Typing tool
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Typing tool
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Complete norovirus genomes
| MW305649 | GII.2 | |
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| GII.P16 |
ORF1: 1..5069
ORF2: 5050..6678
ORF3: 6678..7457
LOCUS MW305649 7498 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg16075 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305649
VERSION MW305649.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7498)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7498)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7498
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg16075"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2018"
/note="genotype: GII.2[GII.P16]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59283.1"
/translation="VACNNNNDKEKSSGEGLFTNVSFTLKKALGARPKQPAPRDKPQK
PPRPPTPELVKRIPPPPPNGEEEEEPVIRYEVKSGISGLPELTTVPQPDVANTAFSVP
PLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAAISMARVELTPL
SLYWRVVYTPQYLIPPETLRRLNGEAFPYTAFDNNCYAFCCWVLDLNDSWLSRRMVQR
TTGFFRPYQEWNRKPLPTMDDSKIKKVANIFLCSLSTLFTRPIKDLIGKIKPLNILNI
LATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELA
MVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRLSTKSASPDIVG
TINALLARIAAARSLVHRAKEELSSRMRPVVVMISGKPGIGKTHLAREVARKVASTLT
GDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELADTCPLTLNCDRI
ENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPEVEKAKRDFPGQP
DMWKDAFKQDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMD
EFELQGPTITTFNFDRNRITAFRQLAAENKYGLMDTMKVGNQLKGVKTMEELKQAIRN
VTIKRCQIIYGGSTYDLESDGKGKVLVEKVKNTSVQTNNELAGALHHLKHARIRYYVK
CVQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNESEIKEEAPKSEDDEFII
SSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLVTGSEIRKRNPD
DFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSPSLFITSTHVIP
AGITEAFGVPIKQIQIHKSGEFCRFRFPKPIRPDVTGMILEEGAPEGTVATVLIKRPT
GELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGDCGCPYIYKRGN
DYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILGPGGAPKLSTKT
KFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPSVLE
AAKQTIINVLEQTLDPPQKWTYAQACASLDKTTSSGHPHHARKNEFWNGETFTGKLAD
QASKANLMFEEGKHMTPVYTAALKDELVKTEKIYRKIKKRLLWGSDLSTMIRCARSFG
GLMDEMKAHCISLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVLASA
LEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTKLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLKEYGLKPTRPDK
TEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPNETMIP
HSQRPIQLMALLGEASLHGPSFYSKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPNFVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6678
/gene="ORF2"
CDS 5050..6678
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59284.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
VISQRDKHNSPGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6678..7457
/gene="ORF3"
CDS 6678..7457
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59285.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQKLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLIAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPNSMRTTSYSGKFTSTAPVRQADFQHTQSRPSSGSSVSSFATQSSRPTLTTTS
