Typing tool
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Typing tool
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Complete norovirus genomes
| MW305613 | GII.6 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6696
ORF3: 6696..7475
LOCUS MW305613 7529 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg10508 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305613
VERSION MW305613.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7529)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7529)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7529
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg10508"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2012"
/note="genotype: GII.6[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59175.1"
/translation="FGSQNSVNDSINTTPSNKEEAGAFSNIKVGFKKMLGAVPKGTKA
PSSDQHCPTVKIGPKTLTVPPEPPNGEDTVQFDAKSETVIGLPDLTTVKNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSGGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLSRRSI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKNIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRIDFLVYAESPEIEKVKRDFPG
QPDMWKDYFKQDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
KDEFQLQGDDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKNVKTLEDLKVAL
RDVKFNECEIIYRNSKYRVSSNGKGSVSVDKVEDHTSQTANEVGSALLRLRQARARYY
VSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQEASEPEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTRKQRKEERGVLGLVTGSDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
VKELFGVEVKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKRVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6696
/gene="ORF2"
CDS 5044..6696
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59176.1"
/translation="MKMASNDAAPSNDGAANLVPEANNEVMALEPVVGASIAAPVVGQ
QNIIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVDNISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQENTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAAIDMLYTDPNESIVVQPQNGRCTLDGTLQGTTQ
LVPTQICAFRGTLISQTARAADSTDSPQRARDHPLHVQVKNLDGTQYDPTDDIPAVLG
AIDFKGTVFGVASQRDVSGTQEQGHYATRAHEAHIDTTDPKYAPKLGTILIKSESTDF
TTNQPIRFTPVGMGDNNWRQWELPDYSGRLTLNMNLAPAVSPSFPGERILFFRSIVPS
AGGFGSGYIDCLIPQEWVQHFYQEAAPSQSAVALVRYVNPDTGRNIFEAKLHREGFLT
VANSGNNPIVVPPNGYFRFEAWVNQFYTLAPMGSGQGRRRAQ"
gene 6696..7475
/gene="ORF3"
CDS 6696..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59177.1"
/translation="MAGAFFAGLAGDVVSNGIGSLINAGANAVNQKVEYDFNKQLQMA
SFKHDKEMLQSQVLATKQLQQEMMNIKQGMLTAGGFSPADAARGAVNAPMTKILDWNG
TRYWAPNSMKTTSYSGQFSSSPVHRSPAPLQHTAPPKSKSQSDSASVYSSPSTVSSQS
THLTVLSAGTGSSRSTPTSTATSTLSRTSDWVRGQNERLSPFMDGALQTTFVTPPSSK
ASSNGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 cctttggcag tcaaaactct gtcaatgaca gtatcaacac caccccttca aacaaagaag
61 aggctggtgc attctccaac atcaaagttg gatttaagaa aatgctgggt gccgtaccta
121 agggcactaa agcacccagc agtgaccagc actgtccaac agttaagatc gggcccaaaa
