Typing tool
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Typing tool
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Complete norovirus genomes
| MW305659 | GII.17 | |
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| GII.P31 |
ORF1: 1..5069
ORF2: 5050..6672
ORF3: 6672..7451
LOCUS MW305659 7507 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 1047SR nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305659
VERSION MW305659.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7507)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7507)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7507
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="1047SR"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Paraguay"
/collection_date="08-Feb-2005"
/note="genotype: GII.17[GII.P31]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59313.1"
/translation="AAANSNNDIAKSSSDGVFSNMAVTFKRALGARPKQPPPKEIPPR
PPRPPTPELVKNIPPPPPNGEDELVVSYSAKGGVSGLPELTTVRQPEENNTAFSVPPL
NQRESRDAKEPLTGTIIEMWDGEIYHYGLYVEKGLILGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLRRLHGESFPYTAFDNNCYAFCCWVLELNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANIFLCTLSSLFTRPIKDIIGKLKPLNILNILA
TCDWTFAGIVESLLLMAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NSLLARIAAARSLVHRAKEELSSRSRPVVVMISGKPGIGKTHLARELAKKIAASLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQPDM
WKNAFSPDFSHIKLSLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEY
ELQGPPLTTFNFDRNKVLAFRQLAAENKYGLMDTMRVGKQLKDVKTMPDLKQALKNVS
IKKCQIVYNGSTYTLEADGKGNVKVDKVQSATVQTNNELTGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTARITKRMNIQNLWSKPQVEDTEETANKEGCPKPKDDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPE
DFKPKGKLWADDDRSVDYNEKLNFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAKEFFGIPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPSVLE
AAKKTIINVLEQTIDPPQKWSFAQACASLDKTTSSGHPHHMRKNDCWNGDSFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYKFHYDADYSRWDSTQQRDVLAAA
LEIMVKFSPEPHLAQVVAEDLLSPSVMDVGDFQISISEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISENLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPAFYSKVSKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6672
/gene="ORF2"
CDS 5050..6672
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59314.1"
/translation="MKMASNDAAPSNDGATGLVPEINNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
VRNTFFHYNNQPANRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTISELTNSRFPVPVDSLFTAQNNNLNVQCQNGRCTLDGELQGTT
QLQPSGICAFRGKITADVHHSHDDRWHMQLTNLNGTPFDPTEDVPAPLGTPDFTGLLY
GVASQRNVQPNPNTTRAHEAVISTTSSQFVPKLGSINFGSTSEDFVVGQPTKFTPVGI
KIETGHDFDQWTLPRYSGHLTLNMNLAPPVAPNFPGEQLLFFRSNVPCAGGVSDGIID
CLLPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRTGYITVAHSGDYPLV
VPSNGYFRFDSWVNQFYSLAPMGTGNGRRRMQ"
gene 6672..7451
/gene="ORF3"
CDS 6672..7451
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59315.1"
/translation="MAGAFIAGLAGDMLTNTVGSLVNAGANAITQKVDFENNKQLQSA
SFQHDKDMLQAQVAATKQLQAEMIAIKQGILTAGGFSPTDAARGAVGAPMTKVLDWSG
