Typing tool
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Typing tool
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Complete norovirus genomes
| MW305705 | GII.1 | |
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| GII.P33 |
ORF1: 1..5075
ORF2: 5056..6663
ORF3: 6663..7436
LOCUS MW305705 7463 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate CMH-N016-12 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305705
VERSION MW305705.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7463)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7463)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7463
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="CMH-N016-12"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Thailand"
/collection_date="27-Jan-2012"
/note="genotype: GII.1[GII.P33]"
gene <1..5075
/gene="ORF1"
CDS <1..5075
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59451.1"
/translation="AAATSNNDIAKSSSDGVLSSMAVTFKRALGARPKQPPPRETTQK
QKPPRPPTPELIKKIPPPPPNGEDDIVVSYSAKDGVSGLPELSTVRQPGETNTAFSVP
PLNQRENRDAKEPLPGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPL
SLYWRPVYTPQYLISPETLKKLHGETFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQR
TTGFFRPYQDWNRKPLPTMDDSKLKKVANIVLCALSSLFTRPIKDIIGKLRPLNILNI
LASCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDETNELA
MVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDLEEEKARRLSTKSASPDIVG
TINSLLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARDLAKKVAATLT
GDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRI
ENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQP
DMWKDAFRSDFSHIKLMLAPQGGFDKNGNTPHGKGVMKTLTSGSLVARASGLLHERLD
EYELQGPTPTTFNFDQNKVFAFRQLAAENKYGLMDTMRVGSQLKNVKTVSELKQALKN
ISIRRCQIVYGGLTYSLESDGKGNVKVEKVQSPAVQTNNELTGALHHLRCARIRYYVK
CVQESLYSIIQIAGAAFVTTRIAKRMNIQNLWSRPQVEDEEETTSKDGCPKPKDEEEF
VISSEDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQ
DRDKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERVSLGLVTGSEIRKRN
PDDFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHV
IPQGAQEFFGVSIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKR
PTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKR
GNDYVVIGVHTAAARGGNTVICATQGSEGEAVLEGGDNKGTYCGAPILGPGGAPKLST
KTKFWRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSV
LEAAKKTIINVLEQTIDPPQKWTFAQACASLDKTTSSGYPHHVRKNEHWNGESFTGKL
ADQASKANLMFEEGKHMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARA
FGGLMDELKTHCVTLPIRVGMNMNEDGPIIFEKHSRYTYHYDADYSRWDSTQQRAVLA
AALEIMVKFSPEPHLAQIVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHW
LLTLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPERLTVKLKEYGLKPTRP
DKTEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETM
IPHSQRPIQLMSLLGEAALHGPSFYSKISKLVISELKEGGMDFYVPRQEPMFRWMRFS
DLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2600
/gene="ORF1"
/product="p22"
mat_peptide 2601..2999
/gene="ORF1"
/product="VPg"
mat_peptide 3000..3542
/gene="ORF1"
/product="Pro"
mat_peptide 3543..5072
/gene="ORF1"
/product="RdRp"
gene 5056..6663
/gene="ORF2"
CDS 5056..6663
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59452.1"
/translation="MKMASNDAAPSNDGAAGLVPEVNNETMALEPVAGASIAAPLTGQ
NNVIDPWIRMNFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPFLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVFAAIPPHFPLENLSPGQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQQPEPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPILTIGELSNSRFPVPIDELYTSPNEGVVVQPQNGRSTLDGELLGTT
QLVPSNICALRGRINAQVPDDHHQWNLQVTNANGTSFDPTEDVPAPLGTPDFLANIYG
VTSQRNPDNTCRAHDGVLATWSPKFTPKLGSVVLGTWEESDLDLNQPTRFTPVGLYDT
NHFDQWILPNYSGRLTLNMNLAPSVAPLFPGEQILFFRSHIPLKGGTSNGAIDCLLPQ
EWIQHFYQESAPSPTDVALIRYTNPDTGRVLFEAKLHRQGFITVANSGSRPIVVPPNG
YFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6663..7436
/gene="ORF3"
CDS 6663..7436
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59453.1"
/translation="MAGAFVAGLAGDIVTNGIGSLVNAGANAINQKVDFENNKQLQQA
SFNHDKEMLQAQIQATKQLQADMIALRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRYWAPGATKTTAFSGGFTSSPNTRTIDLPRKTSNTPAPTPVSRPSSSASTVSTRSTI
VSGTSSPSSSTRSSFNSQPTSSSSRTSEWVRSQNRALEPYMRGALQTAYVTPPSSRAS
SNGTVSTVPKEVLDSWTSVFNTHRQPLFAHLRRRGESQA"
ORIGIN
1 ccgctgctgc taccagcaac aacgacatcg caaagtcttc aagtgatgga gtactaagta
61 gtatggctgt cacttttaaa cgagccctcg gggcccggcc taaacagccg cccccgaggg
121 aaacaacaca aaaacaaaaa cctccacgac cgcccacccc ggagttaatt aaaaagattc
181 cacctccccc gcccaacggg gaggatgaca tagtggtgtc ctacagtgcc aaagatggtg
241 tctccggtct gcctgagcta tccaccgtca ggcagccggg cgagacaaac acagcattta
301 gtgtcccccc actcaaccag agggaaaaca gggatgctaa agaaccgctg cctggcacca
361 tcttggagat gtgggacgga gagatttacc actacggctt gtacgtggag cggggcttgg
421 tgcttggggt gcacaaacca ccagcagcta ttagccttgc gaaggttgaa ctaacgccac
481 tgtctctgta ctggagacca gtgtacaccc ctcagtacct catatccccg gaaactctca
541 aaaagctaca tggagagaca ttcccttaca cggcctttga caacaactgt tatgccttct
601 gttgttgggt cttggatcta aatgactctt ggctcagcag gaggatgata cagagaacaa
661 ctggcttctt cagaccctac caggactgga acaggaaacc tctccccact atggatgact
721 ccaaattgaa aaaggtggct aatatagtcc tgtgtgcttt gtcatcacta ttcaccaggc
781 ccattaagga cataatagga aaactaaggc ccttaaacat actcaatata ctagcttcct
841 gcgactggac tttcgcagga atagtagaat ccctaattct ccttgcagaa ctcttcggag
901 ttttctggac acccccagat gtgtctgcga tgatcgcccc cttgctaggt gactacgaac
961 tacagggacc tgaagatctc gctgtagaac tcgtaccagt agtaatgggg gggataggtt
1021 tggttctagg tttcaccaag gagaagattg gcaagatgct atcatctgcc gcgtctaccc
1081 tcagagcttg taaggacctt ggagcatatg gactggaaat tctgaagttg gttatgaagt
1141 ggttcttccc gaagaaagac gagacaaatg aacttgcaat ggtgagatcc attgaggacg
1201 cagtgctaga cctcgaagca attgaaaata accacatgac taccctactc aaagacaaag
1261 acagcttagc aacctacatg aagactctgg atcttgagga ggagaaagct aggagactct
1321 ccaccaaatc cgcttctcct gacattgtgg gcacaatcaa ttcacttctg gcacggattg
1381 cagctgcccg ttccctggtg catcgggcaa aagaagagct ttccagtagg ccaagacccg
1441 ttgttgtcat gatatcagga aagccaggga tagggaagac ccaccttgcc agagatcttg
1501 caaagaaagt tgcggccacc ctcacaggag accagagggt gggcctcatc ccacggaatg
1561 gtgtcgacca ctgggatgca tacaaaggtg agagagtcgt cctttgggat gactatggaa
1621 tgagcaaccc cattcatgac gcccttaggc tacaagaact tgctgacact tgccccctaa
1681 cattgaattg tgatagaatt gagaacaaag gaaaggtctt tgacagtgat gccataatta
1741 tcacaactaa tctggctaac ccggcaccac tggactatgt taattttgaa gcatgttcga
1801 ggcgcatcga cttcctagtg tatgctgatg cccccgacgt tgaaaaggca aaacgcgact
1861 tcccagggca acctgacatg tggaaggatg cttttagatc tgacttctca cacataaagt
1921 tgatgttggc tcctcagggt ggttttgata agaacggcaa caccccacat ggaaaaggtg
