Typing tool
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Typing tool
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Complete norovirus genomes
| MW305662 | GII.4 US95 | |
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| GII.P4 US95 |
ORF1: 1..5069
ORF2: 5050..6669
ORF3: 6669..7475
LOCUS MW305662 7521 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 1123 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305662
VERSION MW305662.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7521)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7521)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7521
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="1123"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Japan"
/collection_date="18-Dec-1997"
/note="genotype: GII.4[GII.P4]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59322.1"
/translation="AVANSNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPREIPQR
PPRPPTPELVKKVPPPPPNGEDEIVVSYSVKDGVSGLPELSTVRQPEEANTAFSVPPL
NQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLILGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLKKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANIFLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKRIAASLTGD
QRVGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDM
WKNAFSSDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEF
ELQGPALTTFNFDRNKVLAFRQLAAENKYGLMDTMRVGRQLKDVRTMPDLKQALKNIS
IKKCQIVYSGCTYTLESDGKGNVKVDRVQSASVQTNNELAGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVEDTGEAINKDGCPKPKDDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEARIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAKEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKREN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
AAKKTIINVLEQTIDPPEKWSFTQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPIRVGMNMNEDGPIIFERHSRYKYHYDADYSRWDSTQQRAVLAAA
LEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPAFYSKISKLVVAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6669
/gene="ORF2"
CDS 5050..6669
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59323.1"
/translation="MKMASNDANPSDGSTANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFTVPILTVEEMSNSRFPIPLEKLYTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSAVNICTFRGDVTHIAGSHDYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTREDGSTRAHKATVSTGSVHFTPKLGSVQYTTDTNNDFQTGQNTKFTPVGVIQDG
NNHQNEPQQWVLPNYSGRTGHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMNLDC
LLPQEWVQHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKLGYVTVAHTGPHDLVI
PPNGYFRFDSWVNQFYTLAPMGNGAGRRRAL"
gene 6669..7475
/gene="ORF3"
CDS 6669..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59324.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKDMLQAQIEATKKLQQGMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRTNLRATVPARGSSSTIS
STPTAISVYSNQTVSTRLGSSAGSGTSVSSLPSAARTRSWVEDQNRNLSPFMRGALNT
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRV"
