Typing tool
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Typing tool
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Complete norovirus genomes
| MW305648 | GII.14 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6654
ORF3: 6654..7448
LOCUS MW305648 7458 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate Arg16008 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305648
VERSION MW305648.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7458)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7458)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7458
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg16008"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="2017"
/note="genotype: GII.14[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59280.1"
/translation="FGSQNSVNDSNNATPSNKEEVGAFSNIKVGLKKMLGAVPKGTKA
PSSGQHCPTVKIGLKALAIPPEPPNGEDTVQFDAKSETIVGLPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSDGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVSPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLNRRCI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKVKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVSWDDYGMGSPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKNVKTLEDLKIAL
RDVKFNECEIIYKNSKYRVSSNGKGSVSVDKVEDNASQTVNEVQSAILRLRQARARYY
ISCFQDLVYTLIQVAGASFVVSRISRRFCWERWVKPTETQEVSDSEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGSDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
VKELFGVEIKQIQVHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILIKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNEGLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLRPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWSYSQACASLDKTTSSGSPHHVKKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRNILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6654
/gene="ORF2"
CDS 5044..6654
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59281.1"
/translation="MKMASNDATPSDDGAAGLVPEINSEVMALEPVAGASLAAPVVGQ
QNIIDPWIRNNFVQAPAGEFTVSPRNSPGELLLDLELGPELNPYLAHLSRMYNGHAGG
MEVQIVLAGNAFTAGKILFAAIPPSFPYENLSPAQLTMCPHVIVDVRQLEPVLLPMPD
IRNVFYHYNQNNGPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFQFTFLVPP
TVESKTKNFTLPVLRVSEMTNSRFPVVLDQMYTSRNENIIVQPQNGRCTTDGELLGTT
ILQSVSICNFKGTMQAKLNEEPRYQLQITNLDGSPIDPTDDMPAPLGTPDFQAMLYGV
ASQRSSSDNATRAHDAQIDTAGDTFAPKIGQVRFKSSSSDFDLHDPTKFTPIGVNVDD
QHPFRQWSLPNYGGHLALNNHLAPAVTPLFPGEQILFFRSYIPSAGGHTDGAMDCLLP
QEWIEHFYQEAAPSQSDIALVRFINPDTGRVLFEAKLHKQGFLTIAASGDHPIVMPTN
GYFRFEAWVNPFYTLAPVGTGSGRRRIQ"
gene 6654..7448
/gene="ORF3"
CDS 6654..7448
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59282.1"
/translation="MAGAFLAGLAGDVVTSSLGSLVGAGANAINQKVEYDFNRQLQEA
SFRHDKDMLKAQVAATAGLQQAMIDIKREALTAGGFSPADAARGAVKAPMTQILDWNG
SRYWAPNSMKTTGYSGTFVSQGIRNSPHLSNQTPSAVKPIKPLLSISSSSSVYSSPST
APSQSTQSTTLSAGTGSSRPNTVSTKTSTLSRTSDWVRGQNEMLGPFMSGALQTAYVT
PPSSRASSQGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 cctttggcag tcaaaattct gtcaatgaca gcaacaatgc caccccttct aacaaagaag