1981 tcatgaaaac cctcacatct ggctccctcg ttgcccgtgc ttcgggactc ctccacgaaa
2041 gactggacga gtacgagtta caagggccaa cacccacaac cttcaatttc gaccaaaaca
2101 aggtgttcgc ctttagacag ctcgccgctg aaaataaata cgggctgatg gacaccatga
2161 gagtgggaag ccagctcaag aatgtcaaaa ccgtgtcaga gctcaaacag gcacttaaga
2221 acatttcaat tagaaggtgc cagatagtct acggtggtct cacatattca cttgaatctg
2281 atggcaaagg taatgtgaag gttgagaagg tgcaaagtcc agctgtgcaa accaacaatg
2341 agctaactgg cgcattacac catctgagat gcgctaggat tagatattat gttaagtgtg
2401 tccaggaatc tttgtactcc atcatccaaa ttgctggagc cgcgtttgtc accacgcgca
2461 ttgcaaagcg catgaacata caaaacctct ggtccagacc acaggtggag gatgaggaag
2521 agaccaccag caaagacggg tgcccaaaac caaaggatga ggaggagttt gtcatctcgt
2581 ctgaagacat caaagccgaa ggcaagaagg gaaagaacaa gtctggccgt ggcaagaaac
2641 acacagcctt ctcgagtaag ggtcttagtg atgaggagta cgatgagtac aagagaatca
2701 gagaagaaag aaatggcaag tactccatag aagaatacct ccaagacaga gacaagtact
2761 atgaggaggt tgccatagcc agggctactg aagaggactt ctgtgaggaa gaagaagcca
2821 agattcggca gaggattttc agaccaacaa ggaaacaacg caaggaggag agggtttcac
2881 tcggactggt tacaggctca gaaatcagga aaaggaaccc ggatgacttc aaacccaaag
2941 gaaagttgtg ggctgatgac gacaggagtg tcgattacaa tgaaaagctc agttttgaag
3001 cccccccaag catctggtcg agaatagtca actttgggtc aggttggggc ttctgggtct
3061 caccaagtct ctttataaca tccacccatg tcatacctca aggggcacaa gagttcttcg
3121 gtgtttccat caaacagatc caaattcata agtcaggtga gttctgccga ctaagattcc
3181 cgaagccaat tagaactgat gtgacaggta tgatcctgga ggagggggcc cctgaaggca
3241 ctgtggccac actgctcata aagaggccaa ctggagagct gatgccactg gcagctagaa
3301 tgggcaccca tgcaactatg aagatccaag gtcgaactgt cgggggacag atggggatgc
3361 tcctgacagg atccaacgcc aagagcatgg atttgggtac tacaccaggt gactgtggat
3421 gcccatatat ctacaaaaga ggaaatgact acgtggtcat cggagtccac acagctgccg
3481 cccgcggagg gaacactgtc atctgtgcaa ctcaaggaag tgagggcgag gccgtacttg
3541 aaggtggtga caacaaaggc acctattgtg gcgccccaat cctaggtcca ggaggtgcac
3601 ccaaactcag tactaaaacc aaattctgga ggtcctcaac agcaccactc ccacctggca
3661 catatgaacc agcttacctt ggaggcaaag accccagggt aaaaggtggc ccctcattac
3721 agcaagttat gagagaccaa ctgaaaccgt ttacagaacc cagaggtaag ccaccaaagc
3781 ccagtgtatt ggaagcagcc aaaaagacaa tcattaatgt ccttgagcaa acaatagacc
3841 caccccaaaa atggacgttc gcacaggcgt gcgcatccct tgataaaaca acctctagtg
3901 gttacccgca ccacgtgcgg aagaatgaac attggaatgg ggaatctttc acaggaaaat
3961 tggctgatca ggcttcaaaa gctaacttga tgtttgagga aggaaaacac atgacaccag
4021 tctacacagg agctctcaaa gatgagttag tcaaaactga caaaatatat ggtaagatca
4081 agaaaaggtt gttatggggt tcagatctgg caaccatgat ccgttgcgca cgagcgttcg
4141 gagggctgat ggatgaactc aagacccact gtgttacact ccctatcagg gtggggatga
4201 acatgaatga ggatggtccc atcatttttg aaaaacactc taggtacacc taccattatg
4261 atgcagacta ctctcggtgg gactcaacac agcagagagc tgttttagct gcagccctgg
4321 agataatggt aaaattttcc ccagaaccac acctagctca gattgtcgca gaagacctcc
4381 tatctcccag tgtgatggac gtgggcgatt ttaaaatatc aatcactgaa ggactcccct
4441 ctggggtgcc ttgcacttca caatggaact ccattgctca ttggctcctc acgctctgtg
4501 cactatctga ggtaacagat ttatctcctg acatcatcca agcaaactca ctcttctctt
4561 tctatggtga tgatgaaatt gtgagcacag acattaaact agatccagaa aggctaacag
4621 tcaaactaaa agagtatggt ctcaagccaa cccgtcctga caagactgaa ggacctctgg
4681 tcatttctga ggacttagat ggtctgacct tcttgcggag aactgtgacc cgtgacccag
