIDIKQGVLTAAGFSPTDAARGSVGAPVTKLVDWSG
TRYWAPGAMRTTGYSGTFTHLPPVQSASYVNDQNRQFLKVDPSPPSSSGSSVSSVKTQ
STTLSGTSRVGSASQSTLSTRPSTRTSDWVRSQNERLSPFMDGALRTTYVTPPSSRAS
SVSTVSTVPKEVLDSWTPMFNTYRQPLFAHLRRRGESQI"
ORIGIN
1 aataatgcca ccccttctaa caaagaagag gttggtgcat tctccaacat caaagttgga
61 tttaagaaaa tgctgggtgc cgtgcccaag ggtaccaaag cacccagcag tgttcaacat
121 tgccccacag ttaagatcgg gcctaaaaca ttaacaatcc cccctgagcc cccaaatggt
181 gaagacactg tacagtttga tgcaaagtca gaaactataa ttgggttgcc agacttgaca
241 acggtgcaaa atgaacatga aaacacccca tacactgtcc ctccattaag tgagagggag
301 cacagaccgg ccactgaacc acttcctggc acaatattgg agatgtggga tggtgagttt
361 taccattact ccgtgtacgt tagcaacggc aaagctctgg gggtccataa accaccggcg
421 gctataagcc tcgcgacgat agagctcacc cccatatcac tttactggag gcccgtttat
481 acccctaatt acttggtctc cccggacaca ttaaagggcc tcgctggtga gaagttcccc
541 tacacggcct tcagtaacaa ctgttataac ttctgttgct gggtgctaga gctcaacgac
601 acgtggctta acagaagatg catttccaga accaccggct tcttcaaacc ataccagtct
661 tggaacagga aacctctccc aaccgttgat gatgggaaga tcaaaaaggt ggccaacgcg
721 atcctctgcg ctctcggctc gctgttctca aaaccaatca aagacctatt aggcaaactc
781 aagccattga acctactgca cttgctcgcg tcttgtgatt ggacgtttgc gggtatagtg
841 gagacagtca tcctgatggc agagctcttt aatgtcttct ggaccccgcc agatgtctct
901 aattttgtag cctccctaat aggtgatttt gaattgcaag ggcctcagga cctggctgtg
961 gagctcgtcc ccgtggtcat gggcggcata gggatggttc tcggtttcac cgctgagaag
1021 ataggccgca tgctgtcgtc cgctgcatca acactgcggg cgtgcaaaga cctagggaac
1081 tatgccctcg acatactcaa attggtcatg aagtggttct tcccaaagaa ggaagagaaa
1141 gctgagatgg aaaccttgag ggcaatcgaa gatgccgtct tggatatgga agctataggg
1201 aataaccacc tcacaaccct tctcaaggac aaagacagcc tcacggcttt catgaagacc
1261 ctggatctgg aggaggagaa ggcgaggaag ctgtccacta aatcatcttc accggacata
1321 gtcggcacca ttaatgccat actggctagg atagctgctg ccagatccct tctacataag
1381 gccaaagagg agatgttcag caggatcagg ccagtggtcg tgatgatctc aggcagacct
1441 ggcattggaa agacccacat ggcgagacat ttggccaaga gcatcgccaa caccatgagc
1501 ggtgaccaga gagtcgggct cgttccgcgc aacggtgtcg accactggga tgcctacagg
1561 ggagagaggg tggtcttgtg ggatgattac ggtatgggga gccctgttaa agacgcccta
1621 acactacaag agctggctga tacatgtcca gtcactttaa attgtgatag gattgagaat
1681 aaggggaaga tgtttgacag tgatgtcatc ataatcacga ccaacctagt caaccccgca
1741 cccctcgatt atgtgaattt cgaggcgtgt tctaggagag ttgacttcct ggtttatgca
1801 gagtcaccag aaattgaaaa ggtcaagaga gacttccctg gccaacctga catgtggaaa
1861 gaccatttta agccagactt ctcccacatc aagctgaccc tagcccccca gggcgggttt
1921 gacaaaaatg gcaacacccc acacggcaag ggtaccatgc ggtccctaac ccaggggtcc
1981 ctgactgcga gagttgcagg ccttgtccat gagaggagag atgaattcca gctccaagga
2041 aatgacctcc aaacatacaa ctttgacacc aacagagtct ctgcattcag gaaattggct
2101 gcagataaca agtatgggat catggagacg atgagagtgg gtgcggcact caagaatgtg
2161 aagaccctgg aagaccttaa aattgcattg agggatgtaa aattcaatga gtgtgaaata
2221 atttacaaga actctaagta tcgtgtctct tccaacggta aaggttcagt ctctgttggt
2281 aaagttgagg acaatgcatc ccagactgtg aacgaggtac aatcagcact tctcaggctc
2341 aggcaagcga gggccagata ttacatcagc tgcttccaag acctcgtcta cactctcata
