Typing tool

Complete norovirus genomes

MW305627  GII.2
 GII.P2

Length: 7,502 | 3 CDS

ORF1: 1..5069
ORF2: 5050..6678
ORF3: 6678..7457
LOCUS       MW305627                7502 bp    RNA     linear   VRL 06-JUL-2021
DEFINITION  Norovirus GII isolate Arg13737 nonstructural polyprotein (ORF1)
            gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
            cds.
ACCESSION   MW305627
VERSION     MW305627.1
KEYWORDS    .
SOURCE      Norovirus GII
  ORGANISM  Norovirus GII
            Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
            Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE   1  (bases 1 to 7502)
  AUTHORS   Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
            Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
            Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
            Green,K.Y. and Parra,G.I.
  TITLE     Genome-wide analyses of human noroviruses reveal coexistence of
            viral populations evolving under recombination constraints
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7502)
  AUTHORS   Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
            Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
            Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
            Green,K.Y. and Parra,G.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
            Administration, 10903 New Hampshire Avenue, Silver Spring, MD
            20993, USA
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: High-performance Integrated Virtual
                                     Environment (HIVE) v. 2
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..7502
                     /organism="Norovirus GII"
                     /mol_type="genomic RNA"
                     /isolate="Arg13737"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:122929"
                     /country="Argentina"
                     /collection_date="2015"
                     /note="genotype: GII.2[GII.P2]"
     gene            <1..5069
                     /gene="ORF1"
     CDS             <1..5069
                     /gene="ORF1"
                     /codon_start=3
                     /product="nonstructural polyprotein"
                     /protein_id="QPJ59217.1"
                     /translation="AAVNSNNDNTKSSSDGMLNNMAVTLKRALGARPKQPAPREKPPR
                     PPRPPTPELIKRIPPPPPNDGDEPTVMFSTAGGVSGLPELTTVGQPPEASTAFSVPPL
                     SQRENRDAKEPLTGTILEMWDGEIYHYGLYVEKGLVLGVHKPPAAISIAKVELTPLSL
                     YWRPVYTPQYLIPPDTLRKLHGELFPYTAFENNCYAFCCWVLDLNDSWLSRRMISRTT
                     GFFRPYQEWNRKPLPTMDDSKLKKVANIVLCALSSLFTRPIKDIIGKLKPLNILNILA
                     SCDWTFAGIVESLILLAELFDVFWTPPDVSAMIAPLLGDYELQGPEDIAVELVPVVMG
                     GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDEANELAMV
                     RAIEDAVLDLEAIENNHMTTLLKDKNSLAAYMKTLDMEEEKARKLSTKSASPDIVGTI
                     NALLARIAAARSLVHRAKEELSSRPRPVVLMISGKPGIGKTHLARELAKKIASTLTGD
                     QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
                     KGKVFDSDAIIITTNLVNPAPLDYVNFEACSRRIDFLVYADAPEVEKAKRDFPGQPDM
                     WKDAYRSDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTASSLVARASGLLHERLDEY
                     ELQGPPLSTFNFDRNKIAAFRQLAAENKYGLVDTMRVGNQLRNVTTMDELRKAIKNIT
