Typing tool
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Typing tool
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Complete norovirus genomes
| MW305656 | GII.4 US95 | |
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| GII.P4 US95 |
ORF1: 1..5069
ORF2: 5050..6669
ORF3: 6669..7475
LOCUS MW305656 7517 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate 946 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305656
VERSION MW305656.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7517)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7517)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7517
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="946"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Japan"
/collection_date="20-Jan-1997"
/note="genotype: GII.4[GII.P4]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59304.1"
/translation="AVANSNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPREIPQR
PPRPPTPELVKKIPPPPPNGEDEIVVSYSVKDGVSGLPELSTVRQPEEANTAFSVPPL
NQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLILGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLKKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANIFLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKVGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKRIAASLTGD
QRVGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDM
WKNAFSSDFSHIKLTLAPQGGFDKNGNTPHGKGIMKTLTTGSLIARASGLLHERLDEF
ELQGPALTTFNFDRNKVLAFRQLAAENKYGLMDTMKVGRQLKDVRTMPDLKQALKSIS
IKKCQIVYSGCTYTLESDGKGNVKVDRVQSASVQTNNELAGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVEDTGEAINKDGCPKPKDDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAKEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKREN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
AAKKTIINVLEQTIDPSEKWSFTQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
QASKANLMYEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPIRVGMNMNEDGPIIFERHSRYKYHYDADYSRWDSTQQRAVLAAA
LEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6669
/gene="ORF2"
CDS 5050..6669
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59305.1"
/translation="MKMASNDANPSDGSTASLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFTVPILTVEEMSNSRFPIPLEKLYTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSAVNICTFRGDVTHIAGSHDYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTREDGSTRAHKATVSTGSVHFTPKLGSVQYTTDTNNDFQTGQNTKFTPVGVIQDG
NNHQNEPQQWVLPNYSGRTGHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMNLDC
LLPQEWVQHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKTGYVTVAHTGPHDLVI
PPNGYFRFDSWVNQFYTLAPMGNGAGRRRAL"
gene 6669..7475
/gene="ORF3"
CDS 6669..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59306.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQGMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRTNLRATVPARGSSSTLS
STPTATSVYSNQTVSTRLGSSAGSGTSVSSLPSTARTRSWVEDQNRNLSPYMRGALNT
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRV"
