Typing tool
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Typing tool
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Complete norovirus genomes
| MW305614 | GII.6 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6687
ORF3: 6687..7466
LOCUS MW305614 7508 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg10515 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305614
VERSION MW305614.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7508)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7508)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7508
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg10515"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2012"
/note="genotype: GII.6[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59178.1"
/translation="FGSQNSVNDSINTAPSNKEEIGAFSNIKVGFKKILGAVPKGTKA
PSSDQHCPTVKIGTKTLTVPPEPPNGEDAVQFDAKSETVRGLPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSGGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLSRRSI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFNIFWTPPDVSSFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGNDLQTYNFDTNRVSAFRKLAADNRYGIMETMRVGTALKSVKTLEDLKVAL
RDVKFNECEIIYRNSKYRVSSNGKGSVSVDKVEDQTSQTANEVGAALLRLRQARARYY
VSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQETSESEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGSDIRKRRPDDF
QPKGSLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
IKELFGVEIKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSVLVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGSENLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAVLEEA
KKTVMNVLEQIIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6687
/gene="ORF2"
CDS 5044..6687
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59179.1"
/translation="MKMASNDAAPSNDGAANLVPEANNEVMALEPVVGASIAAPVVGQ
QNIIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVENISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQENTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAPIDMLYTDPNEGIVVQPQNGRCTLDGTLQGTTQ
LVPTQICTFRGTLIGQTSRSSDSTDSAPRRRDHPLHVQLKNLDGTQYDPTDEVPAVLG
AIDFKGTVFGVASQRDVSGQQVGATRAHEVHINTTDPRYTPKLGSIIMHSESDDFVTG
QPVRFTPIGMGDNDWHQWELPDYSGRLTLNMNLAPAVAPAFPGERILFFRSIVPSAGG
YGSGQIDCLIPQEWVQHFYQEAAPSQSAVALIRYVNPDTGRNIFEAKLHREGFITVAN
SGNNPIVVPPNGYFRFEAWVNQFYTLTPMGIGQGRRRNQ"
gene 6687..7466
/gene="ORF3"
CDS 6687..7466
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59180.1"
/translation="MASAFLAGLAGDVITNGVGSLINAGANAVNQKVEYDFNKQLQMA
SFKHDKEMLQSQVLATKQLQQEMMNIRQGVLTAGGFSPADAARGAVNAPMTKILDWNG
TRYWAPNSMKTTSYSGQFSSSPVHKSPAPSQHTALPKSRLQNDSASVYSFPSSVSSQS
THSTALSEGTGSSRSISTSTAAPTLSRTSDWVRGQNERLSPFMDGALQTAFVTPPSSK
ASSNGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQV"
ORIGIN
1 cctttggcag ccaaaactct gtcaatgaca gtatcaacac cgccccttct aataaagaag
61 agattggtgc attctccaac atcaaagttg gttttaagaa aatactgggt gccgttccca
121 aggggaccaa agcacccagt agtgatcagc actgccccac agttaagatc gggaccaaaa