                     IRKCQIVYGGNTYTLESDGKGRVVVERVQNASVQINNEIAGAVHHLRCARIRYYVKCV
                     QEAIYSLLQIAGTVFVTSRIVSRMNIQNLWSRPLTEDADEATTKEGCPKPRDEEEFVV
                     SSEDIKPEGKKGKNKSGRGKKHTAFSSKGLSDEEYEEYKRIREERNGKYSIEEYLQDR
                     DKYYEEVAIARATEEDFCEEEEVKIRQRIFRPTRKQRKEERANLGLVTGSEIRKRNPD
                     DFKPKGKLWADDDRSVDYNERISFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
                     QGITEAFGVPIRQVQIHKSGEFCRLRFPKPIRTDVSGMILEEGAPEGTVATILIKRTT
                     GELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
                     DYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKT
                     KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
                     AAKKTIINVLEQTIDPPQKWTYAQACASLDKTTSSGFPHHVRKNEHWNGESFTGKLAD
                     QASKANLMFEEGKHMTPVYTAALKDELVKTEKVYGKIKKRLLWGSDLATMVRCARSFG
                     GLMDELKAHCVTLPIRVGMNMNEDGPIVFEKHSRYRYHYDADYSRWDSTQQRAVLAAA
                     MEIMVKFSAEPQLAQIVAEDLLSPSVVDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
                     TLCALSEVTDLSPDIVQANSLFSFYGDDEIVSTDIKLDPEKLTGKLREYGLKPTRPDK
                     TEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSVLRQLYWTKGPNHEDPFESMIP
                     HSQRPIQLMSLLGEAALHEPSFYSKISKLVISELKEGGMDFYVPRQEPMFRWMRFSDL
                     STWEGDRNLAPSLVNEDGVE"
     mat_peptide     <1..959
                     /gene="ORF1"
                     /product="p48"
     mat_peptide     960..2057
                     /gene="ORF1"
                     /product="NTPase"
     mat_peptide     2058..2594
                     /gene="ORF1"
                     /product="p22"
     mat_peptide     2595..2993
                     /gene="ORF1"
                     /product="VPg"
     mat_peptide     2994..3536
                     /gene="ORF1"
                     /product="Pro"
     mat_peptide     3537..5066
                     /gene="ORF1"
                     /product="RdRp"
     gene            5050..6678
                     /gene="ORF2"
     CDS             5050..6678
                     /gene="ORF2"
                     /note="major capsid protein"
                     /codon_start=1
                     /product="VP1"
                     /protein_id="QPJ59218.1"
                     /translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
                     TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
                     MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
                     VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
                     TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
                     QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
                     IISQRDKQNSPGHNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFA
                     PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
                     IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSTP
                     VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
     gene            6678..7457
                     /gene="ORF3"
     CDS             6678..7457
                     /gene="ORF3"
                     /note="minor structural protein; small basic protein"
                     /codon_start=1