ORIGIN
1 ccgctgttgc caacagcaac aacgacaccg caaaatcttc aagtgacgga gtgctttcta
61 gcatggctgt cacttttaaa cgagccctcg gggcgcggcc taaacagccc cccccgaggg
121 aaataccaca aagaccccca cgaccaccta ccccagaact ggtcaaaaag atcccccctc
181 ccccgcccaa cggggaggat gaaatagtgg tttcttatag tgtcaaagat ggcgtttccg
241 gtctgcctga gctttccacc gtcaggcaac cggaagaagc caacacggcc ttcagtgtcc
301 ccccactcaa ccagagggag aatagggatg ctaaggagcc actaactgga acaattctgg
361 aaatgtggga tggggagatc taccattacg gcctatatgt ggagcgaggt cttatacttg
421 gtgtgcacaa accaccagct gccattagcc tcgccaaggt cgagctaaca ccactctcct
481 tgttctggag acctgtgtat actccccagt atctcatctc tccagacact cttaagaaat
541 tgcacggaga atcgtttccc tacacagcct ttgacaacaa ttgctatgcc ttctgttgct
601 gggtcttgga cctaaacgac tcgtggctga gtaggagaat gatccagaga acaactggtt
661 tcttcagacc ctaccaagat tggaatagga aacccctccc cactatggat gattccaaat
721 taaagaaggt agctaatata ttcctgtgtg ctctatcttc actattcacc aggcccataa
781 aagacataat agggaagcta aggcctctta acatccttaa catcttggcc tcatgtgatt
841 ggactttcgc aggcatagtg gaatccttga tactcttggc agagctcttt ggagttttct
901 ggacaccccc agacgtgtct gcgatgattg cccccttact cggtgattac gagttacaag
961 gacctgagga ccttgcagtg gaactcgttc ctgtagtgat ggggggaatt ggtttggtgc
1021 taggatttac caaagagaag gttggaaaaa tgttgtcatc tgctgcatcc accttaagag
1081 cttgtaaaga tcttggtgca tacgggctgg aaattctaaa gttagtcatg aagtggttct
1141 tcccaaagaa agaggaagca aatgaactgg ctatggtgag atccattgag gatgcagtgc
1201 tggacctcga ggcaattgaa aacaaccata tgaccacctt gctcaaagac aaagacagtc
1261 tggcaaccta catgaggacc cttgaccttg aggaggagaa agccaggaag ctctcaacca
1321 agtccgcttc acctgacatc gtgggcacaa tcaacgccct tctggcgaga atcgctgctg
1381 cacgttccct ggtgcatcga gcgaaggagg agctttccag cagaccaaga cctgttgtct
1441 tgatgatatc aggcagacca gggataggga agacccacct tgctagggaa gtggccaaga
1501 gaatcgcagc ctccctcaca ggagaccagc gtgtaggcct cgtcccacgc aatggcgtcg
1561 atcactggga tgcgtacaag ggggagaggg tcgtcctctg ggacgactat gggatgagta
1621 atcccatcca cgatgccctc aggttgcaag aactcgctga cacttgcccc ctcactctaa
1681 actgtgacag gattgagaac aaaggaaagg tctttgacag tgatgtcata attatcacca
1741 ctaatctggc caacccagca ccactggact atgtcaactt tgaagcatgc tcgaggcgca
1801 tcgatttcct cgtgtatgca gaagcccctg aagtcgaaaa ggcaaaacgt gacttcccag
1861 gccaacctga catgtggaag aacgctttca gttctgattt ctcacacata aaactaacac
1921 tggctccaca gggtggcttc gataagaacg ggaacacccc acacgggaag ggcatcatga
1981 agactctcac cactggctcc cttattgccc gggcatcagg gctactccat gagaggctag
2041 atgagtttga actacagggc ccagctctca ccaccttcaa ctttgatcgc aacaaagtgc
2101 ttgcctttag gcagcttgct gctgaaaaca aatacgggtt gatggacaca atgaaagttg
2161 gaaggcagct caaggatgtc agaaccatgc cagatcttaa acaagcactc aagagtatct
2221 caatcaagaa gtgccagata gtgtacagtg gttgcaccta tacacttgag tctgatggca
2281 agggcaatgt gaaagttgac agagttcaga gcgcctccgt gcagaccaac aacgagctgg
2341 ccggcgccct acaccatcta aggtgcgcca gaatcaggta ctatgtcaag tgtgtccagg
2401 aggccctgta ttccatcatc caaattgctg gagctgcatt tgtcaccacg cgcatcgtca
