Typing tool
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Typing tool
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Complete norovirus genomes
| MW305693 | GII.14 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6654
ORF3: 6654..7448
LOCUS MW305693 7494 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 12146 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305693
VERSION MW305693.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7494)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7494)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7494
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="12146"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Japan"
/collection_date="01-Jan-2014"
/note="genotype: GII.14[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59415.1"
/translation="FGSQNSVNDSINATPSNKEEVGAFSNIKVGFKKMLGAVPKSTRA
PSSGQHCPTVKIGPKTLTIPPEPPNGEDTVQFDAKSETIIGLPDLTTVQNEHENTPYT
VPPLSEREHRSATEPLPGTILEMWDGEFYHYSVYVSDGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVSPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLNRRCI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFNIFWTPPDVSNFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGSPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKNVKTLEDLKFAL
RDVKFNECEIIYKNSKYRVSSNGKGSVSVDKIEDNASQTANEVQSAILRLRQARARYY
ISCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQEVNESEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGTDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
VKELFGVEIKQIQVHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILIKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNEDLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVERGPSLQQVMRDQLRPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWSYSQACASLDKTTSSGSPHHVKKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFIISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6654
/gene="ORF2"
CDS 5044..6654
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59416.1"
/translation="MKMASNDATPSDDGAAGLVPEINSEVMALEPVAGASIAAPVVGQ
QNIIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLAHLARMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNSPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPVVLDQMYTSRNENIIVQPQNGRCTTDGELLGTT
ILQSVSICNFKGTMQARLNEEPRYQLQLTNLDGSPIDPTDDMPAPLGTPDFQAMLYGV
ASQRSSTDNATRAHDAQIDTAGDTFAPKIGQVRFKSSSNDFDLHDPTKFTPIGVNVDD
QHPFRQWSLPSYGGHLALNNHLAPAVTPLFPGEQILFFRSYIPSAGGHTDGAMDCLLP
QEWVEHFYQEAAPSQSDIALVRFINPETGRVLFEAKLHKQGFLTIAASGDHPIVMPTN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6654..7448
/gene="ORF3"
CDS 6654..7448
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59417.1"
/translation="MAGAFLAGLAGDVVTSSLGSLVGAGANAINQKVEYDFNRQLQEA
SFRHDKDMLKAQVAATAGLQQAMIDIKREALTAGGFSPADAARGAVRAPMTQILDWNG
SRYWAPNSMKTTGYSGTFASQGIKSSPHLSNQIPSAVKSTKPLPSVSSSSSVHSSPST
APSQSTQSTTLSVGTGSSRSNTVSTKTSTLSRTSDWVRGQNEMLGPFMSGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 cctttggcag tcaaaactct gtcaatgaca gtatcaacgc caccccttcc aataaggaag
