Typing tool
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Typing tool
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Complete norovirus genomes
| MW305701 | GII.12 | |
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| GII.P12 |
ORF1: 1..5069
ORF2: 5050..6657
ORF3: 6657..7436
LOCUS MW305701 7486 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate CMH-145-05 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305701
VERSION MW305701.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7486)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7486)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7486
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="CMH-145-05"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Thailand"
/collection_date="25-Dec-2005"
/note="genotype: GII.12[GII.P12]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59439.1"
/translation="AAANSNNDTAKSSSDGVLSSMAVTFKRALGARHKQPPPREIPQR
PPRPPTPELVKKIPPPPPNGEDELVVSYSAKDGVSGLPELTTVWQPDENNTAFSVPPL
NQRENRDAKEPLPGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLRRLHGETFPYTAFDNNCYAFCCWVLDLNDSWLCRRMIQRTT
GFFRPYQGWNRKPLPTMDDSKLKKVANIFLCALSSLFTRPIKDIIGKVRPLNILNILA
SCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKERIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDIEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARELAKKIAASLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDM
WKNAFSSDFSHIKLALAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEY
ELQGPTPTTFNFDRNKVLAFRQLAAENKYGLMDTMRIGKQLKDVKTMPELKQALKNVT
IKSCQIVYGGCTYRLESNGKGDVKVDKVQNATVQTNNELAGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIAKRMNIQDLWSKPQVEDTEETASKDGCPKPKDDDEFVV
SSDDIKTEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNERLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAQEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKT
KFWRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
AAKKTIVNVLEQTIDPPQKWSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
QASKANLMYEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
GLMEELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVLAAA
LEIMVKFSPEPHLAQKVAEDLLSPSVMDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPTFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6657
/gene="ORF2"
CDS 5050..6657
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59440.1"
/translation="MKMASNDAAPSNDGAAGLVPEVNNETMALEPVAGASIAAPLTGQ
NNIIDPWIRLNFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVFAAVPPHFPLENISPGQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQQNEPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPILTIGELTNSRFPVPIDQIYTSPNENLVVQPQNGRCALDGELQGTT
QLLPTAICSFRGRINQHVSGDNHVWNMQVTNINGTPFDPTEDVPAPLGTPDFSGKIFG
ILSQRDHDNACRSHDAVIATNSAKFTPKLGAVQIGTWETDDVHINQPTKFTPVGLFED
EGFNQWTLPNYSGALTLNMGLAPPVAPTFPGEQILFFRSHIPLKGGVADPVIDCLLPQ
EWIQHLYQESAPSQSDVALIRFTNPDTGRVLFEAKLHRSGFITVANTGSRPIVVPANG
YFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6657..7436
/gene="ORF3"
CDS 6657..7436
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59441.1"
