Typing tool
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Typing tool
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Complete norovirus genomes
| MW305626 | GII.4 Sydney | |
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| GII.P31 |
ORF1: 1..5069
ORF2: 5050..6672
ORF3: 6672..7478
LOCUS MW305626 7515 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate Arg13435 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305626
VERSION MW305626.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7515)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7515)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7515
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg13435"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="2014"
/note="genotype: GII.4[GII.P31]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59214.1"
/translation="AVANSNNDIAKSSSDGVLSNMAVTFKRALGARPKQPPPKETPPR
PPRPPTPELVKKIPPPPPNGEDELVVSYSAKDGVSGLPELTTVRQPEETNTAFSVPPL
NQRESRDAKEPLTGTIIEMWDGEIYHYGLYVERGLILGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLRRLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANIFLCTLSSLFTRPIKDIIGKLKPLNILNILA
TCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPIVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEVNELAMV
RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NSLLARIAAARSLVHRAKEELSSRPRPVVVMISGRPGIGKTHLARELAKKIAASLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDM
WKNAFSPDFSHIKLSLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEY
ELQGPALTTFNFDRNKILAFRQLAAENKYGLMDTMRVGKQLKDVKTMSDLKQALKNIA
IKKCQIVYSGSTYTLEADGKGSVKVDKVQSATVQTNNELAGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIAKRMNIQNLWSKPQVEDTEEMTNKDGCLKPKDDEEFVV
SSDDIKTEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DRYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPE
DFKPKGKLWADDDRSVDYNEKLNFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAKEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPNVLE
AAKKTIINVLEQTIDPPQKWSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKVYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRDVLAAA
LEIMVKFSPEPHLAQVVAEDLLSPSVMDVGDFQISISEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPFETMIP
HSQRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6672
/gene="ORF2"
CDS 5050..6672
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59215.1"
/translation="MKMASSDANPSDGSAASLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNSYAGG
FEVQVILAGNAFTAGKVIFAAVPPNFPTEGLSPSQVTMFPHIVVDVRQLEPVLIPLPD
VRNNFYHYNQSNDPTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSPVNICTFRGDVTHITGSRNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGVL
TQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTDHDFEANQNTKFTPVGVIQDG
STTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLD
CLLPQEWVQYFYQEAAPAQSDVALLRFVNPDTGRVLFECKLYKTGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRAV"
gene 6672..7478
/gene="ORF3"
CDS 6672..7478
