Typing tool
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Typing tool
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Complete norovirus genomes
| MW305702 | GII.12 | |
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| GII.P33 |
ORF1: 1..5075
ORF2: 5056..6663
ORF3: 6663..7442
LOCUS MW305702 7488 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate CMH-N005-11 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305702
VERSION MW305702.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7488)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7488)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7488
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="CMH-N005-11"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Thailand"
/collection_date="13-Jan-2011"
/note="genotype: GII.12[GII.P33]"
gene <1..5075
/gene="ORF1"
CDS <1..5075
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59442.1"
/translation="AAAISNNDIAKSSSDGVLSSMAVTFKRALGARPKQPPPRETTQK
QKPPRPPTPELIRKIPPPPPNGEDDIVVSYSAKEGVSGLPELSTVRQPDETNSAFSVP
PLNQRENRDAKEPLPGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPL
SLYWRPVYTPQYLISPETLKKLHGETFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQR
TTGFFRPYQDWNRKPLPTMDDSKLKKVANIVLCALSSLFTRPIKDIIGKLRPLNILNI
LASCDWTFAGVVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKVGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDEANELA
MVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDLEEEKARKLSTKSASPDIVG
TINSLLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARDLAKKVAATLT
GDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRI
ENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQP
DMWKDVFRPDFSHIKLMLAPQGGFDKNGNTPHGKGVMKTLTSGSLVARASGLLHERLD
EYELQGPTPTTFNFDQNKVFAFRQLAAENKYGLMDTMRVGSQLKNVKTVSELKQALKN
IAIRKCQIVYSGLTYSLESDGKGNVRVEKVQSPAVQTNNELTGALHHLRCARIRYYVK
CVQEALYSIIQIAGAAFVTTRIAKRMNIQNLWSRPQVEDEEETTSKDGCPKPKDEEEF
VISSEDIKVEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQ
DRDKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRN
PDDFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHV
IPQGAQEFFGVSIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKR
PTGELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKR
GNDYVVIGVHTAAARGGNTVICATQGSEGEAVLEGGDNKGTYCGAPILGPGNAPKLST
KTKFWRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSV
LEAAKKTIINVLEQTIDPPQKWTFAQACASLDKTTSSGYPHHVRKNEHWNGESFTGKL
ADQASKANLMFEEGKHMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARA
FGGLMDEFKAHCVTLPIRVGMNMNEDGPIIFEKHSRYTYHYDADYSRWDSTQQRAVLA
AALEIMVKFSPEPHLAQIVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHW
LLTLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRP
DKTEGPLVVSEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPAETM
IPHSQRPIQLMSLLGEAALHGPSFYSKISKLVISELKEGGMDFYVPRQEPMFRWMRFS
DLSTWEGDRNLAPNFVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2600
/gene="ORF1"
/product="p22"
mat_peptide 2601..2999
/gene="ORF1"
/product="VPg"
mat_peptide 3000..3542
/gene="ORF1"
/product="Pro"
mat_peptide 3543..5072
/gene="ORF1"
/product="RdRp"
gene 5056..6663
/gene="ORF2"
CDS 5056..6663
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59443.1"
/translation="MKMASNDAAPSNDGAAGLVPEVNNETMALEPVAGASIAAPLTGQ
NNVIDPWIRLNFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVFAAVPPHFPLENISPGQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQQNEPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPILTIGELTNSRFPVPIDELYTSPNESLVVQPQNGRCALDGELQGTT
QLLPTAICSFRGRINQKVSGENHVWNMQVTNINGTPFDPTEDVPAPLGTPDFSGKLFG
VLSQRDHDNACRSHDAVIATNSAKFTPKLGAIQIGTWEQDDVHINQPTKFTPVGLFES
EGFNQWTLPNYSGALTLNIGLAPPVAPTFPGEQILFFRSHIPLKGGVADPVIDCLLPQ
EWIQHLYQESAPSQTDVALIRFTNPDTGRVLFEAKLHRSGYITVANTGSRPIVVPANG
YFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6663..7442
/gene="ORF3"
CDS 6663..7442
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59444.1"
/translation="MAGAFIAGLAGDIVTSGIGSLVNAGANAINQKVDFENNKQLQQA
SFNHDKEMLQAQIQATKQLQADMIAIRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRHWAPGAMKTTAFSGGFTSASHARTVDLTRKTSATPASMPVSRPSSTASTVSTRSTL
ISGSSNPSSLVRSSSSISSQSASSSSRTSDWVRSQNRALEPYMSGALRTAYVTPPSSR
ASSNGTVSTVPKEVLDSWTSAFNTHRQPLFAHLRRRGESQV"
ORIGIN
1 ccgctgctgc tatcagcaac aacgacatcg caaaatcttc aagtgacgga gtactaagta
61 gtatggctgt cacttttaaa cgagccctcg gggcccggcc taaacagccg cccccgaggg
121 aaacaacaca aaaacaaaaa cctccacgac cgcccacccc ggagttaatt agaaagattc
181 cacctccccc gcccaacggg gaggacgata tagtggtatc ctacagtgcc aaagaggggg
241 tctccggcct gcctgagcta tccaccgtca gacagccgga tgagacaaac tcagcattta
301 gtgtcccccc actcaaccag agggaaaaca gggatgctaa agaaccgctg cctggcacca
361 tattggaaat gtgggatgga gagatctacc actacggctt gtacgtggag cggggtttgg
421 tgcttggggt gcacaaacca ccagcggcta ttagcctcgc aaaggttgaa ctaacaccgc
481 tgtctctgta ctggagacca gtgtacaccc ctcagtacct catatccccg gaaacgctca
541 aaaagctaca tggagagaca ttcccttata cggcctttga taacaactgt tacgccttct
601 gttgttgggt cttggatcta aacgactctt ggctcagcag gaggatgatt cagagaacaa
661 ctggcttctt cagaccctac caggactgga acaggaaacc tctccccact atggatgatt
721 ccaaattgaa aaaggtggct aatatagtcc tgtgtgcttt gtcatcacta ttcaccaggc
781 ccattaagga cataatagga aaactaaggc ccttaaacat actcaacata ctagcttcct
841 gcgactggac tttcgcagga gtggtggaat ccctaattct ccttgcagaa ctcttcggag
901 ttttctggac acccccagat gtgtctgcga tgatcgcccc cttactaggt gactacgaac
961 tacagggacc tgaagatctc gctgtagaac tcgtaccagt agtaatgggg gggataggtt
1021 tggttctagg tttcaccaag gagaaggttg gcaagatgct gtcatccgcc gcgtccaccc
1081 tcagagcttg taaagacctt ggagcatatg ggttagaaat cctgaagttg gtcatgaaat
1141 ggttcttccc gaagaaagac gaggcaaatg aacttgcaat ggtgagatcc attgaggacg
1201 cagtgctgga cctcgaagca attgaaaaca atcacatgac caccctgctc aaagacaaag
1261 acagtttggc aacctacatg aagactctgg atcttgaaga ggagaaagct aggaaacttt
1321 ccaccaaatc cgcttctcct gatattgtgg gcacaatcaa ttcgcttctg gcacggattg
1381 cagctgcccg ttccttggtg caccgggcaa aggaagagct ttcaagtagg ccaagacccg
1441 ttgtcgttat gatatcagga aagccaggga tagggaagac ccatcttgcc agagatttgg
1501 caaagaaagt tgcagccacc ctcacaggag accagagggt gggcctcatc ccacggaatg
1561 gtgtcgacca ttgggatgca tacaaaggtg agagagtcgt cctttgggat gactatggaa
1621 tgagtaaccc cattcatgac gcccttaggc tacaagaact tgctgacact tgccccctaa
1681 cattaaattg tgatagaatt gagaacaaag gaaaggtttt tgacagtgat gccataatta
1741 ttacaactaa tttggctaac ccggcaccac tggactatgt taactttgaa gcgtgttcga
1801 ggcgtatcga cttccttgtg tacgctgatg cccccgacgt tgaaaaggca aaacgcgact
1861 tcccagggca acctgacatg tggaaggatg tttttagacc tgacttctca cacataaagt
1921 taatgttggc tcctcagggt ggttttgata agaacggcaa caccccacat ggaaaaggtg
