Typing tool
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Typing tool
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Complete norovirus genomes
| MW305622 | GII.1 | |
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| GII.P33 |
ORF1: 1..5075
ORF2: 5056..6663
ORF3: 6663..7436
LOCUS MW305622 7463 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg12827 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305622
VERSION MW305622.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7463)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7463)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7463
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg12827"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2014"
/note="genotype: GII.1[GII.P33]"
gene <1..5075
/gene="ORF1"
CDS <1..5075
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59202.1"
/translation="AAATSNNDIAKSSSDGVLSSMAVTFKRALGARPKQPPPRETEQK
QKPPRPPTPELIKKIPPPPPNGEDDIVVSYSAKDGVSGLPELSTVRQPAGTNTAFSVP
PLNQRENKDAKEPLPGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPL
SLYWRPVYTPQYLISPETLKKLHGETFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQR
TTGFFRPYQDWNRKPLPTMDDSKLKKVANIVLCALSSLFTRPIKDIIGKLRPLNILSI
LASCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLIMKWFFPKKDEANELA
MVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDLEEEKARKLSTKSASPDIVG
TINSLLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARDLAKKVAATLT
GDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRI
ENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQP
DMWKDAFRSDFSHIKLMLAPQGGFDKNGNTPHGRGVMKTLTSGSLIARASGLLHERLD
EYELQGPTPTTFNFDQNKVFAFRQLAAENKYGLVDTMRVGSQLKNVKTVSELKQALKN
ISIRRCQIVYGGLTYSLESDGKGNVRVEKVQSPAVQTNNELTGALHHLRCARIRYYVK
CVQEALYSIIQIAGAAFVTTRIAKRMNVQNLWSRPQVEDEEETTSKDGCPKPKDEEEF
VISSEDIKAEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQ
DRDKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERVSLGLVTGSEIRKRN
PDDFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHV
IPQGAQEFFGVSIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKR
PTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKR
GNDYVVIGVHTAAARGGNTVICATQGSEGEAVLEGGDNKGTYCGAPILGPGNAPKLST
KTKFWRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSV
LEAAKKTIINVLEQTIDPPQKWTFAQACASLDKTTSSGYPHHVRKNEHWNGESFTGKL
ADQASKANLMFEEGKHMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARA
FGGLMDELKAHCVTLPIRVGMNMNEDGPIIFGKHSRYTYHYDADYSRWDSTQQRAVLA
AALEIMVKFSPEPHLAQIVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHW
LLTLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPERLTAKLKEYGLKPTRP
DKTEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETM
IPHSQRPIQLMSLLGEAALHGPSFYSKISKLVISELKEGGMDFYVPRQEPMFRWMRFS
DLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2600
/gene="ORF1"
/product="p22"
mat_peptide 2601..2999
/gene="ORF1"
/product="VPg"
mat_peptide 3000..3542
/gene="ORF1"
/product="Pro"
mat_peptide 3543..5072
/gene="ORF1"
/product="RdRp"
gene 5056..6663
/gene="ORF2"
CDS 5056..6663
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59203.1"
/translation="MKMASNDAAPSNDGAAGLVPEVNNETMALEPVAGASIAAPLTGQ
NNVIDPWIRMNFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPFLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVFAAIPPHFPLENLSPGQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQQPEPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPILTIGELSNSRFPVPIDELYTSPNEGVVVQPQNGRSTLDGELLGTT
QLVPSNICALRGRINAQVPDDHHQWNLQVTNANGTPFDPTEDVPAPLGTPDFLANIYG
VTSQRNPDNTCRAHDGVLATWSPKFTPKLGSVVLGTWEEHDLDLNQPTRFTPVGLYDT
NHFDQWILPNYSGRLTLNMNLAPSVAPLFPGEQILFFRSHIPLKGGTSNGAIDCLLPQ
EWIQHFYQESAPSPTDVALIRYTNPDTGRVLFEAKLHRQGFITVANSGSRPIVVPPNG
YFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6663..7436
/gene="ORF3"
CDS 6663..7436
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59204.1"
/translation="MAGAFVAGLAGDIITNSIGSLVNAGANAINQKVDFENNKQLQQA
SFNHDKEMLQAQIQATKQLQADMIALRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRYWAPGATKTTAFSGGFTSSPNTRTVDLPRKTSTTPAPTPISRPSSSASTVSTRSTI
VSGTSGLSSLTRSSFNSQPTSSSSRTSEWVRSQNRALEPYMRGALQTAYVTPPSSRAS
SNGTVSTVPKEVLDSWTSAFNTHRQPLFAHLRRRGESQV"
ORIGIN
1 ccgctgctgc taccagcaac aacgacatcg caaaatcttc aagtgacgga gtactaagta
61 gtatggctgt cacttttaaa cgagccctcg gggcccggcc taaacagccg cccccgaggg
121 aaacagaaca aaaacaaaaa cctccacgac cgcccacccc ggagttaatc aaaaagattc
181 cacctccccc gcccaacggg gaggacgata tagtggtatc ctatagtgcc aaagatggtg
241 tctccggtct gcctgagcta tccaccgtca ggcaaccagc tgggacaaac acagcattta
301 gtgtcccccc actcaaccag agggaaaaca aagatgctaa agaaccgctg cctggcacca
361 tcttggaaat gtgggacgga gagatttacc actacggctt gtacgtggag cggggcttgg
421 tgcttggggt gcacaaacca ccagcagcta ttagtcttgc aaaggttgaa ctaacaccac
481 tgtctctgta ctggagacca gtgtacaccc ctcagtacct catatccccg gaaactctca
541 aaaagctaca tggagagaca ttcccttaca cggcctttga caacaactgt tacgcctttt
601 gttgttgggt cttggatcta aatgactctt ggctcagcag gaggatgata cagagaacaa
661 ctggcttctt cagaccctac caggactgga acaggaaacc tctccccacc atggatgatt
721 ccaaattgaa aaaggtggct aatatagtcc tgtgtgcatt gtcatcacta ttcaccaggc
781 ccattaagga cataatagga aaactaaggc ccctaaacat actcagtata ctagcttcct
841 gcgattggac tttcgcagga atagtagaat ccctaattct ccttgcagaa ctcttcggag
901 ttttctggac acccccagat gtgtctgcga tgatcgcccc cttactaggc gactacgaac
961 tacagggacc tgaagacctc gctgtggaac tcgtaccagt agtaatgggg gggataggtt
1021 tggttctagg tttcaccaag gagaagattg gtaagatgct atcgtctgcc gcgtccaccc
1081 tcagagcttg taaagacctt ggagcatatg gattggaaat tctgaagttg atcatgaagt
1141 ggttcttccc gaagaaagat gaggcgaatg aacttgcaat ggtgagatcc attgaggatg
1201 cagtgctaga cctcgaagca attgagaaca atcacatgac caccctactc aaagacaaag
1261 acagcttagc aacctacatg aagactctgg accttgagga ggagaaagct aggaaactct
1321 ccaccaaatc cgcttctcct gatattgtgg gcacaatcaa ttcacttctg gcacggattg
1381 cagctgcccg ttccctagta catcgggcaa aagaagagct ttccagcaga ccaagacccg
1441 ttgttgtcat gatatcagga aaaccaggga tagggaaaac ccaccttgcc agagatttgg
1501 caaagaaagt tgcagccacc ctcacaggag accagagggt gggcctcatc ccacggaatg
1561 gtgtcgatca ctgggatgcg tacaaaggtg agagagtcgt cctttgggat gactatggaa
1621 tgagtaaccc catccacgac gcccttaggc tacaagaact tgctgacact tgccccctaa
1681 cattaaattg tgatagaatt gagaacaaag gaaaggtctt tgacagtgat gccataatta
1741 tcacaactaa tctggctaac ccggcaccac tggactatgt taattttgaa gcatgttcga
1801 ggcgcatcga cttcctagtg tatgctgatg cccccgatgt tgaaaaagca aaacgcgact
1861 tcccagggca gcctgacatg tggaaggatg cttttagatc tgacttctca cacataaaat
1921 tgatgttggc tcctcagggt ggttttgata agaatggcaa caccccacat ggaagaggtg
1981 tcatgaaaac cctcacatct ggctccctca ttgcccgtgc ttcaggactc ctccacgaaa