                     /product="VP2"
                     /protein_id="QPJ59219.1"
                     /translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQKLQQN
                     SFNHDKEMLQAQIQATKQLQADMMAIKQGVLTAGGFSPADAARGAVNAPMTQALDWNG
                     TRYWAPGSMRTTSYSGKFTSTAPVRQADFQHTQNRPSSGSSVSSFVTQSSRPTLTTTT
                     GSSHGTASSNSTRSTSLSQSTVSRATSRTSEWVRDQNRNLEPYMHGALQTAFVTPPSS
                     RASDGTVSTVPKGVLDSWTPAFNTHRQPLFAHLRKRGESQA"
ORIGIN      
        1 tcgctgctgt taacagcaac aacgacaaca caaaatcttc aagtgacgga atgcttaaca
       61 acatggccgt cacccttaaa cgagcccttg gggcccgacc caaacagccg gccccgaggg
      121 aaaaacctcc aagaccccct agaccaccaa caccagaact aattaaaaga atcccccccc
      181 caccacctaa tgatggggat gaaccaaccg tgatgtttag cactgcaggt ggtgtgtctg
      241 gcctacctga gctcacaaca gtcggtcaac cacctgaagc tagcacggcc tttagcgtgc
      301 ctcccctcag ccaaagggaa aacagggacg ctaaggagcc gttaactgga actattctgg
      361 aaatgtggga cggggagatt tatcactatg gactgtatgt ggaaaaaggg cttgtgttag
      421 gcgtgcacaa gccaccggct gccatcagca tagccaaagt ggaattaacg cctctctcac
      481 tgtattggag gcctgtgtac acgcctcagt acctcatacc tccagacacc ttgaggaaac
      541 tccacggtga actattcccc tatacagcct ttgaaaacaa ctgttatgcc ttctgctgtt
      601 gggttttgga ccttaacgat tcatggctaa gcaggaggat gattagtagg actactggct
      661 ttttcaggcc ctaccaagag tggaacagga agcccctccc aaccatggat gactcaaaat
      721 tgaaaaaggt cgcaaacatc gttctatgtg cattgtcatc attgttcact agacccatta
      781 aggatataat tggcaagctt aaacccctca acatcctgaa cattctggcc tcgtgcgact
      841 ggaccttcgc tggcatagtt gagtcactaa tcctcttggc tgaactcttt gatgtgttct
      901 ggacaccccc agacgtgtct gcaatgatcg cacccctcct cggtgactat gagctacaag
      961 gccctgaaga catcgctgtg gagctcgtac ccgttgtgat gggtgggata ggtctggtgc
     1021 tgggattcac caaagagaaa ataggtaaga tgctctcctc tgcagcatca actttgaggg
     1081 catgcaaaga tcttggagcc tatggactgg agatattgaa actagtcatg aaatggttct
     1141 tcccaaagaa ggatgaggcc aacgaactgg ctatggttag agccattgaa gacgctgtat
     1201 tagacctgga ggctattgag aacaaccata tgaccactct attgaaagac aagaacagcc
     1261 ttgcagccta catgaagacc ctggacatgg aagaggaaaa agctaggaag ttatccacca
     1321 aatcagcctc ccctgacatt gtgggcacca taaatgccct gttggctagg atcgctgccg
     1381 cgcgctcctt agttcatagg gccaaggagg agctctccag caggccaagg ccggtcgtct
     1441 tgatgatctc tggcaagcca gggataggaa agacccactt ggccagagaa ctggcaaaga
     1501 aaatcgcctc aacactcaca ggagaccaga gagtgggcct catcccacgg aatggagttg
     1561 accattggga tgcctacaaa ggtgagagag tggtgctctg ggatgattac gggatgagca
     1621 accccatcca cgatgcgctg aggttgcaag aactggcaga cacatgtcca ttgactctaa
     1681 attgtgacag gattgaaaac aaggggaaag tcttcgacag cgatgcgatc ataattacca
     1741 ccaatttggt caatcctgcg ccgctggatt atgtcaactt tgaggcctgc tccagacgta
     1801 tagacttcct tgtgtatgct gatgccccag aagtcgagaa agcgaagcgg gacttccccg
     1861 gccaaccaga catgtggaag gacgcctatc gctctgactt ctcacacatc aaactacaac
     1921 ttgcaccaca aggtgggttt gacaaaaatg gtaacacccc tcatggtaaa ggagtgatga
     1981 agactctcac tgccagctca ctggttgcgc gtgcctctgg tctcttgcac gagaggctag
     2041 atgagtacga attgcaaggt ccacccctct caaccttcaa ctttgaccgc aacaaaattg
     2101 cagcgttcag acaactcgct gctgaaaaca agtatggtct ggtagacacg atgagggtgg
     2161 gtaaccagct cagaaatgtc acgaccatgg atgaactcag gaaggctatc aagaacatca
