Typing tool
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Typing tool
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Complete norovirus genomes
| MW305657 | GII.2 | |
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| GII.P34 |
ORF1: 1..5069
ORF2: 5050..6678
ORF3: 6678..7457
LOCUS MW305657 7500 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 953 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305657
VERSION MW305657.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7500)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7500)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7500
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="953"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Japan"
/collection_date="13-Feb-1997"
/note="genotype: GII.2[GII.P34]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59307.1"
/translation="AAANSNNDDVKSSSDGVLSSMAVTFKRALGARPKQPPPREKPPR
PPRPPTPELIRSVPPPPPNGEDELVIHYSAKGGVSGLPELSTVSQPEETNTAFSVPPL
NQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPLSL
YWRPVYTPQYLIPPDTLKKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLCRRMIQRTT
GFFRPYQEWNRKPLPTVDDSKIKKVANIFLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RAIEDAVLDLEAIENNHMTALLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRLRPVVVMISGKPGIGKTHLARELAKKIAMTLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPGVEKAKRDFPGQPDM
WKNAFSPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMDEY
ELQGPTPTTFNFDRNRVLAFRQLAAENKYGLVDTMRVGGQLKGVKTVSELKQALKNIA
IKSCQIVYGGNTYSLESDGKGVVKIDKVQNTNIQTNNELSGALHHLKCARIRYYVKCV
QESIYTILQIAGAAFVTTRIARRINIQNLWSKPQIEDTEDTTTKDGCPKPKDDEEFII
SSEDIKAEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQHR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGRLWADDDRSVDYNEKLSFEAPPSVWSRIVNFGSGWGFWVSPSLFITSTHVIP
HGAQEFFGVPVKQIQIHKTGEFCRMRFPKPIRTDVTGMILEEGAPEGTVATLLIKRPT
GELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKT
KFWRSSNTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPDVLE
AAKKTIINVLEQTIDPPQKWSYAQACASLDKTTSSGHPHHMRKNDCWNGETFTGKLAD
QASKANLMYEEGKNMTPVYTGALKDELVKTEKIYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVALPIRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVLAAA
LEIMVKFSAEPNLAQIVAEDLLSPSVMDVGDFKITINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKVDPGKLTAKLREYGLKPTRPDK
TEGPLLISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPHETMIP
HSQRPIQLMSLLGEAALHGPSFYSKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6678
/gene="ORF2"
CDS 5050..6678
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59308.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEAMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
VISQRDKQNAAGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6678..7457
/gene="ORF3"
CDS 6678..7457
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59309.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQRLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLIAGCFSPADAARGAVNAPMTQALDWNG
TRYWAPGSMRTTSYSGRFTSTAPVRQADFQHTQSRPSSGSSVSSFATQSSRPTLTTTT