2041 gactggatga gtacgagtta caagggccaa cacccacaac cttcaatttc gaccaaaaca
2101 aggtgttcgc ctttagacag cttgccgctg aaaataagta cgggctggtg gacaccatga
2161 gagtgggaag ccagctcaag aatgtcaaga ctgtgtcaga gctcaaacag gcacttaaga
2221 acatttcaat tagaaggtgc cagatagtct atggtggtct cacctactca cttgaatctg
2281 atggcaaagg taatgtgagg gttgagaagg tgcaaagtcc agctgtgcag accaacaatg
2341 agctaactgg cgcactacac cacctgaggt gcgctaggat tagatattat gttaagtgtg
2401 tccaggaagc tttgtattcc atcatccaaa ttgctggagc cgcgtttgtc accacgcgca
2461 ttgcaaagcg catgaacgta caaaacctct ggtccagacc acaggtagag gatgaggaag
2521 agaccaccag caaagacggg tgcccaaaac caaaggatga ggaggagttt gtcatctcgt
2581 ctgaagacat caaagctgaa ggtaagaagg gaaagaacaa gtctggccgt ggtaagaaac
2641 acacagcctt ctcgagtaag ggtcttagtg atgaggagta cgatgagtac aagagaatca
2701 gagaagaaag aaatggcaag tactccatag aagaatacct ccaagacaga gacaagtact
2761 atgaggaggt tgccatagcc agggctactg aagaggactt ctgtgaggaa gaagaggcca
2821 agatccggca gaggattttc agaccaacaa ggaaacaacg caaggaggag agggtttcac
2881 tcggactggt cacaggctca gaaatcagga aaaggaaccc ggatgacttc aaacccaaag
2941 gaaagttgtg ggctgatgac gacaggagtg tcgattacaa tgaaaagctc agttttgaag
3001 ctcccccaag catctggtcg agaatagtca actttggatc aggttggggc ttctgggtct
3061 caccaagcct ttttataaca tccacccatg tcatacctca aggggcacaa gagttcttcg
3121 gtgtttccat caaacagatc caaattcata agtcaggtga gttctgccga ctaagattcc
3181 caaagccaat tagaactgat gtgacaggta tgatcctaga ggagggggcc cctgaaggta
3241 ctgtggccac actgctcata aagaggccaa ctggagagct gatgccacta gcggctagaa
3301 tgggcaccca tgcaactatg aagatccaag gccgaactgt cgggggacag atggggatgc
3361 tcctgacagg atccaatgcc aagagcatgg atttgggcac tacaccaggt gactgtggat
3421 gcccatatat ctacaaaaga ggaaatgact acgtggtcat cggggtccac acagctgccg
3481 cccgcggagg gaacactgtt atctgtgcaa ctcaaggaag tgagggcgag gccgttcttg
3541 aaggtggtga caacaaaggc acctattgtg gcgccccaat cctaggtcca ggaaatgccc
3601 ccaaactcag tactaaaacc aaattctgga ggtcttcaac agcaccactc ccacctggca
3661 catatgaacc agcttacctc ggaggtaaag accccagggt gaaaggtggt ccctcattac
3721 aacaagttat gagagaccaa ttgaaaccgt ttacagaacc cagaggtaag ccaccaaagc
3781 ctagtgtatt ggaagcagcc aaaaagacaa tcattaatgt ccttgagcaa actatagatc
3841 caccccaaaa atggacgttc gcacaggcgt gcgcatccct tgataaaaca acctctagtg
3901 gctacccgca ccacgtgcgg aagaatgaac attggaatgg ggaatctttc acagggaagt
3961 tggctgatca ggcttcaaag gctaatttga tgtttgagga aggaaaacac atgacaccag
4021 tctacacagg agctctcaag gatgagttag tcaaaactga caaaatatat ggtaagatca
4081 agaaaaggtt attatggggc tcagatctgg caaccatgat ccgttgcgct cgagcgttcg
4141 gagggttgat ggatgaactc aaggctcact gtgtcacact ccccatcagg gtggggatga
4201 acatgaatga ggatggtccc atcatttttg ggaaacactc taggtacacc taccattatg
4261 atgcagacta ctctcgatgg gactcaacac agcagagggc tgttttagct gcagccctgg
4321 agatcatggt aaagttttcc ccagaaccac acctggctca aattgtcgca gaagatctcc
4381 tatctcccag cgtgatggac gtgggcgatt tcaaaatatc aatcactgaa ggactcccct
4441 ctggggtgcc ttgcacctca caatggaact ccattgctca ttggcttctc acgctctgtg
4501 cgctctctga ggtaacagat ttatctcctg acatcatcca agcaaactca ctcttctctt
4561 tctatggtga tgatgaaatt gtgagcacag acattaaatt agatccagaa aggctaacag
4621 ccaaactaaa agagtatggt ctcaagccaa cccgcccgga caagactgaa gggcctttgg
4681 tcatttctga ggacttagat ggtctgacct tcttgcggag aactgtgacc cgtgatccag