     2221 caatcagaaa gtgtcagata gtctatggtg gcaacactta cacgcttgag tctgacggca
     2281 agggtagagt tgtggttgag agggtgcaga acgccagcgt gcaaatcaac aatgagatcg
     2341 ctggtgcagt acaccacctt agatgtgcca gaatacggta ttatgttaag tgtgtccaag
     2401 aggctatcta ctcactcctc caaattgctg gcacggtgtt tgtcacttca cgcatcgtaa
     2461 gccgcatgaa catccaaaat ttatggtcca ggccattaac tgaagatgca gatgaggcca
     2521 ccacgaaaga ggggtgccct aaacctaggg atgaagaaga atttgtcgtc tcctcagaag
     2581 atatcaagcc agagggcaag aaaggtaaaa acaagagtgg ccggggcaag aaacacacgg
     2641 cattctcaag caaaggtctc agtgatgagg agtacgaaga gtacaaaagg attagagagg
     2701 agagaaatgg caaatactcc atagaggaat acctacagga cagagacaag tactatgaag
     2761 aggtggccat tgccagggcg actgaagaag acttctgtga agaagaagag gttaagatac
     2821 gtcagaggat cttcaggcca actagaaagc aacgcaagga agaaagagcc aaccttggcc
     2881 tcgtcaccgg atctgagatc aggaagagga acccagatga ctttaaacca aaaggaaagc
     2941 tgtgggccga cgatgatagg agcgtcgact acaacgaaag aatcagcttt gaggccccac
     3001 caagcatttg gtctagaatt gtcaactttg gttctggatg ggggttttgg gtgtcaccta
     3061 gcctcttcat aacatcaaca catgtcatac cccaaggcat aactgaagcc tttggtgtac
     3121 ccataaggca agtgcaaata cacaaatcgg gcgaattctg tcgcctgaga ttcccaaaac
     3181 ccatcaggac agatgtgtca ggtatgatac tggaggaggg agcgcctgaa ggcactgttg
     3241 ccaccatact catcaagaga accactggag aactgatgcc ccttgcagca agaatgggca
     3301 cccacgcgac catgaggata caaggacgca cggtgggcgg ccaaatggga atgctgctca
     3361 ctggatccaa tgcaaagagc atggatcttg gcaccacacc tggtgactgt gggtgtccct
     3421 atatttacaa aaggggcaat gattacatag tcattggagt tcacacagca gctgcccgtg
     3481 gcggaaacac tgttatctgc gccacacaag gtagtgaggg tgaggccaca ctcgagggtg
     3541 gtgacaacaa agggacatac tgtggggcac caatcctagg acccgggagt gccccgaaac
     3601 tgagcactaa gaccaaattc tggaggtcct ctacaacacc actcccaccc ggcacatacg
     3661 agccggcata tctgggagga aaagaccccc gagtcaaagg tgggccatct ctgcaacaag
     3721 tcatgcgaga ccaactgaag ccattcaccg aaccccgtgg taagccacca aaaccaagtg
     3781 tccttgaagc tgccaaaaag acaattatca atgtgctaga gcaaacaata gaccccccac
     3841 agaagtggac gtacgcgcaa gcgtgcgcgt ctcttgacaa aaccacatct agtgggtttc
     3901 cccaccacgt gcgcaaaaac gagcactgga atggggaatc tttcacagga aaattggctg
     3961 atcaggcatc aaaagcaaac ctaatgtttg aagagggaaa gcacatgacc ccagtttaca
     4021 cagctgccct taaggatgag ttggtcaaaa ctgagaaggt gtatgggaag ataaagaaga
     4081 ggttgctttg gggctctgat ctggccacaa tggtgcggtg tgcgcgctct tttggtggtt
     4141 tgatggacga acttaaggcc cactgtgtaa cacttccgat aagggttggc atgaatatga
     4201 atgaagatgg accaatagtc tttgagaaac actccagata caggtatcac tatgatgcag
     4261 actattccag gtgggattca acacagcaga gagccgtcct ggctgcggcc atggagatta
     4321 tggttaaatt ctcagcagaa ccacaactag cccaaatagt tgcagaggat ctactgtcgc
     4381 ctagtgtagt tgatgtgggc gacttcaaaa tttccatcaa cgaagggtta ccatcaggtg
     4441 tcccttgcac ctctcaatgg aactccattg cacactggct cctcaccttg tgtgcccttt
     4501 ctgaagtcac agatctctct cccgatattg tgcaagccaa ctccctcttc tccttctatg
     4561 gtgatgatga aattgtgagt acagacatta aattagaccc agaaaagttg acggggaagt
     4621 tgagagaata cggcctcaaa cccactcggc ctgacaagac tgagggcccc ctgatcatta
     4681 gcgaggatct gaatggcctg accttcttga ggagaaccgt cacccgcgac cctgcaggat
     4741 ggtttggcaa actggaccag agctctgtac tcaggcaatt gtattggacc aagggtccta
     4801 atcatgaaga cccctttgag tcaatgattc cacactccca gaggcccata caactcatgt
