Typing tool
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Typing tool
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Complete norovirus genomes
| MW305638 | GII.6 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6687
ORF3: 6687..7463
LOCUS MW305638 7515 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg14757 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305638
VERSION MW305638.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7515)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7515)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7515
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg14757"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2016"
/note="genotype: GII.6[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59250.1"
/translation="FGSQNSVNDSINTTPSNKEEVGAFSNIKVGFKKMLGAVPKGTKA
PSSDQHCPSVKIGTKTLTVPPEPPNGEDTVQFDAKSETVRGLPDLTTVQNEHENTPYT
VPPLSEREHKPATEPLPGTILEMWDGEFYHYSVYVSGGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLSRRSI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFGIFWTPPDVSSFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGTALKSVKTLEDLKVVL
RDVKFNECEIIYRNSKYRVSSNGKGSVSVDKVEGQTSQTTNEVGAALLRLRQARARYY
VSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQETSESEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLITGSDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
VNELFGVEIKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6687
/gene="ORF2"
CDS 5044..6687
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59251.1"
/translation="MKMASNDAAPSNDGAANLVPEATNEVMALEPVVGASIAAPVVGQ
QNIIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVENISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQENTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAPIDMLYTDPNEAIVVQPQNGRCTLDGTLQGTTQ
LVPTQICSFRGTLISQTSRSADSTDSVPRARNHPLHVQLKNLDGTPYDPTDEVPAVLG
AIDFKGTVFGVASQRNTTGNSIGATRAHEVHIDTTNPRYTPKLGSVLMHSESTDFDDG
QPIRFTPIGMGADDWHQWELPEYSGHLTLNMNLAPAVAPAFPGERILFFRSVVPSAGG
YGSGHIDCLIPQEWVQHFYQEAAPSQSAVALIRYVNPDTGRNIFEAKLHREGFITVAN
SGNNPIVVPPNGYFRFEAWVNQFYTLTPMGTGQGRRRIQ"
gene 6687..7463
/gene="ORF3"
CDS 6687..7463
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59252.1"
/translation="MAGAFLAGLAGDAITSGVGSLINAGANAINQKVEYDFNKQLQLA
SFKHDKEMLQSQVLATKQLQQEMMNIRQGVLSAGGFSPTDAARGAVNAPMTKILDWNG
TRYFAPNSMKTTSYSGQFSSNPVHRQPTLPRSEPPKIKVNSDSASVYSSASTAPSQST
HSTALTAGSSSSRTTSSSAAASTLSRTSDWVRGQNERLSPFMDGALQTTFVTPPSSKA
SSYGSVSTVPKAVLDSWTPMFNTHRQPLFAYVRRRGESQI"
ORIGIN
1 cctttggcag ccaaaactct gtcaatgaca gtatcaacac caccccttct aataaagaag
61 aggttggtgc attctccaac atcaaagttg gttttaagaa aatgctgggt gccgttccca
121 aggggaccaa agcacccagt agtgatcagc actgcccctc agttaagatc gggaccaaga
181 cattaacagt tccccctgag cccccaaatg gtgaagacac cgtacagttt gatgcgaagt
241 cggaaactgt gcgcgggtta ccagacttga caacggtgca gaacgaacac gaaaacacac