GSSHGTASSNSTRSTSLSQSTVSRATSRTGEWVREQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGESQA"
ORIGIN
1 ccgttgcttg caacaacaac aacgacaaag aaaaatcttc aggtgaaggc ttattcacaa
61 atgtgtcttt caccttaaag aaagccctcg gggctaggcc caaacagcct gccccgagag
121 acaagccaca aaagccccca agaccaccaa ctcccgagtt ggtcaagagg ataccccctc
181 ctccacctaa tggcgaagaa gaagaagaac cagtcattag gtatgaggtt aagagtggga
241 tctctggcct gcccgagctc acaacagtcc cccaaccgga cgtggccaac acagcattca
301 gtgtcccacc actgagcttg agagaaaaca gggaggccaa ggaaccgctg acaggggcaa
361 tattagagat gtgggatgga gagatatacc actatggcct gtacgtggag aaaggcttag
421 tgttgggtgt gcacaaacca cctgcagcca taagcatggc aagagtggag ttgacgccgt
481 tgtcattgta ctggcgtgtg gtgtacactc cccaatacct catcccccct gaaactctca
541 ggaggctcaa cggagaggcg ttcccttaca ccgcctttga caacaactgc tatgcctttt
601 gctgctgggt gttagacctc aatgactcat ggcttagcag gaggatggta caaagaacaa
661 cgggcttctt cagaccttac caagagtgga acagaaaacc cctgcctacc atggatgact
721 ccaaaattaa gaaggtagca aatatattcc tatgttcatt gtccacatta ttcaccagac
781 ccataaaaga cctcatagga aaaattaaac cattaaacat attgaatatc ctggcaacgt
841 gtgactggac ttttgccgga atagtggagt ctctgatatt acttgctgaa ctcttcggag
901 ttttctggac acccccagat gtgtctgcta tgatcgctcc cttactcggg gactacgagt
961 tgcaagggcc agaagacctc gccgttgaac tcgtacctgt ggtaatgggg gggattggtt
1021 tggtgttggg attcaccaaa gagaaaattg gcaaaatgtt gtcctcagca gcatcaacac
1081 tcagggcttg caaagatctt ggtgcatatg gcttagagat actcaaattg gtcatgaagt
1141 ggttcttccc aaagaaagag gaggccaatg agctagccat ggtgagggcc atagaggatg
1201 ctgtactaga tcttgaggca atagaaaata accacatgac aaccctgtta aaagacaaag
1261 acagcttagc aacatacatg aaaacactgg acatggagga ggagaaagcc aggaggttgt
1321 ccacaaaatc tgcatcccct gacatagttg ggacaatcaa cgccctgctg gctcgaatag
1381 cagcggccag gtcattggtc cacagggcca aggaagagct atctagcagg atgaggccag
1441 tagttgttat gatatctggc aaaccaggaa taggtaaaac tcatctggcc agggaggtgg
1501 caagaaaggt ggcatccact ctcacagggg atcaaagagt cggactcata ccacgaaacg
1561 gtgtggacca ttgggatgca tacaaaggtg agagagtagt gctgtgggac gactatggca
1621 tgagtaaccc cattcatgat gctcttcgca tacaagaatt ggctgatacg tgtcccctta
1681 ccttaaattg tgacagaatt gaaaataaag gaaaagtttt tgacagtgaa gtcataataa
1741 ttacaacaaa cctcgccaat ccagccccac ttgattatgt caactttgag gcctgctcca
1801 ggagaattga tttcctagtg tacgctgatg caccagaagt agagaaggca aaacgggact
1861 ttcctggtca gccagatatg tggaaggacg ccttcaagca ggacttttca cacatcaagc
1921 tacagcttgc accccagggc ggctttgaca agaatggcaa caccccacat gggaaaggag
1981 tgatgaagac ccttactaca ggttctctga tagcccgtgc atcaggccta ctgcatgaga
2041 ggatggatga atttgaactc caaggtccca caatcaccac cttcaatttc gaccggaaca
2101 gaatcacggc attcagacaa ttggctgcag aaaacaagta tggattgatg gataccatga
2161 aagttggcaa ccaattaaaa ggagtgaaaa ccatggaaga actcaaacaa gcaatcagga
2221 atgtgaccat caagaggtgc cagatcatct acggtggttc cacatatgac cttgagtctg
2281 atggcaaggg caaagtcttg gtggaaaagg tcaagaacac ctctgtacag accaacaacg
2341 agttggctgg ggccctgcac catctcaaac acgcccgaat caggtactat gtcaaatgtg