2401 caggtcgccg gagcgtcatt cgttgtcaac aggatctcca gaaggttctg ctgggaaagg
2461 tgggtcaaac cgaccgagac ccaggaggtg aatgagtccg aaaaggaagt ggcacaaggc
2521 agatgggaaa ttgagcccaa ggacacagaa ccagaaggca agaagggtaa gaataagaaa
2581 ggaaggggta agaaacacac agctttctct agcaaaggcc tgagtgatga agagtatgac
2641 gaattcaaga gaatcaggga ggaaaggaac ggaaagtact ccattgagga atatctgcaa
2701 gaccgggacc gctattatga agaagtggca gttgcccggg cgacagagga ggacttctgt
2761 gaagaggaag aggccaagat aagacaaaga attttccgcc cgacaaagaa gcagaggaag
2821 gaggaaaggg gtgtgcttgg cttagtcacc ggctcagaca tcagaaagag gaggccagat
2881 gacttccaac caaaaggcaa cctatgggca gatgacacca ggagtgtgga ctacaatgag
2941 aggcttgact ttgaagcgcc cccgagtgtc tggtcaagaa tagtcccatt aggcactggt
3001 tggggattct gggtctcatc taaccttctg atcacaacaa cacacgtcct gcctaaaggg
3061 gttaaggagc tctttggagt agaaatcaaa caaatccaag ttcacaaatc tggagagttt
3121 tgcaggttta gattcccaag acctatcagg ccagatgtca caggactcgt actggaggag
3181 ggcgccccag aaggcactgt ttgttctata ctcataaaga gacccacagg tgagatgatc
3241 cccttggcag tgaggatggg cacacatgca tccatgaaaa tacagggcag gactgttggt
3301 ggccagatgg ggatgcttct cacaggagca aacgcgaaga acatggatct cggcaccggt
3361 cctggtgact gcggttgccc ctacatctac aaacgtggca acgacattgt tgtcgcgggt
3421 gttcacaccg cagcagcccg gggaggcaac actgtcatat gtgccaccca agggcaagat
3481 ggggaagcag tcctcgaggg aaatgaggac cttggcacct attgtggcgc cccaattctg
3541 ggccctggca aggcgcctaa actcagcacg aagaccaagt tttggcgctc atcaccagat
3601 gccttgccac ctggcacata tgaacctgct tacctaggag gcaaagaccc tagagtggaa
3661 aaaggtccct ccctgcaaca agtcatgaga gaccagctga gacccttcac agaacccagg
3721 ggcaaaccac ctagacctgc agtcttggag gaagccaaaa agacagtgat gaatgttcta
3781 gaacaaacca ttgaccccgc caagccatgg tcctattcgc aggcatgtgc ctcactggac
3841 aaaaccacct ctagtggtag tccccatcac gttaagaaaa atgaccactg gaatggggag
3901 tccttcactg gtccacttgc agatcaggca tctaaagcca atctcatgta tgagcaggct
3961 aaacatgtgc agcccgtgta tacggccgcg ctcaaagatg agcttgttaa gactgacaag
4021 atctacaaga agataaagaa gaggctccta tgggggtcgg accttggcac aatgatcagg
4081 tgcgccaggg cttttggtgg tctcatggac agcatgaagg caagttgtat agctctccct
4141 tgcagggtag gaatgaacat gaatgaagat ggccccatta tatttgacaa acattctaag
4201 tacaggtacc actatgatgc tgactattct aggtgggact caacccaaca gaggagcatt
4261 ctttccgccg ctatggaagt aatggtgcgg ttctctgctg aaccagaatt ggcacaagtg
4321 gttgcagagg accttttggc acctagccag cttgatgttg gcgattttgt catttcagtc
4381 caggagggtc tgccatcagg agtcccatgt acatcacaat ggaattcaat agcacactgg
4441 atcctaactt tgagtgcaat ggcagaagtg tcagggctct caccagatgt tgttcaagct
4501 cactcctgtt tttcatttta tggggacgat gagatcgtca gtactgatat caaccttgac
4561 cccatgaagt tgacacagaa actcagggag tacggtctgg tccccacccg gcctgacaaa
4621 actgaaggtc ccctcgtcat aactgaagac ctcactggcc tgacgttcct ccgtaggtcg
4681 attgcccggg acccagctgg ttggtttgga aagctggacc aagactcaat ccttaggcag
4741 ctgtactgga caagggggcc taaccatgaa aacccgtacg agagcatggt tcctcattct
4801 cagcgggcca cacaactcat ggcccttctt ggtgaggcct cactgcatgg tccccagttt
4861 tacaagaaag ttagcaagat ggtcatcaat gagattaaga gtggtggtct ggagttttat