61 aggttggtgc attctccaac ataaaagttg gactcaagaa aatgctgggt gccgttccca
121 agggcaccaa agcacccagc agtggccaac attgccccac agtcaagatc gggcttaaag
181 cattagcaat cccccctgag cccccaaatg gtgaagacac cgtacagttt gatgcaaagt
241 cagaaactat agttggattg ccggatttga caacggtgca aaatgaacat gaaaacactc
301 catacactgt ccctccatta agtgagaggg aacacagacc ggctaccgaa ccacttcctg
361 gcacaatatt ggaaatgtgg gatggtgagt tttaccatta ttccgtgtac gtcagcgacg
421 gcaaagctct gggggtccac aaaccaccgg cggctataag cctcgcgacg atagagctca
481 cccccatatc actttactgg aggcccgttt atacccccaa ttacttggtc tccccggata
541 cattaaaggg tctcgctggt gagaagtttc cctacacggc cttcagtaac aactgttata
601 acttttgttg ttgggtgctt gagctcaacg acacgtggct taacagaaga tgcatttcca
661 gaactaccgg cttcttcaag ccataccagt cttggaacag aaaacctctc ccaaccgttg
721 atgatggaaa gatcaaaaag gtggccaatg caatcctctg tgcactcggt tcactgtttt
781 caaaaccaat caaagacctg ttaggtaagc tcaagccatt gaatctgctg cacttgcttg
841 cgtcttgtga ttggacgttt gcgggcatag tggagacagt catcttgatg gcggagcttt
901 tcaatgtctt ttggaccccc ccagatgtct ccaatttcat agcctcccta ataggtgact
961 ttgaattaca agggcctgag gacctggccg tggagctcgt tcccgtggtt atgggcggca
1021 tagggatggt tctcggtttc accgccgaga agataggccg catgctgtcg tccgctgcat
1081 caacactacg ggcgtgcaaa gacctaggga actatgccct tgatatactc aaattggtca
1141 tgaagtggtt cttcccgaag aaggaagaga aagctgagat ggagaccctg agggcgattg
1201 aagatgccgt cctagatatg gaagctatag ggaacaacca cctcacaacc cttctcaagg
1261 acaaagatag cctcacggct ttcatgaaga ccctggatct ggaagaggag aaggcgagga
1321 aactgtccac taaatcatct tcaccggaca tagtcggcac cattaatgcc atactggcta
1381 ggatagctgc tgctagatcc cttctacata aggtcaaaga ggagatgttc agcaggatta
1441 ggccagtggt tgttatgatc tcaggcaggc ctggcattgg aaaaacccac atggcgagac
1501 atttggctaa gagcatcgcc aacaccatga gtggcgacca gagagtcggg ctcgttccgc
1561 gcaacggcgt cgaccactgg gatgcctaca gaggagagag ggtggtctcg tgggatgact
1621 acggcatggg gagccccgtt aaggacgccc taacactaca agagctggcc gacacatgcc
1681 cagtcacttt aaattgtgac aggattgaga acaaggggaa gatgtttgac agtgatgtca
1741 tcataatcac gaccaaccta gtcaaccccg cgcccctcga ctatgtgaac tttgaggcgt
1801 gttctaggag ggttgacttc ctggtctacg cggagtcacc agaaattgaa aaggtcaaga
1861 gagacttccc tggccaacct gacatgtgga aagatcattt taaaccagac ttctcccaca
1921 tcaagctgac tctagccccc cagggtgggt ttgacaaaaa tggcaacacc ccacacggta
1981 agggaaccat gcggtctcta acccaggggt ccctgactgc gagagttgca ggccttgtcc
2041 atgagaggag agatgaattc cagctccaag gtaacgacct ccaaacatac aattttgaca
2101 ccaacagagt ctccgcattc aggaaattgg ctgcagataa caagtatggg atcatggaga
2161 caatgagagt gggtgcggca ctcaagaatg tgaagaccct ggaagacctt aaaattgcat
2221 tgagggatgt aaaattcaat gagtgtgaga taatctacaa gaactctaag taccgggttt
2281 cttccaacgg taaaggctca gtttctgttg acaaagttga ggacaacgca tcccagactg
2341 taaacgaggt acaatcagca attctcaggc tcaggcaagc gagggccaga tattacatca
2401 gctgcttcca agacctcgtc tacactctca tacaggttgc cggagcgtca tttgttgtca
2461 gcaggatctc tagaaggttc tgctgggaga ggtgggtcaa accgaccgag acccaggagg
