Typing tool
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Typing tool
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Complete norovirus genomes
| MW305643 | GII.2 | |
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| GII.P16 |
ORF1: 1..5069
ORF2: 5050..6678
ORF3: 6678..7457
LOCUS MW305643 7498 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg15468 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305643
VERSION MW305643.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7498)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7498)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7498
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg15468"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2017"
/note="genotype: GII.2[GII.P16]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59265.1"
/translation="VACNNNNDKEKSSGEGLFTNMSSTLKKALGARPKQPAPRDKPQK
PPRPPTPELVKRIPPPPPNDEEEEEPVIRYEVKSGISGLPELTTVPQPDVANTAFSVP
PLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAAVSMARVELTPL
SLYWRVVYTPQYLISPETLRRLNGEAFPYTAFDNNCYAFCCWVLDLNDSWLSRRMVQR
TTGFFRPYQEWNRKPLPTMDDSKIKKVANIFLCSLSTLFTRPIKDLIGKIKPLNILNI
LATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELA
MVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRLSTKSASPDIVG
TINALLARIAAARSLVHRAKEELSSRMRPVVVMISGKPGIGKTHLAREVARKVASTLT
GDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELADTCPLTLNCDRI
ENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPEVEKAKRDFPGQP
DMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERMD
EFELQGPTITTFNFDRNRIIAFRQLAAENKYGLVDTMRVGNQLKGVKTMEELKQAIRN
VTIKRCRIIYGGSTYDLESDGKGKVLVEKVKNTSVQTNNELAGALHHLKHARIRYYVK
CVQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNELETKEEAPKSGDDEFII
SSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLVTGSEIRKRNPD
DFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSPSLFITSTHVIP
AGITEAFGVSIKQIQIHKSGEFCRFRFPKPIRPDVTGMILEEGAPEGTVATVLIKRPT
GELMPLAARMGTHATMKIQGRMVGGQMGILLTGSNAKGMDLGTTPGDCGCPYIYKRGN
DYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILGPGGAPKLSTKT
KFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPSVLE
AAKQTIINVLEQTLDPPQKWTYAQACASLDKTTSSGHPYHVRKNEFWNGETFTGKLAD
QASKANLMFEEGKHMTPVYTAALKDELVKTEKIYGKIKKRLLWGSDLSTMIRCARSFG
GLMDEMKAHCISLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVLAAA
LEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKITINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTKLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLKEYGLKPTRPDK
TEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPNETMIP
HSQRPIQLMALLGEASLHGPSFYSKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPNFVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6678
/gene="ORF2"
CDS 5050..6678
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59266.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
IISQRDKHNSPGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6678..7457
/gene="ORF3"
CDS 6678..7457