181 cactaacagt cccccctgaa cccccaaatg gtgaagacac tgtacagttt gatgcaaaat
241 cggaaactgt aattgggcta ccggacttga caacagtgaa aaatgaacat gaaaataccc
301 catacactgt ccctccactg agtgagaggg aacacagacc agccactgag ccgcttcctg
361 gcacaatatt ggagatgtgg gatggtgaat tctaccacta ctccgtgtac gtcagcggcg
421 gcaaagctct gggggttcac aaacctccgg cagctataag cctcgcgaca atagagctca
481 cccccatatc tctatactgg agacctgttt acacccccaa ctacctggtc tgcccagaca
541 cactgaaagg tctcgctggt gaaaagttcc cctacacggc cttcagcaac aattgctaca
601 acttctgctg ctgggtgctt gaactcaatg acacgtggct tagcagaaga agcatttcca
661 gaaccaccgg cttcttcaaa ccgtaccagt cttggaacag gaaacctctc ccaaccgttg
721 atgatggaaa gatcaaaaag gtggccaacg cgatcctttg tgcactcggt tcgctgttct
781 caaaaccaat caaggacctg ctaggcaagc tcaaaccatt gaacttacta catctgctcg
841 cgtcgtgtga ttggacgttt gcaggtatag tggagacagt catcttaatg gcagaactat
901 tcaatgtctt ttggactccg ccagacgtct ctaatttcat agcctccctg ataggtgatt
961 ttgaattgca ggggcctgag gacttggcgg tagagcttgt tcctgtggtc atgggtggta
1021 taggaatggt tctcggcttc acagctgaga agataggtcg catgctgtcg tccgctgcat
1081 caacactgcg ggcgtgtaaa gacttaggga actatgccct tgacatactt aaattggtca
1141 tgaaatggtt cttcccaaag aaagaggaga aagccgagat ggaaaccttg agggcgattg
1201 aggatgccgt cctagatatg gaggccatag gtaacaacca cctcacgacc ctcctcaagg
1261 ataaagacag tctcacggcc ttcatgaaga ccttggacct ggaagaagag aaagcaagga
1321 agctatccac caaatcatcc tcgccggaca tcgtcggcac catcaatgcc atactggcta
1381 ggatagctgc tgctagatcc ctcctgcaca aagccaagga agagatgttc agcaggatca
1441 gaccagtggt tgttatgatc tcaggcagac ctggcattgg caaaacccat atggcgagac
1501 atttggctaa gaacatcgcc aacaccatga gtggtgacca aagagtcggg ctcgttccgc
1561 gcaatggggt tgaccactgg gatgcttaca ggggagagag ggtggtcttg tgggacgatt
1621 atggaatggg gaaccctgtc aaggatgctt taacactgca agagctagct gatacatgcc
1681 cagtcactct aaactgtgac aggatcgaga acaagggaaa aatgttcgac agtgatgtca
1741 tcataatcac gaccaaccta gtcaaccctg cacccctcga ttatgtgaac ttcgaggcgt
1801 gctctagaag aattgatttc ttggtctatg cagagtcacc agaaattgag aaggttaaaa
1861 gagatttccc tggccaacct gacatgtgga aagattattt caaacaagac ttttcccata
1921 taaagctaac cctagccccc caaggcggat ttgacaagaa tggtaacacc ccgcatggta
1981 agggcaccat gcgatccctc acccaggggt ccctgaccgc aagggttgca ggccttgttc
2041 atgagaggaa ggatgagttc cagctacagg gggatgacct ccagacatac aactttgaca
2101 ccaacagggt ctctgcgttc aggaaactgg ctgcagacaa caagtatggg atcatggaaa
2161 caatgagagt gggtgcagcg ctcaaaaatg tcaaaacttt ggaagatctg aaagtcgcct
2221 tgagagatgt aaagttcaat gagtgtgaaa taatttacag gaactctaag taccgggtct
2281 cttccaacgg caagggctct gtttctgttg acaaagttga ggaccacacg tctcagaccg
2341 caaatgaagt gggctcagca ctcctcagac ttagacaagc aagggctaga tactatgtca
2401 gctgcttcca agacctcgtc tacactctca tacaggttgc tggggcgtca ttcgttgtca
2461 acaggatctc caaaaggttc tgttgggaaa ggtgggttaa accaaccgaa acccaagaag
2521 cgagtgagcc cgaaaaggaa gtagctcaag gtagatggga gatagagccc aaagacacag
2581 aaccggaggg caagaagggc aaaaacaaga aagggagagg caagaaacac acagccttct