/translation="MAGAFIAGLAGDIVTNSIGSLVNAGANAINQKVDFENNKQLQQA
SFNHDKEMLQAQVQATKQLQAEMIAIRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRHWAPGATKTTAFSGGFTSASHARTVDLTKKTSATPAPTPVSRPSSTASTVSTRSTL
VSGSSISSSSARSSSSVSSQPTSSSSRTSEWVRSQNKVLEPYMRGALHTTFVTPPSSR
ASSNGTVSTVPKGVLDSWTPAFNTRKQPLFAHLRRRGESQV"
ORIGIN
1 ccgctgctgc taacagcaac aacgacaccg caaaatcttc aagtgacgga gtgctttcta
61 gcatggctgt cacttttaaa cgagccctcg gggcgcggca taaacagcct cccccgaggg
121 aaataccaca aagacctcca cgaccaccca ccccagaact ggtcaaaaag atccctcctc
181 ccccacccaa cggggaggac gaactagtgg tttcttacag cgccaaagat ggcgtttctg
241 gtttgcctga gcttaccact gtctggcaac cggatgaaaa caacacggcg ttcagtgttc
301 ccccactcaa ccagagggag aatagggacg ccaaggagcc gctacccgga acaatcctgg
361 aaatgtggga cggggagatc tatcattacg gcctgtatgt ggaacgaggc cttgtacttg
421 gtgtgcacaa accaccagct gccatcagcc tcgccaaggt tgaactaaca ccactctctc
481 tgttttggag accagtgtat acaccacagt atctcatctc tccagacact ctcaggagac
541 tgcatggaga gacgttcccc tacacagcct ttgacaacaa ctgctatgcc ttctgttgtt
601 gggtcctgga cctaaacgac tcgtggttgt gcaggagaat gatccagagg acaactggtt
661 tcttcagacc ttaccaaggc tggaacagga aacccctccc caccatggat gattccaaat
721 tgaagaaggt agccaacata ttcttgtgtg cgctatcttc gctattcact aggcccatca
781 aagacataat aggaaaggtg agaccgctca acatccttaa catcttggcc tcatgtgatt
841 ggacttttgc aggcatagtg gaatctttga tcctcttggc agagctcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgatcg cccccttact aggtgactac gaactgcagg
961 ggcccgaaga ccttgcagtg gaactcgtac cagtagtgat gggggggatt ggtttggtgc
1021 tgggattcac caaagagagg atcggaaaaa tgctgtcatc tgctgcatcc accttaagag
1081 cttgtaaaga ccttggtgca tacggactgg aaatcctaaa attggtcatg aagtggttct
1141 tcccaaagaa agaggaagca aatgagctgg ctatggtgag gtccattgag gatgcggtgc
1201 tggacctcga agcaattgag aacaatcaca tgactaccct cctcaaagac aaagacagct
1261 tggcaaccta catgagaact cttgacatcg aggaggagaa ggccaggaaa ctttcaacca
1321 aatctgcttc acctgacatc gtgggcacaa tcaacgctct cctagcgaga atcgccgctg
1381 cacgttccct ggtgcatcgg gcgaaagagg aactctctag cagaccaaga cctgttgttg
1441 ttatgatatc aggcaagcca gggataggga aaacccacct tgccagagaa ctggccaaga
1501 aaatcgcagc ttctctcaca ggggaccagc gtgtggggct cattcctcgc aatggcgttg
1561 accactggga tgcatacaag ggagagagag tcgtcctatg ggacgattat gggatgagta
1621 accccatcca cgacgccctc aggttacagg aacttgctga cacctgcccc ctcacgctaa
1681 actgtgatag gattgagaac aaaggcaagg tctttgacag tgatgccata atcatcacca
1741 ctaacctggc caatccagca ccattggact atgtcaactt tgaagcatgc tcgaggcgca
1801 ttgacttcct cgtgtacgca gaagcccctg aggtcgagaa ggcaaagcgt gatttcccag
1861 gtcaacctga catgtggaag aacgcattca gttctgactt ctcgcacata aaactggcgc
1921 tggctccgca aggtggcttc gacaagaatg gaaacacccc acacgggaaa ggcgtcatga
1981 aaaccctcac cactggttcc ctcatcgccc gagcatcagg gctactccat gagaggttag
2041 atgagtatga gctgcagggc ccaaccccca ccacctttaa ctttgaccgc aacaaggtgc
2101 ttgcgttcag acagcttgct gccgaaaaca agtacgggtt gatggacaca atgagaattg
2161 gaaaacagct caaggatgtc aagaccatgc cagagctcaa acaagcactc aagaatgtca
2221 caatcaagag ttgtcagata gtgtatggtg gctgtactta caggcttgag tctaatggca
2281 agggtgatgt gaaagttgac aaagttcaga acgccactgt gcagaccaac aatgaacttg