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59267.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQKLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLTAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPNSMRTTSYSGKFTSTAPVRQADFQHTQSRPSSGSSVSSFATQSSRPTLTTTT
GSSHGTVSSNSTRSTSLSQSTVSRATSRTGEWVRDQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGESQA"
ORIGIN
1 ccgttgcttg caacaacaac aacgacaaag aaaaatcttc aggtgaaggc ttattcacaa
61 atatgtcttc caccttaaag aaagccctcg gggctaggcc caaacagcct gccccgagag
121 acaaaccaca aaagccccca agaccaccaa ctcccgagtt ggtcaagagg ataccccctc
181 ctccacctaa tgacgaagaa gaagaagaac cagtcattag gtatgaggtt aagagtggga
241 tctctggcct gcccgagctc acaacagtcc cccaaccgga cgtggccaac acagcattca
301 gtgttccacc attgagcttg agagaaaaca gggaggccaa ggaaccgcta acaggggcaa
361 tattagagat gtgggatgga gagatatacc actatggcct gtacgtggag aaaggcttag
421 tgttgggtgt gcacaaacca cctgcagccg taagcatggc aagagtggag ctgacgccgc
481 tgtcattgta ctggcgtgtg gtgtacactc cccaatacct catctcccct gaaactctca
541 ggagactcaa cggagaggca ttcccttaca ccgcctttga caataactgc tatgcctttt
601 gctgctgggt gttagacctc aatgactcat ggcttagcag gaggatggtg caaagaacaa
661 cgggcttctt cagaccttat caagagtgga acagaaaacc cctgcccacc atggatgact
721 ccaaaattaa gaaggtagca aatatattcc tatgttcatt gtccacatta ttcaccagac
781 ccataaaaga cctcatagga aaaattaaac cattaaacat attaaatatc ctggcaacgt
841 gtgactggac ttttgccgga atagtggagt ctctgatatt acttgctgaa ctcttcggag
901 ttttctggac acccccagat gtgtctgcta tgatcgctcc cttactcggg gactacgagt
961 tgcaggggcc agaagacctc gccgttgaac tcgtacctgt ggtaatgggt gggattggtt
1021 tggtgttggg attcaccaaa gagaaaattg gcaaaatgtt gtcctcagca gcatcaacac
1081 tcagggcttg caaagatctt ggtgcctatg gcttagagat actcaaattg gtcatgaagt
1141 ggttcttccc aaagaaagag gaggccaatg agttagccat ggtgagggcc atagaggatg
1201 ctgtactaga tcttgaggca atagaaaata accacatgac aaccctgttg aaagacaaag
1261 acagcttggc aacatacatg aaaacactgg acatggagga ggagaaagcc aggaggttgt
1321 ccacaaaatc tgcatcccct gacatagttg ggacaatcaa cgccctgctg gctcgaatag
1381 cagcggccag gtcattagtc cacagggcca aggaagagct atctagcagg atgagaccag
1441 tagttgttat gatatctggc aaaccaggaa taggcaaaac tcatctggcc agggaggtgg
1501 caagaaaggt ggcgtccact ctcacagggg atcaaagagt cggactcata ccaagaaacg
1561 gtgtggacca ttgggatgca tacaaaggtg agagagtcgt gctgtgggac gactatggca
1621 tgagtaaccc cattcatgat gctcttcgca tacaagaatt ggctgatacg tgtcccctta
1681 ccttaaattg tgacagaatt gaaaacaagg gaaaagtttt tgacagtgag gtcataataa
1741 ttacaacaaa ccttgccaat ccagccccac ttgattatgt taattttgag gcctgttcca
1801 ggagaattga tttcctggtg tacgctgatg caccagaagt agaaaaggca aaacgggact
1861 ttcctggtca gccagatatg tggaaggacg ccttcaagcc ggacttttca cacatcaagc
1921 tacagcttgc accccagggc ggctttgaca agaatggcaa caccccacat gggaaaggag
1981 tgatgaagac cctcactacc ggttctctga ttgcccgtgc atcaggccta ctgcatgaga
2041 ggatggatga atttgaactc caaggtccca caatcaccac cttcaatttc gaccggaaca
2101 gaatcatagc attcagacaa ttggccgcag aaaacaagta tggattggtg gacaccatga
2161 gagttggcaa tcaactaaaa ggagtgaaaa ccatggagga acttaaacaa gcaatcagga
2221 atgtgaccat caagaggtgt cggatcatct acggtggctc cacgtatgac cttgaatctg
2281 atggcaaggg caaagttttg gtggaaaagg tcaagaacac ctctgtacag accaacaacg