     4861 cactcttggg cgaagcagca ctgcatgaac catcgtttta cagcaagatc agcaagcttg
     4921 tgatatctga gttgaaagaa ggtggaatgg atttttacgt gcccaggcaa gaacccatgt
     4981 tcaggtggat gagattctcg gatttgagca cgtgggaggg cgatcgcaat cttgctccca
     5041 gtcttgtgaa tgaagatggc gtcgaatgac gccgctccat ctactgatgg tgcagccggc
     5101 ctcgtgccag aaagtaacaa tgaggtcatg gctcttgaac ccgtggctgg tgccgccttg
     5161 gcagccccag tcaccggtca aacaaatatt atagaccctt ggattagagc aaattttgtc
     5221 caggccccca atggtgaatt tacagtttct ccccgtaatg cccctggtga agtgctactg
     5281 aatctagagt tgggtccaga attaaatcct tatctggcac atttagcaag aatgtataac
     5341 gggtatgccg gtgggatgga ggtgcaggtc atgttggctg ggaacgcgtt cacagccggc
     5401 aagttggtct tcgccgctgt gccacctcac ttcccggttg aaaaccttag cccacagcaa
     5461 attaccatgt tccctcatgt gattatagat gtaaggacct tagaacctgt tttattacca
     5521 cttcctgatg ttaggaacaa tttcttccat tataatcaga aagatgatcc taaaatgaga
     5581 attgtggcta tgctttacac cccccttagg tctaatggtt caggtgatga tgtgttcaca
     5641 gtctcctgca gggtgttgac tagaccctcc cctgattttg atttcacata cctggtgcca
     5701 ccaacagtgg aatctaaaac aaaaccattc actctcccaa tcctcacact tggggaactt
     5761 tccaattcta ggttcccagt gtccatagac cagatgtaca ccagccccaa tgaggttata
     5821 tcagtgcagt gtcaaaatgg taggtgcaca ttggacgggg agcttcaggg gacaacacaa
     5881 ctccaagtca gtggtatttg tgctttcaag ggggaagtga ccgcccattt gcatgacaat
     5941 gaccacctat ataatgtcac catcacaaac ctgaatgggt ccccctttga cccctccgag
     6001 gacatccctg cccctctggg cgtgcctgat ttccagggaa gggtctttgg tatcatctcc
     6061 caaagagata aacagaacag ccctggacac aatgaaccag caaacagagg acacgacgct
     6121 gtggtcccta cttacacagc acagtacacc ccaaaattgg gtcagattca aattggcaca
     6181 tggcagaccg acgacctcac agtcaatcaa ccagtcaaat ttgccccagt cggtctcaat
     6241 gacactgaac attttaacca atgggtggtc cccagatacg ctggtgccct aaacctcaac
     6301 acaaaccttg ccccttctgt tgctccagtg tttccaggag agcgcctgct tttcttcaga
     6361 tcatatattc ctctcaaggg tggttatgga aatccagcca ttgattgcct actaccacaa
     6421 gagtgggtgc aacacttcta tcaggaagct gccccatcaa tgagtgaggt ggcccttgtc
     6481 agatacatca acccggacac tggtcgggca ctgtttgagg ccaagctcca cagagctggt
     6541 ttcatgacag tctcgagcaa caccagtacc ccggtggttg tgcctgccaa tggatacttc
     6601 agatttgact cttgggtgaa tcaattctat tctctcgccc ccatgggaac tggaaatggg
     6661 cgtagaaggg ttcaataatg gctggagctt ttgtagctgg tcttgcaggg gacgtgctca
     6721 gcaatgggct cagttcatta attaatgcag gtgctaatgc aataaatcag agggcagaat
     6781 ttgattttaa tcagaaatta cagcaaaatt cttttaatca tgataaggag atgttgcagg
     6841 ctcagattca agcaactaag cagctgcagg cagacatgat ggctattaaa cagggggttc
     6901 tgaccgctgg cggcttttcc cctgctgatg cagccagagg tgccgtgaat gcgcccatga
     6961 cacaggcgct ggactggaac ggtacaaggt actgggcacc aggctctatg aggaccacat
     7021 cttattctgg gaaattcaca tcaaccgccc cagtgaggca ggccgacttt cagcacaccc
     7081 aaaaccggcc atcgagtggc tcttctgtgt cctcctttgt cactcaatct tcaaggccaa
     7141 ctctgaccac aaccactggg tcctcacatg gcacagcctc atcaaattca actcgcagca
     7201 cgagcctctc ccaatcaacg gtctctagag ctacatctag gactagtgag tgggttagag
     7261 atcaaaatag aaatttggaa ccctacatgc atggtgcctt acagacagcc tttgtcaccc
     7321 caccctccag cagggcgtct gatgggacag tctcaaccgt cccaaagggt gttttggact
     7381 cctggacacc tgcgttcaac acccacaggc agccgctctt tgcacacctc cgtaagaggg
     7441 gggagtcaca agcttagtga aaaggtggaa aatttgttta gaataaattg attttacctt
     7501 tt
//