Typing tool
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Typing tool
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Complete norovirus genomes
| MW305696 | GII.4 | |
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| GII.P39 |
ORF1: 1..5069
ORF2: 5050..6669
ORF3: 6669..7475
LOCUS MW305696 7520 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate C127 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305696
VERSION MW305696.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7520)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7520)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7520
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="C127"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="French Guiana"
/collection_date="05-Jun-1978"
/note="genotype: GII.4[GII.P39]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59424.1"
/translation="AVANSNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPRETPQR
PPRPPTPELIKKVPPPPPNGEDEPVISYNAKSGVSGLPELSTVRQPDENNTAFSVPPL
NQRENRDAKEPLTGTILEMWDGEIYHYGLYVDRGLVLGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLRRLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANIFLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEASELAMV
RSIEDAVLDLEAIENNHLTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARELAKKIATTLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPDVEKAKRDFPGQPDM
WKNAFSPDFSHIKLMLAPQGGFDKNGNTPHGKGVMKTLTIGSLIARASGLLHERLDEY
ELQGPALTTFNFDRNKVLAFRQLAAENKYGLMDTMRVGGQLKGVRTMPELKQALKNIS
IKRCQIVYGGSTYTLESDGKGSVRVDKVQSATVQTNNELAGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQLEDTEEATGKDGCPKPKDDEEFVV
SSDDIKVEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGTQEFFGVSIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNNGTYCGAPILGPGSAPKLSTKT
KFWRSSTAPLPPGTYEPAYLGGKDPRIKGGPSLQQVMRDQLKPFTEPRGKQPKPSVLE
AAKRTIINVLEQTIDPPQKWTFAQACASLDKTTSSGHPHHIRKNECWNGDSFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPVRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRAILAAA
LEIMVKFSPEPHLAQIVAEDLLSPSVMDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTDLSPDIVQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPTQLMSLLGEAALHGPAFYSKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6669
/gene="ORF2"
CDS 5050..6669
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59425.1"
/translation="MKMASSDANPSDGSAANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNIIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLSRMYNGYAGG
FEVQVILAGNAFTAGKVIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQAHDSTLKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFTVPILTVEEMSNSRFPIPLEKLYTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSAVNICNFRGDVTRVGTSHDYTMNLVSQNWNNYDPTEEIPAPLGTPDFVGKIQGLL
TQTTRADGSTRAHKATVSTGSVHFTPKLGSVQFTTDTDNDFQTGQNTKFTPVGVIQDG
DHHQNEPQQWVLPNYSGTSGHNVHLAPAVAPAFPGEQLLFFRSTMPGCSGYPNMNLDC
LLPQEWVLHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYITVAHTGPYDLVI
PPNGYFRFDSWVNQFYTLAPMGNGTGRRRAL"
gene 6669..7475
/gene="ORF3"
CDS 6669..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59426.1"
