Typing tool
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Typing tool
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Complete norovirus genomes
| MW305650 | GII.3 | |
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| GII.P3 |
ORF1: 1..5078
ORF2: 5059..6705
ORF3: 6705..7469
LOCUS MW305650 7506 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 101-4 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305650
VERSION MW305650.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7506)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7506)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7506
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="101-4"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="USA"
/collection_date="05-Nov-1987"
/note="genotype: GII.3[GII.P3]"
gene <1..5078
/gene="ORF1"
CDS <1..5078
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59286.1"
/translation="VAGKNNNNDKEKSSSDSLFSNMTVTFKKALGARPKQPPPGETKQ
TQKPPRPPTPELVKRIPLPPPNGEDEPKVVYRVGEGVSGLPDLTTVAQPDAQNTAYSV
PPLSQREVGEAKEPLPGSILEMWDGEIYHYGLYVERGHILGVHKPPAAISLAKIELTP
LSLYWRVVYTPQYLIAPDTLKNLSGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQ
RTTGFFRPYQDWNRKPLPTMDEPKIKKAANAVLCALSSLFTRPIKDIIGKLKPMNILN
ILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYEMQGPEDLAVELVPV
VMGGVGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANEL
AMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEERARKLSTKSASPDIV
GTINALLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLARELAKKVASTL
SGDQRIGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCPLTLNCDR
IENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEKAKRDFPGQ
PDMWKDHYRPDFAHIKLQLAPQGGFDKNGNTPHGKGVVKSLTIGSLIARASGLLHERM
DEFELQGPNLPTFNFDRNKIAAFRQLAAENKYGMVDTLRVGNQLKSVKTMDELKQAIK
NITIKKCQIVYNGCTYTMESDGRGKVSVDKVQNATVQTNNELSGALHHLRSARIRYYV
KCFQEAVYSLLQIAGAAFVTSRIVRRMNISSLWSKPPVEESDESEDKEGCPKPRDEDD
LTIDSKDIKVEGKKGKNKSGRGKKHTAFSAKGLSDEEYDEYKRIREERNGKYSIEEYL
QDRDRYYEELAIAKATEENFCEEEEIKIRQRIFRPTRKQRKEERATLGLVTGSEIRKR
NPDDFKPKGKLWADDNRSVDYNERIDFEAPPSVWSRIVNFGTGWGFWVSPSLFITSTH
VIPKGITEAFGVPMNQIQIHKSGEFCRLRFPKPIRPDVSGMILEEGAPEGTVASILIK
RTTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYK
RGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGNAPKLS
TKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPNPS
VLESAKKTIINVLEQVIDPPQKWSYAQACASLDKSTSSGHPHHVRKNDYWSGESFTGK
LADQASKANLMYEEGKHMPPVYTAALKDELVKTDKIYGKIKKRLLWGSDLSTMIRCAR
AFGGLMDELKANCITLPIRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRAVL
AAALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCTSQWNSIAH
WLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTR
PDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQNSILRQLYWTRGPNHEDPSET
MIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQESMFRWMRF
SDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..968
/gene="ORF1"
/product="p48"
mat_peptide 969..2066
/gene="ORF1"
/product="NTPase"
mat_peptide 2067..2603
/gene="ORF1"
/product="p22"
mat_peptide 2604..3002
/gene="ORF1"
/product="VPg"
mat_peptide 3003..3545
/gene="ORF1"
/product="Pro"
mat_peptide 3546..5075
/gene="ORF1"
/product="RdRp"
gene 5059..6705
/gene="ORF2"
CDS 5059..6705
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59287.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNEAMALDPVAGAAIAAPLTGQ
QNIIDPWIMNNFVQAPGGEFTVSPRNSPGEVLLNLELGPEINPYLAHLARMYNGYAGG
FEVQVVLAGNAFTAGKVIFAAIPPNFPIDNLSAAQITMCPHVIVDVRQLEPINLPMPD
VRNNFFHYNQGSDSRLRLIAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFSFNFLVPP
TVESKTKPFTLPILTISEMSNSRFPVPIDSLHTSPTESIVVQCQNGRVTLDGELMGTT
QLLPNQICAFRGTLTRSTNRASDQADTATPRLFNHHWHIQLDNLNGTPYDPAEDIPAP
LGTPDFRGKVFGVASQRNPDSTTRAHEAKVDTTSGRFTPKLGSLEITTESDDFDPNQS
TKFTPVGIGVDNEADFQQWSLPDYSGQFTHNMNLAPAVAPNFPGEQLLFFRSQLPSSG
GRSNGILDCLVPQEWVQHFYQESAPAQTQVALVRYVNPDTGRVLFEAKLHKLGFMTIA
KNGDSPITVPPNGYFRFESWVNPFYTLAPMGTGNGRRRIQ"
gene 6705..7469
/gene="ORF3"
CDS 6705..7469
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59288.1"
/translation="MVGAFIAGLAGDMLTNTVGSLVNAGASAINQKVDFENNKYLQNA
SFNHDKEMLNAQIEATKRLQADMIAIKQGVLTAGGFSPTDAARGAINAPMTKVLDWSG
TRYWAPNATSTTSMSGGFTSQVVHRTTPNFRANQAPKLTPSSGSSVRSSSTQLTSLSS
HSSGSSRSSGSTVVSSLPSSSRTRDWVNQQNLNLEPHMPGSLRTAFVTPPSSTASSSD
TVSTVPKNVLDSWTSAFNTHRQPLFAHLRRRGESNA"
ORIGIN
1 ccgttgctgg caaaaacaac aacaacgaca aggaaaaatc ttcaagtgac agcttgtttt
61 ctaacatgac tgttactttt aagaaagccc tcggggcgcg gcctaaacaa ccgcccccgg
121 gagaaacaaa acaaacacaa aaaccaccaa gaccaccaac accggaattg gtgaaaagaa
181 tacccctacc cccacccaac ggcgaggatg aaccaaaggt ggtatacagg gtgggagaag
241 gtgtgtccgg gctgcccgac ttaacaaccg tggcgcagcc tgacgcacaa aacacagctt
301 atagtgtgcc cccacttagc caaagagagg taggcgaagc taaggaaccg ctacctggat
361 ccattctgga aatgtgggat ggtgagatct accactatgg gctgtacgtt gagcgggggc
421 acatacttgg ggtgcataaa ccacctgctg caataagcct cgccaaaatt gaattaacac
481 cactgtctct ctactggaga gtggtttaca ctccccagta cttgatagcc ccagacactc
541 tgaagaactt gagtggagaa tcattcccat acacggcctt tgacaacaac tgttacgcct
601 tctgttgttg ggtcttagat ctcaatgact cttggcttag caggagaatg attcaaagga
661 caaccggctt cttcaggccg taccaagatt ggaatagaaa acccctgcca accatggatg
721 agccaaaaat caagaaggcc gcgaatgctg ttctgtgcgc tctctcctca ctcttcacta
781 gacccattaa ggacattatt ggaaagctca aaccaatgaa catcctcaat atattagcaa
841 cttgtgactg gacttttgca ggcatagtgg aatcccttat tcttcttgct gaactctttg