2341 ccggcgccct acaccatctt aggtgtgcca gaatcagata ttatgtcaag tgtgttcagg
2401 aggccctgta ttccatcatc caaattgctg gagctgcatt tgtaaccacg cgcattgcca
2461 agcgcatgaa catacaagac ctctggtcca agccacaggt ggaggataca gaggagaccg
2521 ccagcaagga tgggtgccca aaacccaagg atgatgacga gttcgttgtc tcatccgatg
2581 acatcaaaac cgagggcaag aaagggaaaa acaagtctgg tcgtggtaag aagcacacag
2641 cattctcaag caaaggtctc agtgatgaag agtacgatga gtacaagaga atcagagaag
2701 aaagaaatgg caaatactcc atagaggaat accttcagga cagagacaag tattatgagg
2761 aggtggccat cgccagggca accgaagagg acttctgtga agaagaagag gccaagatcc
2821 gacaaaggat tttcaggcca acaaggaaac aacgcaaaga ggagagggcc tctctcggtt
2881 tggtcacggg ctctgaaatc aggaagagga acccagacga cttcaagcct aaaggaaagt
2941 tgtgggctga tgacgacagg agtgttgact acaatgagag actcagtttt gaagccccac
3001 caagcatctg gtcgaggata gtcaactttg gttcaggttg gggtttctgg gtttccccca
3061 gcctgttcat aacatcaact catgtcatac cccagggcgc acaggagttc tttggtgttc
3121 ccatcaaaca aattcagata cacaaatcag gtgaattctg tcgtttgagg tttccaaaac
3181 caatcagaac tgacgtgaca ggcatgatct tggaagaagg tgcaccagaa gggaccgtgg
3241 tcacactact catcaagagg ccaactggag aactcatgcc cttggcagcc agaatgggaa
3301 cccatgcaac aatgaaaatt caagggcgca ctgttggagg tcaaatgggc atgctcctaa
3361 caggatccaa cgccaagagt atggatctgg gcaccacacc aggtgactgt ggctgtccct
3421 acatttacaa gagggggaat gactacgtag tcattggagt ccacacagct gccgcccgtg
3481 gaggaaacac tgtcatatgt gccacccagg ggagtgaggg agaagccaca cttgaaggcg
3541 gtgacaacaa ggggacctac tgcggtgcac caatcttagg tccaggaagt gccccaaagc
3601 tcagcaccaa gactaaattc tggagatcat ccacggcacc actcccacct ggtacctatg
3661 agccagccta cctcggcggc aaagacccca gagtcaaggg tggcccttca ttgcaacaag
3721 ttatgaggga ccagctaaaa ccattcactg aacccagggg aaaaccacca aaaccaagtg
3781 tgttagaagc tgccaagaag actattgtca atgtccttga acaaacaatt gatccacctc
3841 aaaaatggtc atttgcgcag gcgtgcgcat cccttgacaa gaccacttcc agcggtcacc
3901 cgcaccatat gcggaaaaac gattgctgga acggggagtc cttcacaggc aaattggcag
3961 accaggcttc caaagccaac ctgatgtacg aagagggaaa gaacatgacc ccagtctaca
4021 caggtgcgct taaggacgag ttggtcaaga ctgataaaat ttatggcaag atcaaaaaga
4081 ggcttctctg gggctcggac ctggcgacca tgatccggtg cgctcgagca ttcgggggcc
4141 tgatggagga actcaaggca cattgtgtca cactacctgt cagagtgggt atgaatatga
4201 atgaggatgg tcctatcatc tttgagaaac actccagata caaataccac tatgatgctg
4261 attactcccg atgggactca acacaacaaa gagccgtgtt ggcagcggcc ttagaaatca
4321 tggtcaagtt ctccccagag ccgcatctgg cccaaaaggt tgcagaagac cttctctctc
4381 ccagcgtgat ggacgtgggt gatttcaaaa tatcaatcaa tgagggtctc ccctccgggg
4441 tgccctgcac ctcccaatgg aattccatcg cccactggct cctcactctc tgtgcactct
4501 ctgaggttac aaacctgtcc cctgatatta tccaggccaa ctctctcttt tctttctacg
4561 gtgatgatga aattgtgagc acagacataa aattggatcc agaaaagttg acagcaaaac
4621 tcaaggaata cgggttgaaa ccgacccgcc ccgataagac tgagggaccc cttgttatct
4681 ctgaagacct ggatggccta accttcctgc ggaggaccgt gacccgtgac ccagcaggct
4741 ggtttggaaa gttggaacag agttcaatac tcagacaaat gtattggact aggggcccca
4801 accatgaaga tccatctgaa acaatgatac cacactccca gaggcccata caattgatgt