301 catacactgt ccccccattg agtgaaaggg agcacaaacc agctactgaa ccgcttcctg
361 gcacaatact ggagatgtgg gatggtgaat tctaccacta ctctgtgtac gtcagcggtg
421 gcaaagcctt aggggttcac aagccccctg cagcgataag cctcgcgacg atagagctca
481 cacccatatc tctttattgg aggcccgttt acacccccaa ctatctggtc tgcccagaca
541 cgttgaaggg ccttgctggt gagaagttcc cctacacggc cttcagcaac aactgctaca
601 acttctgttg ctgggtgctt gagctcaatg acacgtggct tagcaggaga agcatttcta
661 ggaccaccgg cttcttcaaa ccataccagt cttggaatag gaaacccctt ccaaccgttg
721 atgatggaaa gatcaaaaag gtggccaatg caattctctg tgcacttgga tcactgtttt
781 caaagccaat caaggaccta ttgggcaaac ttaaaccatt gaacttgctg cacttgctcg
841 catcatgtga ctggacgttt gcgggtatag tagagacagt catcctaatg gcggaacttt
901 tcggcatctt ttggacgccg ccagatgttt ccagtttcat agcctctctg ataggtgatt
961 ttgaattgca agggccggag gacctggctg tggagcttgt acccgtggtc atgggtggca
1021 taggaatggt ccttggcttt actgctgaga agataggccg catgctatcg tccgctgcat
1081 caacactacg ggcgtgcaaa gacttgggga attatgctct tgacatattg aaactggtta
1141 tgaagtggtt cttcccaaag aaagaggaga aagctgagat ggaaacccta agggcgattg
1201 aggatgctgt cctggacatg gaagctatag gaaataacca tctcacaacc ctcctcaagg
1261 acaaggatag cctcacggct ttcatgaaga ctctagatct agaggaagag aaggcgagga
1321 agctgtccac caaatcatcc tcgccggaca ttgtcggcac cattaatgcc atactggcta
1381 gaatagctgc tgccaggtcc ctcttgcaca aggctaaaga agaaatgttc agcaggatca
1441 gacccgtggt tgtcatgatc tcaggtagac ctggcattgg caaaacccac atggcaagac
1501 atttggctaa gagtatcgcc aacaccatga gcggcgacca gagagtgggg ctcgtcccac
1561 gcaacggggt tgatcattgg gacgcctaca ggggagagag ggtggtttta tgggatgatt
1621 atggcatggg aaaccctgtc aaagatgcct taacactgca agagctggcc gacacctgcc
1681 cagtgactct aaactgtgat aggattgaga acaaggggaa gatgtttgac agtgatgtca
1741 tcataatcac gaccaattta gtcaacccag cgcccctcga ctatgtgaac ttcgaggcgt
1801 gctccagaag ggtcgacttt ctggtctatg cagagtcgcc agaaatcgag aaggttaaga
1861 gagacttccc tggccaacct gacatgtgga aggatcattt caagccagac ttttcccaca
1921 taaaactgac tctagcccca cagggtggat ttgacaagaa tggcaacacc ccgcatggta
1981 agggcaccat gcgatcccta acccaggggt ccctgactgc aagggttgca ggtctcgttc
2041 atgagaggag agacgagttt cagctccagg ggaacgacct tcaaacatat aactttgata
2101 ccaacagagt ctctgcattt aggaagctgg ccgcagacaa caagtatggg atcatggaga
2161 ctatgagagt gggcacagcg cttaagagcg tcaagacctt ggaagatctg aaagttgtac
2221 tgagggatgt gaagttcaat gagtgtgaga taatttacag aaactccaaa taccgagtct
2281 cttccaatgg taaaggttct gtctctgttg acaaagttga gggccaaaca tcccagacca
2341 caaacgaagt gggtgcagca ctccttagac tcagacaggc aagagccagg tactatgtca
2401 gctgcttcca agacctcgtt tacactctaa tacaggtcgc cggagcatca ttcgttgtca
2461 acaggatctc taaaaggttc tgctgggaga gatgggtcaa accaaccgaa acccaggaaa
2521 cgagtgaatc cgaaaaggaa gtggcccaag gcagatggga gattgagccc aaggacacag
2581 agccagaagg taagaagggt aagaataaga aaggaagagg caagaaacac acagctttct
2641 ccagtaaagg cctaagtgat gaggagtatg acgagttcaa gagaatcaga gaagaaagga