ORIGIN
1 ccgctgttgc caacagcaac aacgacaccg caaaatcttc aagtgacgga gtgctttcta
61 gcatggctgt cacttttaaa cgagccctcg gggcgcggcc taaacagccc cccccgaggg
121 aaataccaca aagaccccca cgaccaccta ccccagaact ggtcaaaaag gtcccccctc
181 ccccgcccaa cggggaggat gaaatagtag tttcttatag tgtcaaagat ggcgtttccg
241 gtctgcctga gctttccacc gtcaggcaac cggaagaagc caatacggcc ttcagtgtcc
301 ccccactcaa ccagagggaa aatagggatg ctaaggagcc attgactgga acaattctgg
361 aaatgtggga tggggagatc taccattacg gcctatatgt ggagcgaggc cttatacttg
421 gtgtgcacaa accaccagct gccattagcc tcgccaaggt cgagctaaca ccactctcct
481 tgttctggag acctgtgtat actccccagt acctcatctc tccagacact ctcaagaaat
541 tacacggaga atcgtttccc tacacagcct ttgacaacaa ttgctatgcc ttctgttgct
601 gggtcttgga cctaaacgac tcgtggctga gtaggagaat gatccagaga acaactggtt
661 tcttcagacc ctaccaagat tggaatagga aaccccttcc cactatggat gactccaaat
721 taaagaaggt agctaatata ttcctgtgtg ctctatcttc actattcacc aggcccataa
781 aagacataat aggtaagcta aggcctctta atatccttaa catcttggcc tcatgtgatt
841 ggactttcgc aggcatagtg gaatccttga tactcttggc agagctcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgattg cccccttact cggtgattac gagttacaag
961 gacctgagga ccttgcagtg gaactcgttc ctgtagtgat ggggggaatt ggtttggtgc
1021 taggatttac caaagagaag attggaaaaa tgttgtcatc tgctgcatcc accttaagag
1081 cttgcaaaga tcttggtgca tacgggctgg aaatcctaaa gttagtcatg aagtggtttt
1141 tcccaaagaa agaggaagca aatgaactgg ctatggtgag atccatcgag gatgcagtgc
1201 tggacctcga ggcaattgaa aacaaccata tgaccacctt gctcaaagac aaagacagcc
1261 tggcaaccta catgaggacc cttgaccttg aggaggagaa agccaggaag ctctcaacca
1321 agtccgcttc acctgacatc gtgggcacaa tcaacgccct gctggcgagg atcgctgctg
1381 cgcgttccct ggtgcatcga gcgaaggagg agctttccag cagaccaaga cctgttgtct
1441 tgatgatatc aggcagacca ggaataggga agacccacct tgctagggaa gtggccaaga
1501 gaatcgcagc ctccctcaca ggagaccagc gtgtaggcct cgtcccacgc aatggcgtcg
1561 atcactggga tgcatacaag ggggagaggg tcgtcctatg ggacgattat gggatgagca
1621 atcccatcca cgatgccctc aggttgcaag aactcgctga cacttgcccc ctcactctaa
1681 actgtgacag gattgagaac aaaggaaagg tctttgacag tgatgtcata attatcacca
1741 ctaatctggc caacccagca ccactggact atgtcaactt tgaagcatgc tcgaggcgca
1801 tcgatttcct cgtgtatgca gaagcccctg aagtcgaaaa ggcgaaacgt gacttcccag
1861 gccaacctga catgtggaag aacgctttca gttctgattt ctcacacata aaactaacac
1921 tggctccaca gggtggcttc gataagaacg ggaacacccc acacgggaag ggcgtcatga
1981 agactctcac cactggctcc cttattgccc gggcatcagg gctactccat gagaggctag
2041 atgagtttga actacagggc ccagctctca ccaccttcaa ctttgatcgc aacaaagtgc
2101 ttgcctttag gcagcttgct gctgaaaaca aatacgggtt gatggacaca atgagggttg
2161 gaaggcagct caaggatgtc agaaccatgc cagatcttaa acaagcactc aagaatatct
2221 caatcaagaa gtgccagata gtgtacagtg gttgcaccta cacacttgag tctgatggca
2281 agggcaatgt gaaagttgac agagttcaga gcgcctccgt gcagaccaat aacgagctgg
2341 ccggcgccct acaccatcta aggtgcgcca gaatcaggta ttatgtcaag tgtgtccagg
2401 aggccctgta ttccatcatc caaatcgctg gggctgcatt tgtcaccacg cgcatcgtca