61 aggttggtgc attctccaac atcaaagttg gatttaagaa aatgctgggt gctgtaccca
121 agagcaccag ggcacccagc agtggtcaac attgccccac agttaagatc gggcctaaaa
181 cattaacaat tccccctgag cccccaaatg gtgaagacac tgtgcagttt gatgcaaagt
241 cggaaactat aatcgggctg ccggacttga caacggtgca aaacgaacat gaaaacaccc
301 catacaccgt ccccccatta agtgagaggg agcatagatc ggccactgaa ccactacctg
361 gcacaatatt ggagatgtgg gatggtgaat tttaccacta ctccgtgtat gtcagcgatg
421 gcaaagctct gggggtccac aaaccaccgg ctgctataag cctcgcgacg atagaactca
481 cccccatatc tctctactgg agacccgttt acacccccaa ctatttggtc tccccagaca
541 cattgaaagg cctcgctggt gagaagttcc cttacacggc cttcagtaac aattgttata
601 acttttgttg ttgggtgctt gagctcaacg acacgtggct caatagaaga tgcatttcca
661 gaaccaccgg cttcttcaaa ccctatcagt cctggaacag gaagcccctc ccaaccgtcg
721 atgatggaaa gatcaaaaag gtggccaacg cgatcctctg tgcacttggc tcactgttct
781 caaagccaat taaagatttg ttaggcaaac ttaagccatt gaacctgcta cacttgcttg
841 cgtcatgcga ttggacgttt gcaggtatag tggagacagt catcttaatg gcagaacttt
901 tcaatatctt ctggaccccg ccagatgtct ctaattttat agcctccctg ataggtgatt
961 ttgagttaca agggcccgag gacctggctg tggaactcgt tcctgtggtt atgggtggca
1021 taggaatggt tctcggcttc accgctgaga agataggccg tatgctgtca tccgccgcat
1081 caacactgcg ggcatgcaaa gacctaggga actatgccct tgacattctc aaattggtca
1141 tgaagtggtt cttccccaag aaggaagaga aagctgagat ggaaacctta agggcgatcg
1201 aggatgccgt cctagatatg gaagctatag ggaataacca tctcacgacc ctcctcaagg
1261 acaaagacag cctcacggcc tttatgaaga ccctggactt agaagaggaa aaagctagaa
1321 aactgtccac taagtcatct tcaccggaca tcgtcggcac cattaacgcc atactagcca
1381 ggattgccgc tgccagatcc cttctacata aagccaaaga agagatgttt agtaggatca
1441 gaccagtggt cgttatgata tcaggcagac ctggcattgg caaaactcac atggcaagac
1501 atttggctaa gagcatcgcc aacaccatga gtggcgacca gagagtcggg ctcgtcccac
1561 gcaacggtgt cgaccactgg gatgcctaca gaggagagag ggtggtcttg tgggacgact
1621 acggtatggg gagccctgtt aaagatgcct tgacactaca ggagctggcc gacacctgcc
1681 cagtcacttt aaattgtgat aggattgaga acaaggggaa gatgttcgac agtgatgtca
1741 tcataatcac aaccaacctg gtcaaccccg cgcccctcga ttatgtaaac ttcgaggcgt
1801 gctccaggag agttgacttc ttggtctatg cagagtcacc agagattgaa aaggtcaaaa
1861 gggacttccc tggccaacct gacatgtgga aggaccattt taagccagac ttttctcaca
1921 tcaagctaac tttagccccc cagggcgggt ttgacaagaa tggtaacact ccgcacggta
1981 agggtaccat gcggtccctg acccaggggt ccctgactgc aagagttgcg ggccttgtcc
2041 atgagaggag agatgagttc caactccaag gaaacgatct ccaaacatac aattttgaca
2101 ccaacagagt ctccgcattc agaaaactgg ctgcagataa caagtatggt atcatggaaa
2161 cgatgagagt aggtgcggca ctcaaaaatg taaagacctt ggaagatcta aaatttgcat
2221 taagggatgt aaaattcaat gagtgtgaaa taatttacaa gaactctaag tatcgagtct
2281 cttccaacgg taaaggctca gtttctgttg acaaaattga ggacaatgca tcccagaccg
2341 cgaacgaggt acaatcagca attctcaggc tcaggcaagc gagggccaga tattacatca
2401 gctgcttcca agacctcgtc tacactctca tacaggttgc cggagcatca ttcgttgtca
2461 acagaatctc caaaaggttc tgctgggaaa ggtgggtcaa accaaccgag acccaggaag