2701 acggaaaata ctccattgag gaatacctgc aagaccggga tcgttactat gaggaagtag
2761 cagttgcccg ggcgacagag gaggacttct gtgaagagga ggaggccaag ataagacaaa
2821 gaatctttcg ccccacaaag aaacagagga aggaagaaag gggtgtgctt ggtttgatta
2881 ctggctcaga catcaggaag agaagaccag acgattttca accgaagggc aacctgtggg
2941 cagacgacac caggagtgtg gactacaacg agagacttga tttcgaggcc cccccgagtg
3001 tctggtcaag aatagtccca ttgggcactg gctggggctt ctgggtctca tcaaacctcc
3061 tgatcacaac aacgcacgtc cttcctaagg gggttaatga actctttgga gttgagatca
3121 aacagattca gattcataag tctggagagt tctgcaggtt cagattccca agaccaatta
3181 gaccagatgt cacagggctc gtgttggagg aaggcgctcc agaaggcact gtctgctcca
3241 tactcgtaaa gagacctaca ggtgagatga tccccctggc agtgaggatg ggtacgcatg
3301 catccatgaa gatacagggt aggaccgtcg gtggccagat ggggatgctc ctcacagggg
3361 caaatgcgaa gaacatggat cttggcaccg gtcctggtga ctgcggttgc ccttacatct
3421 acaaacgtgg caatgatata gttgtcgcgg gtgtccacac cgcagcagcc cggggaggca
3481 acactgtcat atgtgccact caagggcaag atggggaagc agtccttgag ggaaatgaga
3541 accttggcac ttactgtggt gctccaatct tgggtccagg caaggcgccc aaacttagca
3601 cgaagaccaa gttctggcgt tcatcaccag acgctttgcc gccaggcact tatgagcccg
3661 cctacttggg gggtaaggac cctagagtgg aaaaaggacc atccctgcaa caagtcatga
3721 gggaccagct aaaacctttc acagaaccca ggggcaagcc acctagacct gcagtcttag
3781 aagaagccaa aaagacagtg atgaatgttc tagagcaaac cattgaccct gctaaaccat
3841 ggacctattc ccaagcatgt gcctcactgg acaagaccac ttccagtggt agtccccatc
3901 atgtcaggaa aaatgaccat tggaatgggg aatccttcac tggccccctc gcagaccaag
3961 catccaaagc caacctcatg tacgagcagg ccaagcatgt gcagcccgtg tacacggccg
4021 cacttaaaga tgaactagtc aaaactgata agatctacaa gaagataaag aaaaggctct
4081 tatgggggtc ggatcttggt acaatgatca ggtgtgccag ggcctttggc ggtctcatgg
4141 atagcatgaa ggcaagctgc atagccctcc catgtagggt aggaatgaat atgaatgaag
4201 atggccccat catatttgac aagcattcta agtataggta ccattatgat gctgactatt
4261 ccaggtggga ctcaacccag caaaggagca tcctctcggc cgctatggaa gtgatggtac
4321 ggttctctgc cgaaccagag ctggcacaag tggttgcaga ggacctcctg gcacccagcc
4381 aactagatgt tggcgatttc gtcatctcag tccaggaagg tctgccatca ggggtcccat
4441 gcacatcaca atggaattca atagcacact ggatcctaac cttgagtgca atggcagaag
4501 tatcgggtct ctcaccagat gttgttcaag cccactcctg tttctcattc tacggtgatg
4561 atgagatagt cagcactgac atcaaccttg accccatgaa gttgacacag aagctcagag
4621 agtatggcct ggtccccacc cgacctgaca aaactgaggg tcccctcgta ataactgaag
4681 atctcaccgg cctaacgttc ctgcgtaggt cgattgcacg ggacccagct gggtggtttg
4741 gaaaattgga ccaagactca atcctcagac agttgtactg gacaaggggc cccaaccatg
4801 agaacccata tgagagtatg gtccctcatt cccagcgggc cacacaactt atggcccttc
4861 tcggtgaggc ttcactgcat ggtcctcagt tttacaagaa agttagcaag atggttatta
4921 atgagatcaa aagtggtggt ctggaattct atgtgcccag acaagaggcc atgttcagat
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgagggtg
5041 tgaatgaaga tggcgtcgaa tgacgctgct ccatcgaatg atggtgctgc caacctcgta