181 cattaacagt tccccctgag cccccaaatg gtgaagacgc cgtgcagttt gatgcgaagt
241 cagaaactgt gcgcgggcta ccagacttga caacggtgca gaatgaacac gaaaacacac
301 catacactgt ccccccattg agtgaaaggg aacacaggcc agccactgag ccgcttcctg
361 gcacaatact ggagatgtgg gatggtgaat tctaccatta ctccgtgtac gtcagcggtg
421 gcaaagccct aggggttcac aagccccctg cggcgataag cctcgcgacg atagagctca
481 cacccatatc tctttattgg aggcccgttt acacccccaa ctatctggtt tgtccagaca
541 cgctgaaagg tctcgctggt gagaagttcc cctacacggc cttcagcaac aactgttaca
601 acttctgttg ctgggtgctt gagctcaatg acacgtggct tagcaggaga agcatctcca
661 ggaccaccgg cttctttaaa ccatatcagt cttggaatag gaaacccctc ccaaccgttg
721 atgatggaaa gatcaaaaag gtggccaacg caattctctg cgcacttgga tcactgtttt
781 caaaaccaat caaggaccta ttgggcaaac ttaaaccatt gaatttgctg cacttgctcg
841 catcatgtga ctggacgttt gcgggtatag tggagacagt tatcctaatg gcggaactgt
901 tcaacatctt ttggacaccg ccagatgttt ccagcttcat agcctccctg ataggtgact
961 ttgaattgca agggcctgag gacctggctg tggagcttgt ccccgtggtc atgggtggca
1021 taggaatggt tctcggcttt accgctgaga agataggccg catgctgtcg tccgctgcat
1081 caacgttgcg ggcatgcaaa gacttgggga attatgccct tgacatattg aaactggtta
1141 tgaagtggtt cttcccaaag aaagaagaga aagccgagat ggaaacccta agggcgatcg
1201 aggatgccgt cctggacatg gaagctatag gaaacaacca tctcacaacc ctcctcaagg
1261 acaaggatag tctcacggct ttcatgaaga ctctggatct agaagaggag aaggctagga
1321 agctgtctac caagtcatcc tcgccagaca tcgtcggcac tattaatgcc atactggcca
1381 ggatagctgc tgccaggtcc ctattacaca aggctaaaga agaaatgttt agcaggatca
1441 gacccgtggt cgttatgatt tcgggtagac ctggcattgg caaaacccac atggcaaggc
1501 acttggccaa gagtatcgcc aacaccatga gcggcgacca gagagtaggg ctcgtcccac
1561 gcaacggggt cgatcactgg gacgcctaca ggggagagag ggtggtctta tgggatgatt
1621 atggcatggg aaaccctgtc aaagatgcct taacactgca agagttggct gacacctgcc
1681 cagtaactct aaactgtgat aggattgaga acaaggggaa gatgttcgac agtgatgtca
1741 tcataatcac gaccaacttg gtcaacccag cacccctcga ttatgtaaac ttcgaggcgt
1801 gctccagaag ggtcgacttc ctggtctatg cagagtcgcc agaaattgag aaggttaaga
1861 gagatttccc cggccaacct gacatgtgga aggaccattt taagccagac ttttcccaca
1921 taaaactgac tctagcccca cagggtggat ttgacaagaa tggcaacacc ccgcatggta
1981 agggcaccat gcgatcccta acccaggggt ccctgactgc aagggttgca ggtcttgttc
2041 atgagaggag agacgagttt cagctccagg ggaacgacct tcaaacatac aactttgaca
2101 ccaacagggt ctctgcattc aggaagctgg ccgcagacaa caggtatggg atcatggaga
2161 caatgagagt aggcacggcg cttaagagtg ttaagacctt ggaagatctg aaagttgccc
2221 tgagggatgt gaagtttaat gagtgtgaga taatttacag aaactccaaa taccgagtct
2281 cttccaatgg taaaggttct gtctctgttg acaaagttga ggaccaaaca tcccagactg
2341 caaacgaagt gggtgcagca ctccttagac tcaggcaggc aagagccaga tactatgtca
2401 gctgcttcca agatctcgtc tatactctaa tacaggtcgc cggagcatca ttcgttgtca
2461 acaggatctc taaaaggttc tgctgggaga gatgggtcaa accaaccgag acccaggaaa
2521 cgagtgaatc cgaaaaggaa gtagctcaag gcagatggga gattgaaccc aaggacacgg
2581 aaccagaagg taagaagggc aagaacaaga aaggaagagg caagaaacac acagctttct