GSSHGTTSSNSTRSTNLSQSTVSRATSRTGEWVRDQNKNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGESQA"
ORIGIN
1 ccgctgctgc caacagcaac aacgacgacg taaaatcttc aagtgacgga gtgctttcaa
61 gcatggctgt cactttcaaa cgagccctcg gggcccggcc caaacagccg cccccgaggg
121 aaaaaccacc gagacccccc cgaccaccca ctcctgaact aataaggagc gtgcctcctc
181 ccccacccaa cggggaggat gaactggtca tccattacag tgccaaggga ggtgtctcgg
241 gtcttcccga actctcgacg gtcagccaac cagaggaaac caacacggca tttagcgttc
301 cccctcttaa ccaaagggag aacagggatg ctaaagagcc cctgaccggc accattctag
361 aaatgtggga cggggagatt tatcattatg gtttatatgt agagcgtggg ttagtacttg
421 gcgtgcacaa accaccagca gccattagcc tcgccaaagt ggagctgaca cctctgtctc
481 tatactggag accagtgtac accccccagt atcttattcc cccagacacc ctaaagaaat
541 tacacgggga gtcgttccct tacactgcct ttgacaacaa ttgttatgct ttctgttgct
601 gggttttgga cctaaacgac tcctggttgt gtaggagaat gatacaaagg acaactggct
661 tcttcagacc ctaccaagaa tggaacagga agcctctccc cactgtggat gactccaaaa
721 taaagaaggt ggccaacata tttctgtgtg ctttgtcctc actattcaca agacctatca
781 aagacataat tgggaagtta aggccactca acatcttaaa cattctggct tcctgtgact
841 ggacctttgc aggtatagtg gaatcattaa tccttctggc tgaactcttc ggagtgttct
901 ggacaccccc agatgtgtct gcgatgatcg cccccctact tggtgactac gagcttcaag
961 gacctgaaga cctcgcggtg gagctagtac cagtagtgat gggagggata ggtttggtgc
1021 tcggatttac caaggagaag attgggaaga tgctctcttc tgcagcttca acactcagag
1081 cttgcaaaga tcttggtgca tatgggctgg agatcctaaa acttgtgatg aaatggttct
1141 tcccgaagaa ggaagaggcg aatgaactag caatggtgag agccatcgag gatgcagtac
1201 tagatttaga ggcaattgag aacaaccaca tgacagccct actcaaggat aaagacagtc
1261 ttgcaacata catgagaacc ctcgacctgg aggaagaaaa ggctagaaaa ctctccacca
1321 agtctgcctc acctgacatc gtgggtacga taaatgctct gttagcaagg atcgcagcag
1381 cccggtccct cgtgcacaga gccaaagaag agctgtccag taggctgaga cctgtcgtgg
1441 tgatgatctc tgggaagcca ggcattggga agacccacct tgctagggaa ctggcgaaga
1501 aaatcgctat gaccctcaca ggggaccaga gggtgggctt aatcccacgg aacggtgtgg
1561 accactggga cgcgtataaa ggtgaaagag ttgtcctgtg ggacgactat ggaatgagca
1621 accccatcca cgatgctctc aggctccaag agttggctga cacttgcccc ttgacactga
1681 actgtgacag gattgagaac aaaggaaagg tctttgatag tgatgccata atcatcacca
1741 ccaacttggc caatccggca ccattggact atgtcaactt tgaggcctgc tccaggcgca
1801 ttgactttct tgtgtacgcc gatgcccccg gggtcgagaa ggctaagcgt gacttcccag
1861 gacaaccaga catgtggaag aatgctttca gcccggactt ctcacacatc aagctacaac
1921 tcgcccccca gggtggcttt gacaagaatg gcaacacccc acacgggaaa ggggtcatga
1981 aaactctcac aactggttcc cttattgccc gtgcctcggg tcttctccat gaaaggatgg
2041 atgagtacga acttcaaggc cccaccccca caaccttcaa cttcgatcgc aacagagtgc
2101 tggctttcag acaactcgcc gctgagaata aatacggcct ggtcgacaca atgagggtag
2161 ggggacaact caaaggtgtc aaaactgtgt cagagcttaa acaagcactt aagaacattg
2221 caatcaaaag ctgccagata gtgtatggcg gcaacacata ctcacttgaa tctgatggga
2281 agggtgtcgt gaaaatcgac aaagtccaga acaccaatat ccaaactaac aatgaacttt
2341 ctggcgccct gcaccaccta aaatgtgcca gaatcagata ctatgtcaaa tgtgtccaag