901 gggtgttctg gacaccccca gatgtgtctg cgatgattgc tcccttactc ggtgactacg
961 agatgcaagg ccccgaagac ctggccgtgg aacttgtacc cgtggtgatg ggaggggtag
1021 gtttggtgtt gggattcacc aaggagaaga tcggcaagat gctttcatca gctgcatcca
1081 cgcttagggc ctgcaaagat ctaggagcct atggattgga gatacttaaa ttggtcatga
1141 agtggttctt ccctaagaaa gaagaggcta acgagttagc catggtaagg gccatcgagg
1201 atgcagtcct ggacttagag gcaatagaaa acaaccacat gaccactctt ctcaaggaca
1261 aagacagtct ggccacatac atgaggactc ttgacctgga ggaagagaga gcaaggaaac
1321 tgtccaccaa atccgcatca cctgacattg tgggcacaat aaatgcatta ttggcaagga
1381 ttgcagccgc taggtcacta gtccacaagg ctaaggagga gctttcaagc agacagaggc
1441 ctgtcgtcgt gatgatatct ggcagaccag gcatagggaa gacccacctc gccagagagc
1501 tagccaagaa agttgcatca acactgtcgg gcgaccaaag gattggactg gtgcctagaa
1561 acggtgtaga ccactgggat gcctacaagg gggaaagagt ggtgctatgg gatgactatg
1621 gcatgagcaa ccccatacag gatgcactga gacttcaaga gttggctgat acctgtcctc
1681 taactctaaa ctgtgataga attgaaaaca agggaaaagt gtttgacagt gatgccataa
1741 tcataacaac caaccttgca aacccagcac cgctggatta tgtcaacttt gaggcttgct
1801 ccagacgcat agacttctta gtgtatgcag atgcacctga cattgagaaa gccaagcgtg
1861 acttccctgg ccaaccagat atgtggaaag atcactacag accagacttt gcacacatca
1921 aacttcagct agcaccacag ggaggttttg ataagaatgg caacacccca catggtaaag
1981 gtgtagtgaa gtctctgacg attgggtcat tgatcgccag ggcttctggc ttgctccacg
2041 agagaatgga tgaattcgag ctccaaggcc ctaacctacc aaccttcaat ttcgaccgca
2101 acaagatcgc cgccttcagg caattggcag ctgaaaacaa atatggtatg gtagacacac
2161 tgagggtcgg taatcaactg aagagtgtca agaccatgga tgagctcaaa caggctataa
2221 agaatatcac cattaagaag tgccaaatag tgtacaatgg gtgtacctac acaatggagt
2281 ctgatggaag aggcaaggtt tcagttgaca aggtgcaaaa tgcaacagtc caaactaata
2341 atgagctttc aggagcgctg caccacttaa gatctgcaag aataagatat tatgtcaaat
2401 gtttccagga agctgtctat tctttgctac aaatcgctgg tgcggccttt gtcacctcac
2461 gcattgtgag gcgcatgaac atctcaagcc tctggtcgaa gccacccgtt gaagagagtg
2521 atgaatctga agacaaagaa gggtgcccca agcccagaga tgaagatgat ctcactatcg
2581 attccaagga cattaaagtg gaaggaaaga aaggcaagaa caagtccggc cgaggtaaga
2641 aacacacagc cttctcagct aagggcctca gtgatgaaga gtacgatgag tacaagagaa
2701 tcagagaaga gaggaatggc aaatactcaa tagaggagta cctccaagac agggacaggt
2761 actatgaaga gcttgccatt gctaaggcca ctgaagagaa cttctgtgaa gaggaggaga
2821 tcaaaatccg tcagagaatc ttccgcccca ccagaaagca gcggaaagag gaaagggcta
2881 cacttgggct cgtcacaggg tcggagatca gaaagaggaa tccagatgac ttcaaaccaa
2941 aagggaaatt gtgggctgat gataacagga gtgtggacta caatgagagg atagattttg
3001 aagcaccccc tagcgtttgg tcaaggatag tcaactttgg cacaggctgg ggattctggg