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59216.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSEADAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGKANLRDAVPARGSSSKSS
NSSAATSVYSNQTTSTRLGSTAGSGTSVSSLPSTARTRSWVEDQSRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEVLDSWTGAFNTRRQPLFAHIRKRGESRA"
ORIGIN
1 ccgctgttgc caacagcaac aacgacatcg caaaatcttc aagtgacggt gtgctttcta
61 acatggctgt cacttttaag cgggccctcg gggcgcggcc taaacagccg cccccgaagg
121 agacaccacc cagacccccg cgaccaccca caccagaatt ggtcaaaaag atccctcctc
181 ccccacccaa cggggaggat gaactagtgg tctcttacag cgccaaagat ggcgtttccg
241 gactgcctga gctcaccact gtcagacaac cggaagaaac caacacggcg ttcagtgtcc
301 ccccactcaa ccaaagggag agcagggacg ccaaggagcc actaactgga acaataattg
361 aaatgtggga tggagaaatc taccattacg gcttgtacgt ggaacgaggt cttatacttg
421 gtgtgcacaa accaccggca gccatcagcc ttgccaaggt cgagctaaca ccgctctctt
481 tgttctggag acctgtatac accccccagt atctcatctc tccagacact cttaggagat
541 tacatggaga gtcattcccc tatactgcat ttgacaacaa ttgctacgcc ttttgttgtt
601 gggtattaga cctaaacgac tcatggctaa gcagaagaat gattcagaga acaacaggtt
661 tcttcaggcc gtaccaggat tggaacagga aacccctccc cactatggat gattccaaat
721 taaagaaggt agccaacata ttcttgtgca ctttgtcttc actattcacc agacccatta
781 aggacataat agggaagttg aaacctctta acatccttaa cattctggct acatgtgatt
841 ggaccttcgc aggcatagtg gaatctttaa tactcttagc agaactcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgatcg cccccttgct aggtgattat gaactgcaag
961 gacctgagga ccttgcagtg gaactggtcc caatagtgat gggggggata ggtttggtgc
1021 taggatttac caaagagaaa attggaaaga tgttatcatc cgctgcatcc actttaagag
1081 cttgtaaaga ccttggtgca tacggactgg aaatcttaaa attggtcatg aagtggttct
1141 tcccaaagaa agaggaagta aatgaactgg ctatggtgag atccatcgag gatgcagtgc
1201 tagacctcga ggcaattgaa aacaaccaca tgaccaccct actcaaagac aaagacagct
1261 tggcaaccta catgagaacc cttgaccttg aggaggagaa agccagaaaa ctctcaacca
1321 aatctgcttc acccgacatt gtgggcacaa tcaactctct tctggcaaga atcgctgctg
1381 cacgctccct agtgcatcgg gcgaaagaag agctctccag caggccgaga cctgtcgttg
1441 tgatgatatc gggaagacca gggataggga aaactcacct tgccagggag ctggccaaga
1501 agatcgcggc ctcgctcaca ggggaccagc gtgtgggtct catcccacgc aatggtgtcg
1561 atcactggga cgcatacaag ggcgaaagag ttgtcctatg ggacgactat ggaatgagca
1621 accccatcca tgatgccctc aggttgcagg agcttgctga cacttgcccc ctcacgctaa
1681 attgtgacag aattgagaac aaagggaaag tctttgacag tgatgccata attatcacca
1741 ccaatttggc caacccagca ccactggatt atgtcaactt tgaagcgtgc tcgagacgta
1801 ttgacttcct cgtgtacgca gaagcccctg aggtggagaa ggcaaagcgc gacttcccag
1861 gtcaacctga catgtggaag aacgctttca gtcctgactt ctcacacata aaactgtcat
1921 tggctccaca gggtggtttt gacaagaacg gcaacacccc gcatggaaaa ggggtcatga
1981 agaccctcac cactggctcc ctcatcgccc gagcatcagg gttactccat gagaggctag
2041 atgaatatga actgcaaggc ccagccctca ccactttcaa ctttgaccgc aacaagatac
2101 ttgcttttag acagcttgct gctgaaaaca agtatgggct gatggacaca atgagagttg
2161 gaaaacagct caaggatgtc aagaccatgt cagacctcaa acaagcactc aagaacatcg
2221 cgatcaagaa gtgccagata gtgtacagtg gtagcaccta cacacttgag gccgatggca
2281 agggtagtgt gaaagttgac aaagtgcaaa gtgccactgt gcagaccaac aatgaactag