2401 agtccatcta caccatcctc cagattgccg gggccgcttt tgtcacgaca cgcatagcaa
2461 gacgcatcaa catccagaac ctctggtcga aaccacaaat agaagacaca gaggacacca
2521 ctactaagga tggatgcccg aaacccaaag acgatgagga gttcatcatc tcatctgaag
2581 acatcaaggc agagggcaag aaggggaaga acaagaccgg tcgtggcaag aagcacacag
2641 cattctcgag taaaggtctt agtgatgaag agtacgatga gtacaagagg atcagagaag
2701 agcggaatgg aaaatactcc atagaagagt accttcaaca tagagacaag tactatgagg
2761 aggtggccat agctagagca actgaggagg acttctgtga ggaggaagaa gcaaagatcc
2821 ggcagaggat attcaggcca accaggaaac aacgtaaaga ggaaagggca tcccttggtt
2881 tggtaacagg ctcagaaatt aggaagagga atccagatga cttcaaaccc aaaggcagat
2941 tatgggctga tgatgacaga agtgttgact acaacgagaa gctcagcttc gaggccccac
3001 cgagtgtttg gtcgcgaata gtcaactttg gttcaggttg gggcttctgg gtctctccaa
3061 gcctattcat aacatcaact catgtcatac cccatggtgc tcaggaattc tttggagtgc
3121 ccgtcaaaca aatccaaata cacaagacag gtgagttctg tcgtatgaga tttccaaaac
3181 caatcaggac tgacgtgacg ggaatgatcc tagaggaggg agcccctgaa ggaacagttg
3241 ccacactgct catcaaaaga ccaactggcg aactcatgcc ccttgccgcc agaatgggca
3301 cacatgccac catgaagatc caaggccgca tggttggtgg ccaaatgggc atgctgctga
3361 caggttccaa cgctaagagc atggacctag gcacaacacc cggtgattgt ggctgcccct
3421 acatctataa gagaggaaat gactatgtgg tcattggagt ccacacagca gcagctcgcg
3481 ggggaaacac tgtcatttgt gcaacccagg ggagtgaggg cgaagccacg cttgaaggtg
3541 gagacaacaa gggaacctat tgcggtgccc caatccttgg tccaggaagt gcccctaagc
3601 tcagcaccaa gaccaaattt tggagatcct caaacacacc cctcccgccc ggcacctacg
3661 aaccagctta tttgggtggc aaagacccaa gagtcaaagg gggtccctca ctccaacaag
3721 ttatgaggga tcaattaaag ccattcactg aacctagggg caagccacct aaaccagatg
3781 tcttggaggc cgccaagaaa accatcatca atgtgctaga gcagacaata gacccacccc
3841 aaaaatggtc gtacgcgcag gcgtgcgcat cccttgacaa gaccacttcg agtggccacc
3901 cccatcatat gaggaaaaat gattgctgga atggagagac cttcacgggc aagctggcag
3961 accaagcatc aaaggccaac ttaatgtatg aagaggggaa gaacatgacc ccagtctaca
4021 caggggcact caaagatgag ttggttaaga ctgaaaagat ctatggcaaa atcaagaaaa
4081 gactcttatg ggggtcagac ctagcaacca tgatcagatg tgcccgggcc tttgggggat
4141 tgatggacga acttaaggca cactgtgttg cgctccccat cagggttggt atgaacatga
4201 atgaggatgg ccccataatc tttgagaaac attccagata caagtatcac tatgatgcag
4261 actactcccg ctgggattca acacaacaga gagctgtgct agccgcagcc ttagagatca
4321 tggtcaaatt ttcagcagaa ccaaacttgg cccaaatagt ggctgaggat ctcttgtctc
4381 ccagtgtgat ggatgtaggt gacttcaaga taacaatcaa tgaagggctc ccctcggggg
4441 tgccatgcac ttcacaatgg aattccatcg cccattggct cctcacactc tgtgcactat
4501 ctgaagtcac ggatctgtct cctgacatca ttcaagctaa ttctctattc tccttctatg
4561 gtgatgatga aattgtgagc acggacatca aagtggaccc aggaaaactg acagcaaagc
4621 tgagggaata cgggttgaag ccaacacgcc ctgataaaac tgaagggccc ctactcatct
4681 cagaggacct gaatggccta accttcctga ggagaactgt gacccgggac ccagctggat
4741 ggtttggtaa actggaccaa agctcaatac tcaggcaaat gtactggact agaggaccca
4801 atcatgaaga cccccatgaa acaatgatac ctcactctca gaggccaata caacttatgt
4861 ctctacttgg tgaagccgcc ctacacggcc catcatttta cagcaaaatc agcaagctgg
4921 tcatcacaga actaaaggaa ggtggcatgg atttttacgt gcccaggcaa gagcccatgt