4861 ctttactggg tgaggctgca ctccacggcc caacattcta cagcaaaatc agcaaactgg
4921 tcattgcaga gttgaaggaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctcg gatctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccgctccat ctaatgatgg tgcagccggt
5101 ctcgtaccag aggtcaacaa tgagaccatg gcacttgaac cggtggctgg ggcctcaata
5161 gccgccccac tcaccggtca aaacaatatt atagacccct ggattagatt aaattttgtg
5221 caggctccca atggggagtt cacggtttcg ccccgtaact cgcccgggga agtcctatta
5281 aatttggaat taggccccga actaaatcca tacctagcac acctttctag aatgtataat
5341 ggttacgcag gtggagttga ggtgcaagtg ctactggctg ggaacgcgtt cacagctgga
5401 aaactggtgt ttgccgcagt tccccctcac tttccattag aaaatataag ccctggccag
5461 ataactatgt tccctcatgt aattattgat gttaggactt tagaaccagt tttgttgccc
5521 cttccagatg ttaggaataa tttctttcat tataatcaac aaaatgaacc aaggatgaga
5581 cttgtggcaa tgctttacac tcctcttaga tctaatggtt ctggtgatga tgtgtttact
5641 gtctcttgca gggtgcttac ccgcccttcc cctgattttg actttaacta cttggtcccc
5701 cctaccgttg aatctaaaac taaacccttc acactcccca tcttgaccat tggggagtta
5761 accaactcta ggttccctgt gcccatagat cagatctaca ccagtcccaa tgagaatctg
5821 gtggtgcaac cccaaaatgg gagatgcgcg ctagatgggg agctgcaggg cacgacccag
5881 cttctcccta cggcgatttg ctcattcagg ggccggatca atcagcatgt gagtggagat
5941 aaccatgttt ggaacatgca ggtcaccaac atcaacggga ccccttttga cccaacagag
6001 gatgttccgg ctcccctagg caccccagat ttctctggta agatctttgg catactaagc
6061 cagagggacc atgacaacgc ctgtaggagc catgatgcag taattgcaac caactctgcc
6121 aaatttactc caaaattggg cgctgtacaa attggcacat gggaaacaga tgacgtgcac
6181 atcaaccaac ctaccaaatt cactccagtt ggcttgtttg aagatgaggg tttcaaccag
6241 tggacactcc ccaactactc tggagcttta acacttaaca tggggttggc cccccctgtg
6301 gcccctacct tccctggtga acaaatcctt ttctttagat cccacattcc tcttaaagga
6361 ggtgtggcgg acccagttat tgactgtctc ttgccccaag aatggatcca acatctttac
6421 caagaatcag ccccctcaca atcagatgtg gcattgatta ggtttacaaa tccagacaca
6481 ggacgtgttc tatttgaagc aaaattacac aggagtggtt tcatcacagt ggccaacact
6541 ggcagcagac cgattgtggt gccagctaat ggttatttca ggtttgactc ttgggttaat
6601 caattctatt ctctcgcccc catgggaact ggaaacgggc gcagaagggt gcagtaatgg
6661 ctggagcttt tatagcaggg cttgctggtg acatagtcac caatagcatt ggctcacttg
6721 tgaacgctgg ggctaatgca ataaatcaaa aagtagactt tgaaaacaac aagcaactac
6781 agcaggcttc tttcaatcat gataaagaga tgttgcaagc tcaagtccag gccaccaaac
6841 agctgcaggc tgaaatgatt gcaattagac aaggggtgtt gaccgcgggc ggcttctccc
6901 ctactgatgc agcaagaggt gcagttaatg cacctatgac ccaggtctta gactggaacg
6961 ggaccaggca ttgggccccc ggagccacca aaactactgc tttctccggt gggttcacca
7021 gtgcttccca tgccagaact gtcgacctaa ccaagaagac atcagccaca ccagccccta
7081 cgcctgtttc tagacctagc tctactgcct ctacagtctc cacccgctca acattggtta
7141 gcgggtcttc tatttcttcc tcttcagcta ggagttcttc tagtgtttcc tctcaaccca
7201 cctcctcctc ttctcggacc agcgagtggg tgcgcagcca aaacaaggtg ttggagcctt
7261 acatgagagg ggcgttgcac acaacctttg tgacgcctcc ctctagtagg gcttctagca
7321 atggcacagt ctcaaccgtg ccaaaagggg ttttggactc ctggacacct gcgtttaaca
7381 cccgcaagca gccgctattc gctcatctcc gtcggagagg ggagtcacaa gtttagtgaa
7441 aagatgatct ttattttctt tcctttgaaa attctttttg tctttt
//