/translation="MAGPFFAGLASDVLGSGLGSLISAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATQKLQQELMKVKQAVLLEGGFSTTDAARGAIN
APMTKALDWSGTRYWAPDARITTYNAGRFSTPQPLGALPGRTNPRVPASARSSPSSLS
NAPTATSVYSNQTASTRLGSSAGSGAGVSSLPSTARTRSWVEDQNKNLSPFMKGALNT
SFVTPPSSRSSNQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRV"
ORIGIN
1 ccgctgttgc taacagcaac aacgacaccg caaaatcttc aagtgacgga gtactttcta
61 gtatggctgt cacttttaaa cgagccctcg gggcgcggcc taagcagccg cccccgaggg
121 aaacaccaca aagaccccca cgaccgccca ctccggagtt gatcaagaag gtccctcccc
181 ccccgcccaa cggggaggac gaaccagtga tttcttacaa cgccaagagt ggcgtttctg
241 gactgcctga gctttccact gtcaggcaac cagatgagaa caacacggca tttagtgtcc
301 ccccacttaa ccaaagggag aacagggatg ccaaggagcc acttactgga acaatcctgg
361 agatgtggga tggggagatc taccattacg gcttgtatgt ggatcgaggc ctggtgctcg
421 gcgtacacaa accgccagca gctattagcc tcgctaaggt tgaactgaca ccactctctt
481 tgttttggag acctgtctac accccccagt acctcatctc cccagacacc cttaggagat
541 tacatggtga atcgttccct tacacagcct ttgacaacaa ctgctatgcc ttctgttgct
601 gggttttgga cctgaacgac tcatggctga gtaggaggat gatacagagg acaactggct
661 tcttcagacc ttaccaggat tggaacagga agcctctccc caccatggat gattctaaat
721 taaagaaagt ggccaacata ttcctgtgtg ctttgtcttc actgttcacc agacctatca
781 aggacataat aggaaagcta agacctctta acattctcaa tattttagct tcatgtgact
841 ggacctttgc aggcatagtg gagtctctaa tcctcttggc agaactcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgattg cccccttact gggtgactat gaactgcagg
961 ggcctgagga cctcgcagta gagctagtgc cagtagtaat ggggggaata ggtttggtgc
1021 taggatttac caaagaaaag attgggaaga tgttgtcatc tgccgcatcc acactgaggg
1081 cctgtaaaga ccttggtgca tatgggctgg agatcttgaa actagtcatg aagtggttct
1141 tcccgaagaa agaggaggcg agtgagttgg ccatggtgag atccatcgag gacgcggtgt
1201 tggacctcga agcaattgaa aacaatcatt tgaccactct gcttaaggac aaggacagcc
1261 tggcaactta catgagaact cttgaccttg aggaagagaa agccaggaag ctctcaacca
1321 agtctgcctc acctgacatc gtgggtacaa tcaatgctct cctggcgagg atcgcggctg
1381 cccgttccct ggtacaccga gcaaaagaag aactttccag caggccaagg cctgttgtcg
1441 tgatgatatc aggaaaacca ggaataggga agacccacct tgccagagag ctggctaaga
1501 aaatcgcaac cacccttacg ggagaccaga gggtgggcct catcccacgc aatggtgttg
1561 accactggga tgcgtacaag ggagaaaggg tcgtcctttg ggatgactac ggtatgagta
1621 accccatcca cgatgccctc aggttgcagg agcttgctga cacttgcccc ctaacactaa
1681 attgtgacag gattgagaac aaaggtaaag tttttgacag tgatgctata attatcacca
1741 ctaacttggc caacccagca ccactggact atgtcaactt tgaggcatgc tcgaggcgca
1801 ttgacttcct cgtgtacgcc gaagctcctg atgttgagaa agcgaagcgc gacttcccag
1861 gccaacctga catgtggaag aatgctttca gccctgactt ctcccacata aagctgatgc
1921 tggccccgca gggtggcttt gacaagaatg gcaatacccc acatgggaag ggtgttatga
1981 agaccctcac catcggttct ctcatcgccc gtgcttcagg actcctccat gaaaggctgg
2041 atgagtacga gttgcaaggc ccagccctca caaccttcaa ctttgaccga aacaaagtgc
2101 tcgctttcag gcagcttgct gctgaaaaca agtacgggtt gatggatacg atgagagttg
2161 gagggcaact caagggcgtc agaaccatgc cagagctcaa gcaagcactc aagaacatct
2221 caattaagag gtgccagata gtgtatggtg gcagcaccta cacacttgaa tctgatggca
2281 agggtagtgt gagggttgac aaggtccaga gtgccactgt gcaaaccaac aacgaactag