2341 agttggctgg ggccctgcac catctcaaac acgcccgaat caggtactat gtcaaatgtg
2401 tgcaagaagc agtctattcc atcatacaaa ttgccggcgc tgcgtttgtc accacgcgca
2461 ttgcacgccg catgaacata caagaactct ggtcgaagcc acaattagat caaaatgaat
2521 tagagactaa ggaagaggcc cccaagtcag gggatgacga gttcatcata tcttctaagg
2581 acatcaagga ggaaggaaag aagggcaaaa acaaaactgg ccgtggcaag aaacacactg
2641 cattctccag caagggcttg agcgatgagg agtatgacga gtacaagagg ataagagaag
2701 agagaaatgg gaagtactcc atagaggagt atcttcaaga cagagacagg tactatgagg
2761 agctcgccat tgccaaagcc acggaagaag acttctgtga agaggaggag atcaaaatcc
2821 gtcagagaat ttttcgtccc accaggaaac aaagaaagga agagagggcc acattagggc
2881 tagtaacagg ttcagaaatc agaaaaagaa accctgatga cttcaaaccc aaagggaagc
2941 tgtgggccga tgacaacagg agtgttgact acaatgagaa actggacttt gaggcccccc
3001 caagcatatg gtctaggatt gtgagctttg gttctggttg gggcttctgg gtgtcaccaa
3061 gccttttcat aacgtcaact catgtaatcc ccgcaggcat aacagaagca tttggagtct
3121 ccatcaaaca aattcagatc cacaaatcag gtgagttttg ccgattcaga ttcccaaaac
3181 caattagacc agatgtgaca gggatgatct tggaagaagg tgcgcctgag ggcaccgtgg
3241 caactgtgct catcaaacgc cccaccggag agctcatgcc tcttgcagcc agaatgggaa
3301 cacacgcaac catgaaaatt caaggccgca tggttggcgg acagatgggt atattgctca
3361 ctggatcaaa tgctaaagga atggatttgg gaacaactcc tggtgactgt ggctgtcctt
3421 acatctataa aaggggcaat gactatatag tcattggggt gcacactgca gcagcccgtg
3481 gtggaaacac cgtcatctgt gctacgcagg gaagtgaggg tgaggcaact cttgagggtg
3541 gagatgacaa aggaacatac tgtggagcgc ccattctagg ccctgggggt gcaccaaaat
3601 tgagcaccaa aaccaaattt tggaggtcgt cgaacacgcc ccttccacca gggacatatg
3661 aacctgccta cctcggtggc cgtgatccgc gtgttaaggg tgggccctcc ctgcagcagg
3721 taatgagaga ccagttgaag ccattcactg aacccagggg caaacctcca cgaccaagtg
3781 tattggaagc ggccaaacaa accatcatca atgtcctcga acaaaccctg gaccctccac
3841 aaaaatggac atacgcacag gcgtgtgcct cacttgacaa gaccacctca agcgggcatc
3901 cctatcacgt ccgaaagaat gaattctgga atggtgagac cttcactggt aaattggcag
3961 accaagcatc aaaagcaaac ctaatgttcg aggaagggaa acacatgaca ccagtgtaca
4021 cagcagcact caaggacgag ctagtcaaga ctgagaaaat ctatggaaag atcaagaaga
4081 gactgctctg gggctctgat ttgtccacca tgatccggtg cgctaggtca tttggtgggc
4141 tcatggacga gatgaaggca cactgcatat cactcccagt ccgagttggc atgaatatga
4201 atgaagatgg cccaataata tttgagaaac attccagata caaatatcac tatgatgcag
4261 actactctcg ttgggattca acacaacaga gggcagtact agcagcagcc ttggaaatta
4321 tggtcagatt ctctgcagaa ccacaattgg cacaaatagt cgctgaggat ctgctggccc
4381 ctagtgtagt agatgtagga gactttaaaa ttacaataaa tgaagggctc ccctctggtg
4441 tgccatgcac ttctcaatgg aactccatcg cacactggct gctaactctt tgtgccttgt
4501 ctgaagtcac caaactgtcc cctgacatta tacaggcaaa ttccatgttc tcattttacg
4561 gcgatgacga gattgtcagc accgacataa aattggaccc tgaacagtta accgccaaat
4621 tgaaggagta cggcctgaaa ccaacccgcc cagacaaaac cgagggaccc ctgattatca
4681 gtgaagattt gaacggactc actttccttc gaaggacagt gactcgtgac ccagctggct
4741 ggtttggaaa actggaccaa agctcaattt tgaggcagat gtactggact agaggaccaa
4801 atcatgaaga ccccaatgag acaatgatac cccattctca aagacccata cagctcatgg
4861 cactacttgg tgaagcctct cttcacggac cctccttcta cagtaaaatc agcaaattgg
