Typing tool
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Typing tool
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Complete norovirus genomes
| MW305676 | GII.12 | |
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| GII.P33 |
ORF1: 1..5075
ORF2: 5056..6663
ORF3: 6663..7442
LOCUS MW305676 7488 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 11298 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305676
VERSION MW305676.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7488)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7488)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7488
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="11298"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Japan"
/collection_date="13-Dec-2012"
/note="genotype: GII.12[GII.P33]"
gene <1..5075
/gene="ORF1"
CDS <1..5075
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59364.1"
/translation="AAAISNNDIAKSSSDGVLSSMAVTFKRALGARPKQPPPRETIQK
QKPPRPPTPELIKKIPPPPPNGEDDIVVSYSAKEGVSGLPELSTVRQPDETNTAFSVP
PLNQRENRDAKEPLPGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPL
SLYWRPVYTPQYLISPETLKKLHGETFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQR
TTGFFRPYQDWNRKPLPTMDDSKLKKVANIVLCALSSLFTRPIKDIIGKLRPLNILNI
LASCDWTFAGVVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDEANELA
MVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDLEEEKARKLSTKSASPDIVG
TINSLLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARDLAKKVAATLT
GDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRI
ENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQP
DMWKDAFRPDFSHIKLMLAPQGGFDKNGNTPHGKGVMKTLTSGSLVARASGLLHERLD
EYELQGPTPTTFNFDQNKVFAFRQLAAENKYGLMDTMRVGSQLKNVKTVSELKQALKN
IAIRRCQIVYSGLTYSLESDGKGNVRVEKVQSPAVQTNNELTGALHHLRCARIRYYVK
CVQEALYSIIQIAGAAFVTTRIAKRMNIQNLWSRPQVEDEEETTSKDGCPKPKDEEEF
VISSEDIKVEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQ
DRDKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRN
PDDFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFVTSTHV
IPQGAQEFFGVSIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKR
PTGELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKR
GNDYVVIGVHTAAARGGNTVICATQGSEGEAVLEGGDNKGTYCGAPILGPGNAPKLST
KTKFWRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSV
LEAAKKTIINVLEQTIDPPQKWTFAQACASLDKTTSSGYPHHVRKNEHWNGESFTGKL
ADQASKANLMFEEGKHMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARA
FGGLMDEFKAHCVALPIRVGMNMNEDGPIIFEKHSRYTYHYDADYSRWDSTQQRAVLA
AALEIMVKFSPEPHLAQIVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHW
LLTLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRP
DKTEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPAETM
IPHSQRPIQLMSLLGEAALHGPSFYSKISKLVISELKEGGMDFYVPRQEPMFRWMRFS
DLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2600
/gene="ORF1"
/product="p22"
mat_peptide 2601..2999
/gene="ORF1"
/product="VPg"
mat_peptide 3000..3542
/gene="ORF1"
/product="Pro"
mat_peptide 3543..5072
/gene="ORF1"
/product="RdRp"
gene 5056..6663
/gene="ORF2"
CDS 5056..6663
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59365.1"
/translation="MKMASNDAAPSNDGAAGLVPEVNNETMALEPVAGASIAAPLTGQ
NNVIDPWIRLNFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVFAAVPPHFPLENISPGQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQQNEPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPILTIGELTNSRFPVPIDELYTSPNESLVVQPQNGRCALDGELQGTT
QLLPTAICSFRGRINQKVSGENHVWNMQVTNINGTPFDPTEDVPAPLGTPDFSGKLFG
VLSQRDHDNACRSHDAVIATNSAKFTPKLGAIQIGTWEQDDVHINQPTKFTPVGLFES
EGFNQWTLPNYSGALTLNMGLAPPVAPTFPGEQILFFRSHIPLKGGVADPVIDCLLPQ
EWIQHLYQESAPSQTDVALIRFTNPDTGRVLFEAKLHRSGYITVANTGSRPIVVPANG
YFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6663..7442
/gene="ORF3"
CDS 6663..7442
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59366.1"
/translation="MAGAFIAGLAGDIVTNGIGSLVNAGANAINQKVDFENNKQLQQA
SFNHDKEMLQAQIQATKQLQADMIAIRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRHWAPGAMKTTAFSGGFTSASHARTVDLTRKTSATPASMPVSRPSSTASTVSTRSTL
ISGSSNPSSLARSSSSISSQSTSPSSRTSDWVRSQNRALEPYMSGALRTAYVTPPSSR
ASSNGTVSTVPKEVLDSWTSAFNTHRQPLFAHLRRRGESQA"
ORIGIN
1 ccgctgctgc tatcagcaac aacgacatcg caaaatcttc aagtgacgga gtactaagta
61 gtatggctgt cacttttaaa cgagccctcg gggcccggcc taaacagccg cccccgaggg
121 aaacaataca aaaacaaaaa cctccacgac cgcccacccc ggagttaatc aaaaagattc
181 cacctccccc gcccaacggg gaggacgata tagtggtatc ctacagtgcc aaagaggggg
241 tctccggcct gcctgagcta tccaccgtca ggcagccgga tgagacaaac acagcattta
301 gtgtcccccc actcaaccag agggaaaaca gggatgctaa agaaccgctg cctggcacca
361 tattggaaat gtgggacgga gagatctacc attacggctt gtacgtggag cggggtttgg
421 tgcttggggt gcacaaacca ccagcggcta ttagcctcgc aaaggttgaa ctaacaccac
481 tgtctttgta ctggagacca gtgtacaccc ctcagtacct catatccccg gaaacgctca
541 aaaagctaca tggagagaca ttcccttaca cggcctttga taacaactgt tacgccttct
601 gttgttgggt cttggatcta aacgattctt ggctcagcag gaggatgatt cagagaacaa
661 ctggcttctt cagaccctac caggactgga acaggaaacc tctccccact atggatgatt
721 ccaaattgaa aaaggtggct aatatagtcc tgtgtgcttt gtcatcacta ttcaccaggc
781 ccattaagga cataatagga aaactaaggc ccttaaacat actcaacata ctggcttcct
841 gcgactggac tttcgcagga gtagtggaat ccctaattct ccttgcagaa ctcttcggag
901 ttttctggac acccccagat gtgtctgcga tgatcgcccc cttactaggt gactacgaac
961 tacagggacc tgaagatctc gctgtagagc tcgtaccagt agtaatgggg gggataggtt
1021 tggttctagg tttcaccaag gagaagattg gcaaaatgct gtcatccgcc gcgtccaccc
1081 ttagagcttg taaagacctt ggagcatatg ggttagaaat cctgaagttg gtcatgaaat
1141 ggttcttccc gaagaaagac gaggcaaatg aacttgcaat ggtgagatcc attgaggacg
1201 cagtgctgga cctcgaagca attgaaaaca atcacatgac caccctgctc aaagacaaag
1261 acagtttggc aacctacatg aagactctgg atcttgaaga ggagaaagct aggaaactct
1321 ccaccaaatc cgcttctcct gatattgtgg gcacaatcaa ttcacttctg gcacgaattg
1381 cagctgcccg ttccctggta caccgggcaa aagaagagct ttccagtagg ccaagacccg
1441 ttgttgttat gatatcagga aagccaggaa tagggaagac ccatcttgcc agagatttgg
1501 caaagaaagt tgcagccacc ctcacaggag accagagggt gggcctcatc ccacggaatg
1561 gtgtcgacca ttgggatgca tacaaaggtg agagagtcgt cctttgggat gactatggaa
1621 tgagtaaccc cattcatgac gcccttaggc tacaagaact tgctgacact tgccccctaa
1681 cattaaattg tgatagaatt gagaacaaag gaaaggtttt tgacagtgat gccataatta
1741 ttacaactaa tttggctaac ccggcaccac tggactatgt taactttgaa gcatgttcga
1801 ggcgtatcga cttccttgtg tacgctgatg cccccgacgt tgaaaaggca aaacgcgact
1861 tcccagggca acctgacatg tggaaggatg cttttagacc tgacttctca cacataaagt
1921 taatgttggc tcctcagggt ggttttgata agaacggcaa caccccacat ggaaaaggtg
1981 tcatgaaaac cctcacatct ggctccctcg ttgcccgtgc ttcaggactc ctccacgaaa
