Typing tool
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Typing tool
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Complete norovirus genomes
| MW305695 | GII.5 | |
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| GII.P22 |
ORF1: 1..5105
ORF2: 5086..6708
ORF3: 6708..7484
LOCUS MW305695 7519 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate C22 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305695
VERSION MW305695.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7519)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7519)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7519
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="C22"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="French Guiana"
/collection_date="01-Feb-1978"
/note="genotype: GII.5[GII.P22]"
gene <1..5105
/gene="ORF1"
CDS <1..5105
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59421.1"
/translation="TAGKTSTNSEIHNQDANPTSNLFANMTVGLKRALGARPKQSAPR
VSSPNREGKLDTTPRAPSPNKGGKINIPPIPPPPPNGEDIVIKYTKQDDVVEGVPTVA
TVDVPLTHNTAYSVPPLDQREKVDAKEPLTGSILEMWDGEIYHYGLYVEKGLVLGVHK
PPAAISFARIELTPLSLYWRVVYTPPYLIAPETLRKLHGESFPYTAFDNNCYSFCCWV
LDLNDSWLNRKFVSRTTGFYRPYQEWNRKPLPTMDEGKLKKVANVLLCGLSGLFTRPI
KDLIGKLRPLNILNIITNCDWTFPGVVEALILLAELFGVFWTPPDISTFIASLLGDYE
MQGPEDIAVEVVPVILGGIGMVLGFTKERIGRLLSSAASSLRACREIGNYGIEVVKLV
MKWFFPTKDETNEMDMVRAIEDAVLDFEAIQNNHMTALLKDKNSLATFLRELDMEEEK
ARKLSTKSASPDIIGTINALLARIAAARSLVHKAKEEMSSRMRPVVIMISGRPGIGKT
HLARDLAKKMAATLSGDQRVGLVPRNGVDHWDAYKGERIVLWDDYGMSNPVTDALRLQ
ELADTCPLTLNCDRIENKGKVFDSDTIIITTNLANPAPLDYVNFEACSRRIDFLVYAD
SPSVDKAKRDFPGQPDMWKDAFKSDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTH
SLIARATGLLHERLDEFDLQGPELPVYNFDHNRVAAFRRLAADNKYGLMETMKVGNKL
KGVKNLEQLKDALKDISIRPCRIVYNSMAYDLDSNGSGRVNVKKAVDHKVQTNNELNS
ALNNLRGARVRYYVKCVQEMVYSLLQIAGAAFVTSRMTRRLNISSIWARPEKQMEAAE
EPPAPPTEDWTIIPANAAQEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERQ
GKYSIEEYLQDRDRYYEELAIAKATEENFCEEEEIKIRQRVFRPTRKQRKEERATLGL
VTGSEIRKRNPDDFKPKGKLWADDDRSVNYNEKIDFEAPPSLWSRIVNFGSGWGFWVS
SNLFITSTHVIPPNMTEAFGVPIGQIQVHRSGEFCKMRFPKAIRPDVSGMILEEGAPE
GTVVTILIKRTTGELMPLAARMGTHATMKIQGKMLGGQMGMLLTGSNAKNMDLGTIPG
DCGCPYVYKRGNDWVVIGVHTAAARGGNTVICATQGPDGEATLEGGDNHGTYCAAPIL
GPGSAPKLSTKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTA
PRGKPPRPAILEAAKETICNVLEQIIDPPLKWSYAQACASLDKTTSSGHPHHMKKNDN
WNGESFTGVLADQASKANLMYEQGKHMQPVYTAALKDELVKTSKIYESIKKRLLWGSD
LGTMVRCARAFGGLMDEMKANCVNLPIRVGMNMNEDGPIIFEKHSKYKYHYDADYSRW
DSTQQRHILGAALEIMVRFSAEPELAQIVSEDLLAPSVVDVGDFKIAINEGLPSGVPC
TSQWNSISHWLITLCAISEVSGLSPDVVQTNSCFSFYGDDEIVSTDIKLDPMKLTNKL
KEYGLIPTRPDKTEGPLIIKENLEGLTFLRRDVCRDPAGWYGKLDQSSIMRQLFWTKG