4921 tcataactga actcaaagaa ggtgggatgg acttttacgt gccaaggcag gaacccatgt
4981 tcaggtggat gaggttttct gacttgagca cgtgggaggg cgatcgcaat ctggctccca
5041 attttgtgaa tgaagatggc gtcgaatgac gccgctccat ctactgatgg tgcagccggc
5101 ctcgtgccag aaagtaacaa tgaggttatg gctcttgaac ccgtggctgg tgccgccttg
5161 gcagccccgg tcactggtca aacaaatatt atagaccctt ggattagagc aaattttgtc
5221 caggccccca atggtgaatt tacagtctct ccccgtaatg cccctggtga agtgctactg
5281 aatctagagt tgggtccaga attaaatcct tatctggcac atttagcaag aatgtacaat
5341 gggtatgccg gtgggatgga ggtgcaggtc atgttggctg ggaacgcgtt cacagccggc
5401 aagttggtct tcgccgccgt gccacctcac ttcccagttg aaaaccttag cccacagcaa
5461 atcaccatgt ttcctcacgt gatcatagat gtgagaacct tggaacctgt tctgttacca
5521 ctccctgatg ttaggaataa tttcttccat tataatcaga aagatgatcc caagatgaga
5581 attgtggcta tgctttatac ccccctcagg tctaatggtt caggtgatga tgtgtttaca
5641 gtctcctgca gagtgttgac tagaccttcc cctgactttg acttcacata cctggtgcca
5701 ccaacagtgg agtctaaaac aaaaccattc accctcccaa tcctcacact tggggaactt
5761 tccaattcca gattcccagt gtccatagac cagatgtata ccagccctaa tgaagttata
5821 tcagtgcagt gtcaaaatgg taggtgcaca ctggacgggg agctccaggg gacaacacaa
5881 ctccaagtca gtggcatttg tgctttcaaa ggtgaagtga ccgcccactt gcatgacaat
5941 gatcacctat ataatgttac catcacaaac ttgaatgggt ccccttttga tccctccgag
6001 gatatccctg cccctctggg tgtgcctgac ttccagggaa gggtttttgg tatcatctcc
6061 cagagggaca aacacaatag tcctgggcat aatgaaccag caaacagggg gcacgacgct
6121 gtggtcccca cttacacagc acagtacact ccaaaactgg gacaaattca aattggcaca
6181 tggcagactg acgaccttac agtcaaccaa ccagtcaaat tcaccccagt tggactcaat
6241 gacactgaac attttaacca atgggtggtc cccaggtatg ctggtgccct aaacctcaat
6301 acaaaccttg ccccttctgt tgctccagta tttccaggag agcgcctgct cttcttcaga
6361 tcatacattc ccctcaaggg cggttatgga aacccagcca ttgattgcct actaccacaa
6421 gagtgggtgc aacacttcta tcaggaagca gccccttcaa tgagtgaggt ggccctcgtc
6481 agatacatca acccggacac tggtcgggca ctgtttgagg ccaagctcca cagagctggt
6541 ttcatgacag tctcgagcaa caccagtgcc ccggtggttg tgcctgccaa cggatacttc
6601 agatttgatt cttgggtgaa ccaattttat tctctcgccc ccatgggaac tgggaatggg
6661 cgtagaaggg ttcaataatg gctggagctt ttgtagctgg tcttgcaggg gatgtgctca
6721 gcaatgggct tagttcatta attaatgcag gtgctaatgc aataaatcag agggcagaat
6781 ttgattttaa tcagaaattg cagcaaaatt cttttaatca tgataaggag atgttgcagg
6841 ctcagattca ggcaactaag cagctgcagg cagacatgat ggctataaaa caaggggtct
6901 tgaccgctgg cggcttttcc cctgctgatg cagccagagg tgctgtgaac gcgcccatga
6961 cacaagcgct ggattggaat ggtacaaggt attgggcacc aaactccatg aggaccacat
7021 cttattctgg aaaattcaca tcaaccgccc cagtgaggca ggccgacttc cagcacaccc
7081 aaagccggcc ttcgagtggc tcctctgtgt cttcctttgc cactcagtct tcaaggccaa
7141 ctctgaccac aaccactggt tcctcacatg gcacagtctc atcaaattca actcgcagca
7201 caagcctctc ccaatcaacg gtctccagag ctacatctag gactggtgag tgggttagag
7261 atcaaaatag aaatttggaa ccctacatgc atggtgcctt acagacagcc tttgtcaccc
7321 caccttccag cagggcatct gacgggacag tctcaaccgt cccgaaaggt gttttggact
7381 cctggacacc tgcgtttaac acccgcaggc agccgctttt tgcacacctc cgtaagaggg
7441 gggagtcaca agcttagtga aaaggtgaaa atttatttag gatgaattga ttttacct
//