2461 agcgcatgaa catacaagac ctctggtcca agccacaagt ggaagacaca ggggaggcta
2521 tcaacaagga cgggtgccca aaacccaaag atgatgagga gttcgtcatt tcatccgacg
2581 atatcaaaac tgagggcaag aaagggaaga acaagactgg ccgcggcaag aagcacacag
2641 ccttctcaag caaaggtctc agtgatgaag agtacgacga gtacaagagg attagagaag
2701 aaagaaatgg caagtactcc atagaagagt accttcagga cagggacaaa tactatgagg
2761 aggtggccat tgccagggcg accgaggaag acttctgtga agaggaggag gccaagattc
2821 ggcaaaggat tttcaggcca acaaggaaac aacgcaagga ggaaagggcc tctctcggtt
2881 tagttacagg ttctgaaatc aggaaaagga acccagatga tttcaagccc aaggggaaac
2941 tgtgggctga tgatgacaga agtgtggact acaatgagaa actcagtttt gaggccccac
3001 caagcatctg gtcgaggata gtcaactttg gttcaggttg gggcttttgg gtctctccca
3061 gtcttttcat aacatcaacc catgtcatac cccagggcgc aaaggagttc tttggagtcc
3121 ccatcaagca aattcagata cacaaatcag gcgaattctg tcgcttgagg ttcccaaaac
3181 caattaggac tgatgtgacg ggcatgatct tagaagaagg tgcgcccgaa ggcaccgtgg
3241 tcacactact catcaagagg cctactggag aacttatgcc cctagcagct agaatgggga
3301 cccatgcaac catgaaaatt caagggcgta ctgttggagg tcagatgggc atgcttctga
3361 caggatccaa cgccaaaagc atggacctag gcaccacacc aggtgactgc ggctgcccct
3421 acatctacaa gagggaaaat gactatgtgg ttattggagt ccacacggct gccgctcgtg
3481 ggggaaacac tgtcatatgt gccacccagg ggagtgaggg ggaggctaca cttgaaggtg
3541 gtgacagtaa gggaacatac tgtggtgcac caatcctagg cccagggagt gccccaaaac
3601 tcagcaccaa gaccaaattc tggagatcat ccacaacacc actcccacct ggcacctatg
3661 aaccagccta tcttggtggt aaggacccca gagtcaaggg tggcccttca ttgcaacaag
3721 ttatgaggga tcagttgaaa ccatttacag agcccagggg caaaccacca aagccaagtg
3781 tgttggaagc tgccaagaaa accatcatca atgtccttga acaaacaatc gatccatccg
3841 agaaatggtc attcacgcaa gcttgcgcgt cccttgacaa gactacttcc agtggccatc
3901 cgcaccacat gcggaaaaac gattgctgga acggggagtc cttcacaggc aagttggcag
3961 accaggcttc caaggccaac ctgatgtacg aagaggggaa gaacatgacc ccagtctaca
4021 caggtgcgct taaggatgag ttagttaaaa ctgacaaaat ttatggtaag atcaagaaga
4081 ggcttctctg gggctcggac ttagcgacca tgatccggtg cgctcgagca ttcggaggct
4141 taatggatga actcaaagca cactgtgtta cacttcctat cagagttggt atgaatatga
4201 atgaggacgg ccccatcatc ttcgagaggc attccaggta caaatatcac tatgatgctg
4261 attactctcg gtgggattca acacaacaga gagccgtgtt ggcagcagcc ctagaaatca
4321 tggttaaatt ctcctcagaa ccacatttgg ctcaggtagt cgcagaagac cttctttctc
4381 ctagcgtggt ggatgtgggt gacttcaaaa tatcaatcaa tgagggtctc ccctccgggg
4441 tgccctgcac ctcccaatgg aactccatcg cccactggct tctcactctc tgtgcgctct
4501 ctgaagttac aaacttgtcc cctgacatca tacaggctaa ttccctcttc tccttctatg
4561 gtgatgatga gattgttagt acagatataa agttggaccc agagaaattg acagcaaaac
4621 tcaaggaata cgggttgaaa ccaacccgcc ctgacaaaac tgaagggccc cttgtcattt
4681 ctgaagactt aaatggtctg accttcctgc ggagaactgt gacccgcgac ccagctggtt
4741 ggtttggaaa attggagcag agttcaatac tcagacaaat gtactggact aggggcccca
4801 accatgaaga cccatctgaa acaatgattc cacattccca aagacccata caattgatgt
4861 ccctactggg agaggccgca ctccacggcc cagcattcta cagcaaaatt agcaagttag