2041 gactggacga gtacgagttg caagggccaa cacccacaac cttcaatttc gaccaaaaca
2101 aggtgttcgc ctttaggcag ctcgctgctg aaaataaata cgggctgatg gacaccatga
2161 gagtgggaag ccagctcaag aatgtcaaaa ctgtgtcaga gctcaaacag gcactcaaga
2221 acattgcaat tagaaggtgc cagatagtct acagtggtct cacatactca cttgaatctg
2281 atggcaaagg taatgtaagg gtcgagaagg tgcaaagtcc agctgtgcag accaacaatg
2341 agctaactgg cgcactacac catctgaggt gcgctaggat tagatattat gttaagtgtg
2401 ttcaggaagc tttgtattcc atcatccaaa ttgctggggc cgcgtttgtc accacgcgca
2461 ttgcaaagcg catgaacata caaaacctct ggtccagacc acaggtggag gatgaggaag
2521 agaccaccag caaagacgga tgcccaaaac caaaggatga ggaggagttt gtcatctcgt
2581 ctgaagacat caaagtcgaa ggcaagaagg gaaagaacaa gtctggccgt ggcaagaaac
2641 acacagcctt ttcgagtaaa ggtcttagtg atgaggagta cgatgagtat aaaagaatta
2701 gagaagaaag aaatggtaag tactccatag aagaatacct ccaggacaga gacaagtact
2761 atgaggaggt ggccatagcc agggctactg aagaggactt ctgtgaggaa gaagaagcca
2821 agattcgtca gaggattttc agaccaacaa ggaaacaacg caaggaggag agggcttcac
2881 tcggactggt tacaggctca gaaatcagga aaaggaaccc ggatgacttc aaacccaaag
2941 gaaaactgtg ggctgatgat gacaggagtg tcgattacaa tgaaaagctc agttttgagg
3001 cccccccaag catctggtcg agaatagtca actttggatc aggttggggc ttctgggtct
3061 caccaagcct ttttgtaaca tccacccatg tcatacctca aggggcacaa gaatttttcg
3121 gtgtttccat caaacagatc caaattcaca agtcgggtga attctgccgg ctaagattcc
3181 caaaaccaat tagaactgat gtgacaggta tgatcctgga ggagggggcc cctgaaggga
3241 ctgtggccac actgctcata aagaggccaa ctggagagct gatgccactg gcagctagaa
3301 tgggtaccca tgcaactatg aggatccagg gtcgaactgt cggggggcag atggggatgc
3361 tcctgacggg atccaacgcc aagagcatgg atttgggtac cacaccaggt gactgtggat
3421 gcccatacat atacaaaaga ggaaatgact acgtagtcat cggggtccac acagctgccg
3481 cccgcggagg gaacactgtc atctgtgcaa cacaaggaag tgagggcgag gctgtgcttg
3541 aaggtggcga caacaaaggc acctattgtg gcgccccaat cctaggtcca ggaaatgccc
3601 ccaaactcag tactaaaacc aaattctgga ggtcctcaac agcaccactc ccacctggca
3661 catatgaacc agcttacctc ggaggcaaag accccagagt aaaaggtggc ccctcattac
3721 agcaagttat gagagaccaa ctgaaaccat ttacagaacc cagaggtaag ccaccaaagc
3781 ccagtgtact agaagcagcc aaaaagacaa tcattaatgt ccttgagcaa acaatagacc
3841 caccccaaaa atggacgttc gcacaggcgt gcgcatccct cgacaaaaca acctctagtg
3901 gctacccgca ccacgtgcgg aagaatgaac attggaatgg ggaatctttc acaggaaaat
3961 tggctgatca ggcttcaaaa gctaacctga tgtttgagga aggtaaacac atgacaccag
4021 tctacacagg agccctcaag gatgagttag tcaaaactga taaaatatat ggcaagatca
4081 agaagaggtt gctatggggt tcagatctgg caaccatgat ccgctgcgct cgagcgttcg
4141 gagggttaat ggatgaattc aaggctcact gtgtcgcact ccccatcagg gtagggatga
4201 acatgaatga ggatggcccc atcatttttg agaaacactc tagatacacc taccattatg
4261 atgcagacta ctctcggtgg gactcaacac agcagagagc tgttttagca gcagccctgg
4321 agatcatggt aaaattttcc ccagaaccac acctggccca gatcgttgca gaggatctcc
4381 tatctcccag cgtgatggac gtgggcgatt ttaaaatatc aatcactgaa ggactcccct
4441 ctggggtgcc ttgcacctca caatggaatt ctattgctca ttggctcctc acgctttgtg
4501 cactctctga ggtaacagat ttgtctcctg acatcatcca agcaaactca ctcttctctt
4561 tctatggtga cgatgaaatt gtgagcacag acatcaaatt agatccagaa aagctgacag
4621 ctaaactaaa agagtatggt ctcaagccaa cccgtcctga caagactgaa gggcctctgg
4681 tcatttctga ggacttagat ggtctgacct tcttacggag gactgtgacc cgtgacccag