2341 ccggtgccct acaccaccta aggtgcgcta gaatcagata ctatgttaag tgcgtccagg
2401 aggcactgta ttccatcatc caaatcgctg gggctgcatt cgtcaccacg cgcatcgcta
2461 agcgcatgaa tatacagaat ctctggtcca agccacaggt tgaagacaca gaagagatga
2521 ccaacaaaga tggttgccta aaacccaaag atgatgaaga gtttgtcgtc tcatccgacg
2581 acatcaaaac tgagggcaag aaagggaaga acaagtccgg ccgtggcaag aaacacacag
2641 ccttttcaag caaagggctc agtgatgagg agtacgatga gtacaagaga atcagagaag
2701 aaaggaatgg taagtactcc atagaagagt accttcagga cagagacagg tactacgagg
2761 aggtggccat tgccagggca accgaagagg acttctgtga agaagaggag gccaaaatcc
2821 ggcagagaat ttttagacca acaaggaaac aacgcaaaga agagagggcc tctctcggct
2881 tggtcacagg ctctgaaatc aggaagagaa acccagaaga cttcaaaccc aagggaaagc
2941 tgtgggctga tgatgacaga agtgttgact acaatgagaa actcaacttt gaggccccac
3001 caagcatctg gtcgcggata gtcaactttg gttcaggctg gggcttctgg gtctccccca
3061 gtctgtttat aacatcaacc catgtcatac cccaaggtgc aaaagagttc ttcggagtcc
3121 ctatcaagca aatccagata cacaaatcag gtgaattctg ccggttgaga ttcccaaagc
3181 caatcagaac tgatgtgacg ggcatgattc tagaagaagg tgcgcccgag gggaccgtgg
3241 ccacactgct catcaagaga ccaactggag agctcatgcc tctggcagcc agaatgggga
3301 cccatgcaac catgaaaatt caggggcgca cagttggagg gcaaatgggt atgctcctga
3361 caggatccaa cgccaagagt atggacctag gcacaacacc aggcgactgc ggctgcccct
3421 acatctataa gagggggaat gactacgtgg tcataggagt ccatacggcc gctgcccgtg
3481 gaggaaacac tgtcatatgt gccacccagg ggagtgaggg agaagccaca cttgaaggag
3541 gtgacagtaa agggacatac tgtggcgcac caatcttggg cccagggagc gctccgaagc
3601 tcagtaccaa gactaagttt tggagatcat ccacaacacc actcccacct ggcacctacg
3661 aaccagccta cctcggtggc aaagacccca gagtcaaagg tggcccttca ttgcaacaag
3721 ttatgaggga ccagctaaag ccattcacag aacccagagg caaaccacca agaccaaatg
3781 tgttggaagc tgccaagaaa accatcatca atgtccttga gcaaacaatt gatccacccc
3841 aaaaatggtc atttgcgcaa gcttgcgcat cccttgacaa aaccacctcc agcggtcacc
3901 cacatcacat gcggaaaaac gattgttgga atggggagtc cttcacagga aaattggctg
3961 atcaagcctc caaggccaac ctaatgtttg aagagggaaa gaacatgact ccagtctaca
4021 caggtgcact taaagatgag ttggtaaaga ccgataaagt ttatggtaag atcaagaaga
4081 ggcttctgtg gggttcagat ctggcaacca tgatacggtg cgcccgagct tttggaggcc
4141 ttatggatga gctcaaggcg cactgtgtca cacttcctgt cagagttggt atgaacatga
4201 acgaggatgg ccccatcatc tttgagaagc actccagata tagatatcac tatgatgctg
4261 attattcccg gtgggactca acacaacaaa gggatgtgct agcagcagca ctagaaatca
4321 tggttaagtt ctctccagaa ccacacctgg cccaggtagt tgcagaagac ctcctttccc
4381 ctagcgtaat ggatgtgggt gactttcaaa tatcaataag tgagggtctt ccctctgggg
4441 taccctgtac ctcccagtgg aattccatcg cccactggct cctcactctt tgtgcactct
4501 ctgaagtcac gaacctgtcc cctgacatca ttcaggccaa ctcccttttc tccttctatg
4561 gtgatgatga gattgtgagc acagacataa agttggaccc agagaagctg acagcgaaac
4621 tcaaggagta cgggctgaaa ccaacccgcc ccgacaaaac tgaaggaccc cttgttatct
4681 ctgaagacct ggatggcctg acattcctcc ggagaactgt gacccgtgat ccagctggct
4741 ggtttggaaa attggaacaa agttcaattc tcagacaaat gtactggacc aggggtccca
4801 accatgaaga tccatttgaa acaatgatac cacactccca aagacccata caattgatgt
4861 ccttgctggg cgaggctgca ctccacggcc cggcatttta tagcaaaatt agcaaattag