PNHEDPNETMIPHSQRPIQLMSLLGEAALHGPTFYKKVSKLVITELKEGGMDFYVPRQ
EPMFRWMRFSDLSTWEGDRNLAPEGVNEDGVE"
mat_peptide <1..1010
/gene="ORF1"
/product="p48"
mat_peptide 1011..2108
/gene="ORF1"
/product="NTPase"
mat_peptide 2109..2645
/gene="ORF1"
/product="p22"
mat_peptide 2646..3029
/gene="ORF1"
/product="VPg"
mat_peptide 3030..3572
/gene="ORF1"
/product="Pro"
mat_peptide 3573..5102
/gene="ORF1"
/product="RdRp"
gene 5086..6708
/gene="ORF2"
CDS 5086..6708
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59422.1"
/translation="MKMASNDAAPSNDGAAGLVPESSNEAMALEPVVGASLAAPVTGQ
TNIIDPWIRTNFVQAPNGEFTVSPRNSPGEVLVNLELGPELNPYLGHLARMYNGYAGG
MEVQVLLAGNAFTAGKIIFAAVPPYFPVENLSPSQITMFPHVIIDVRTLEPVLLPMPD
VRSTLFHFNQKDEPKMRLVAMLYTPLRSNGSGDDVFTVSCRILTRPSPEFDFTYLVPP
TVESKTKPFTLPVLTLGELSNSRFPLSIDEMVTSPNESIVVQPQNGRVTLDGELLGTT
QLQACNICSIRGKVTGQVPNEQHMWNLEITNLNGTQFDPTDDVPAPLGVPDFAGEVFG
VLSQRNRGESNPANRAHDAVVATYSDKYTPKLGLVQIGTWNTNDVENQPTKFTPIGLN
EVANGHRFEQWTLPRYSGALTLNMNLAPAVAPLFPGERLLFFRSYVPLKGGFGNPAID
CLVPQEWVQHFYQESAPSLGDVALVRYVNPDTGRVLFEAKLHKGGFLTVSSTSTGPVV
VPANGYFRFDSWVNQFYSLAPMGTGNGRRRFQ"
gene 6708..7484
/gene="ORF3"
CDS 6708..7484
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59423.1"
/translation="MAGAFIAGLAGDVLSNGLGSLINAGANAINQRAEFDFNRQLQQN
SFNHDKEMLSAQIQATKQLQADMIAIKQGVLAAGGFSPTDAARGAVNAPMTQALDWNG
TRYWAPGSVKTTSYSGKFVSMNPVRQVEFPQPKKSAAIPSSASSVSSGRTNLTNSTQS
TVVSASSVPPSRGPSAPSTLSRATARTSNWVEEQNRNLEPYMKGALQTAFVTPPSSRA
SSNGTVSTVPKGVLDSWTPAFNTRRQPLFAYLRKKGESQA"
ORIGIN
1 cgaccgctgg caaaaccagc acaaacagtg aaattcacaa tcaagatgca aaccctacat
61 caaacctctt tgccaacatg actgttggct tgaagagggc cctgggggcg aggccaaaac
121 agtccgctcc cagggtctcc tcccccaaca gggagggaaa gctcgatacc actcccagag
181 ccccctctcc caacaaggga ggaaaaatca acatcccccc aataccaccc ccaccgccca
241 acggtgagga catagtcatc aaatacacca aacaagatga tgtagttgaa ggggtaccca
301 ccgtcgccac ggtggacgtt cctcttacac acaacaccgc ctacagtgtt ccccccttgg
361 accagaggga aaaggttgat gcgaaggaac ccctgacagg ttcgatactt gaaatgtggg
421 atggggaaat ctaccattat gggctatatg tggagaaggg cttggtcctt ggtgtgcata
481 aacccccagc cgccataagc tttgcacgca tagaactcac tcccctttct ctatactgga
541 gggtagtcta taccccacct tacctaatag ccccagaaac cctcaggaaa ctccatgggg
601 agtcgtttcc atacacagcc tttgacaata actgctattc cttctgctgt tgggtcctgg
661 atctgaacga ttcttggctc aataggaagt ttgtgtcaag gaccacgggt ttctacaggc
721 cctaccaaga gtggaacaga aaacccctac caactatgga tgagggaaag cttaagaagg
781 tggccaatgt gctcctatgt ggcctctctg ggctctttac taggcccatc aaggacctca
841 taggaaaatt gaggccgctg aacatactca acatcatcac caattgtgat tggaccttcc
901 ccggagttgt ggaggctctc atactacttg cagaactctt tggagtcttt tggacaccac