2401 tacaagaagc agtctattcc atcatacaaa ttgccggcgc tgcgtttgtc accacgcgca
2461 ttgcacgccg catgaacata caagaactct ggtcgaagcc acaactagat caaaatgaat
2521 cagagattaa ggaagaggcc cccaagtcag aagatgacga gttcatcata tcttctaagg
2581 acatcaagga ggaaggaaag aagggcaaaa acaaaactgg ccgtggcaag aaacacactg
2641 cattctccag caagggcttg agcgatgagg agtatgacga gtacaagagg ataagagaag
2701 agaggaatgg gaaatactct atagaggagt atcttcaaga cagagacagg tactatgagg
2761 agctcgccat tgccaaggcc acggaagaag acttctgtga agaggaggag attaaaatcc
2821 gtcagagaat tttccgtccc accaggaaac aaagaaagga agagagggcc acattagggc
2881 tagtaacagg ttcagaaatc agaaaaagaa accctgatga cttcaaaccc aaagggaagc
2941 tgtgggccga tgacaacagg agtgttgact acaatgagaa actggacttt gaggcccccc
3001 caagcatatg gtctaggatt gtgagctttg gttctggctg gggcttctgg gtgtcaccaa
3061 gccttttcat aacatcaact catgtaatcc ccgcaggcat aacagaagca tttggagtcc
3121 ccatcaaaca aattcagatc cacaaatcag gcgaattttg ccgattcaga ttcccaaaac
3181 caattaggcc agatgtgaca ggaatgatct tggaagaagg tgcgcctgag ggcaccgtgg
3241 caactgtgct catcaaacgc cccaccggag agctcatgcc tcttgcagcc agaatgggaa
3301 cacacgcaac catgaaaatt caaggccgca tggttggcgg acagatgggt atgttgctca
3361 ctggatcaaa tgctaaagga atggacttgg gaacaactcc tggtgactgt ggctgtcctt
3421 atatctataa aaggggcaat gactatatag tcattggggt gcacactgca gcagcccgtg
3481 gtggaaacac cgtcatctgt gccacacagg gaagtgaggg tgaggcaact cttgagggtg
3541 gagatgacaa aggaacatac tgtggggcac ccattctagg ccctgggggt gcaccaaaat
3601 tgagcaccaa aaccaaattt tggaggtcat cgaacacgcc ccttccacca gggacatatg
3661 agcctgccta cctcggtggc cgtgatccgc gtgttaaggg tgggccttcc ctgcagcagg
3721 taatgagaga tcagttgaag ccattcactg aacccagggg caaacctcca agaccaagtg
3781 tattggaagc agccaaacaa accatcatca atgtcctcga acaaaccctg gaccctccac
3841 aaaaatggac atacgcacag gcgtgtgcct cacttgacaa aaccacctcc agtgggcacc
3901 cccatcacgc ccgaaagaat gaattctgga atggtgagac cttcactggt aaactggcag
3961 accaagcatc aaaagcaaat ctaatgtttg aggaagggaa acacatgaca ccagtgtaca
4021 cagcagcact caaggacgag ctagtcaaga ctgagaaaat ctatagaaag atcaagaaga
4081 gattgctctg gggctctgac ttatccacca tgatccggtg cgctaggtca tttggtgggc
4141 tcatggacga gatgaaggca cactgcatat cacttccagt ccgagttggc atgaatatga
4201 atgaagatgg tccaataata ttcgagaaac actccagata caaatatcac tatgatgcag
4261 actactctcg ttgggattca acacaacaga gggcagtact agcatcagcc ttggaaatca
4321 tggtcagatt ttctgcagaa ccacaattgg cacaaatagt cgctgaggac ctgctggctc
4381 ctagtgtagt agatgtagga gactttaaaa ttacaataaa tgaagggctc ccttctggtg
4441 tgccatgcac ttctcaatgg aactccatcg cacactggct gctaactctc tgtgccttgt
4501 ctgaagtcac caaactgtcc cctgacatta tacaggcaaa ttccatgttc tcattttacg
4561 gtgatgacga gattgtcagc accgatataa aattggaccc tgaacagtta accgccaaat
4621 tgaaggagta cggcctgaaa ccaacccgcc cagataaaac cgagggaccc ctgattatca
4681 gtgaagattt gaacggtctt actttcctcc gaaggacggt gactcgtgac ccagctggct
4741 ggtttggaaa actggaccaa agttcgattt tgaggcagat gtactggact agaggaccaa
4801 atcatgaaga ccccaatgag acaatgatac cccattctca aagacccata cagctcatgg
4861 cactgcttgg tgaagcctct cttcacggac cctctttcta cagtaaaatc agtaaattgg