2461 agcgcatgaa catacaagac ctctggtcca agccacaagt ggaagacaca ggggaggcta
2521 tcaacaagga cgggtgccca aaacccaaag atgatgagga gttcgtcatt tcatccgacg
2581 acatcaaaac tgagggcaag aaagggaaga acaagactgg ccgcggcaag aagcacacag
2641 ccttctcaag caagggtctc agtgatgaag agtacgacga gtacaagagg attagagaag
2701 aaagaaatgg caagtactcc atagaagagt accttcagga cagggacaaa tactatgagg
2761 aggtggccat tgccagggcg accgaggaag acttctgtga agaggaggag gctaggattc
2821 ggcaaaggat tttcaggcca acaaggaaac aacgcaagga ggaaagggcc tctctcggtt
2881 tagtcacagg ttctgaaatc aggaaaagga acccagatga tttcaagccc aaggggaagc
2941 tgtgggctga tgatgacagg agtgtggact acaatgagaa actcagtttt gaggccccac
3001 caagcatctg gtcgaggata gtcaactttg gttcaggttg gggtttttgg gtctctccca
3061 gtctgttcat aacatcaacc catgtcatac cccagggcgc aaaggagttc tttggagtcc
3121 ccatcaaaca aattcagata cacaaatcag gcgaattctg tcgcttgagg ttcccaaaac
3181 caatcaggac tgatgtgacg ggtatgatct tagaagaagg tgcgcccgaa ggcaccgtgg
3241 tcacactact catcaagagg cctactggag aacttatgcc cttagcagcc aggatgggga
3301 cccatgcaac catgaaaatc caagggcgta ctgttggagg tcagatgggc atgcttctga
3361 caggatccaa cgccaaaagc atggacctgg gtaccacacc aggtgactgc ggctgcccct
3421 acatctacaa gagggaaaat gactatgtgg ttattggagt ccacacggct gccgctcgtg
3481 ggggaaacac tgtcatatgt gccacccagg ggagtgaggg ggaggctaca cttgaaggtg
3541 gtgacagcaa gggaacatac tgtggtgcac caatcctagg cccagggagt gccccaaaac
3601 tcagcaccaa gaccaaattc tggagatcgt ccacaacacc actcccacct ggcacctatg
3661 aaccagccta tctcggtggt aaggacccca gagtcaaggg tggcccttca ttgcaacaag
3721 ttatgaggga tcagttgaaa ccatttacag agcccagggg aaaaccacca aagccaagtg
3781 tgttggaagc tgccaagaaa accatcatca atgtccttga acaaacaatc gatccacccg
3841 agaaatggtc attcacgcaa gcttgcgcgt ctcttgacaa gaccacttcc agtggccatc
3901 cgcaccacat gcggaaaaac gactgctgga acggggagtc cttcacaggt aagctggcag
3961 accaggcttc caaggccaac ctgatgttcg aagaggggaa aaacatgacc ccagtctaca
4021 caggtgcgct taaggatgag ttagttaaaa ctgacaaaat ttatggtaag atcaagaaga
4081 ggcttctctg gggctcggac ttagcgacca tgatccggtg cgctcgagca ttcggaggct
4141 taatggatga actcaaagca cactgtgtta cacttcctat cagagttggt atgaatatga
4201 atgaggacgg ccccatcatc ttcgagaggc attccaggta caaatatcac tatgatgctg
4261 attactctcg gtgggactca acacaacaaa gagccgtgtt ggcagcagcc ctagaaatca
4321 tggttaaatt ctcctcagaa ccacatttgg ctcaggtggt cgcagaagac cttctttctc
4381 ctagcgtggt ggatgtgggt gacttcaaaa tatcaatcaa tgagggtctc ccctctgggg
4441 tgccctgcac ctcccaatgg aactccatcg cccactggct tctcactctc tgtgcgctct
4501 ctgaagttac aaacttgtcc cctgacatca tacaggctaa ttccctcttc tccttttatg
4561 gtgatgatga aattgttagt acagatataa agttggaccc agagaaattg acagcaaaac
4621 tcaaggaata cgggttgaaa ccaacccgcc ctgacaaaac tgaagggccc cttgttattt
4681 ctgaagactt aaatggtctg accttcctgc ggagaactgt gacccgcgac ccagctggtt
4741 ggtttggaaa attggagcag agttcaatac tcaggcaaat gtactggact aggggcccca
4801 accatgaaga cccatctgaa acaatgattc cacattctca aagacccata caattgatgt
4861 ccctactggg agaggccgca ctccacggcc cagcattcta cagcaaaatt agcaagttag