3061 tttctccaag tctcttcata acctcgacac acgtgatacc aaaaggaatc acggaggcat
3121 ttggggtgcc catgaaccaa atccaaattc ataaatcagg ggaattctgc cgcttacggt
3181 ttccaaaacc aatcaggcca gacgtaagtg ggatgatttt ggaagagggt gcccctgaag
3241 gaactgttgc gtccatcctc atcaaaagaa caacagggga gttgatgcct cttgcagcca
3301 gaatgggaac ccacgccaca atgaaaatcc aaggaagaac ggtgggtggc cagatgggca
3361 tgttactcac cggttcaaat gccaaaagca tggacctagg cacaacacca ggtgactgtg
3421 ggtgccccta catatacaag aggggcaatg acttcgtggt cattggcgtg cacactgcag
3481 cagcacgtgg aggaaacaca gttatatgtg ccacacaagg aagcgaaggt gaagccactc
3541 ttgagggagg tgacaacaag ggcacctatt gtggagcccc cattttagga cctggcaatg
3601 caccaaaatt gagcacaaaa acaaaattct ggagatcttc caacgcaccg ctcccgccag
3661 gcacctatga accagcatac ctgggtggga aagatccacg tgtgaagggt ggtccgtctc
3721 tgcaacaggt catgagagac caacttaaac ctttcacaga gcccagaggg aaaccaccaa
3781 acccaagtgt cctagaatca gcaaagaaaa ctatcatcaa tgttctagag caggtcattg
3841 acccccccca gaagtggtcc tatgcccaag cttgtgcatc ccttgacaaa tcaacctcca
3901 gtggacaccc gcaccacgtt cggaagaatg attactggag tggtgaatcc ttcacaggaa
3961 aacttgcaga ccaggcatca aaagcaaatc tcatgtacga agaaggcaaa cacatgccac
4021 cagtttacac cgcagcgctc aaggacgagc tggtgaaaac tgacaaaatc tatggtaaaa
4081 ttaagaaaag gctcctgtgg ggttctgacc tctccaccat gattcgatgc gccagagcat
4141 ttggtggcct catggatgaa ctcaaagcaa attgcatcac acttcctatc agagttggca
4201 tgaacatgaa tgaagatggt cccataatat ttgagaaaca ttccagatac agataccact
4261 atgatgcaga ttactcccgc tgggattcca cgcagcagcg ggcagtgttg gcagcagcac
4321 ttgaaatcat ggtgaggttc tctgctgaac cacagttagc acaaatagta gctgaagatc
4381 tgctagcacc aagtgtggtt gatgtgggtg acttcaagat caccattaat gaaggcctac
4441 cttctggtgt gccttgcacc tcacagtgga actccattgc ccactggttg cttactctgt
4501 gtgccctttc tgaagtgaca ggactaggcc ctgacatcat acaagctaat tccatgtact
4561 ctttctatgg tgatgatgag attgtgagca ctgacataaa attggaccca gagaaactga
4621 ctgcaaaact caaagagtac ggcctcaaac ccactcgccc cgacaaaacc gaagggccgc
4681 tggtaatcag tgaagacttg aatggtttga cgttcctccg ccgaacggtc acccgtgacc
4741 cagcaggttg gtttggaaag ctggatcaaa attccatcct caggcagcta tactggacaa
4801 gaggacccaa ccatgaagac cccagtgaaa ccatgatacc acatgcgcag agacccgtgc
4861 agctcatggc actgctggga gaatcctccc tacatggacc ctcattttac agcaaggtta
4921 gcaagctggt tatatctgaa cttaaggagg gaggaatgga tttttatgtg cccagacaag
4981 agtcaatgtt caggtggatg aggttctcag atctaagcac atgggagggc gatcgcaatc
5041 tggctcccag ttttgtgaat gaagatggcg tcgaatgacg ctgctccatc taatgatggt
5101 gccgccggcc tcgtcccaga gatcaacaat gaggcaatgg cgctagatcc agtggcgggt
5161 gcagcgatag cagcacccct cactggccag caaaatataa ttgatccctg gattatgaat
5221 aactttgtgc aagcacctgg tggtgagttt acagtgtcac ctaggaattc ccctggtgaa