4921 tcataactga actcaaagaa ggtgggatgg acttttacgt gccaaggcag gaacccatgt
4981 tcaggtggat gaggttttct gacttgagca cgtgggaggg cgatcgcaat ctggctccca
5041 attttgtgaa tgaagatggc gtcgaatgac gccgctccat ctactgatgg tgcagccggc
5101 ctcgtgccag aaagtaacaa tgaggtcatg gctcttgaac ccgtggctgg tgccgccttg
5161 gcagccccgg tcaccggtca aacaaatatt atagaccctt ggattagagc aaattttgtc
5221 caggccccta atggtgaatt tacagtctct ccccgaaatg cccctggtga agtgctactg
5281 aatctggagt tgggtccaga attaaatcct tatctggcac atttagcaag aatgtacaat
5341 gggtatgccg gtgggatgga ggtgcaggtc atgttggctg ggaacgcgtt cacagccggc
5401 aagttggtct tcgccgccgt gccaccccac ttcccggttg aaaaccttag cccacagcaa
5461 atcaccatgt tccctcatgt gatcatagat gtgagaacct tggaacctgt tttattacca
5521 ctccctgatg ttaggaacaa tttcttccat tataatcaga aagatgatcc caagatgaga
5581 attgtggcta tgctttatac ccccctcagg tctaatggtt caggtgatga tgtgtttaca
5641 gtctcctgta gggtgttaac tagaccttcc cctgactttg acttcacata cctggtgcca
5701 ccaacagtgg agtctaaaac aaagccattc accctcccaa tcctcacact tggggaactt
5761 tccaattcta ggttcccagt gtccatagac cagatgtaca ccagccctaa tgaagttata
5821 tcagtgcagt gtcaaaatgg taggtgcaca ctggacggag agctccaagg gacaacacaa
5881 ctccaagtca gtggcatttg tgctttcaaa ggtgaagtga ccgcccactt gcatgacaat
5941 gatcacctat acaatgttac catcacaaac ttgaatgggt ccccttttga tccctccgag
6001 gatatccctg cccctctggg tgtgcctgac ttccagggaa gggtttttgg tgtcatctcc
6061 caaagagaca aacacaatag tcccgggcat aatgaaccag caaacagggg acacgacgct
6121 gtggtcccta cttacacagc acagtatact ccaaaactgg gacaaattca aattggcaca
6181 tggcaaactg acgaccttac agtcaaccaa ccagtcaaat tcaccccagt tggactcaat
6241 gacaccgaac attttaacca atgggtggtc cctaggtatg ctggtgccct aaacctcaat
6301 acaaaccttg ccccttctgt tgctccagta tttccaggag agcgcttgct cttcttcaga
6361 tcatatattc ccctcaaggg cggttatgga aacccagcca ttgattgcct actaccacaa
6421 gagtgggtac aacacttcta tcaggaagca gccccttcaa tgagtgaggt ggccctcgtc
6481 agatacatca acccggacac tggtcgggca ctgtttgagg ccaagctcca cagagctggt
6541 ttcatgacag tctcgagcaa caccagtgcc ccggtggttg tgcctgccaa tggatacttc
6601 agatttgatt cttgggtgaa ccaattttac tctctcgccc ccatgggaac tgggaatggg
6661 cgtagaaggg ttcaataatg gctggagctt ttgtagctgg tcttgcaggg gatgtgctca
6721 gcaatgggct tagttcatta attaatgcag gtgctaatgc aataaatcag agagcagaat
6781 ttgattttaa tcagaaattg cagcaaaatt cttttaatca tgataaggag atgttgcagg
6841 ctcaaattca ggcaactaag cagctgcagg cagacatgat ggctataaaa caaggggtct
6901 tgatcgctgg cggcttttcc cctgctgatg cagccagagg tgctgtgaac gcgcccatga
6961 cacaggcgct ggattggaat ggcacaaggt attgggcacc aaactccatg aggaccacat
7021 cttattctgg aaaattcaca tcaaccgccc cagtgaggca ggctgacttc cagcacaccc
7081 aaagccggcc ttcgagtggt tcctctgtgt cttcctttgc cactcagtct tcaaggccaa
7141 ctctgaccac aacttctggt tcctcacatg gcacagcctc atcgaattca actcgcagca
7201 caagcctctc ccaatcaacg gtctccagag ctacatctag gactggtgag tgggttagag
7261 aacaaaatag aaatttggaa ccctacatgc atggtgcctt acagacagcc tttgtcaccc
7321 caccttccag cagggcatct gacgggacag tctcaaccgt cccgaaaggt gttttggact
7381 cctggacacc tgcgtttaac acccgcaggc agccgctttt tgcacacctc cgtaagaggg
7441 gggagtcaca agcttagtga aaaggtgaaa atttatttag gatgaattga ttttacct
//