4921 ttgttgcaga gctaaaagaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccaacccat ctgatgggtc cacagccaac
5101 ctcgtcccag aggtcaacaa tgaggttatg gctttggagc ccgttgttgg tgccgctatt
5161 gcggcacctg tggcgggcca acaaaatgta attgacccct ggattagaaa taattttgta
5221 caagcccctg gtggagagtt tacagtatcc cctagaaacg ctccgggtga gatactatgg
5281 agcgcgccct tgggccctga tttgaacccc tatctttctc atttggccag aatgtacaat
5341 ggttatgcag gtggttttga agtgcaggta atcctcgcgg ggaacgcgtt caccgccggg
5401 aaaatcatat ttgcagcagt cccaccaaat tttccaactg aaggcttgag ccccagccag
5461 gttactatgt tcccccatat aatagtagat gttaggcaat tggaaccagt gttgatcccc
5521 ttacctgatg ttaggaataa cttctatcat tacaatcaat caaatgattc taccattaaa
5581 ttgatagcaa tgctgtatac accacttagg gctaataatg ctggggatga cgtcttcaca
5641 gtctcttgtc gagtcctcac gaggccatcc cccgattttg atttcatatt cttggtgcca
5701 cccacagttg aatcaagaac taaaccattc accgtcccaa tcttaactgt tgaggaaatg
5761 tccaattcaa gattccccat tcctttggaa aagttgtaca cgggtcccag cagtgctttt
5821 gttgtccaac cacaaaatgg caggtgcacg actgatggcg tgctcttagg cactacccag
5881 ctgtctgctg tcaacatctg caccttcaga ggggatgtca cccacattgc aggcagtcat
5941 gactatacaa tgaatttggc ttctcaaaat tggaacaatt atgacccaac agaagaaatc
6001 ccagcccctc tgggaactcc agatttcgtg ggaaagatcc aaggcatgct cacccaaacc
6061 acaagagagg atggttcgac ccgcgcccac aaagctacag tgagcactgg gagtgtccac
6121 tttactccaa agctgggcag tgttcaatac accactgaca caaataatga ttttcaaact
6181 ggccaaaaca cgaaattcac cccagtcggc gtcatccagg acggtaataa ccatcaaaat
6241 gaaccccaac aatgggtgct cccaaattac tcaggtagaa ctggtcataa tgtgcatcta
6301 gctcctgccg ttgcccccac tttcccgggt gagcaacttc ttttctttag gtccactatg
6361 cccggatgta gcgggtatcc caacatgaac ctggattgcc tactccccca ggaatgggtg
6421 cagcatttct accaagaagc agctccagca caatctgatg tggctctgct gagatttgtg
6481 aatccagaca caggtagggt tctgtttgag tgcaagctcc ataaattagg ctatgtcaca
6541 gtggctcaca ctggcccgca tgatttggtt atccccccaa atggttactt cagatttgat
6601 tcctgggtca accagttcta cacacttgcc cccatgggaa atggagcggg gcgcagacgt
6661 gcgttataat ggctggagct ttctttgctg gattggcatc tgatgtcctt ggctctggac
6721 ttggttccct aatcaatgct ggggctgggg ccatcaacca aaaagttgaa tttgaaaaca
6781 acagaaaatt gcaacaagct tccttccaat ttagtagcaa tctgcaacag gcttccttcc
6841 aacatgataa ggacatgctc caagcacaaa ttgaggccac taagaaactg caacagggta
6901 tgatgaaggt taaacaggcg atgctcctag agggtggatt ctctgaaaca gatgcagccc
6961 gtggggcaat caacgccccc atgacaaagg ctctggactg gagcggaaca aggtactggg
7021 ctcctgatgc caggaccaca acatacaatg caggccgctt ttccacccct caaccttcgg
7081 gggcattgcc aggaagaact aatcttaggg ctactgtccc cgctcggggc tcctctagta
7141 caatttctag tactcccact gctatttctg tgtattcaaa tcaaactgtt tcaacgagac
7201 ttggttcttc agctggttct ggtaccagtg tctcgagtct cccgtcagct gcaaggacta
7261 ggagctgggt tgaggatcaa aacagaaatt tgtcaccttt tatgaggggg gctcttaaca
7321 catcattcgt caccccacca tctagtagat cctctagcca aggcacagtc tcaaccgtgc
7381 ctaaagaaat tttggactcc tggactggcg ctttcaacac gcgcaggcag cctctcttcg
7441 ctcacatccg taagcgaggg gagtcacggg tgtaatgtga aaagacaaaa ttgattatct
7501 ttcctttctt tagtgtcttt t
//