4981 ttaggtggat gagattctca gacttgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccgctccat ctactgatgg tgcagccggc
5101 ctcgtgccag aaagtaataa tgaggccatg gctcttgaac ccgtggctgg tgccgctttg
5161 gcagccccgg tcaccggtca aacaaatatt atagaccctt ggattagagc aaattttgtc
5221 caggccccta atggtgagtt tacagtttct ccccgtaatg cccctggtga agtgctattg
5281 aatctagagt tgggtccaga attaaatcct tatctggcac atttagcaag aatgtacaac
5341 gggtacgccg gtgggatgga ggtgcaggtc atgttggctg ggaacgcgtt cacagccggc
5401 aagttggtct tcgccgctgt gccacctcat ttcccggttg aaaaccttag tccacagcaa
5461 attaccatgt tccctcatgt gattatagat gtaaggactt tggaacctgt tttattacca
5521 ctccctgatg ttagaaataa tttcttccat tataatcaga aagatgatcc caagatgagg
5581 attgtggcta tgctttatac cccccttagg tctaatggtt caggtgatga tgtgtttaca
5641 gtctcctgca gggtgttgac tagaccctcc cctgattttg atttcacata tctggtgcca
5701 ccaacagtgg aatccaaaac aaaaccattt acccttccaa tcctcacact tggggagctt
5761 tccaattcta gattcccagt gtctatagat cagatgtaca ctagccccaa tgaagttata
5821 tctgtgcagt gtcaaaatgg taggtgcaca ctggatgggg agctccaagg aacaacacaa
5881 ctccaggtca gtggcatttg tgctttcaag ggagaagtga ccgcccactt gcatgacaat
5941 gaccacctat ataatgtcac cattacaaac ttgaatgggt ccccttttga cccctccgag
6001 gacatccccg cccctctggg cgtgcctgac ttccagggaa gggtctttgg tgtcatctcc
6061 caaagagaca aacagaatgc cgctggacat aatgaaccag caaacagggg acacgacgct
6121 gtggttccta cttatacagc acagtacact ccaaaattgg gtcagattca aattggcaca
6181 tggcagaccg acgatctcac agtcaatcaa ccagttaaat ttaccccagt tggcctcaat
6241 gatactgaac attttaacca atgggtggtc cctagatatg ctggtgctct aaatcttaac
6301 acaaatcttg ccccttctgt tgctccagta tttccagggg agcgcctgct ctttttcaga
6361 tcatacatcc ccctcaaggg tggttatgga aatccagcca ttgattgtct actaccacaa
6421 gagtgggtgc aacatttcta tcaggaagca gccccttcaa tgagtgaggt ggctcttgtc
6481 agatacatca acccagacac tggtcgggca ctgtttgagg ccaagctcca cagagctggt
6541 ttcatgacgg tctcaagcaa caccagtgct ccggtggttg tgcctgccaa cggatacttc
6601 agatttgact cttgggtgaa ccaattctat tctctcgccc ccatgggaac tggaaatggg
6661 cgtagaaggg ttcaataatg gctggagctt ttgtagctgg tcttgcaggg gacgtgctca
6721 gcaatgggct cagttcatta attaatgcag gtgctaatgc aataaatcag agggcagaat
6781 ttgattttaa tcagagatta cagcaaaatt cttttaatca tgataaggag atgttgcagg
6841 ctcagattca ggcaactaag cagctgcagg cagacatgat ggctataaag cagggggttc
6901 tgatcgctgg ctgcttttcc cctgctgacg cagccagagg tgctgtgaat gcgcccatga
6961 cacaggcgct ggattggaac ggcacaaggt attgggcacc aggctccatg aggactacat
7021 cttactctgg aagattcaca tcgaccgctc cggtgaggca ggccgatttc caacacaccc
7081 aaagccggcc ttcgagcggc tcttctgtgt cctcctttgc tactcagtct tcaaggccaa
7141 ctctgaccac aaccactggg tcctcacatg gcacaacctc atccaattcg actcgcagca
7201 caaacctctc ccagtcaacg gtctctaggg ctacatctag gactggtgaa tgggttagag
7261 atcaaaataa aaatttggaa ccctacatgc atggtgcctt acagacagcc tttgtcaccc
7321 caccttccag cagggcgtct gacgggacgg tctcaaccgt cccaaaaggt gttttggact
7381 cctggacacc tgcgttcaac acccgcaggc agccgctttt tgcacacctc cgtaagaggg
7441 gggagtcaca agcttagtga aaaggtgaaa atttatttaa aatgaattaa tcttaccttt
//