4741 caggttggtt tggaaaattg gaacaaagct caatacttag acagatgtat tggaccaggg
4801 gccccaatca tgaggacccc tctgaaacaa tgataccaca ctcccaacga cccatacagt
4861 tgatgtccct actaggtgaa gctgcattac atggcccatc attctacagc aaaatcagca
4921 aattggtcat atcagagttg aaagaaggtg gcatggactt ttacgtgcca aggcaagagc
4981 caatgttccg atggatgagg ttctcagact tgagcacgtg ggagggcgat cgcaatctgg
5041 ctcccagttt tgtgaatgaa gatggcgtcg aatgacgccg ctccatctaa tgatggtgca
5101 gccggtctcg taccagaggt caacaacgag acgatggcac ttgagccggt ggctggggct
5161 tccatagctg cccctctaac cggccaaaat aatgtgatag acccctggat tagaatgaat
5221 tttgtccaag ctccaaatgg tgaatttaca gtgtcccccc gtaattcccc aggtgaagtg
5281 ttgttaaatt tggaattagg ccctgaatta aatccattcc tggcacacct ttcaagaatg
5341 tacaatggtt atgctggtgg ggttgaagtg caggtgctac ttgctgggaa tgcgttcaca
5401 gcaggaaaac tagtgtttgc agcaatcccc ccacacttcc ctcttgagaa tctgagtcct
5461 ggtcaaatta caatgttccc tcatgtaatt attgatgtta gaactttgga acctgtcctc
5521 ttgcctttgc cagatgttag aaataatttc tttcattaca atcagcagcc tgagccccgt
5581 atgagacttg tggctatgtt gtatactcct cttagatcta atggttctgg tgatgatgtg
5641 ttcacagtct cttgtagggt cctcactcgc ccctctccag actttgattt taattatttg
5701 gtccccccaa ctgtggaatc taaaaccaaa ccattcaccc tgccaatatt gaccatcgga
5761 gaactgtcaa attctaggtt cccagtacca atagatgaat tgtacaccag ccctaatgaa
5821 ggagtggttg tgcaacctca aaatggcaga tcaacactcg atggtgaact gcttggtacc
5881 acacaacttg taccatcaaa catctgtgcc ttgcgagggc gcatcaacgc ccaagtgcca
5941 gacgatcacc atcaatggaa cttgcaggtt acaaatgcaa atgggacttc ctttgacccc
6001 actgaagatg tccctgcacc attgggcacg ccggatttcc tggcaaacat ctacggagtc
6061 actagtcaga ggaatcctga taacacttgc cgtgcccatg atggggtttt ggcaacctgg
6121 agccctaaat ttacacccaa gttaggatct gtggttttgg gcacttggga agaaagtgat
6181 cttgatctta atcagcctac cagatttaca cctgttggtt tgtatgatac aaaccacttt
6241 gatcagtgga ttctacccaa ctattctgga agattgacct taaacatgaa tttggcgccc
6301 tccgttgctc ccctcttccc aggtgaacaa atactcttct ttaggtccca cataccactt
6361 aaaggaggca cttccaacgg tgccattgac tgtctactcc ctcaggagtg gatccagcat
6421 ttctatcagg agtcagcccc gtcacccaca gatgttgctc tgattaggta caccaaccct
6481 gacacgggcc gtgtcctttt tgaggccaaa ctacatagac agggattcat cacagtagca
6541 aattctggtt ctagacctat tgttgtccct cctaatggtt attttaggtt tgattcttgg
6601 gttaatcagt tttattctct cgcccccatg ggaactggga atgggcgtag aagggtgcag
6661 taatggctgg agcttttgta gcagggcttg ccggtgacat agtcaccaat ggcattggtt
6721 cacttgtgaa cgctggagcc aatgcaataa accaaaaagt agattttgaa aacaacaaac
6781 aactacagca ggcctctttc aaccatgata aggaaatgtt gcaagctcaa attcaggcca
6841 caaaacaatt acaggctgac atgattgcgc tcagacaagg ggtattgacc gcaggcggct
6901 tttcccctac tgatgcagca agaggggcgg ttaatgcgcc catgacgcaa gtcttggact
6961 ggaatgggac taggtactgg gcccccggag ccacgaaaac aactgctttc tccggcgggt
7021 tcacaagctc tcccaatacc aggactattg atttgcctag gaaaacatca aacacaccag
7081 cccccacgcc tgtgtctaga cctagttctt ctgcttctac tgtttctacc cgctcaacaa
7141 ttgttagcgg gacttctagc ccttcttctt cgactaggag ctcttttaat tcccagccca
7201 cctcctcttc ttctcggact agcgaatggg tgcgtagtca aaacagggcg ctggaaccct
7261 acatgagggg agcgttacaa actgcttacg tgacgcctcc ctctagtagg gcctccagca
7321 atggtacagt ctcaaccgtg ccaaaagaag ttttggactc ctggacatct gtgttcaaca
7381 cccacagaca accgcttttc gctcatctcc gtcggagagg ggagtcacag gcttagtgaa
7441 aagatgattt ttcttctatt ctt
//