961 cagacatttc cacctttata gcatcactgc tgggtgatta tgaaatgcaa ggccctgagg
1021 atatcgcggt tgaggtcgtg ccggtgatcc tcggtggcat aggcatggtg cttggattca
1081 ccaaagaaag gatcggccga ctgttgagct ctgccgcgtc ttcgctcagg gcatgcaggg
1141 agattggtaa ctacgggata gaagtggtga aactggtgat gaagtggttt ttccccacca
1201 aggatgagac aaacgagatg gatatggtga gggcgataga ggatgctgtg ctcgattttg
1261 aagccataca gaacaatcat atgacagcat tactcaaaga caaaaacagt ctggcaacct
1321 tcctcaggga gttagatatg gaagaggaaa aggcgcggaa gctgtcaacg aaatctgcgt
1381 ccccagatat tattggcacc ataaatgccc ttctagccag gattgccgcc gctaggtccc
1441 tagtccacaa ggccaaggaa gaaatgtcat ctaggatgcg tcctgttgtc atcatgatct
1501 ccggtcgacc cgggatagga aaaacacact tggctcgtga cctggccaag aagatggcag
1561 cgaccctctc aggtgatcag agggtggggc tcgtaccgag gaatggtgtc gaccattggg
1621 atgcatataa aggagagagg attgtgcttt gggacgacta cggcatgagc aaccctgtga
1681 ccgacgcact gcggctccag gagttggccg acacatgccc cttgacactc aattgtgata
1741 gaatagaaaa caaggggaaa gtgtttgaca gtgacaccat aatcatcacc accaatctag
1801 ccaaccctgc tcctctagac tatgttaatt ttgaagcttg ctcccgccgt atcgatttcc
1861 ttgtctacgc agactcccct tcggttgaca aagcgaagag agacttccct ggtcaaccag
1921 acatgtggaa agatgccttc aaatcagact tttcacatat aaagcttcag ttggcgccac
1981 aagggggctt tgataagaac ggaaacaccc cccacgggaa aggtgtcatg aaaacgctga
2041 ccacacactc ccttattgcc cgcgccacgg gcctcctgca cgagagactg gatgagttcg
2101 acctgcaggg acctgagttg cctgtgtaca actttgacca caacagggtg gctgctttca
2161 ggagacttgc agctgacaac aagtatggcc ttatggaaac catgaaagtg ggcaacaaac
2221 tgaagggtgt caagaatctg gaacaactca aggatgctct aaaggacata agtatcagac
2281 cttgcaggat agtctacaac tcgatggctt acgacctcga ctcgaacggg tcagggagag
2341 tcaacgtcaa aaaggctgta gaccacaagg tccaaaccaa caacgaactc aactccgcgc
2401 tcaacaatct gcgtggcgcc agagtgagat actatgtcaa gtgtgttcaa gagatggtgt
2461 actctctcct ccagatcgct ggcgcggcct tcgtcacttc aaggatgaca cggagactga
2521 acatcagcag tatttgggcc aggccagaaa aacaaatgga ggccgctgag gaacccccag
2581 cccccccaac tgaggactgg actataatac cagcaaatgc agcccaggaa ggtaagaagg
2641 gtaagaacaa gagtggtaga ggcaagaaac acaccgcctt ctccagcaaa ggcctcagtg
2701 atgaagagta tgatgagtac aaaagaatca gagaagagag acagggaaaa tactctatag
2761 aagagtacct tcaggacagg gaccggtact atgaagaact agccatagcc aaagcaacag
2821 aagagaactt ctgtgaggag gaagaaataa aaattagaca gagggtcttc cgcccgacca
2881 ggaaacagcg taaggaagag agagcgactc tgggcctggt tacgggcagt gaaataagga
2941 agaggaaccc agatgacttc aagccaaagg gaaaactgtg ggctgatgat gaccgcagtg
3001 taaactacaa tgagaaaata gactttgaag cgccccccag cctctggtcc cgaatagtga
3061 actttggatc aggttggggc ttctgggtgt cttccaattt gttcatcaca tcaacacatg
