Typing tool
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Typing tool
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Complete norovirus genomes
| MW305645 | GII.2 | |
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| GII.P16 |
ORF1: 1..5068
ORF2: 5049..6677
ORF3: 6677..7456
LOCUS MW305645 7497 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg15734 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305645
VERSION MW305645.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7497)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7497)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7497
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg15734"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2017"
/note="genotype: GII.2[GII.P16]"
gene <1..5068
/gene="ORF1"
CDS <1..5068
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ59271.1"
/translation="VACNNNNDKEKSSGEGLFTNVSFTLKKALGARPKQPAPRDKPQK
PPRPPTPELVKRIPPPPPNGEKEEEPVIRYEVKSGISGLPELTTVPQPDVANTAFSVP
PLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAAISMARVELTPL
SLYWRVVYTPQYLISPETLRRLNGEAFPYTAFDNNCYAFCCWVLDLNDSWLSRRMVQR
TTGFFRPYQEWNRKPLPTMDDSKIKKVANIFLCSLSTLFTRPIKDLIGKIKPLNILNI
LATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELA
MVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRLSTKSASPDIVG
TINALLARIAAARSLVHRAKEELSSRMRPVVVMISGKPGIGKTHLAREVARKVASTLT
GDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELADTCPLTLNCDRI
ENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQP
DMWKDAFKQDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMD
EFELQGPTITTFNFDRNRITAFRQLAAENKYGLVDTMKVGNQLKGVKTMEELKQAIRN
VTIKRCQIIYAGSTYDLESDGKGKVLVEKVKNTSVQTNNELAGALHHLKHARIRYYVK
CVQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNESDTKEEAPKSEDDEFII
SSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTKKQRKEERATLGLVTGSEIRKRNPD
DFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSPSLFITSTHVIP
AGITEAFGVPTKQIQIHKSGEFCRFRFPKPIRPDVTGMILEEGAPEGTVATVLIKRPT
GELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGDCGCPYIYKRGN
DYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILGPGGAPKLSTKT
KFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPSVLE
AAKQTIINVLEQTLDPPQKWTYAQACASLDKTTSSGHPHHVRKNEFWNGETFTGKLAD
QASKANLMFEEGKHMTPVYTAALKDELVKTEKIYGKIKKRLLWGSDLSTMIRCARSFG
GLMDEMKAHCISLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVLASA
LEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTKLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLKEYGLKPTRPDK
TEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPNETMIP
HSQRPIQLMALLGEASLHGPSFYSKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPNFVNEDGVE"
mat_peptide <1..964
/gene="ORF1"
/product="p48"
mat_peptide 965..2062
/gene="ORF1"
/product="NTPase"
mat_peptide 2063..2593
/gene="ORF1"
/product="p22"
mat_peptide 2594..2992
/gene="ORF1"
/product="VPg"
mat_peptide 2993..3535
/gene="ORF1"
/product="Pro"
mat_peptide 3536..5065
/gene="ORF1"
/product="RdRp"
gene 5049..6677
/gene="ORF2"
CDS 5049..6677
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59272.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
VISQRDKHNSPGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6677..7456
/gene="ORF3"
CDS 6677..7456
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59273.1"
/translation="MAGAFVAGLAGDVLSNGLSSLVNAGANVINQRAEFDFNQKLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLIAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPNSMRTTSYSGKFTSTTPVRQADFQHTQSRPSSGSSVSSFATQSSRPTLTTTT
GSSHGTASSNSTRSTSLSQSTVSRATSRTGEWVREQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGESQA"
ORIGIN
1 cgttgcttgc aacaacaaca acgacaaaga aaaatcttca ggtgaaggct tattcacaaa
61 tgtgtctttc accttaaaga aagccctcgg ggctaggccc aaacagcctg ccccgagaga
121 caaaccacaa aagcccccaa gaccaccaac tcccgagttg gtcaagagga taccccctcc
181 tccacctaat ggcgaaaaag aagaagaacc agtcattagg tatgaggtta agagtgggat
241 ctctggcctg cccgagctca caacagtccc ccaaccggac gtggccaaca cagcattcag
301 tgtcccacca ctgagcttga gagaaaacag ggaggctaag gaaccgctga caggggcaat
361 attagagatg tgggatggag agatatacca ctatggcctg tacgtggaga aaggcttagt
421 gttgggtgtg cacaaaccac ctgcagccat aagcatggca agagtggagc tgacgccgtt
481 gtcattgtac tggcgtgtgg tgtacactcc ccaatacctc atctcccctg aaactctcag
541 gaggctcaac ggagaggcat tcccttacac cgcctttgac aacaactgct atgccttttg
601 ctgctgggtg ttagacctca atgactcatg gcttagcagg aggatggtac aaagaacaac
661 gggcttcttc agaccttacc aagagtggaa cagaaaaccc ctgcctacca tggatgactc
721 caaaattaag aaggtagcaa atatattcct atgttcattg tccacactat tcaccagacc
781 cataaaagac ctcataggaa aaattaaacc attaaacata ttgaatatcc tggcaacgtg
841 tgactggact tttgccggaa tagtggagtc tctgatatta cttgctgaac tcttcggagt
901 tttctggaca cccccagatg tgtctgctat gatcgctccc ttactcgggg actacgagtt
961 gcaagggcca gaagacctcg ccgttgaact cgtacctgtg gtaatggggg ggattggttt
1021 ggtgttggga ttcaccaaag agaaaattgg caaaatgttg tcctcagcag catcaacact
1081 cagggcttgc aaagatcttg gtgcctatgg cttagagata ctcaaattgg tcatgaagtg
1141 gttcttccca aagaaagagg aggccaatga gctagccatg gtgagggcca tagaggatgc
1201 tgtactagac cttgaggcaa tagaaaataa ccacatgaca accctgttga aagacaaaga
1261 cagcttagca acatacatga aaacactgga catggaggag gagaaagcca ggaggttgtc
1321 cacaaaatct gcatcccctg acatagttgg gacaatcaac gccctgctgg ctcgaatagc
1381 agcggccagg tcattagtcc acagggccaa ggaagagcta tctagcagga tgaggccagt
1441 agttgttatg atatctggca aaccaggaat aggcaaaact catctggcca gggaggtggc
1501 aagaaaggtg gcatccactc tcacagggga tcaaagagtc ggactcatac cacgaaacgg
1561 tgtggaccat tgggatgcat acaagggtga gagagtcgtg ctgtgggacg actatggcat
1621 gagtaacccc attcatgatg ctcttcgcat acaagaattg gctgatacgt gtccccttac
1681 cttaaattgt gacagaattg aaaataaggg aaaagttttt gacagtgaag tcataataat
1741 tacaacaaac ctcgccaatc cagccccact tgattatgtc aactttgagg cctgctccag
1801 gagaattgat ttcctggtgt acgctgaggc accagaagta gaaaaggcaa aacgggactt
1861 tcctggtcag ccagatatgt ggaaggacgc cttcaagcag gacttttcac acatcaagct
1921 acagcttgca ccccagggcg gctttgacaa gaatggcaac accccacacg ggaaaggagt
1981 gatgaagacc ctcactaccg gttctctgat tgcccgtgca tcaggcctac tacatgagag
2041 gatggatgaa tttgaactcc aaggtcccac aatcaccacc ttcaatttcg accggaacag
2101 aatcacggca ttcagacaac tggctgcaga aaacaagtat ggattggtgg ataccatgaa
2161 agttggcaac caattaaaag gagtgaaaac catggaagaa ctcaaacaag caatcaggaa