2521 tgaatgagtc cgaaaaggaa gtggctcaag gtagatggga aattgagccc aaggacacag
2581 aaccagaagg caagaaaggt aagaacaaga aaggaagggg caagaaacac acagctttct
2641 ctagcaaggg cctgagtgat gaagagtatg acgagttcaa gagaatcagg gaagaaagga
2701 atggaaagta ctccattgag gaatacctgc aagaccggga ccgctattat gaagaagtgg
2761 cagttgcccg ggcaacagag gaggacttct gtgaggagga agaggccaaa ataagacaaa
2821 gaattttccg cccgacaaag aaacaaagga aggaggaaag gggtgtactt ggcttagtca
2881 ccggcacaga catcagaaag aggagaccag acgattttca accaaaaggc aatctatggg
2941 cagatgacac caggagtgtg gactacaatg agagacttga ttttgaagcg cccccaagtg
3001 tctggtcaag aatagttcca ttaggcactg gttggggttt ctgggtttca tccaaccttc
3061 taatcacaac aacacacgtc ctgcctaaag gggttaagga actctttgga gttgaaatta
3121 aacagatcca agttcacaag tctggggagt tttgcaggtt cagattccca agaccaatca
3181 ggccagatgt cacagggctc gtgctggagg aaggcgcccc agaaggcact gtctgttcta
3241 tactcataaa aagacccaca ggtgagatga tccccttggc agtgaggatg ggcacacacg
3301 catccatgaa aatacaaggt aggaccgttg gtggccagat gggaatgctt ctaacaggag
3361 caaatgcaaa gaacatggat cttggcaccg gccctggtga ctgcggttgt ccctacatct
3421 acaaacgcgg caacgacata gttgtcgcgg gtgtccacac cgcagcagcc cgaggaggta
3481 acactgtcat atgcgccact caagggcaag atggggaagc agtccttgag ggaaatgagg
3541 acctcggcac ctactgtggc gctccaattc tgggccctgg taaggcgcct aaactcagca
3601 cgaagaccaa gttttggcgc tcatcaccag atgccttgcc acctggcaca tatgaacctg
3661 cctacctggg aggaaaagac cccagagtgg aaagaggacc ttccctgcag caagtcatga
3721 gagaccagtt gagacccttc acagaaccca ggggaaagcc gcctagacct gcagtcttag
3781 aagaagccaa gaagacagtg atgaatgttt tagaacaaac cattgaccct gcaaaaccgt
3841 ggtcctactc gcaagcatgc gcctcactgg acaaaaccac ttctagtggt agcccccatc
3901 atgtaaagaa aaatgaccac tggaatggag agtccttcac tggtcccctt gcagatcagg
3961 catccaaagc caacctcatg tatgaacagg ccaaacatgt gcagcccgtg tacacggccg
4021 cgctcaaaga tgagcttgtt aagactgaca agatctacaa aaagataaag aagagactcc
4081 tatggggatc ggaccttggt acaatgatca ggtgcgccag ggcttttggt ggtctcatgg
4141 acagcatgaa ggcaagctgt atagctcttc catgcagggt aggaatgaac atgaatgaag
4201 atggccctat catatttgac aaacattcta agtataggta ccactatgat gctgactatt
4261 ctaggtggga ctcaacccag caaaggagca ttctttctgc cgctatggaa gtgatggtgc
4321 gattttctgc tgaaccagaa ttggcacaag tggttgcaga ggacctttta gcgcctagtc
4381 agcttgatgt tggtgatttt atcatctcag ttcaggaggg cctgccatca ggagtcccat
4441 gtacatcaca atggaactca atagcacact ggatcctaac tttgagtgcg atggcagaag
4501 tgtcaggtct ctcaccagat gttgtccaag ctcattcctg cttttcattt tatggggacg
4561 atgagatcgt cagcactgat atcaaccttg accccatgaa gttgacacag aaactcaggg
4621 agtacggcct ggttcccacc cgacctgata aaactgaagg tcccctcgtc ataactgaag
4681 acctcaccgg cctgacgttc cttcgtaggt cgattgcacg ggacccagct gggtggtttg
4741 gaaaattgga ccaagattca atcctcaggc aactatactg gacaaggggg cctaaccatg
4801 agaacccgta cgagagcatg gtccctcatt ctcagcgggc cacacagctt atggcccttc
4861 ttggcgaggc ttcactgcat ggcccccaat tttacaagaa agtcagcaaa atggttatca
4921 atgagattaa gagtggtggt ctggaatttt atgtgcccag acaggaggcc atgtttaggt