2641 ccagcaaagg cctgagtgat gaggagtatg acgagttcaa gagaatcagg gaagaaagga
2701 acggaaaata ctccattgag gaatacctgc aagaccggga tcgctactat gaggaagtgg
2761 cagttgcccg ggcgacagag gaggacttct gtgaagaaga ggaggccaag ataagacaga
2821 gaatctttcg ccccacaaag aagcagagga aggaagaaag gggggtgctt ggtttggtca
2881 ctggctcgga catcaggaaa aggagaccag atgattttca accgaagggc agtctgtggg
2941 cagacgacac caggagtgtg gactacaacg agagacttga tttcgaggct cccccgagtg
3001 tctggtcacg aatagtccca ttgggcactg gctggggctt ctgggtctca tccaatctcc
3061 tgatcacaac aacacacgtc ctgccaaagg ggattaagga actttttgga gttgaaatca
3121 aacagattca aatccataag tctggagagt tctgcaggtt cagattccca agaccaatca
3181 ggccagatgt cacagggctc gtgttggagg aaggtgctcc agaaggcacc gtctgctccg
3241 tgcttgtaaa aagacctaca ggtgagatga ttcccctggc agtgaggatg ggcacgcatg
3301 cgtccatgaa aatacagggt aggaccgtcg gtggccagat ggggatgctc ctcacagggg
3361 caaatgcgaa gaacatggat cttggcaccg gtcctggcga ctgcggttgc ccttacatct
3421 acaaacgcgg caatgatata gttgtcgcgg gtgtccacac cgcagcagcc cggggaggca
3481 acactgttat atgtgccact cagggacaag atggggaggc agtccttgag ggaagtgaga
3541 accttggcac ttactgcggt gccccaattt tgggtccagg caaggcgccc aaacttagca
3601 cgaaaaccaa attctggcgt tcatcaccag acgctttgcc gccaggcact tatgagcctg
3661 cctacttggg aggcaaggac cccagagtgg aaaaaggacc atccctgcag caagtcatga
3721 gggaccagct aaaacctttc acagaaccta ggggcaagcc acctagacct gcagtcttag
3781 aagaagccaa aaagacagtg atgaatgttc tggaacaaat cattgaccct gctaaaccat
3841 ggacctattc ccaagcatgt gcctcactgg acaagaccac ctccagtggt agcccccatc
3901 atgtcaggaa aaatgaccat tggaacgggg aatccttcac tggccccctt gcagaccaag
3961 catccaaagc caacctcatg tacgagcagg ccaaacatgt gcagcccgtg tatacggccg
4021 cactcaaaga tgagctagtc aaaactgaca agatctacaa aaagataaag aaaaggctct
4081 tatgggggtc ggatcttggt acaatgatta ggtgcgccag ggcctttggc ggtctcatgg
4141 acagcatgaa ggcaagttgc atagccctcc catgtagggt aggaatgaac atgaatgaag
4201 atggtcccat tatatttgac aaacactcta agtataggta ccattatgat gctgactatt
4261 ccaggtggga ctcaacccag caaaggagca ttctctcggc cgctatggaa gtgatggtgc
4321 ggttctctgc cgaaccagag ctggcacaag tggttgcaga ggacctcctg gcacccagcc
4381 aactagatgt tggtgacttt gtcatctcag tccaggaggg tttgccatca ggagtcccgt
4441 gcacatcaca atggaattca atagcacatt ggatcctaac cttgagtgcg atggcggaag
4501 tgtcgggtct ctcaccagat gttgttcaag cccactcctg tttctcattc tacggcgatg
4561 acgagatcgt cagcactgac atcaaccttg atcccatgaa gttgacacag aagctcagag
4621 aatatggtct ggtccccact cgacctgaca agactgaggg tccccttgta ataactgaag
4681 atctcaccgg cctgacgttc ctgcgtagat caattgcgag ggacccagct gggtggtttg
4741 gaaaattgga ccaagactca atcctcagac agttgtactg gacaaggggc cctaatcatg
4801 agaacccata tgagagcatg gtccctcatt cccagcgggc cacacagctc atggcccttc
4861 tcggtgaggc ttcactgcat ggtccccagt tttacaagaa ggttagcaag atggtcatca
4921 atgaaatcaa aagtggtggt ctggaattct atgtgcccag acaagaggcc atgttcagat
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgagggtg
5041 tgaatgaaga tggcgtcgaa tgacgctgct ccatcgaatg atggtgctgc caacctcgta
5101 ccagaggcca acaatgaggt tatggcactt gaaccggtgg tgggagcctc aatcgcagct
5161 cctgtcgtcg gccaacaaaa cataattgac ccctggatta gagaaaattt tgtccaagca
5221 ccacagggcg agtttaccgt ttcaccgagg aactcgcctg gtgagatgct attaaatctt
5281 gaattgggcc cagaactcaa cccttatctg agtcacctgt cccgtatgta taatgggtat
5341 gctggtggca tgcaggttca ggtggtccta gctgggaatg cgttcacagc tgggaaaatc
5401 atctttgccg ccgtaccacc acattttccc gtagaaaaca tcagtgcagc ccaaataact
5461 atgtgccccc atgtaattgt tgatgtgaga caacttgaac cagtacttct gccccttcct
5521 gacataagga acaggttctt tcattacaat caggagaaca cccctcggat gagacttgtg
5581 gctatgcttt atacccccct gagggccaac tctggtgaag atgtgtttac tgtttcttgt
5641 agggtcttga cccgtcctgc ccctgatttt gaatttactt tcttggtacc accaactgta
5701 gaatcaaaga ctaaaccttt cacactgccc atattaactc ttggtgagtt atctaattcc
5761 agattcccag ccccaataga tatgttatac actgacccaa atgagggaat tgtggtccaa
5821 ccacaaaatg gtaggtgcac tcttgatggc actctgcaag gcaccacaca actggtcccc
5881 acccaaattt gtactttcag gggcacacta attggccaaa catcaagatc ttcagactca
5941 accgactccg cccctcggag aagggatcac ccactccatg tgcaattgaa gaaccttgat
6001 ggcacgcagt acgacccgac tgatgaagtg ccagcagtcc ttggtgccat tgacttcaag
6061 gggactgtct ttggggtggc cagtcagaga gatgtgtcag ggcaacaagt gggagcaact
6121 cgagctcatg aagtgcatat caacacaacc gatcctaggt atacaccaaa actgggatcc
6181 attatcatgc actcagagtc ggacgacttt gtgactggac agccggtccg tttcacaccc
6241 ataggaatgg gtgacaacga ctggcaccag tgggagctgc ctgactactc tggacgccta
6301 accctgaaca tgaaccttgc cccagcagtc gctcctgctt tcccgggcga gaggattctt
6361 ttcttcaggt caatagtccc gtctgctggt ggctatgggt ctggacaaat agattgcctc
6421 ataccacagg agtgggttca gcatttctac caggaagctg caccatccca atctgccgtg
6481 gcactcatta ggtatgtcaa tcctgacaca ggcagaaaca tctttgaggc taaattgcac
6541 agggaaggtt tcatcaccgt ggcaaattct ggtaacaacc ctattgttgt cccccctaac
6601 gggtatttta ggtttgaggc ttgggtgaat caattttata ctttgacccc catgggaatt
6661 ggtcaggggc gtaggaggaa tcaataatgg ctagtgcttt tcttgcaggt cttgctggcg
6721 acgtcataac aaatggcgtt gggtctttaa taaatgctgg agctaatgca gttaatcaga
6781 aagttgaata tgattttaat aaacagcttc aaatggcatc atttaaacat gataaagaga
6841 tgttacaatc acaagtgctg gcaaccaaac agttgcagca ggagatgatg aacataaggc
6901 agggggtgtt gactgctggc ggcttctccc ccgcggatgc tgctagaggg gcagtcaatg
6961 ccccaatgac aaagattctg gactggaatg gcaccaggta ttgggcaccg aatagcatga
7021 aaaccacaag ttattcagga cagttttcta gcagccctgt tcacaagtcc cctgctcctt
7081 ctcagcatac tgctttgcca aagagtagat tgcaaaatga ttctgctagt gtatatagtt
7141 tcccttcctc tgtctcttca caatcaaccc attcaacagc gctgtcagaa ggaaccgggt
7201 cttccaggtc catctccaca tccacagcgg cccctacctt gtctagaacc agcgactggg
7261 ttaggggaca gaatgagagg ctcagcccgt ttatggatgg tgctctccaa actgcctttg
7321 tcacacctcc atcgagcaaa gcttcttcaa atggtacggt ctcaaccgtt cccaaagctg
7381 ttttggactc ctggacccct atgtttaaca cacataggca gcctctcttc gcccacctac
7441 gtaggcgagg ggagtcacaa gtttagtgaa aagagtgatt aggttttctc cctttctttt
7501 ctcctttt
//