1981 tcatgaaaac cctcacatct ggctccctcg ttgcccgtgc ttcaggactc ctccacgaaa
2041 gactggacga gtacgagttg caagggccaa cacccacaac cttcaatttc gaccaaaaca
2101 aggtgttcgc ctttaggcag ctcgccgctg aaaataaata cgggctgatg gacaccatga
2161 gagtgggaag ccagctcaag aatgtcaaaa ctgtgtcaga gctcaaacag gcactcaaga
2221 acattgcaat tagaaagtgc cagatagtct acagtggtct cacatactca cttgaatctg
2281 atggcaaagg taatgtaagg gttgagaagg tgcaaagtcc agctgtgcag accaacaatg
2341 agctaactgg cgcactacac catctgaggt gcgccaggat tagatattat gttaagtgtg
2401 ttcaggaagc tttgtattcc atcatccaaa ttgctggggc cgcgtttgtc accacgcgca
2461 ttgcaaagcg catgaacata caaaacctct ggtccagacc acaggtggag gatgaggaag
2521 agaccaccag caaagacggg tgcccaaaac caaaggatga ggaggagttt gtcatctcgt
2581 ctgaagacat caaagtagaa ggcaagaagg gaaagaacaa gtctggccgt ggcaagaaac
2641 acacagcctt ttcgagtaaa ggtcttagtg atgaggagta cgatgagtat aaaagaatta
2701 gagaagaaag aaatggtaag tactccatag aagaatacct ccaggacaga gacaagtact
2761 atgaggaggt ggccatagcc agagctactg aagaggactt ctgtgaggaa gaagaagcca
2821 agattcgtca gaggattttc agaccaacaa ggaagcaacg caaggaggag agggcttcac
2881 ttggactggt tacaggctca gaaatcagga aaaggaaccc ggatgacttc aaacccaaag
2941 gaaaactgtg ggctgatgat gacaggagtg tcgattacaa tgaaaagctc agctttgagg
3001 cccccccaag catctggtcg agaatagtca actttggatc aggctggggc ttctgggtct
3061 caccaagcct ttttataaca tccacccatg tcatacctca aggggcacaa gaattcttcg
3121 gtgtttccat caaacagatc caaattcaca agtcgggtga attctgccga ctaagattcc
3181 caaaaccaat tagaactgat gtgacaggta tgatcctgga ggagggggcc cctgaaggga
3241 ctgtggccac actgctcata aagaggccaa ctggagagct gatgccactg gcagctagaa
3301 tgggtaccca tgcaactatg aggatccagg gtcgaactgt cggggggcag atggggatgc
3361 tcctgacggg atccaacgcc aagagcatgg atttgggcac cacaccaggt gactgtgggt
3421 gcccatacat atacaaaaga ggaaatgact acgtagtcat cggggtccac acagctgccg
3481 cccgcggagg gaacactgtc atctgtgcaa cacaaggaag tgagggcgag gctgtgcttg
3541 aaggtggcga caacaaaggc acctattgtg gcgccccaat cctaggtcca ggaaatgccc
3601 ccaaactcag tactaagacc aaattctgga ggtcctcaac agcaccactc ccacctggca
3661 catatgaacc agcttacctc ggaggcaaag accccagagt aaaaggtggc ccctcattac
3721 agcaagttat gagagaccaa ctgaaaccat ttacagaacc cagaggtaag ccaccaaagc
3781 ccagtgtact agaagcagcc aaaaagacaa tcattaatgt ccttgagcaa acaatagacc
3841 caccccaaaa atggacgttc gcacaggcgt gcgcatccct cgacaaaaca acctctagtg
3901 gctacccgca ccacgtgcgg aagaatgaac attggaatgg ggaatctttc acaggaaaat
3961 tggctgatca ggcttcaaaa gctaacctga tgtttgagga aggtaaacac atgacaccag
4021 tctacacggg agccctcaag gatgagttgg tcaaaaccga taaaatatat ggtaagatca
4081 agaagaggtt gctatggggt tcagatctgg caaccatgat ccgttgcgct cgagcgttcg
4141 gagggttaat ggatgaattc aaggctcact gtgtcacact ccccatcagg gtagggatga
4201 acatgaatga ggatggcccc atcatttttg agaaacactc tagatacacc taccattatg
4261 atgcagacta ctctcggtgg gactcaacac agcagagagc tgttttagct gcagccctgg
4321 agatcatggt aaaattttcc ccagaaccac acctggccca gatcgttgca gaggatctcc
4381 tatctcccag cgtgatggac gtgggcgatt tcaaaatatc aatcactgaa ggactcccct
4441 ctggggtgcc ttgcacctca caatggaatt ctattgctca ttggctcctc acgctttgtg
4501 cactctctga ggtaacagat ttgtctcctg acatcatcca agcaaactca ctcttttctt
4561 tctatggtga cgatgaaatt gtgagcacag acatcaaatt agacccagaa aagttgacag
4621 ctaaactaaa agaatatggt ctcaagccaa cccgtcctga caagactgaa gggcctctgg
4681 tcgtttctga ggacttagat ggtctgacct tcttacggag gactgtgacc cgtgacccag