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgaaggtg
5041 tgaatgaaga tggcgtcgaa tgacgctact ccatctgatg atggtgcagc cggcctcgta
5101 ccagagatca acagtgaggt tatggctctt gaacccgtcg ctggggcctc cattgcagcc
5161 cccgtagtcg gccaacagaa tataattgat ccctggatta gaaataattt tgtacaagcc
5221 cctgctggtg aattcacagt ttcccctaga aactctcctg gagaacttct acttgatttg
5281 gaattgggtc ctgaacttaa tccctatctt gcacatttgg ccaggatgta caatgggcat
5341 gcaggaggaa tggaagtgca gatagtactg gctgggaatg cgttcacagc tggtaaaatc
5401 ctatttgctg ccatcccgcc tagcttcccc tatgaaaatt tgtcacccgc tcagttgact
5461 atgtgccccc atgtgatagt ggatgtgaga caattggaac cagtgcttct gccaatgcca
5521 gatataagaa atgttttcta tcactataac cagaacaata gtcccaaact taggcttgta
5581 gctatgcttt atactcctct gagggccaac aactcaggtg atgacgtgtt cacggtctct
5641 tgccgcgttt taacacgccc ttctccagat ttccagttca cctttttggt ccctcctaca
5701 gttgagtcta aaactaagaa tttcaccctt cccgttctca gagtctcaga gatgacaaat
5761 tcaaggttcc ccgttgtctt ggaccaaatg tatacaagca ggaatgaaaa catcattgtc
5821 cagccccaaa acggcaggtg cacgactgac ggtgagctgc ttggcactac catcttgcag
5881 tctgtgtcta tttgcaattt taaaggaaca atgcaggcaa ggctgaatga agaaccacga
5941 taccagttac aactcaccaa cctggatgga tcacccatag atccaacaga tgatatgcct
6001 gcccctcttg gcacaccaga tttccaggcc atgttatatg gcgttgcaag tcaacgctct
6061 tccacagaca atgccaccag ggcacatgat gcacagattg acactgcggg tgacacattc
6121 gccccgaaaa ttggccaggt tcgtttcaaa tcaagctcta atgattttga cctacatgac
6181 cctacaaaat tcacacctat tggtgtcaat gtggatgatc agcacccttt cagacagtgg
6241 tccctaccaa gctacggtgg tcaccttgcc ctgaacaatc acttagcccc cgctgtgaca
6301 ccactctttc ctggcgagca gattttgttc ttcaggtcat acattccaag cgccggaggc
6361 cacacagacg gtgctatgga ctgcttgctg ccccaagagt gggtagagca cttctaccag
6421 gaggctgctc cttcccaatc tgacatcgca ctggtaaggt tcatcaaccc tgaaacagga
6481 agagtgctct ttgaagctaa attgcataaa caaggtttcc tcacaattgc agcatctgga
6541 gatcacccta ttgtgatgcc cactaatggt tactttaggt ttgaagcttg ggtcaaccct
6601 ttctatactc tcgcccccgt gggaactggg tctgggcgca ggaggattca ataatggctg
6661 gagctttcct tgcaggtttg gcaggtgacg ttgtgacttc cagcttgggc tcacttgtgg
6721 gcgctggagc caacgccatc aaccagaaag tggagtatga cttcaacaga cagctccagg
6781 aggcatcttt tagacatgat aaggatatgc tcaaagccca ggttgcagca acagcaggcc
6841 ttcaacaggc catgatagac atcaagcggg aggcattgac cgcaggcggc ttttcccccg
6901 ctgatgctgc aagaggtgca gttagagcgc ctatgacaca gattcttgac tggaatggtt
6961 ctaggtattg ggcccccaac tccatgaaga caactggcta ttcaggcaca tttgcctccc
7021 aaggcattaa aagttccccc cacctgtcta atcaaattcc aagtgctgtt aaatctacta
7081 aacctttacc atctgtatct agttcttcta gtgtacatag ttctccttct actgcccctt
7141 cacaatcaac acaatcaaca acgctgtctg taggaacagg gtcctccaga tctaacaccg
7201 tgtccacaaa gacctccaca ctgtcgagga cgagtgactg ggtcagaggt caaaatgaga
7261 tgcttggccc gttcatgagt ggtgcactcc aaactgctta tgtcacacca ccatcaagca
7321 gggcctcatc acaaggtacg gtctcgaccg tacccaaggc tgttttggac tcctggactc
7381 ccatgttcaa cacccacagg cagcctctct tcgcccactt gcgtaggcga ggggagtcac
7441 agatttagtg aaaaggatga ttagggtttc ttcctttccc cttcttattc tttt
//