TRYWAPNSTRTTGYSGQFTSTPVHMPTKTTQPAPAKRTQPPSSSSGSIYSLSTQSTVL
TKPSSGSSSVSSASTQSTQLSSISSMDRTENWVNQQRSLSPYMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTHRQPLFAHLRVRGESRV"
ORIGIN
1 ccgctgctgc caacagcaac aacgacatcg caaaatcttc aagtgacgga gtgttttcta
61 acatggctgt cactttcaaa cgggccctcg gggcgcggcc caaacagccg cccccgaagg
121 aaataccacc cagaccccca cgaccaccca caccagaact ggtcaaaaat atccctcctc
181 ccccgcccaa cggggaggat gaactagtgg tttcctacag cgccaaaggt ggcgtttccg
241 gcctgcctga actcaccact gtcagacaac cggaagaaaa caacacggcg ttcagtgttc
301 ccccactcaa ccagagggag agtagggacg ccaaggaacc actaactgga acaattattg
361 aaatgtggga tggagaaata taccattacg gtctgtacgt ggaaaaaggt ctcatacttg
421 gtgtgcataa gccacctgca gccatcagcc ttgccaaggt tgagctgaca ccactttctc
481 tgttctggag acctgtgtac accccccagt atctcatttc tccagacact cttaggagac
541 tgcatggaga atcattcccc tacacagcat ttgacaataa ttgctacgcc ttctgttgtt
601 gggtgttgga actaaacgat tcatggctaa gtaggaggat gatccagaga acaacaggtt
661 tcttcagacc atatcaagac tggaacagga aacccctccc cactatggat gactccaaat
721 taaagaaggt agccaacata ttcttgtgta ctctgtcttc gctattcacc agacccatca
781 aggacataat agggaagcta aaacctctta acatcctcaa tattttggcc acatgtgatt
841 ggaccttcgc aggcatagtg gaatccctat tactcatggc agaactcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgattg cccccttact aggtgattac gagctgcaag
961 gacctgagga ccttgcagta gaactcgtcc cagtagtgat gggggggata ggtttggtgc
1021 taggattcac caaagagaaa attgggaaga tgttgtcatc cgctgcatcc actttgagag
1081 cttgtaaaga ccttggtgca tacggactgg aaattttaaa attggtcatg aaatggttct
1141 tcccaaagaa agaggaagca aatgagttgg ccatggtgag agccatcgag gatgcggtgc
1201 tggacctcga ggcaattgaa aacaaccaca tgaccaccct gcttaaagat aaagacagct
1261 tggcaaccta catgagaacc cttgaccttg aggaggagaa agccagaaaa ctctcaacca
1321 aatctgcttc acccgatatt gtgggcacaa tcaattctct tctggcaagg atcgctgctg
1381 cacgctccct agtgcatcgg gcgaaagaag agctctccag caggtcaaga cctgttgttg
1441 tgatgatatc gggaaaacca ggaataggga aaactcacct tgccagggaa ctggctaaga
1501 agatcgcggc ttccctcaca ggggaccaac gtgtgggcct cataccgcgc aatggtgttg
1561 accattggga cgcatacaag ggagaaaggg tggtcctatg ggatgactac ggaatgagca
1621 accccatcca tgacgccctc aggttgcagg agcttgctga cacttgtccc ctcacgctga
1681 actgtgacag gattgagaac aaaggaaaag tttttgacag tgatgctata attatcacca
1741 ccaatctggc caacccagca ccactggatt atgtcaactt tgaagcgtgt tcgaggcgca
1801 ttgacttcct cgtgtacgca gatgctcctg atgtagagaa ggcaaaacgc gacttcccag
1861 gccagcccga catgtggaag aacgctttca gtcccgactt ctcacacata aaactgtcac
1921 tggccccaca gggtggcttc gataagaacg gaaacacccc acatgggaaa ggcgtcatga
1981 aaaccctcac cactggctcc cttatcgccc gagcatcagg gttgctccat gaaaggctag
2041 atgaatatga gttgcagggc ccgcctctca ccactttcaa ctttgaccgc aataaggtcc
2101 ttgctttcag acagcttgct gctgaaaaca agtatgggtt gatggacaca atgagagttg
2161 gaaaacagct caaggatgtc aagaccatgc cagacctcaa gcaagctctc aaaaatgtct
2221 cgatcaagaa gtgtcaaata gtgtacaatg gtagcaccta cacacttgag gccgatggca
2281 agggtaatgt gaaggttgac aaagtacaaa gtgccaccgt gcaaaccaac aatgaactaa
2341 ctggtgccct acaccatcta aggtgcgcca gaattaggta ctatgtcaag tgtgtccagg