2521 tgagtgattc cgaaaaggaa gtggcgcaag gcagatggga aattgagccc aaggatacag
2581 aaccagaagg caagaagggc aagaacaaga aaggaagggg taagaaacac acagctttct
2641 ctagcaaagg cctgagtgat gaagaatatg acgagtacaa gagaatcagg gaagaaagaa
2701 acggaaagta ctccattgag gaatacctgc aagaccggga ccgctattat gaagaagtgg
2761 cagttgctcg ggcgacagag gaggactttt gtgaagagga agaggccaag ataagacaaa
2821 gaattttccg cccgacaaag aaacagagga aggaggagag gggtgtgctt ggcttagtca
2881 ccggctcaga catcagaaag aggagaccag atgacttcca accaaaaggc aacctgtggg
2941 cagatgacac cagaagcgtg gactacaatg agaggcttga ttttgaagcg cccccgagtg
3001 tttggtcaag aatagtccca ttaggcactg gttgggggtt ttgggtttca tccaaccttc
3061 tgatcacaac aacacacgtc ctgcctaaag gggttaagga gctctttgga gttgaaatca
3121 agcaaatcca agttcataag tctggagagt tttgcaggtt caggttccca aggcctatca
3181 ggccagatgt cacagggctc gtgctggagg aaggcgcccc agaaggcact gtttgctcta
3241 tactcataaa aagacctaca ggtgagatga tccccttagc agtgaggatg ggcacacatg
3301 catccatgaa aatacagggt aggactgttg gtggccagat gggaatgctt ctcacaggag
3361 caaacgcgaa gaacatggac ctcggcaccg gtcctggtga ctgcggttgt ccttacatct
3421 acaaacgtgg caacgacatt gttgtcgcag gtgttcatac cgcagcagca agaggaggca
3481 acactgttat ctgtgccacc caagggcaag atggggaagc agtccttgag gggaatgagg
3541 gccttggcac ctattgcggc gccccaattc tgggccccgg caaggcacct aaactcagca
3601 cgaagaccaa gttttggcgt tcatcaccag atgccttgcc acctggcaca tatgaacctg
3661 cttacctagg gggtaaagac cctagagtgg aaaaaggtcc ttcccttcaa caagtcatga
3721 gagatcagtt gagacccttc acggaaccca ggggcaaacc acctaggcct gcagttttgg
3781 aggaagccaa aaagacagtg atgaatgttc tagaacaaac cattgacccc gccaagccat
3841 ggtcctactc gcaggcatgt gcctcactgg acaaaaccac ctctagtggt agtccccacc
3901 atgttaagaa aaatgaccac tggaatgggg agtccttcac tggcccactt gcagatcagg
3961 catctaaagc caacctcatg tatgagcagg ctaagcatgt gcagcccgtg tatacggccg
4021 cgctcaaaga tgagcttgtt aaaactgaca agatctacaa aaagataaag aagaggctcc
4081 tatgggggtc ggaccttggc acaatgatca ggtgcgccag ggcctttggt ggcctcatgg
4141 acagcatgaa ggcaagttgt atagctctcc cttgtagggt agggatgaac atgaatgaag
4201 atggccctat tatatttgac aaacattcta agtacaggta ccactatgat gctgactatt
4261 ctaggtggga ctcaacccaa caaaggaaca ttctttctgc cgccatggaa gtgatggtgc
4321 ggttctctgc tgaaccagaa ttggcacaag tggttgcaga ggacctttta gcacctagcc
4381 agcttgatgt tggcgatttt gtcatctcag tccaggaggg tctgccatca ggagtcccat
4441 gcacatcaca atggaattca atagcacact ggatcctaac tttgagtgca atggcagaag
4501 tgtcaggtct ctcaccagat gtcgtccaag ctcactcttg tttttccttt tacggggacg
4561 atgagatcgt cagtactgat atcaaccttg accccatgaa gttgacacag aaactcaggg
4621 agtatggtct ggttcccact cggcctgata aaactgaagg tccccttgtc ataactgaag
4681 acctcaccgg cctgacgttc ctccgtaggt cgattgctcg ggacccagct ggctggtttg
4741 gaaaactgga ccaagactca atccttaggc agctgtactg gacaaggggg cctaaccatg
4801 agaacccata cgagagcatg gttcctcatt ctcagcgggc cacacaactc atggcccttc
4861 ttggcgaggc ctcactacat ggtccccagt tttacaagaa agttagcaag atggtcatca
4921 atgagattaa gagtggtggt ctggagttct atgtgcccag acaagaggcc atgttcaggt