2341 ccggcgccct gcatcatctc aggtgcgcca ggatcagata ctatgtcaag tgtgtccagg
2401 aagctctgta ctccatcatt caaattgcag gggctgcgtt tgtcaccacg cgcattgtca
2461 agcgcatgaa catacaggat ctatggtcca agccacaact ggaggatacg gaagaagcca
2521 ctggtaaaga cggatgccca aaacccaaag atgatgagga gtttgttgtc tcatccgacg
2581 acatcaaggt tgagggcaag aaagggaaga acaagactgg tcgcggcaag aagcacacag
2641 ccttctcgag taaaggtctc agtgatgagg agtacgacga gtacaaaaga atcagggagg
2701 aaagaaacgg taaatactct atagaggagt acctccaaga cagagacaag tattatgagg
2761 aggttgccat cgccagggcg actgaagagg atttctgtga agaagaagag gccaagattc
2821 gacagagaat ctttaggcca acaaggaaac aacgcaagga ggagagggct tctctcggtc
2881 tagtcacagg ttctgagatc aggaaaagaa acccagatga cttcaaaccc aagggaaagt
2941 tgtgggccga tgacgacaga agtgtcgatt acaacgagaa gctcagtttt gaagccccac
3001 caagcatctg gtcaaggata gtcaactttg gttcgggttg gggtttctgg gtttccccca
3061 gtctgttcat aacatcaact catgttatac cccagggcac acaggagttc ttcggagtgt
3121 ccatcaaaca aatccagata cacaaatcag gcgaattctg ccgcctgagg ttcccaaaac
3181 caatcaggac tgatgtgaca ggcatgatct tagaggaggg tgcccccgaa ggcaccgtgg
3241 ccacattact catcaagaga ccaactggtg agctcatgcc tttagcagcc aggatgggca
3301 ctcatgcaac catgaagatc caaggtcgta ctgttggagg tcaaatgggt atgctcctga
3361 cagggtccaa tgccaaaagt atggacctgg gcaccacacc tggcgactgt ggttgtccct
3421 acatttacaa gagagggaac gactacgtgg tcatcggggt tcacacggct gctgcccgag
3481 gagggaacac tgtcatatgt gccacccagg gaagcgaagg tgaggccaca cttgagggcg
3541 gtgacaacaa tggtacttac tgtggcgccc cgatcctagg tccaggaagt gccccaaagc
3601 tcagcaccaa aaccaaattc tggagatcat ccacagcacc actcccacct ggtacctatg
3661 aaccagccta cctcggtggt aaggacccca gaatcaaggg tggcccctca ctacaacaag
3721 ttatgaggga ccagttgaaa ccattcacgg agccaagagg caaacaacca aagccaagtg
3781 tgttggaagc tgccaagaga accattatta acgtccttga acaaacaata gacccacctc
3841 agaaatggac gtttgcgcaa gcttgcgcgt ctcttgacaa gaccacctcc agtggtcatc
3901 cacaccacat acggaagaat gaatgctgga atggagattc cttcacaggc aagttggcag
3961 atcaggcctc aaaggccaac ttgatgtttg aggaggggaa gaacatgact ccagtttaca
4021 caggtgccct caaggatgag ttggttaaaa cagacaagat atatggcaag attaagaaga
4081 gactactttg gggatcggac ctggcaacca tgatccggtg tgcccgggcg ttcgggggcc
4141 taatggatga actcaaggcc cactgtgtca cactccctgt cagagttggt atgaacatga
4201 atgaggatgg ccccatcatc tttgaaaggc actccaggta taggtatcac tatgatgcag
4261 actattccag atgggactca acacaacaaa gagctatatt ggctgcagcc ctagagatca
4321 tggtcaaatt ctccccagag ccgcacttag cccagatagt tgcagaagac cttctatccc
4381 ccagcgtgat ggatgtgggt gatttcaaga tttcaatcaa cgagggcctc ccctctgggg
4441 tgccttgcac ttcacaatgg aactctattg cccactggct cctcaccctc tgtgctctct
4501 ctgaagtcac ggatctctcc cctgacatcg ttcaagccaa ttctctcttc tctttctatg
4561 gtgatgatga aattgtgagt acagatataa aattggaccc agaaaaactg acggcaaagc
4621 tgaaggaata cggactgaag ccaacccgcc ctgacaagac tgaaggaccc ctaatcattt
4681 ctgaggatct aaatggtttg accttcttgc gaaggactgt aacccgtgat ccagctggtt
4741 ggtttggtaa attggaacaa agttcaatac tcaggcagat gtactggacc aggggcccca
4801 accatgagga cccatctgaa acaatgatac cacattccca aaggcccacg cagttgatgt
4861 ctttgctggg tgaggctgca ctgcacggcc cagcattcta cagcaagatc agtaaactag