3121 tcatcccccc aaacatgacc gaggcttttg gtgtaccaat aggtcaaata caagtgcaca
3181 ggagtgggga gttctgcaaa atgaggttcc ctaaagctat aagacctgat gtctcaggca
3241 tgatccttga ggaaggagcc cccgagggaa cagtggtgac cattctgatc aagagaacaa
3301 ctggtgaact catgccactg gcagcccgga tgggcactca cgccaccatg aaaatacagg
3361 ggaagatgct tggaggccaa atgggcatgc ttctcacagg gtccaatgcc aagaacatgg
3421 atcttggcac catccccggg gactgtggct gtccttatgt gtacaagaga ggcaatgatt
3481 gggtggtcat aggggtgcac accgcagctg ccagaggcgg caacacggtg atttgcgcca
3541 cccagggacc agatggtgag gccacgcttg aggggggaga caatcacggg acttactgtg
3601 ctgcaccaat acttggacca gggagtgcac caaagctcag caccaagacg aagttctgga
3661 ggtcatccaa cgccccactc ccacctggta cttatgaacc cgcctaccta ggcggaaagg
3721 acccaagggt caagggaggg ccatcactgc agcaagtcat gagggaccaa ctcaagccct
3781 tcaccgcccc ccgagggaag ccaccacgac cggcgatcct ggaggctgct aaagagacca
3841 tctgcaatgt gcttgaacaa atcattgacc cacccctaaa atggtcttac gcccaagcct
3901 gtgcctcatt ggataagaca acatcaagtg gccaccctca tcatatgaaa aagaatgaca
3961 actggaacgg ggagtccttt actggcgtgc tagctgacca ggcctccaag gcaaacctca
4021 tgtatgaaca ggggaaacac atgcagcctg tgtacactgc tgccctcaag gatgagctcg
4081 ttaagaccag caaaatttat gagagcatta agaaaaggct cctatggggc tcagatctgg
4141 gcacaatggt tcgctgtgct agagcttttg gtggtcttat ggatgagatg aaagcaaatt
4201 gtgtgaactt accaattaga gttggcatga acatgaacga ggatgggccc attatttttg
4261 aaaaacattc aaagtataag taccattatg atgctgacta ctctaggtgg gactcaaccc
4321 aacagaggca catcttgggg gctgcccttg aaataatggt tagattctca gctgaacctg
4381 aattggcaca aattgtgtct gaggacctct tagcccccag cgtggtggac gttggtgact
4441 ttaaaattgc cataaatgag ggtttgccct ctggggtgcc gtgcacatca caatggaact
4501 caatctctca ttggctaata acattatgtg ccatatcaga agtctcaggg ttgtcgccag
4561 atgtggtgca aacaaactcc tgtttctctt tctacgggga tgatgagata gtcagcactg
4621 acatcaagtt agatcccatg aaactaacca acaagttgaa ggagtacggg ttgattccaa
4681 caagaccaga caagacagag gggccactca taattaaaga aaaccttgag ggtttgactt
4741 tcctgaggag ggacgtgtgc cgggacccag ctggttggta cggaaaactt gatcaatcct
4801 caatcatgag acaattgttc tggaccaagg gacccaatca tgaagacccc aatgaaacaa
4861 tgattccaca ctctcagagg cccatacaac taatgtcact gctaggggag gcagcactgc
4921 atggaccaac tttctacaag aaagtcagca aattggttat cactgagctc aaagagggtg
4981 ggatggattt ctacgtgcca agacaggaac ctatgttcag gtggatgaga ttctctgatc
5041 tcagcacttg ggagggcgat cgcaatcttg ctcccgaagg tgtgaatgaa gatggcgtcg
5101 aatgacgccg ctccatcaaa tgatggtgcc gccggcctcg tgccagaaag tagtaatgag
5161 gcaatggctc tggaacccgt ggtgggggca tctttagccg cccctgtcac tggccaaact
5221 aatataatag acccctggat tagaactaat tttgtccaag cccctaatgg tgaattcaca
5281 gtttcccctc gaaactcccc tggagaggta ttggtcaatt tggagctagg tccagaactg