4921 tcattgcaga gttgaaggaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgagtgac gccaacccat ctgatgggtc cgcagccagc
5101 ctcgtcccag aggtcaacaa tgaggttatg gctctggagc ccgttgttgg tgccgccatt
5161 gcggcacctg tagcgggcca acaaaatgta attgacccct ggattagaaa caattttgta
5221 caagcccctg gtggagagtt tacagtatcc cctagaaacg ctccaggtga aatactatgg
5281 agcgcgccct tgggccctga tctaaatccc tacctatccc atttggccag aatgtacaat
5341 agttatgcag gtggttttga agtgcaggta attctcgcgg ggaacgcgtt caccgctggg
5401 aaggtcatat ttgcagcagt cccaccaaat ttcccaactg aaggcttgag ccccagccag
5461 gtcactatgt tcccccatat agtagtagat gttaggcaac tagaacctgt gttgattccc
5521 ttacccgatg ttaggaataa tttctatcat tataatcaat caaatgaccc cactattaag
5581 ttgatagcaa tgttgtatac accacttagg gctaataatg ctggggatga tgtcttcaca
5641 gtttcttgcc gagttctcac gagaccatcc cctgattttg atttcatatt cctagtgcca
5701 cccacagttg agtcaagaac taaaccattc tctgtcccag ttttaactgt tgaggagatg
5761 accaattcaa gattccccat tcctttggaa aagttgttca cgggtcccag cagtgccttt
5821 gttgtccaac cacaaaacgg caggtgcacg actgatggcg tgctcctagg caccacccaa
5881 ctgtctcctg tcaacatctg caccttcaga ggagatgtca cccatatcac aggtagtcgt
5941 aactacacaa tgaatttggc ttctcaaaat tggaacaatt atgacccaac agaagaaatc
6001 ccagcccctc taggaactcc agactttgtg gggaagattc aaggcgtgct cacccaaacc
6061 acaaggacag atggctcaac acgcggccac aaagccacag tgtacactgg gagcgccgac
6121 tttgctccaa aactgggtag agttcaattt gaaactgaca cagaccatga ttttgaagct
6181 aaccaaaaca caaagttcac cccagtcggt gtcatccaag atggtagcac cacccaccga
6241 aatgaacccc aacagtgggt gctcccaagt tactcaggca gaaatactca taatgtgcat
6301 ctggcccccg ctgtagcccc cacttttccg ggtgagcaac ttctcttctt cagatccacc
6361 atgcccggat gcagcgggta ccccaacatg gatttggact gtctgctccc ccaggaatgg
6421 gtgcagtact tctaccaaga ggcagcccca gcacaatctg atgtggctct gctaagattt
6481 gtgaatccag acacaggtag ggttttgttt gagtgtaagc tttataaaac aggctatgtt
6541 acagtggctc acactggtca acatgatttg gtcattcctc ccaatggtta ttttagattt
6601 gattcctggg tcaaccagtt ctacacgctt gcccccatgg gaaatggaac ggggcgtaga
6661 cgtgcagtat aatggctgga gctttctttg ctggattggc atctgatgtc cttggttctg
6721 gacttggttc ccttatcaat gctggggctg gggccatcaa ccaaaaagtt gagtttgaaa
6781 ataacagaaa attgcaacaa gcatccttcc aatttagcag caatctacaa caggcttcct
6841 ttcaacatga caaagagatg ctccaagcac aaattgaggc cactaaaaag ctacaacagg
6901 aaatgatgaa agttaagcag gcaatgctcc tagagggtgg gttctctgag gcagatgcag
6961 cccgcggggc aatcaacgcc cccatgacaa aagctttgga ctggagcggg acaaggtact
7021 gggctcccga tgctaggact acaacataca atgcaggccg tttttccacc cctcaaccat
7081 cgggggcact gccaggaaaa gccaatctta gggatgctgt ccctgctcgg ggttcctcca
7141 gtaaatcttc taactcttct gctgctactt ctgtgtactc aaatcaaact acttcaacga
7201 gacttggttc tacagctggt tctggtacca gtgtctcgag cctcccgtca actgcaagga
7261 ctaggagctg ggttgaggat caaagtagga atttgtcacc tttcatgagg ggggcccaca
7321 acatatcgtt tgtcacccca ccatctagca gatcctctag ccaaggcaca gtctcaaccg
7381 tgcctaaaga ggttttggac tcctggactg gcgctttcaa cacgcgcagg cagccactct
7441 tcgctcacat tcgtaagcga ggggagtcac gggcgtaatg tgaaaagaca aaattgatta
7501 tccttctttt tcttt
//