2641 ccagcaaagg cctaagtgat gaagagtatg atgagttcaa gagaatcaga gaagagagga
2701 acggaaaata ctccattgag gaatacctgc aagaccggga ccgctactat gaagaagtgg
2761 cagttgcccg agcaacagaa gaggactttt gtgaagaaga agaagccaag ataagacaaa
2821 gaatctttcg cccaacaagg aagcaaagaa aggaggaaag gggggtactt ggcttagtca
2881 ctggctcaga catcaggaag aggagaccag atgattttca gccaaaaggc aacctatggg
2941 cagatgacac taggagtgtg gactacaatg agagacttga ctttgaggct ccaccaagcg
3001 tctggtcaag aatagtccca ttgggcactg gttggggctt ctgggtctca tcaaacctcc
3061 tgatcacaac aacacacgtc ctgcccaagg gggtcaagga actctttggg gtcgaagtca
3121 aacaaattca aatccacaag tctggagagt tctgcaggtt taggttccca agaccaatca
3181 ggccagatgt cacaggactc gtgttggagg aaggtgctcc tgagggtact gtctgttcta
3241 tactcgttaa gaggcctaca ggtgagatga tccccttagc agtgaggatg ggcacacatg
3301 catccatgaa aatacagggt aggaccgtcg gtggtcagat gggaatgctt ctcacagggg
3361 caaatgcaaa gaacatggat cttggcaccg gtcctggtga ctgcggttgt ccttacatct
3421 acaagcgtgg caacgacata gttgtcgcag gtgtccacac cgcagcagcc cgggggggca
3481 acactgttat ttgtgccact caaggacaag acggagaggc agtcctcgag ggaaatgaaa
3541 accttggcac ctactgtggt gctccaattc tgggccctgg caaagcgcct aaactcagca
3601 caaaaaccaa attttggcgc tcatcaccag atgccctacc tcctggcaca tatgaacctg
3661 cttatctggg gggcaaggat cccagagttg aaaaggggcc ctccctacag caagttatga
3721 gagaccagct gaaaccattc actgagccca ggggcaaacc acctagacca gcagttttag
3781 aagaggctaa aaagacagtg atgaatgttc tagaacagac cattgaccct gctaaaccat
3841 ggacttactc acaagcatgt gcttcactgg acaagaccac ttctagtgga agcccccacc
3901 atgtcaggaa aaatgaccac tggaatgggg agtcttttac tggtccccta gcagatcaag
3961 catccaaagc caacctcatg tatgaacagg caaaacatgt gcagcccgtg tacacggccg
4021 cgctcaaaga tgagcttgtt aagactgata agatctacaa gaaaataaag aagagacttc
4081 tgtgggggtc agaccttggt acgatgatca ggtgtgctag ggcttttggc ggccttatgg
4141 acagtatgaa agcgagttgt atagcccttc catgcagagt agggatgaac atgaatgagg
4201 atggccccat catatttgac aagcactcca agtataggta ccactatgat gctgactact
4261 ctaggtggga ctcgacccag caaaggagca ttctttccgc cgccatggag gtgatggtga
4321 ggttctctgc tgaaccagaa ttggcacaag tggtcgcaga ggaccttttg gcgcctagcc
4381 agctagatgt tggcgatttt gtcatctcag tccaggaggg cctgccatca ggagtcccat
4441 gtacgtcaca atggaattca atagcgcact ggattctaac tctgagcgca atggcagaag
4501 tgtcaggtct ctcaccagac gttgtccaag cccactcctg tttttcattt tatggcgacg
4561 atgagatcgt cagcactgac atcaaccttg accccatgaa attgacacag aaactcaggg
4621 agtatggtct ggtccccacc cggcctgata agactgaagg ccccctcgtt ataactgaag
4681 acctaaccgg cctgactttc ctgcgtagat cgattgcacg ggatccagct ggatggtttg
4741 gaaaattgga tcaagactca atcctcaggc aattgtactg gacaaggggg cctaatcatg
4801 aaaacccata cgagagcatg gttccccact cccagcgagc tactcagctc atggcccttc
4861 ttggtgaggc ttcattgcat ggtccccagt tttacaagag agtcagcaag atggttatca
4921 atgagattaa gagtggtggt ctggagtttt atgtgcccag acaagaggcc atgtttaggt
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgagggtg
5041 tgaatgaaga tggcgtcgaa tgatgccgct ccatcaaatg atggtgctgc caacctcgta