5341 aacccttatc tgggacactt agctaggatg tacaatggtt atgcgggtgg tatggaagtg
5401 caagtgttgc tcgcagggaa cgcgttcact gctggcaaga tcatctttgc tgccgtgcca
5461 ccttactttc cagtggaaaa tcttagccct tctcaaataa caatgttccc acatgtgatt
5521 attgatgtta gaaccttgga acctgtatta ctcccaatgc ctgatgttag aagtaccttg
5581 ttccatttta atcaaaagga tgagcctaag atgagacttg ttgctatgct ttatacccct
5641 cttcgttcta atggttctgg tgacgatgtt ttcaccgtct cgtgtaggat ccttactagg
5701 ccctcccctg aatttgattt cacatattta gtaccaccaa cagtagaatc aaaaaccaaa
5761 ccattcacac tacctgtact aacactggga gaattgtcta actctagatt tcccctctct
5821 attgatgaaa tggttaccag ccccaatgag tccatagttg tccagccaca gaatggtagg
5881 gttacgctgg atggggagct gttgggcaca actcaattac aagcatgcaa catttgctct
5941 ataaggggga aggtaacagg gcaggttcct aatgaacaac atatgtggaa cctagagatc
6001 acaaacctaa atgggacaca atttgacccc acagatgatg tcccagcccc ccttggtgtg
6061 cccgactttg caggtgaggt ttttggtgta ctcagccaga gaaatagagg tgagagcaat
6121 ccagcaaaca gggctcatga tgctgtcgtg gctacctaca gtgacaagta cacccccaaa
6181 ctgggcttag tgcaaattgg aacttggaac accaatgatg ttgaaaatca gccaacaaaa
6241 ttcaccccaa ttggtttgaa tgaggttgcc aatggccatc gatttgaaca gtggactttg
6301 cctaggtatt ctggtgccct aacactaaac atgaatttag cccctgctgt ggctccgctc
6361 tttcctggag agcgtctcct tttcttccgc tcttatgttc cattaaaagg tggatttggt
6421 aaccctgcta tagattgtct ggtgcctcaa gagtgggttc aacacttcta tcaggagtct
6481 gccccctctc tgggggatgt ggccttggtc aggtacgtca acccagacac cgggcgcgtc
6541 ctttttgagg ccaaactcca caagggtgga ttcctgactg tgtcaagcac tagcacaggg
6601 cctgttgtgg tgccagccaa tggctatttc agatttgatt cttgggttaa tcaattttac
6661 tctcttgccc ccatgggaac tgggaatggg cgcagaagat ttcagtaatg gcaggagctt
6721 ttatagcagg tttagcaggt gatgtgctta gtaatggcct cggttcgctg attaatgccg
6781 gagccaatgc tatcaatcaa agagcagaat ttgattttaa taggcaattg caacaaaatt
6841 ctttcaatca tgataaagaa atgttaagtg cccaaattca agcaacaaaa cagttgcagg
6901 ctgatatgat agcaatcaaa cagggagtcc tggctgctgg aggtttctcc ccaactgatg
6961 cagccagagg agctgttaac gcacccatga cccaagcact agattggaat ggcactaggt
7021 actgggcccc tggctcagtg aagaccacca gctactctgg aaagtttgtg tccatgaatc
7081 ctgttaggca ggttgaattc ccgcagccca aaaagagtgc ggccatacca tcaagtgcca
7141 gctccgtgtc ttctggtaga actaatttga caaattccac tcaatcaact gttgttagtg
7201 cttcctcagt gccaccttct aggggcccct ctgctccttc tactctgtca agggccacag
7261 ccagaacttc caattgggtt gaggaacaaa acaggaattt ggaaccctac atgaagggtg
7321 cccttcaaac agcatttgtc acccccccct ctagccgggc atctagtaat ggaacagtct
7381 caactgtgcc aaaaggtgtt ttggactcct ggacacctgc gttcaacacc cgcaggcagc
7441 cgcttttcgc ttaccttcgt aagaaggggg agtcacaagc ttagtgaaaa gataattaat
7501 gattaataat tgatctttt
//