2401 aggcactgta ttccatcatc caaattgctg gggctgcgtt cgtcaccgcg cgcatcacta
2461 agcgtatgaa catacagaat ctctggtcca agccacaggt agaagacaca gaagagacgg
2521 ccaacaaaga aggttgccca aaacccaaag atgatgaaga gtttgtcatt tcatccgacg
2581 atataaaaac tgagggtaag aaagggaaga acaagactgg ccgtggtaag aagcacacag
2641 ccttttcaag taaagggctc agtgatgagg agtacgatga gtacaaaagg atcagagaag
2701 aaaggaatgg taagtattcc atagaagagt accttcagga cagagataag tactatgagg
2761 aggtggccat tgccagggca accgaagagg acttctgtga agaagaagaa gccaaaatcc
2821 ggcagaggat tttcaggcca acaaggaaac aacgcaaaga agagagggcc tctcttggtt
2881 tagtcacagg atctgaaatc agaaaaagaa acccagaaga cttcaaaccc aagggaaaac
2941 tgtgggctga tgatgacaga agtgttgact acaatgagaa actcaacttt gaagctccac
3001 caagcatctg gtcgcggata gtcaattttg gctcaggttg gggcttttgg gtttccccca
3061 gcctgttcat aacatcaacc catgtcatac cccaaggtgc aaaagagttc ttcggaatcc
3121 ccatcaaaca aattcagata cacaaatcag gcgaattctg ccgattgagg ttcccaaaac
3181 caatcaggac tgatgtgacg ggcatgatcc tagaagaggg tgcacccgaa gggaccgtgg
3241 tcacactact aatcaagagg ccaactggag aactcatgcc tctggcagct agaatgggga
3301 cccatgcaac catgaagatt caagggcgca cagttggggg gcaaatgggc atgcttctga
3361 cagggtccaa cgccaaaagt atggacctag gcacaacacc gggtgactgc ggctgtccct
3421 acatctacaa aaggggaaat gactacgtgg tcattggagt ccatacggcc gctgcccgtg
3481 gaggaaacac tgtcatatgt gccacccagg ggagtgaggg agaagctaca cttgaaggtg
3541 gtgacaacaa gggaacctac tgtggtgcgc caatcttggg tccaggaagt gccccaaaac
3601 tcagcaccaa gaccaagttt tggagatcat ccacaacacc actcccacct ggcacctatg
3661 aaccagccta cctcggtggt aaggacccta gagtcaaagg tggcccttca ttgcaacaag
3721 ttatgaggga ccaactaaaa ccatttacag aacccagggg caagccgcca agaccaagtg
3781 tgttggaagc tgccaagaag accattatca atgttcttga gcaaacaatt gacccacccc
3841 agaaatggtc attcgcacaa gcttgcgcgt cccttgacaa gaccacctcc agtggccacc
3901 cgcaccacat gcggaaaaac gactgctgga acggggactc ctttacaggc aaattggcag
3961 atcaggcttc caaggccaac ctgatgtttg aagaggggaa gaacatgacc cctgtctaca
4021 caggtgcact taaggatgaa ttggtcaaaa ctgataaaat ttatggcaag atcaagaaga
4081 ggctcctgtg gggctcagac ctggcgacca tgatccggtg cgctcgagcc tttggaggcc
4141 ttatggatga acttaaggca cactgtgtta cgcttcctgt tagagttggt atgaacatga
4201 atgaggatgg ccctatcatc tttgagaagc actccagata taaatttcac tatgatgctg
4261 attattcccg gtgggactca acacaacaaa gagatgtgct agcggcagcc ctagaaatca
4321 tggtcaaatt ctctccagaa ccacacctgg cccaggtagt tgcagaagac ctcctctccc
4381 ccagtgtaat ggatgtgggt gatttccaaa tctcaataag tgagggactc ccctccgggg
4441 tgccttgcac ctcccaatgg aattccattg cccattggct cctcactctt tgtgcgctct
4501 ctgaagtcac ggacctgtcc cctgacatca ttcaggccaa ttcccttttc tccttttatg
4561 gtgatgatga gattgtgagc acagacataa agttggaccc agagaaactg acagcaaaac
4621 tcaaagagta cgggctgaaa ccaacccgcc ccgacaaaac tgaaggaccc cttgttatct
4681 ctgaaaatct ggatggcctg acattcctac ggagaactgt gacccgtgac ccagctggct
4741 ggtttggaaa attggagcag agctcaattc tcaggcaaat gtactggacc aggggcccca
4801 accatgaaga tccatctgaa acaatgatac cacactccca aagacccata caactgatgt
4861 ccttgctggg cgaggctgca ctccacggcc cggcgtttta tagcaaagtt agcaagttag