2221 tgtgaccatc aagaggtgcc agatcatcta cgctggttcc acgtatgacc ttgaatctga
2281 tggcaagggc aaagttttgg tggaaaaggt caagaacacc tctgtacaga ccaacaacga
2341 gttggctggg gccctgcacc atctcaaaca tgcccgaatc aggtactatg tcaaatgtgt
2401 gcaagaagca gtctattcca tcatacaaat tgccggcgct gcgtttgtca ccacgcgcat
2461 tgcacgccgc atgaacatac aagagctctg gtcgaagcca caactagatc aaaatgaatc
2521 agatactaag gaagaggccc ccaagtcaga agatgacgag ttcatcatat cttctaagga
2581 catcaaggag gaaggaaaga agggcaaaaa caaaactggc cgtggcaaga aacacactgc
2641 attctccagc aagggcttga gcgatgagga gtatgacgag tacaagagga taagagaaga
2701 gagaaatggg aaatactcta tagaggagta tcttcaagac agagacaggt actatgagga
2761 gctcgccatt gccaaggcca cggaagaaga cttctgtgaa gaggaggaga tcaaaatccg
2821 tcagagaatc ttccgtccca ccaagaaaca aagaaaggaa gagagggcca cattaggact
2881 agtaacaggt tcagaaatca gaaagagaaa ccctgatgac ttcaaaccca aagggaagct
2941 gtgggccgat gacaacagga gtgttgacta caatgagaaa ctggactttg aggccccccc
3001 aagcatatgg tctaggattg tgagctttgg ttctggatgg ggcttctggg tgtcaccaag
3061 ccttttcata acatcaactc atgtaatccc cgcaggcata acagaagcat ttggagtccc
3121 caccaaacaa attcagatcc acaaatcagg cgaattttgc cgattcagat tcccaaaacc
3181 aattaggcca gatgtgacag gaatgatctt ggaagaaggt gcgcctgagg gcaccgtggc
3241 aacagtgctc atcaaacgcc ccaccggaga gctcatgcct cttgcagcca gaatgggaac
3301 acacgcaacc atgaaaattc aaggccgcat ggttggcgga cagatgggta tgttgctcac
3361 tggatcaaat gctaaaggaa tggacttggg aacaactcct ggtgactgtg gctgtcctta
3421 tatctataaa aggggcaatg actatatagt cattggggtg cacactgcag cagcccgtgg
3481 tggaaacact gtcatctgtg ccacacaggg aagtgagggt gaggcaactc ttgagggtgg
3541 agatgacaaa ggaacatact gtggggcacc cattctaggc cctgggggtg caccaaaatt
3601 gagcaccaaa accaaatttt ggaggtcatc gaacacgccc cttccaccag ggacatatga
3661 gcctgcctac ctcggtggcc gtgatccgcg tgttaagggt gggccttccc tgcagcaggt
3721 aatgagagat cagttgaagc cattcactga acccaggggc aaacctccaa gaccaagtgt
3781 attggaagca gccaaacaaa ccatcatcaa tgtcctcgaa caaaccctgg accctccaca
3841 aaaatggaca tacgcacagg cgtgtgcctc acttgacaaa accacctcca gtgggcaccc
3901 ccatcacgtc cgaaagaatg aattctggaa tggtgagacc ttcactggta aactggcaga
3961 ccaagcatca aaagcaaatc taatgtttga ggaagggaaa cacatgacac cagtgtacac
4021 agcagcactc aaggacgagc tagtcaagac tgagaaaatc tatggaaaga tcaagaagag
4081 actgctctgg ggctctgact tgtccaccat gatccggtgc gctaggtcat ttggtgggct
4141 catggacgag atgaaggcac actgcatatc acttccagtc cgagttggca tgaatatgaa
4201 tgaagatggc ccaataatat tcgagaaaca ttccagatac aaatatcact atgatgcaga
4261 ctactctcgt tgggattcaa cacaacagag ggcagtacta gcatcagcct tggaaatcat
4321 ggtcagattc tctgcagaac cacaattggc acaaatagtc gctgaggatc tgctggctcc
4381 tagtgtagta gatgtaggag actttaaaat tacaataaat gaagggctcc cttctggtgt
4441 gccatgcact tctcaatgga actccatcgc acactggctg ctaactctct gtgccttgtc
4501 tgaagtcacc aaactatccc ctgacattat acaggcaaat tccatgttct cattttacgg
4561 tgatgacgag attgtcagca ccgatataaa attggaccct gaacagttaa ccgccaaatt
4621 gaaggagtac ggcctgaaac caacccgccc agacaaaacc gagggacccc tgattatcag
4681 tgaagatttg aacggtctca ctttcctccg aaggacggtg actcgtgacc cagctggctg
4741 gtttggaaaa ctggaccaaa gctcaatttt gaggcagatg tactggacta gaggaccaaa
4801 tcatgaagac cccaatgaga caatgatacc ccattctcaa agacccatac agctcatggc