4921 tcatcacaga gttaaaggaa ggtggcatgg atttttacgt gcccagacaa gaaccgatgt
4981 tcaggtggat gagattctca gacctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgagtgac gccaacccat ctgatgggtc cgcagccaac
5101 ctcgtcccag aggtcaacaa tgaggttatg gctttggagc ctgttgttgg tgctgccatt
5161 gcagcacctg tagcaggcca gcaaaatata attgacccct ggattagaaa taattttgta
5221 caagcccctg gtggagaatt cacagtgtcc cctagaaacg ctccaggtga aatactgtgg
5281 agcgcgccct taggccctga tttgaacccc tatctctctc acctgtccag aatgtacaat
5341 ggttatgcag gtggttttga agtgcaagta atcctcgcgg ggaacgcgtt caccgccggg
5401 aaagtcatat ttgcagcagt tccaccaaat tttccaactg aaggcctaag ccccagtcag
5461 gttactatgt tcccccatat aattgtggat gttaggcaat tggaacctgt attgatcccc
5521 ctacctgatg ttaggaataa tttctatcat tataatcaag cacatgattc caccctcaaa
5581 ttgatagcaa tgttgtacac accactcaga gctaacaatg ccggggatga tgtttttaca
5641 gtctcttgtc gagtcctcac gagaccatcc cctgattttg attttatatt cctggtgcca
5701 cccacagttg aatcaagaac taaaccattt actgtcccaa tcttaactgt tgaggaaatg
5761 tccaattcaa gattccccat ccctttggaa aagctgtaca cgggtcctag cagtgctttt
5821 gttgtccaac cacaaaatgg cagatgcacg actgatggcg tgctcttagg cactactcag
5881 ctgtcagctg tcaacatctg caacttcagg ggggatgtca cccgtgttgg gaccagccat
5941 gattatacaa tgaatttggt gtcccaaaat tggaataatt atgacccaac agaagaaatc
6001 ccagctcccc tggggacacc agactttgta ggaaagatcc aaggtttgct cacccaaact
6061 acaagagcgg acggctcgac ccgcgcccac aaggccacag tgagcaccgg gagtgtccac
6121 ttcactccaa agctgggtag tgttcaattc accaccgata cggacaatga tttccaaact
6181 ggccaaaaca caaaatttac cccagttggt gtcatccaag acggtgacca ccatcagaat
6241 gaaccccaac aatgggtact cccaaattac tcaggcacat ctggtcacaa tgtgcatctg
6301 gcccctgccg ttgcccccgc cttcccgggt gagcagcttc ttttctttag gtccactatg
6361 cccgggtgta gcgggtaccc caacatgaat ttggattgcc tactccccca ggagtgggtg
6421 ctgcactttt accaggaggc agccccagca caatccgatg tggccctgct gaggtttgtg
6481 aacccagaca caggtagggt tctgtttgag tgcaaactcc ataagtcagg ctatatcaca
6541 gtggctcata ctggcccata tgatttggtt atccccccca atggttactt cagatttgat
6601 tcttgggtca accagttcta cacactcgcc cccatgggaa atggaacggg gcgcaggcgt
6661 gcattataat ggctggacct ttctttgctg gattggcatc tgatgtcctc ggttctggac
6721 ttggttctct aatcagtgct ggagctggag ccatcaatca aaaagttgaa tttgaaaaca
6781 atagaaaatt gcaacaagct tcttttcaat tcagtagtaa tctgcaacag gcttccttcc
6841 agcatgataa agagatgctc caagcacaaa ttgaggctac tcaaaaattg cagcaagaat
6901 tgatgaaagt taaacaggcg gtgctcctag agggtgggtt ttccacaaca gatgcggccc
6961 gtggggcaat caacgccccc atgacaaagg ctctggactg gagcggaaca aggtattggg
7021 ctcctgatgc caggatcaca acatacaatg caggccgctt ctccacccct cagcctttgg
7081 gagcattgcc tgggagaacc aatcctaggg ttcctgcatc tgctcggagc tcccccagtt
7141 cactttccaa tgctcctact gctacttctg tgtattccaa tcaaactgct tcaacgagac
7201 taggttcttc agctggttct ggtgccggtg tctcaagtct cccgtcaact gcaaggacta
7261 ggagctgggt tgaggaccaa aacaaaaatt tgtcgccttt catgaagggg gctctcaaca
7321 catcatttgt gacccctcca tctagtagat cctccaacca aggcacagtc tcaaccgtgc
7381 ctaaagagat tttggactcc tggactggcg cttttaatac gcgcaggcag cctctcttcg
7441 cacacattcg taagcgaggg gagtcacggg tgtaatgtga aaagacaaat tgattatctt
7501 tcttttcttt agtgtctttt
//