5101 ccagaggcca ccaatgaggt tatggcactt gagccggtgg tgggagcctc aattgctgct
5161 cctgtcgtcg gccaacaaaa tataattgac ccctggatta gagaaaattt tgttcaggca
5221 ccacagggtg agtttactgt atcgccaagg aactcacctg gtgagatgct tttaaatctt
5281 gaattaggcc ctgagcttaa tccttatctg agtcacttgt cccgcatgta taacggctat
5341 gctggtggta tgcaggttca ggtggtccta gctgggaatg cgttcacagc tggtaaaatc
5401 atctttgccg ccgtcccacc acatttccct gttgagaaca ttagtgcagc ccaaatcaca
5461 atgtgtcccc atgtaattgt tgatgtaaga cagcttgagc cagtgctttt gcccctccct
5521 gacataagga atagattctt tcattataat caggaaaata ccccccggat gagacttgtg
5581 gctatgttgt atacacccct tagagcaaat tctggtgagg atgtgtttac ggtgtcttgc
5641 agagttctga cccgccctgc ccccgacttt gagttcacgt ttttggtgcc accaactgtg
5701 gagtcaaaga ctaagccctt tacactccct attctgactc ttggagagct gtccaactcc
5761 agattccccg ctccgataga catgttgtac actgacccca atgaggcaat tgtggtgcaa
5821 ccacaaaatg gcaggtgcac tctagatgga acacttcagg gaaccaccca actggtaccc
5881 acccaaattt gctccttcag gggcacgcta attagccaga cgtcgaggtc tgctgattca
5941 acagattcag tcccacgggc gaggaaccac cctctccacg ttcagctgaa gaacctcgat
6001 gggacaccat atgacccaac agatgaggtg ccagcagttt tgggtgccat agatttcaaa
6061 ggaactgtgt ttggggtcgc tagccaaaga aacaccacag ggaactctat aggagcaacc
6121 cgcgcccatg aagtgcacat agataccaca aaccctagat acaccccaaa gcttggctct
6181 gtgttgatgc attctgaatc tactgatttt gatgatggac aacccatccg ctttaccccc
6241 attggtatgg gagccgatga ttggcaccaa tgggaattgc ccgaatattc tggtcacctt
6301 actcttaaca tgaatttggc ccccgcagtt gcccctgcct tccctggtga gcgcattctc
6361 ttcttcagat cagtggtgcc gtctgctggt ggctatggat caggtcacat agattgcctc
6421 atcccacagg agtgggttca gcatttctac caggaggccg ctccatcaca gtctgcggtg
6481 gctcttatca gatatgtcaa ccctgacact ggaagaaaca tctttgaggc aaaactgcat
6541 agagaagggt tcatcactgt ggcaaattct ggaaacaacc ccatagttgt gcccccaaat
6601 ggttacttca ggtttgaggc ctgggtcaat cagttctaca cactcacccc catgggaact
6661 ggacaggggc gcagaagaat ccaataatgg caggagcttt cctagctgga ttggctggtg
6721 acgccataac gagtggtgtc gggtccctaa tcaatgctgg ggccaacgca attaaccaaa
6781 aggtagaata tgactttaat aaacagctcc aattggcatc ctttaaacat gacaaagaga
6841 tgttgcaatc acaagtactg gccactaaac agctccagca ggagatgatg aacataaggc
6901 aaggggtctt gtccgctggc ggcttttccc ctacagatgc cgcgagaggc gctgtgaacg
6961 cgccgatgac aaaaattttg gattggaatg gaacaaggta ctttgccccg aatagtatga
7021 agacaaccag ttattcgggc cagttttcca gcaaccctgt gcataggcaa cccactttgc
7081 cccgttctga acccccaaaa attaaggtta atagtgattc tgctagtgtg tatagttctg
7141 catctactgc tccttcacaa tcaactcact caacggcttt gactgcgggg tctagctcat
7201 ctaggacaac atcctcttct gcagcagctt ccaccctatc taggactagt gactgggtga
7261 gaggacaaaa tgaaaggctt agcccgttca tggatggtgc tctccaaaca acttttgtca
7321 caccaccatc aagcaaagct tcatcatatg ggtcggtctc aaccgttccc aaagctgttt
7381 tggactcctg gacccctatg ttcaataccc ataggcagcc tctcttcgct tacgtgcgca
7441 ggcgagggga gtcacagatt tagtgaaaag attgattagg ttttctttct ttcttctttt
7501 ccttttcttt ctttt
//