4741 caggttggtt tggaaaattg gaacaaagct caatacttag acagatgtat tggaccaggg
4801 gccccaacca tgaggatccc gctgaaacaa tgataccaca ctcccaaaga cccatacagt
4861 tgatgtccct attaggtgaa gctgcattac atggcccatc attctacagc aaaatcagca
4921 aattggtcat ctcagagtta aaagaaggtg gcatggactt ttacgtgcca aggcaagagc
4981 caatgtttcg atggatgagg ttctcagact tgagcacgtg ggagggcgat cgcaatctgg
5041 ctcccaattt tgtgaatgaa gatggcgtcg aatgacgccg ctccatctaa tgatggtgca
5101 gccggtctcg taccagaggt caacaatgag accatggcac ttgaaccggt ggctggggct
5161 tcaatagccg ccccactcac cggtcaaaat aatgttatag acccctggat tagattaaac
5221 tttgtgcaag ctcccaatgg agagtttaca gtttcacccc gcaattcgcc tggggaagtc
5281 ctactaaact tggaattagg ccctgaacta aatccatatt tggcacacct ttccagaatg
5341 tacaatggtt atgcaggtgg agttgaggtg caggtactac tggctgggaa cgcgttcacg
5401 gctggaaaac tggtattcgc cgcagttccc cctcattttc cattagaaaa cataagccct
5461 ggccaaataa ccatgttccc tcatgtaatt attgatgtta ggactttaga accagtccta
5521 ttgcctcttc cagatgttag gaacaatttc tttcactaca atcagcaaaa cgaaccgagg
5581 atgaggcttg tggcaatgct ctacaccccc cttaggtcta atggttctgg tgatgatgta
5641 tttactgtct cctgtagagt gcttactcga ccctctcctg attttgattt caattatttg
5701 gttcccccta cagttgaatc taaaactaaa cccttcacac tccccatctt gaccataggg
5761 gagttaacca actccagatt ccctgtgcct atagatgaac tctacactag ccccaatgag
5821 agtttggtgg tgcaacccca gaacgggagg tgcgcgctgg atggggagtt gcagggcacc
5881 actcagctcc tccccacggc gatctgctcg ttcaggggtc ggattaatca gaaagtgagt
5941 ggagagaacc atgtttggaa tatgcaagtc accaacatta acggaacccc ttttgatcca
6001 acagaggatg tcccagctcc tctaggtaca ccagactttt ctggcaagct ctttggcgtt
6061 ctaagccaga gggaccatga taatgcctgt aggagccatg atgcagtgat tgcaactaat
6121 tctgctaaat ttactccaaa gttgggcgct atacaaattg gcacatggga acaagatgat
6181 gtacacatca accaacccac caaatttact ccagttggct tgtttgaaag tgaaggtttt
6241 aatcagtgga cactccctaa ttattctgga gccttaacac tcaacatagg gttggccccc
6301 cctgtggccc ccacatttcc tggtgagcaa attcttttct ttagatccca cattcctctt
6361 aaaggaggtg tggcagaccc agtcattgat tgtctcttgc cccaagagtg gatccaacac
6421 ctttatcagg agtcagcccc ttcacaaaca gatgtagcac tgatcagatt cacaaatcca
6481 gacacagggc gtgtcctatt tgaagcaaaa ttgcacagga gtggctacat cacagtggcc
6541 aacactggta gcagaccaat tgtggtgcca gctaatggtt acttcaggtt tgactcttgg
6601 gttaatcagt tttattctct cgcccccatg ggaactggga atgggcgcag gagggtgcag
6661 taatggctgg agctttcata gcaggtcttg ctggtgatat agtcaccagt ggtattggct
6721 cactcgtgaa cgctggggcc aatgcaataa accaaaaagt agactttgaa aacaataagc
6781 aactacagca ggcatccttc aatcatgaca aagagatgct gcaagctcaa attcaagcca
6841 ccaaacagct acaggctgat atgattgcaa tcagacaagg ggtgttgacc gcgggcggct
6901 tctcccccac tgatgcagca agaggtgcag tcaacgcacc catgacacag gtcttggact
6961 ggaacgggac tagacattgg gcccccggag ccatgaaaac aactgctttc tccggtgggt
7021 tcaccagtgc ttctcatgcc aggaccgttg acctgactag gaagacatca gccacaccag
7081 cctctatgcc tgtctctagg cccagttcta ctgcttctac tgtttccacc cgttctacct
7141 tgattagtgg atcctctaat ccttcttctc tagttaggag ttcttccagt atttcttccc
7201 aatctgcttc ctcatcctct cggactagtg attgggtgcg tagccaaaac agagcactgg
7261 agccttatat gagcggggcg ctgcgtacag cctacgtgac acctccatcc agtagggctt
7321 ctagcaatgg cacagtctca accgtgccaa aagaggtttt ggactcctgg acatctgcat
7381 tcaacacaca cagacaaccg ctgtttgctc atctccgtcg gagaggggag tcacaagttt
7441 agtgaaaaga tggtcttttc tttcattcct ttgaaatctc tgtctttt
//