4921 ttattgcaga gctaaaagaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccaacccat ctgatgggtc cacagccagc
5101 ctcgtcccag aggtcaacaa tgaggttatg gctttggagc ccgttgttgg tgccgctatt
5161 gcggcacctg tagcgggcca acaaaatgta attgacccct ggattagaaa taattttgta
5221 caagcccctg gtggagagtt tacagtatcc cctagaaacg ctccgggtga gatactatgg
5281 agcgcgccct tgggccctga tttgaacccc tacctttctc atttggccag aatgtacaat
5341 ggttatgcag gtggttttga agtgcaggta atcctcgcgg ggaacgcgtt caccgccggg
5401 aaaatcatat ttgcagcagt cccaccaaat tttccaactg aaggcttgag ccccagccag
5461 gttactatgt tcccccatat aatagtagat gttaggcaat tggaacctgt gttgatcccc
5521 ttacctgatg ttaggaataa tttctatcat tataatcaat caaatgattc tactattaaa
5581 ttgatagcaa tgctgtatac accacttagg gctaataatg ctggggatga tgtcttcaca
5641 gtctcttgtc gagtcctcac gaggccatcc cccgattttg atttcatatt cttggtgcca
5701 cccacagttg aatcaagaac taaaccattc accgtcccaa tcttaactgt tgaggaaatg
5761 tccaattcaa gattccccat tcctttggaa aagttgtaca cgggtcccag cagtgctttt
5821 gttgtccaac cacaaaatgg caggtgcacg actgatggcg tgctcttagg cactacccag
5881 ctgtctgctg tcaacatctg caccttcaga ggggatgtca cccacattgc aggcagtcat
5941 gactatacaa tgaatttggc ttctcaaaat tggaacaatt atgacccaac agaagaaatc
6001 ccagcccctc tgggaactcc agatttcgtg ggaaagatcc aaggcatgct cacccaaacc
6061 acaagagagg atggctcgac ccgcgcccat aaagctacag tgagcactgg gagtgttcac
6121 tttactccaa agctgggcag tgttcaatac accactgaca caaacaatga ttttcaaact
6181 ggccaaaaca cgaaattcac cccagtcggc gtcatccagg acggtaataa ccatcaaaat
6241 gaaccccaac aatgggtact cccaaattac tcaggtagaa ctggtcataa tgtgcaccta
6301 gctcctgccg ttgcccccac tttcccgggt gagcaacttc ttttctttag gtccactatg
6361 cccggatgta gcgggtatcc caacatgaat ctggattgcc tactccccca ggaatgggtg
6421 cagcacttct accaagaagc agctccagca caatctgatg tggctctgct gagatttgtg
6481 aatccagaca ccggtagggt tctgtttgag tgcaagctcc ataaaacagg ctatgtcaca
6541 gtggctcaca ctggcccgca tgatttggtt atccccccca atggttactt tagatttgat
6601 tcctgggtca accagttcta cacacttgcc cccatgggaa atggagcggg gcgtagacgt
6661 gcattataat ggctggagct ttctttgctg gattggcatc tgatgtcctt ggctctggac
6721 ttggttccct aatcaatgct ggggctgggg ccatcaacca aaaagttgaa tttgaaaata
6781 acagaaaatt gcaacaagct tccttccaat ttagtagcaa tctacaacag gcttccttcc
6841 aacatgataa agagatgctc caagcacaaa ttgaggccac taaaaaattg caacagggta
6901 tgatgaaggt taaacaggcg atgctcctag agggtggatt ctctgaaaca gatgcagccc
6961 gtggggcaat caacgccccc atgacaaagg ctctggactg gagcggaaca aggtactggg
7021 ctcctgatgc caggaccaca acatacaatg caggccgctt ttccacccct caaccttcgg
7081 gagcattgcc aggaagaact aatcttaggg ctactgtccc cgctcggggc tcctctagta
7141 cactttctag tactcccact gctacttctg tgtattcaaa tcaaactgtt tcaacgagac
7201 ttggttcttc agctggttct ggtaccagtg tctcgagtct cccgtcaact gcaaggacta
7261 ggagctgggt tgaggatcaa aacagaaatt tgtcacctta catgaggggg gctctcaaca
7321 catcattcgt caccccacca tctagtagat cctctagcca aggcacagtc tcaaccgtgc
7381 ctaaagaaat tttggactcc tggactggcg ctttcaacac gcgcaggcag cctctcttcg
7441 ctcacattcg caagcgaggg gagtcacggg tgtaatgtga aaagacaaaa ttgatctttc
7501 cttttttagt gtctttt
//