4921 gtgcccagac aagaggccat gttcaggtgg atgagattct ctgacctcag cacgtgggag
4981 ggcgatcgca atcttgctcc cgaaggtgtg aatgaagatg gcgtcgaatg acgcagctcc
5041 atctaatgat ggtgcagcag gcctcgtacc agagatcaac aatgaggtca tgccccttga
5101 gcccgtggct ggcgcatcgc tggcgacacc agttgtcggg caacaaaata taattgatcc
5161 ctggataaga aataattttg tacaagctcc tgcaggtgag tttacagttt cccctagaaa
5221 ttcccctggt gaaattttgc ttgatttgga gttggggcca gaactgaacc cctatctcgc
5281 ccatctggcc cgtatgtata atgggcacgc tggtggcatg gaagtgcaaa ttgtgttggc
5341 tgggaacgcg ttcacagctg gcaagatcat atttgctgcc atccccccag ggttcccata
5401 tgaaaatttg tcaccttcac aaatcacaat gtgccctcat gttataattg atgttaggca
5461 attagaacca gttctactac ctatgccaga tattaggaac aatttcttcc attacaatca
5521 gggcaatgac ccaaaattga gattggtagc catgctctat acccctttaa gggctaacaa
5581 ttctggtgat gatgtgttca cagtttcttg tagggtcctc actaaaccgt cacctgattt
5641 tgagttcaca tttttggttc cccccacggt tgaatctaag accaaacagt tcacattacc
5701 catcctcaaa atatcagaga tgaccaactc aagattccca gtgccagtgg agatgatgta
5761 cacagcaagg aatgagaacc aagttgttca gccacagaat ggtagggtca cacttgatgg
5821 cgagctatta ggcaccacac ccttgttggc tgtcaacatc tgcaaattca agggggaggt
5881 tatagccaag aatggagatg tgagatccta taggatggac atggaaatca ccaacactga
5941 tggcacccca attgacccca cagaagacac acccggtccc attggttcac ctgacttcca
6001 aggcatactc tttggcgttg ccagccaacg caataagaat gagcaaaacc ctgccacgag
6061 agcccatgaa gccaacatta acactggtgg ggaccaatat gcccccaaat tggcccaagt
6121 gaaattcttc tcagagtccc aggattttga ggtgcaccag cccacagttt tcaccccagt
6181 tggtgtggca ggcgacactt cccacccttt cagacagtgg gtcctgcctc gatatggtgg
6241 gcatctcacc aacaacaccc acttggctcc agcagtggcc cccctatttc caggtgagca
6301 gattctattc tttagatcac aaatacccag ctcaggtggc catgaattgg gttacatgga
6361 ctgccttgtc ccacaagaat gggtccaaca cttctatcaa gaagctgcca cagctcagtc
6421 tgaggtggca ctcataaggt tcatcaaccc agacactggc agagtcctct ttgaggccaa
6481 gctgcacaag caaggcttta taactgtggc tcatactggt gataacccaa ttgtcatgcc
6541 accaaatggg tactttagat ttgaagcctg ggttaatcag ttttactcac tcgcccccgt
6601 gggaactggg aatgggcgca ggaggatcca ataatggcta gtgcttttct tgtaaatttg
6661 gcaggaggcg ttgcctccaa tggaattagt tcactcataa atgctggggc taatgctatt
6721 aaccaaaagg ttgagtttga ttataataaa caactccaaa atgcatcctt ctcccatgat
6781 aaggaaatgc tccaagccca aattgaagcc actaaacgtc tgcaacaaga gatgattgac
6841 ataaagcaag gggtgctgac agctgcggga ttctctccta cagatgccgc gaggggttct
6901 gtcggcgcgc cagtgacaaa attagttgat tggagtggca ctagatattg ggcgcctggt
6961 gccatgagga caacaggtta ttcagggact tttacccacc tgccccctgt gcagtccgct
7021 tcatatgtta atgatcaaaa tagacaattt cttaaagtag atccttctcc tccttcttcg
7081 agtggttctt ctgtttcttc tgttaaaaca caatcaacta ccctttcagg cacttcaagg
7141 gtgggctccg catcccagtc aaccctgtcg accaggccga gcacaaggac atctgattgg
7201 gtgcgcagcc agaatgaaag gttgagtccc ttcatggatg gagcgttgcg aacaacgtat
7261 gtaacgccac catccagtag ggcatcaagt gtcagcacag tctcgaccgt gccgaaagag
7321 gttttggact cctggacgcc tatgtttaac acctacaggc agccactctt cgcccatttg
7381 cgtaggagag gggagtcaca gatttagtga aaagattggt taggaaagtt gattagtttg
7441 ttcttccttt ctactattcc ttt
//