5281 gtgcttctta acttggaatt aggtccagaa ataaatccct atttggctca tcttgctaga
5341 atgtacaatg gttatgcagg tgggtttgaa gtgcaagtgg tcctggctgg aaatgcgttt
5401 acagcaggaa aggtgatctt tgcagctata ccccccaact tccctattga taatctgagc
5461 gcagcacaga tcacaatgtg cccgcacgtg attgtggatg tcaggcagtt ggaaccaatc
5521 aatcttccga tgcctgatgt ccgcaacaat ttctttcatt ataatcaagg gtctgattca
5581 agattacgtt taattgcaat gctgtataca cctcttaggg caaataattc tggagatgat
5641 gtttttactg tgtcttgtag ggtgttaact aggcctagcc ctgatttctc attcaatttt
5701 cttgtcccac ccactgtgga atcaaagaca aaacctttta ccctccccat tttaaccatc
5761 tctgaaatgt ctaattccag gtttccggtg ccaattgact ctctgcacac cagcccaact
5821 gagagtatcg ttgtccagtg ccaaaatggg cgcgtcactc ttgacggtga gttaatgggc
5881 accacccaac tcttaccgaa ccaaatatgt gctttcaggg gaacacttac tagatcaaca
5941 aacagggcca gtgaccaagc cgacacagca acccccaggc tatttaacca tcattggcac
6001 atacaattgg ataatctaaa tggaaccccc tacgaccctg cagaggacat accagctcct
6061 ttgggtacac cagacttccg gggcaaagtc tttggcgtag ccagccagag aaaccccgac
6121 agcacaacaa gggcacatga agcaaaagtg gacacaacat ctggccgctt caccccaaaa
6181 ttgggctccc tagaaataac cactgaatct gatgactttg acccaaacca gtcaacaaaa
6241 ttcaccccag ttggcattgg agttgacaat gaggcagatt ttcagcaatg gtccttacct
6301 gactattccg gtcagtttac tcataacatg aacttagccc cagctgtcgc ccccaatttt
6361 cctggtgaac agcttctttt cttccgatca cagctgccat cttctggtgg gcggtctaac
6421 gggattctag actgcctggt cccccaggaa tgggttcaac acttctacca agaatcagcc
6481 cccgcccaaa cacaggtggc cctggttagg tatgtcaacc ctgacactgg tagagtgcta
6541 tttgaggcca agctacacaa attgggtttt atgactatag caaagaatgg tgactcccca
6601 ataactgtcc ctccaaatgg gtattttaga tttgaatctt gggttaaccc cttttacaca
6661 cttgccccca tgggaactgg aaacgggcgt agaaggattc aataatggtt ggagccttta
6721 tagcaggatt ggctggtgac atgctcacaa acactgtggg atctttggtt aatgcagggg
6781 ctagtgctat caatcaaaaa gttgattttg aaaataataa atatttgcaa aatgcatctt
6841 ttaatcatga taaggagatg ttaaatgcac aaattgaggc aacaaagagg ctgcaggctg
6901 acatgattgc tatcaagcaa ggggtcttga ccgctggcgg cttttccccc actgatgcag
6961 cacgtggggc aattaatgcc ccaatgacaa aagttttgga ttggagtgga acaaggtact
7021 gggcaccaaa cgccacctcc acaacttcaa tgtcaggtgg cttcacaagc caagttgtgc
7081 acagaaccac accaaatttt agagcgaacc aggcccccaa actcacaccc agcagtgggt
7141 cttcagtgag atcaagctca acccaactca ctagcttgag ctcacactca tccgggtcgt
7201 cccgatctag cgggtctacg gttgttagct cgttgccgtc ctccagtagg actagggact
7261 gggtcaatca acagaatctc aatttggaac cacacatgcc tggatctctc aggacagctt
7321 ttgtcactcc accatctagc acagcctcta gttcagacac ggtctcaacc gtgcccaaaa
7381 atgttttgga ctcctggaca tctgcgttta atacgcacag acagccgcta tttgcacacc
7441 ttcgtagaag gggggagtca aatgcttagt gaaaagatta ttcctaaatt taatttagaa
7501 tctttt
//