Typing tool
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Typing tool
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Complete norovirus genomes
| MW305612 | GII.2 | |
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| GII.P2 |
ORF1: 1..5069
ORF2: 5050..6678
ORF3: 6678..7457
LOCUS MW305612 7501 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg9847 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305612
VERSION MW305612.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7501)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7501)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7501
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg9847"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2012"
/note="genotype: GII.2[GII.P2]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59172.1"
/translation="AAVNSNNDNTKSSSDGMFNNMAVTLKRALGARPKQPAPREKPPR
PPRPPTPELIKRIPPPPPNDGDEPTVMFSTAGGVSGLPELTTVGQPPEANTAFSVPPL
SQRENRDAKEPLTGTILEMWDGEIYHYGLYVEKGLVLGVHKPPAAISIAKVELTPLSL
YWRPVYTPQYLISPDTLRKLHGELFPYTAFENNCYAFCCWVLDLNDSWLSRRMISRTT
GFFRPYQEWNRKPLPTMDDSKLKKVANIVLCALSSLFTRPIKDIIGKLKPLNILNILA
SCDWTFAGIVESLILLAELFDVFWTPPDVSAMIAPLLGDYELQGPEDIAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDEANELAMV
RAIEDAVLDLEAIENNHMTTLLKDKNSLAAYMKTLDMEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVLMISGKPGIGKTHLARELAKKIASTLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLVNPAPLDYVNFEACSRRIDFLVYADAPEVEKAKRDFPGQPDM
WKDAYRSDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTASSLVARASGLLHERLDEY
ELQGPPLSTFNFDRNKIAAFRQLAAENKYGLVDTMRVGNQLRNVTTMDELKKAIKNII
IRKCQIVYGGNTYSLESDGKGRIVVERVQNASVQINNEIAGAVHHLRCARIRYYVKCV
QEAIYSLLQIAGTVFVTSRIVSRMNIQNLWSRPLTEDADEATMKEGCPKPRDEEEFVV
SSDDIKPEGKKGKNKSGRGKKHTAFSSKGLSDEEYEEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEVKIRQRIFRPTRKQRKEERANLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNERISFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGITEAFGVPIRQVQIHKSGEFCRLRFPKPIRTDVSGMILEEGAPEGTVATILIKRTT
GELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGNAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
AAKKTIINVLEQTIDPPQKWTYAQACASLDKTTSSGYPHHVRKNEHWNGESFTGKLAD
QASKANLMFEEGKHMTPVYTAALKDELVKTEKVYGRIKKRLLWGSDLATMVRCARSFG
GLMDELKAHCVTLPIRVGMNMNEDGPIVFEKHSRYRYHYDADYSRWDSTQQRDVLAAA
MEIMVKFSAEPQLAQIVAEDLLSPSVVDVGDFRISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTDLSPDIVQANSLFSFYGDDEIVSTDIKLDPEKLTGKLREYGLKPTRPDK
TEGPLTISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQLYWTKGPNHEDPSESMIP
HSQRPIQLMSLLGEAALHEPSFYSKISKLVISELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSLVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6678
/gene="ORF2"
CDS 5050..6678
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59173.1"
/translation="MKMASNDAAPSTDGAAGLVPESNNEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLHDNDHLYNVTITNLNGSPFDPSEDIPAPLGMPDFQGRVFG
IISQRDKHNSPGYNEPANRGHDAVVPTYTAQYTPKLGQIQIGTWQTDDLTVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYIPLKGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6678..7457
/gene="ORF3"
CDS 6678..7457
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59174.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQKLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLTAGGFSPADAARGAVNAPMTQALDWNG
TRYWAPGSMRTTSYSGKFTSTAPVRQADFHHTQSRPSSGSSVSSFATHSSRPTLTTTT
GSSHGTTSSNSTRSTSLSQSTVSRATSRTGEWVRDQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGESQA"
ORIGIN
1 ccgctgctgt taacagcaac aacgacaaca caaaatcttc aagtgatgga atgtttaaca
61 acatggccgt caccctcaaa cgagcccttg gggcccggcc caaacagccg gccccgaggg