4921 tcattgcaga gctgaaggaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccgctccat ctaatgatgg tgctacgggc
5101 ctcgtcccag agatcaacaa cgagaccctt cctctggaac cagtggcggg tgcagctatt
5161 gccgcgcctg ttactggcca aaataatata attgatccct ggattagaac aaattttgta
5221 caagcaccca atggggagtt tacagtctca cccagaaact ctcctggaga aattctctta
5281 aatctggaat tgggtcctga tttgaatccg tatttggcac acctatctag aatgtataat
5341 gggtatgctg gtggcgtaga agtccaagtc ctcctagcag ggaatgcgtt cactgcagga
5401 aagattctct tcgctgccgt accaccaaat ttcccagttg aattcttgag tcctgcacaa
5461 attaccatgt tgccacattt aatagttgat gttagaaccc ttgaacctat catgatacca
5521 ctcccagatg tcaggaacac cttcttccat tacaacaatc aacctgccaa tcgcatgcga
5581 ttggtggcca tgctgtatac ccccttgaga tctaatggtt ctggtgatga tgtcttcaca
5641 gtgtcatgta gagtgctaac taggcccacc ccagattttg agtttacata tttggtcccc
5701 ccttcggtag agtccaagac caaacccttt tctctgccca tattgaccat ctctgaattg
5761 accaactcaa gattccctgt accggtggat tcattgttca cagcccaaaa caacaatctc
5821 aatgtccagt gtcaaaatgg tcgttgcaca ctggatggtg agttgcaggg aaccactcag
5881 ttacaaccat caggcatctg cgcctttaga ggcaaaataa cggcagatgt gcaccatagc
5941 cacgatgaca gatggcacat gcaactgaca aatctcaatg gaaccccctt cgatccaaca
6001 gaggatgtgc cagctccact gggcactcca gacttcacag gccttctcta cggagttgcg
6061 agccaaagga atgttcaacc caacccaaac accaccagag cacatgaagc tgtgatctcc
6121 acaaccagtt cgcagtttgt gccaaaatta gggtcaatca actttggtag cacaagtgaa
6181 gacttcgtcg tgggccaacc taccaaattc acaccagttg gtattaagat tgagactgga
6241 catgatttcg atcaatggac cctacctaga tattcaggcc atttgacact caatatgaac
6301 cttgccccac ccgttgctcc aaatttccct ggtgaacagt tacttttctt cagatcaaac
6361 gtcccctgtg ccggtggcgt cagtgatggt atcatcgact gcctgttgcc tcaggagtgg
6421 atacagcact tctaccagga gtctgctccc tcccaatctg atgtggccct gatcagatat
6481 gtcaaccctg acacgggtcg tacactcttt gaggcgaaac tccacagaac gggctacatc
6541 actgttgctc attcaggtga ctatcccctt gttgtcccct ccaatggata ttttagattt
6601 gactcttggg tgaaccagtt ttactcactc gcccccatgg gaactgggaa tgggcgcagg
6661 cggatgcagt aatggcagga gctttcatag caggtctagc aggtgacatg ctcaccaaca
6721 cagttggttc actggtgaat gccggggcca atgctatcac ccaaaaggtg gactttgaaa
6781 ataacaaaca gctccaatct gcctccttcc aacatgacaa agacatgctc caagcacaag
6841 tggctgccac caagcagtta caggctgaaa tgatcgccat caagcagggg atattgaccg
6901 caggcggctt ttcccctact gacgcggcga gaggagcagt gggtgcaccc atgaccaaag
6961 tccttgattg gtccggtact cgttactggg ctccaaattc cacgcggaca actggctatt
7021 cagggcagtt cacatcaaca cccgtgcata tgcccacaaa gacaactcag cctgctcctg
7081 caaaaaggac tcaaccccct tcttcctctt caggtagcat ttatagtctt tcaacacaga
7141 gtactgtttt gaccaagcct tcttcaggct cctcttctgt ttcttctgct tctacacaat
7201 ctacacaatt gagttcaatt tcttcaatgg atagaacaga aaattgggta aatcagcaaa
7261 gaagtctcag cccctacatg agtggtgcac ttaacatatc tcatgtaaca cctccatcga
7321 gcagggcttc gagttcagga acagtctcaa ctgtacccaa agaagttttg gactcctgga
7381 catctgcatt caacacacac agacagccgc tcttcgcaca cctcagagtg aggggggagt
7441 cacgtgttta gtgaaaagaa ccaattaatt ttaattagtt gtgattgagt tctaaattgg
7501 atctttt
//