5101 ccagaggcca acaatgaggt tatggcactt gaaccggtgg tgggagcttc aatcgcagct
5161 cctgttgtcg gtcaacagaa tataattgac ccctggatta gagaaaattt tgttcaagcg
5221 ccacagggcg agtttactgt ttcaccaagg aactcgcccg gtgaaatgct tctaaatctt
5281 gaattgggcc cagaacttaa cccctatttg agtcatttgt cccgcatgta caatgggtat
5341 gctggtggca tgcaggttca ggtggtccta gctgggaatg cgttcacagc tgggaagatc
5401 atctttgccg ctgtgccacc acacttccct gtggataata ttagtgcagc ccagataact
5461 atgtgccccc atgtgattgt tgatgtgaga cagcttgaac cagtgcttct acccctcccc
5521 gacataagga acaggttctt ccattacaac caggaaaaca ccccccggat gagactcgtg
5581 gccatgctct acacgcctct aagggctaat tccggagagg atgtgttcac tgtgtcctgt
5641 agagttctga ctcgccccgc tccagatttt gaatttacat ttttagttcc accaactgtt
5701 gaatcaaaaa caaaaccctt tactctacct attctaacct tgggtgagtt gtctaattcc
5761 cgttttcctg ctgctataga tatgctttac actgatccta atgaatcaat agttgttcag
5821 ccccaaaatg gtagatgcac tcttgacggc acgttgcaag gcacaacaca attggtccca
5881 acacagatct gtgcctttag aggtactctg atcagccaga ctgcgagagc ggccgattca
5941 acagattccc cccagagagc ccgtgatcac ccgttgcacg tccaggtcaa gaacctagat
6001 ggcacgcagt atgacccaac agatgacatc cctgcagtcc ttggggccat tgacttcaaa
6061 ggtacggtgt tcggagtggc aagtcagagg gacgtctctg gaacacaaga acagggccat
6121 tatgccaccc gggctcatga agcacacatt gatacaactg acccaaagta tgcacctaaa
6181 ttaggcacaa ttctcatcaa atctgaatct actgatttca ccactaatca gcccattagg
6241 ttcactccag tgggtatggg tgataacaat tggagacagt gggaattgcc tgactactct
6301 ggtagattga ctctgaatat gaatcttgcc cctgctgttt ccccatcctt ccctggcgaa
6361 cgaatccttt tctttaggtc tatagtacca tcagctggag gcttcgggtc tggctatata
6421 gactgtctca taccccagga atgggtgcaa cacttctacc aggaggcagc accttcacag
6481 tctgctgttg cactggttag gtacgtcaac cccgacactg ggcgtaacat ctttgaggcc
6541 aagttgcaca gagaagggtt cctcaccgtg gccaattctg gaaacaatcc tattgtggtt
6601 ccccctaatg gttattttag atttgaggct tgggttaacc aattctacac acttgccccc
6661 atgggatctg gacaggggcg tagaagagct cagtaatggc tggagccttc ttcgcagggt
6721 tagcaggtga tgtcgtgtcg aacggcatcg gttccctcat caatgcaggt gctaatgcag
6781 tcaatcaaaa ggttgagtat gattttaata agcaacttca gatggcatca tttaaacatg
6841 ataaggagat gttacaatca caggtgttgg caaccaaaca actgcagcag gaaatgatga
6901 acataaagca ggggatgttg accgctggcg gcttttcccc tgcggacgct gctagagggg
6961 ctgttaacgc tccaatgaca aaaatactgg attggaatgg cacaagatat tgggcaccta
7021 atagcatgaa aaccacaagc tattcgggac aattctctag cagccccgtc cacaggtctc
7081 ctgctcccct ccagcacact gccccaccaa aaagtaagtc gcaaagtgat tctgctagtg
7141 tgtatagctc cccttccact gtttcttcac aatcaactca tttaacagtg ttgtctgcag
7201 gaactgggtc ctccagatcc acccccacgt ccacagcaac ctccaccctg tctaggacca
7261 gcgactgggt tagaggacag aatgaaaggc ttagcccgtt tatggatggt gctctccaaa
7321 ctacttttgt cacaccacca tcgagcaaag cttcatcaaa tgggacagtc tcgaccgtgc
7381 ccaaagctgt tttggactcc tggactccta tgttcaacac acataggcag cctctcttcg
7441 cccatttgcg taggcgaggg gagtcacaaa tttagtgaaa agagtgatta ggttttcttt
7501 tccttcttct tcctcctttt ctctctttt
//