4861 actgcttggt gaagcctctc ttcacgggcc ctctttctac agtaaaatca gtaaattggt
4921 cataactgaa ctcaaagaag gtgggatgga cttttacgtg ccaaggcagg aacccatgtt
4981 caggtggatg aggttttctg acttgagcac gtgggagggc gatcgcaatc tggctcccaa
5041 ttttgtgaat gaagatggcg tcgaatgacg ccgctccatc tactgatggt gcagccggcc
5101 tcgtgccaga aagtaacaat gaggtcatgg ctcttgaacc cgtggctggt gccgccttgg
5161 cagccccggt caccggtcaa acaaatatta tagacccttg gattagagca aattttgtcc
5221 aggcccccaa tggtgaattt acagtctctc cccgaaatgc ccctggtgaa gtgctactaa
5281 atctggagtt gggtccagaa ttaaatcctt atctggcaca tttagcaaga atgtacaatg
5341 ggtatgccgg tgggatggag gtgcaggtca tgttggctgg gaacgcgttc acagccggca
5401 agttggtctt cgccgccgtg ccaccccact tcccggttga aaaccttagc ccacagcaaa
5461 tcaccatgtt ccctcatgtg atcatagatg tgagaacctt ggaacctgtt ttattaccac
5521 tccctgatgt taggaataat ttcttccatt ataatcagaa agatgatccc aagatgagaa
5581 tcgtggctat gctttacacc cccctcaggt ctaatggttc aggtgatgat gtgtttacag
5641 tctcctgtag ggtgttgact agaccttccc ctgactttga cttcacatac ctggtgccac
5701 caacagtgga gtctaaaaca aagccattca ccctcccaat cctcacactt ggggaacttt
5761 ccaattctag gttcccagtg tctatagacc agatgtacac cagccctaat gaagttatat
5821 cagtacagtg tcaaaatggt aggtgcacac tggacgggga gctccaaggg acaacacaac
5881 tccaggtcag tggcatttgt gctttcaaag gtgaagtgac cgcccacttg catgacaatg
5941 atcacctata caatgttacc atcacaaact tgaatgggtc cccttttgat ccctccgagg
6001 atatccctgc ccctctgggt gtgcctgact tccagggaag ggtttttggt gtcatctccc
6061 aaagagacaa acacaatagt cccgggcaca atgaaccagc aaacagggga cacgacgctg
6121 tggtccctac ttacacagca cagtatactc caaaactggg acaaattcaa attggcacat
6181 ggcaaactga cgaccttaca gtcaaccaac cagtcaaatt caccccagtt ggactcaatg
6241 acaccgaaca ttttaaccaa tgggtggtcc ctaggtatgc tggtgcccta aacctcaata
6301 caaaccttgc cccttctgtt gctccagtat ttccaggaga gcgcttactc ttctttagat
6361 catatattcc cctcaagggt ggttatggaa acccagccat tgattgccta ctaccacaag
6421 agtgggtgca acacttctat caggaagcag ccccttcaat gagtgaggtg gccctcgtca
6481 gatacatcaa cccggacact ggtcgggcac tgtttgaggc caagctccac agagctggtt
6541 tcatgacagt ctcgagcaac accagtgccc cggtggttgt gcctgccaat ggatacttca
6601 gatttgattc ttgggtgaac caattttatt ctctcgcccc catgggaact gggaatgggc
6661 gtagaagggt tcaataatgg ctggagcttt tgtagctggt cttgcagggg atgtgctcag
6721 caatgggctt agttcattag ttaatgcagg tgctaatgta ataaatcaga gggcagaatt
6781 tgattttaat cagaaattgc agcaaaattc ttttaatcat gataaggaga tgttgcaggc
6841 tcagattcag gcaactaagc agctgcaggc agacatgatg gctataaaac aaggggtctt
6901 gatcgctggc ggcttttccc ctgctgatgc agccagaggt gctgtgaacg cgcccatgac
6961 acaggcgctg gattggaatg gcacaaggta ttgggcacca aactccatga ggaccacatc
7021 ttattctgga aaattcacat cgaccacccc agtgaggcag gctgacttcc agcacaccca
7081 aagccggcct tcgagtggct cctctgtgtc ttcctttgcc acccagtctt caaggccaac
7141 tctgaccaca accactggtt cctcacatgg cacagcctca tcaaattcaa ctcgcagcac
7201 aagcctctcc caatcaacgg tctccagagc cacatctagg actggtgagt gggttagaga
7261 acaaaataga aatttggaac cctacatgca tggtgcctta cagacagcct ttgtcacccc
7321 gccttccagc agggcatctg acgggacagt ctcaaccgtc ccgaaaggtg ttttggactc
7381 ctggacacct gcgtttaaca cccgcaggca gccgcttttt gcacacctcc gtaagagggg
7441 ggagtcacaa gcttagtgaa aaggtgaaaa tttatttagg atgaattgat tttacct
//