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgaaggtg
5041 tgaatgaaga tggcgtcgaa tgacgctacc ccatctgatg atggtgcagc cggcctcgta
5101 ccagagatca acagtgaggt tatggctctt gaacccgtcg ctggggcctc tcttgcagcc
5161 cctgtagtcg gtcaacaaaa tattattgat ccctggatta gaaataactt tgtacaagcc
5221 cctgctggtg aatttacagt ttcccctaga aactctcctg gagaacttct tcttgatttg
5281 gaattgggtc ctgaacttaa tccctatctt gcacatctgt ctaggatgta caatgggcat
5341 gcaggaggaa tggaagtgca gatagtactg gctgggaatg cgttcacagc tggtaagatt
5401 ctatttgctg ccatcccgcc tagcttcccc tatgaaaatt tgtcacccgc tcaattgact
5461 atgtgccccc atgtgatagt ggatgtgaga caattagaac cagtgctcct gccaatgcca
5521 gacataagaa atgttttcta ccattataat cagaacaatg gtcccaagct taggcttgta
5581 gctatgcttt atacccctct gagggctaac aactcaggtg atgacgtgtt cacggtgtct
5641 tgccgggttt tgacacgccc ttctccagat tttcagttca cttttctggt cccacctaca
5701 gttgagtcta aaactaagaa cttcaccctt cctgttctca gggtctcaga gatgacaaac
5761 tcaaggttcc ccgtcgtttt ggaccaaatg tacacaagca ggaatgaaaa catcattgtc
5821 caaccccaaa acggcaggtg tacgactgac ggtgagctac ttggcactac catcttacag
5881 tctgtgtcca tttgcaactt taaagggaca atgcaggcaa agctgaatga ggagccacga
5941 taccagctac aaatcaccaa cttggatgga tcacctatag atccaacaga tgatatgcct
6001 gctcctcttg gcacaccaga tttccaggcc atgttatatg gcgttgcaag ccaacgctct
6061 tccagtgaca atgccaccag ggcacatgat gcacagattg acactgcggg tgacacattc
6121 gccccgaaaa ttggccaggt tcggtttaaa tcaagctcta gtgattttga cctacatgac
6181 cctacaaaat tcacacctat tggagtcaat gtggatgacc agcacccttt cagacagtgg
6241 tccctgccaa actacggtgg gcaccttgcc ctgaacaatc acttagcccc agctgtgaca
6301 ccactcttcc ctggagagca gattttgttc tttaggtcat acatcccaag cgccggaggc
6361 cacacagacg gtgctatgga ctgcctgctg ccccaagagt ggatcgagca cttctatcag
6421 gaagcggctc cttcccaatc tgacatcgca ctggtaaggt tcattaaccc tgacacagga
6481 agagtgctct ttgaagctaa attgcacaaa caaggtttcc tcacaattgc agcatctggg
6541 gatcacccta ttgtgatgcc cactaatggt tatttcagat ttgaagcttg ggtcaacccc
6601 ttctatactc tcgcccccgt gggaactggg tctgggcgca ggaggattca ataatggctg
6661 gagctttcct cgcaggcttg gcaggtgacg ttgtgacttc cagcttgggc tcacttgtgg
6721 gcgctggagc caacgccatt aatcagaaag tggagtatga cttcaacaga cagctccagg
6781 aggcatcttt tagacatgat aaggatatgc tcaaagccca ggttgcagca accgcaggcc
6841 ttcaacaagc catgatagac atcaagcggg aggcattgac cgcaggcggc ttttcccccg
6901 cagatgctgc aagaggtgca gtcaaagcgc ctatgacaca gatccttgat tggaatggtt
6961 ccaggtattg ggctcctaac tctatgaaga caactggcta ttcaggtaca tttgtctccc
7021 aaggcattag aaattcccct catctgtcta atcaaactcc aagtgctgtt aaacctatta
7081 aacctttgct atctatatct agttcttcta gtgtatatag ttctccttct actgccccct
7141 cacaatcaac acaatcaaca acgctgtctg cagggacagg gtcctccaga cctaacactg
7201 tgtccacaaa gacctccaca ctgtcgagga caagtgactg ggtcagaggc caaaatgaga
7261 tgcttggccc gttcatgagt ggtgcactcc aaactgctta tgtcacgcca ccatcgagca
7321 gagcctcatc acaagggacg gtctcgaccg tgcccaaggc tgttttggac tcctggactc
7381 ccatgtttaa tacccacagg cagcctctct tcgcccattt gcgtaggcga ggggagtcac
7441 agatttagtg aaaaggat
//