4741 caggttggtt tggaaaattg gaacaaagct caatacttag acagatgtat tggaccaggg
4801 gccccaacca tgaggaccct gctgaaacaa tgataccaca ctcccaaaga cccatacagt
4861 tgatgtccct attaggtgaa gctgcattac atggcccatc attctacagc aaaatcagca
4921 aattggtcat ctcagagtta aaagaaggtg gcatggactt ttacgtgcca aggcaagagc
4981 caatgtttcg atggatgagg ttctcagact tgagcacgtg ggagggcgat cgcaatctgg
5041 ctcccagttt tgtgaatgaa gatggcgtcg aatgacgccg ctccatctaa tgatggtgca
5101 gccggtctcg taccagaggt caacaatgag accatggcac ttgaaccggt ggctggggct
5161 tcaatagccg ccccactcac cggtcaaaat aatgttatag acccctggat tagattaaac
5221 tttgtgcaag ctcccaatgg agagtttaca gtttcacccc gcaattcgcc tggggaagtc
5281 ctactaaact tggaattagg ccctgaacta aatccatatt tggcacacct ttccagaatg
5341 tacaatggtt atgcaggtgg agttgaggtg caagtactac tggctgggaa cgcgttcacg
5401 gctggaaaac tggtattcgc cgcagttccc cctcattttc cattagaaaa cataagccct
5461 ggccaaataa ccatgttccc tcatgtaatt attgatgtta ggactttaga accagtccta
5521 ttgcctcttc cagatgttag gaacaatttc tttcactaca atcagcaaaa cgaaccgagg
5581 atgaggcttg tggcaatgct ctataccccc cttaggtcta atggttctgg tgatgatgta
5641 tttactgtct cctgtagagt gcttactcga ccctctcctg attttgattt caattatttg
5701 gtacccccta cagttgaatc taaaactaaa cccttcacac tccccatctt gaccataggg
5761 gagttaacca attccagatt ccctgtgccc atagatgaac tctacactag ccccaatgag
5821 agtttggtgg tacaacccca gaacgggaga tgcgcgctgg atggggagtt gcagggtact
5881 actcagctcc tccccacggc gatctgctcg ttcaggggtc ggattaatca gaaagtgagt
5941 ggagagaacc atgtttggaa tatgcaagtc accaacatta atggaacccc ttttgatcca
6001 acagaggatg ttccagctcc tctaggtaca ccagactttt ctggcaagct ctttggcgtc
6061 ctaagccaga gggaccatga taatgcctgt aggagccatg atgcagtgat tgcaactaat
6121 tctgctaaat ttaccccaaa attgggcgct atacaaattg gcacatggga acaagatgat
6181 gtacacatca accaacccac caaatttact ccagttggct tgtttgaaag tgaaggtttt
6241 aatcagtgga cactccctaa ttattctgga gccttaacac tcaacatggg gttggccccc
6301 cctgtggccc ccacatttcc tggcgagcaa attcttttct tcagatccca cattcctctt
6361 aaaggaggtg tggcagaccc agttattgat tgtctcttgc cccaagagtg gatccaacac
6421 ctttatcagg agtcagcccc ttcacaaaca gatgtagcac tgatcagatt cacaaatcca
6481 gacacagggc gtgtcctatt tgaagcaaaa ttgcacagga gtggctacat cacagtggcc
6541 aacactggta gcagaccaat tgtggtgcca gctaatggtt acttcaggtt tgactcttgg
6601 gttaatcagt tttattctct cgcccccatg ggaactggga atgggcgcag aagggtgcag
6661 taatggctgg agctttcata gcaggtcttg ctggtgatat agtcaccaat ggaattggtt
6721 cactcgtgaa cgctggggcc aatgcaataa accaaaaagt agactttgaa aacaataagc
6781 aactacagca ggcatccttc aatcatgaca aagagatgct gcaagctcaa attcaagcca
6841 ccaaacagct acaggctgat atgattgcaa tcagacaagg ggtgttgacc gcgggcggct
6901 tctcccccac tgatgcagca agaggtgcag tcaacgcacc catgacacag gtcttggact
6961 ggaacgggac tagacattgg gcccccggag ccatgaaaac aactgctttc tccggtgggt
7021 tcaccagtgc ttctcatgcc aggaccgttg acctgactag gaaaacatca gccacaccgg
7081 cctctatgcc tgtctctagg cccagttcta ctgcctctac tgtttccacc cgttctacct
7141 tgattagtgg atcctctaat ccttcttctc tagctaggag ttcttccagt atttcttccc
7201 aatctacttc cccatcctct cggactagtg attgggtacg tagccaaaac agagcactgg
7261 agccttatat gagcggggcg ctgcgtacag cctacgtgac acctccatcc agtagggctt
7321 ctagcaatgg cacagtctca accgtgccaa aagaggtttt ggactcctgg acatctgcat
7381 tcaacacaca cagacaaccg ctgtttgctc atctccgtcg gagaggggag tcacaagctt
7441 agtgaaaaga tggtcttttc ttttgttcct ttgaaatctc tgtctttt
//