4741 caggttggtt tggaaaattg gaacaaagct caatactaag acagatgtat tggaccaggg
4801 gccccaatca tgaagacccc tctgaaacaa tgataccaca ttcccaacga cccatacagt
4861 tgatgtccct attgggtgaa gctgcattgc atggcccatc gttctacagc aaaatcagca
4921 aattggtcat ctcagagttg aaagaaggtg gcatggactt ttacgtgcca agacaagagc
4981 caatgttccg gtggatgagg ttctcagact tgagcacgtg ggagggcgat cgcaatctgg
5041 ctcccagttt tgtgaatgaa gatggcgtcg aatgacgccg ctccatctaa tgatggtgca
5101 gccggtctcg taccagaggt caacaacgag acgatggcac ttgagccggt ggctggggct
5161 tctatagctg cccctttaac cggccaaaat aatgtgatag acccctggat tagaatgaat
5221 tttgtccaag ctccaaatgg tgaatttaca gtgtcccccc gtaattcccc aggtgaagtg
5281 ttgttgaatt tggaattagg ccctgaatta aatccattcc tggcacacct ttcaagaatg
5341 tataatggtt atgccggtgg ggttgaagtg caggtgctac ttgctgggaa tgcgttcaca
5401 gcaggaaaac tagtgtttgc agcaatcccc ccacattttc ctcttgagaa tctgagtcct
5461 ggtcaaatta caatgttccc tcacgtgatt attgatgtta gaactttaga acctgtcctc
5521 ttgcctttac cagatgttag aaataatttc tttcattaca atcagcagcc tgagccccgt
5581 atgagacttg tggctatgtt gtatactcct cttagatcta atggctctgg tgatgatgtg
5641 ttcacagtct cttgtagggt cctcacccgc ccctctccag actttgattt taattatttg
5701 gttcccccaa ccgtggaatc taaaaccaaa ccatttaccc tgccaatatt gaccattgga
5761 gaattgtcaa attctaggtt cccagtgcca atagatgaat tgtataccag ccccaatgaa
5821 ggagtggttg tgcaacctca aaatggcaga tcaacactcg atggtgaact gcttggtacc
5881 acacaacttg taccatcaaa catctgtgcc ttgcgagggc gcatcaacgc ccaagtgcca
5941 gacgaccacc atcaatggaa cttgcaggtt acaaacgcaa atgggactcc cttcgacccc
6001 actgaagatg tccctgcgcc attgggcacg ccggatttcc tggcaaacat ctacggagtt
6061 actagccaga ggaaccctga caacacttgc cgtgcccatg atggggtttt ggcaacctgg
6121 agccctaaat ttacacccaa gttaggatct gtggttttgg gtacttggga agaacatgat
6181 cttgatctca atcaacctac cagattcaca cctgttggtt tgtatgatac aaaccacttt
6241 gatcagtgga ttctacccaa ctactctgga agattgacct taaacatgaa tttggcgccc
6301 tccgttgctc ccctttttcc aggtgaacaa atactcttct ttaggtccca cataccactt
6361 aaaggaggca cttccaacgg tgccattgac tgtctactcc ctcaggagtg gatccagcat
6421 ttctatcagg aatcagcccc gtcacccaca gatgttgctc tgattaggta caccaaccct
6481 gacacgggcc gtgtcctttt tgaggccaaa ctacatagac agggattcat cacagtagca
6541 aattctggtt ctagacctat tgttgtcccc cctaatggtt attttaggtt tgattcttgg
6601 gttaatcagt tttattctct cgcccccatg ggaactggga atgggcgtag aagggtgcag
6661 taatggctgg agcttttgta gcaggtcttg ctggtgatat aatcaccaat agcattggtt
6721 cacttgtgaa cgctggagcc aatgcaataa accaaaaagt agattttgaa aacaacaaac
6781 aactacagca ggcctctttc aaccatgata aggaaatgtt gcaagctcaa attcaggcca
6841 caaaacaatt acaggctgac atgattgcgc tcagacaagg ggtgttgacc gcaggcggct
6901 tctcccctac tgatgcagca agaggggcgg ttaatgcgcc catgacgcaa gtcttggact
6961 ggaatgggac taggtattgg gcccccggag ccaccaaaac aactgctttc tccggtgggt
7021 tcacaagctc ccccaatacc aggactgttg atttgcctag gaaaacatca accacaccag
7081 cccccacacc tatatctaga cctagttctt ctgcttctac tgtttctacc cgctcaacaa
7141 ttgttagcgg gacttctggc ctttcttctt tgactaggag ctctttcaat tcccagccca
7201 cctcctcttc ttctcggact agcgaatggg tgcgtagtca aaacagggcg ctggagccct
7261 acatgagggg agcgctgcaa actgcttacg tgacgcctcc ctctagtaga gcatccagca
7321 atggcacagt ctcaaccgtg ccaaaagaag ttttggactc ctggacatct gcgttcaaca
7381 cccacagaca accgcttttc gctcatctcc gtcggagagg ggagtcacag gtttagtgaa
7441 aagatgattt ttcttccatt ctt
//