121 aaaaaccccc aagaccccct agaccaccaa caccagaact aatcaaaaga atcccccccc
181 caccacctaa tgatggggat gaaccaaccg tgatgtttag cactgcaggt ggtgtgtctg
241 gcctacctga gctcacaaca gtcggtcaac cacctgaggc taacacggcc tttagcgtgc
301 ctcccctcag ccaaagggaa aacagggacg ctaaggaacc gttaactgga actattctgg
361 aaatgtggga tggggagatt tatcattatg gactgtatgt ggagaaaggg cttgtgttag
421 gcgtgcacaa gccaccggct gccatcagca tagccaaagt ggaattaacg cctctctcac
481 tgtattggag gcctgtgtac acgcctcagt atctcatatc tccagacacc ttgaggaaac
541 tccacggtga actatttccc tacacagcct ttgaaaacaa ctgttatgcc ttctgctgtt
601 gggttttgga ccttaacgat tcatggctaa gcagaaggat gattagtagg actactggct
661 ttttcaggcc ctaccaagag tggaacagga agcccctccc aaccatggat gactcaaaat
721 tgaagaaggt cgcaaacatc gttctatgtg cattgtcatc attgttcact agacccatta
781 aggatataat tggcaagctt aagcccctca acatcctaaa cattctggcc tcatgcgact
841 ggaccttcgc tggcatagta gagtcactaa tcctcttggc tgaactcttt gatgtgttct
901 ggacaccccc agatgtgtct gcaatgatcg cacccctcct cggtgactat gagctacaag
961 gccctgaaga catcgctgtg gagctcgtgc ccgttgtgat gggtgggata ggtctggtgt
1021 tgggattcac caaagagaaa ataggtaaga tgctctcctc tgcagcatca actctgaggg
1081 cgtgcaaaga tcttggagcc tatggactgg agatactgaa actagtcatg aaatggtttt
1141 tcccaaagaa ggatgaggcc aacgaactgg ctatggttag agccattgaa gacgctgttt
1201 tggacctgga ggccattgag aacaaccata tgaccactct attgaaagac aagaacagcc
1261 ttgcagccta catgaagacc ctggacatgg aagaggaaaa agctaggaag ctatccacca
1321 aatcagcttc ccctgacatt gtgggcacca taaacgccct gctggctagg atcgctgccg
1381 cgcgttcctt agttcatagg gccaaagagg agctctccag caggccaagg ccagtcgtct
1441 tgatgatctc tggcaagcca gggataggaa agacccactt ggccagagaa ctggcaaaga
1501 aaatcgcctc gacactcaca ggagaccaga gggtgggcct catcccacgg aatggagttg
1561 accattggga cgcctacaaa ggtgagagag tggtgctctg ggatgactac gggatgagca
1621 accccatcca cgatgcgctg aggttgcagg aactggcaga cacatgtcca ttgactctaa
1681 attgtgacag gattgaaaac aaggggaaag tcttcgacag cgatgcgatc ataattacca
1741 ccaatttggt taatcccgca ccgctggatt atgtcaactt tgaggcctgc tccagacgta
1801 tagacttcct tgtgtatgct gatgccccag aagtcgagaa agcaaagcgg gacttccccg
1861 gccaaccgga catgtggaag gacgcctatc gctctgactt ctcacacatc aaactacaac
1921 ttgcaccaca aggtgggttt gacaaaaatg gtaacacccc acatggtaaa ggagtgatga
1981 agactctcac tgccagctca ctggttgcgc gtgcctctgg tctcttgcac gagagactag
2041 atgagtacga gttacaaggt ccacccctct caaccttcaa ctttgaccgc aacaaaattg
2101 cagcattcag acaactcgcc gctgaaaaca agtatggtct ggtagacacg atgagggtgg
2161 gtaaccagct cagaaatgtc acgaccatgg atgaactcaa gaaggctatc aagaacatca
2221 taatcagaaa gtgccagata gtctatggtg gcaatactta ctcgcttgag tctgacggca
2281 agggtagaat tgtagttgag agggtgcaga acgccagcgt gcaaatcaac aatgagatcg
2341 ctggtgcggt acaccacctc agatgtgcca gaatacggta ctatgttaag tgtgtccaag
2401 aggccatcta ctcactcctc caaattgctg gcacggtgtt tgtcacttca cgcatcgtaa
2461 gccgcatgaa catccaaaat ttatggtcca ggccattaac tgaagacgca gatgaggcca
2521 ccatgaaaga ggggtgccct aaacctaggg atgaagaaga atttgtcgtc tcctcagatg
2581 atatcaagcc agagggcaag aaaggtaaaa acaagagtgg ccggggcaag aaacacacgg
2641 cattctcaag caaaggtctc agtgatgagg agtacgaaga gtacaaaaga atcagagagg
2701 agagaaatgg caagtactcc atagaggaat acctacagga cagagacaaa tactatgaag
2761 aggtggccat tgccagggca actgaagaag acttctgtga agaagaagag gttaagattc
2821 gtcagaggat cttcaggcca acaagaaagc aacgcaagga agaaagagcc aaccttggcc
2881 tcgtcaccgg atctgagatc aggaagagaa acccagatga ctttaaacca aaaggaaagc
2941 tgtgggccga cgatgatagg agcgtcgact acaatgaaag aatcagcttt gaggctccac
3001 caagcatttg gtctagaatt gtcaactttg gttctggatg ggggttttgg gtgtcaccta
3061 gcctcttcat aacatcaaca catgtcatac ctcaaggcat aactgaagcc tttggtgtac
3121 ccataaggca ggtgcaaata cacaaatcgg gcgaattttg tcgcctgaga ttcccaaaac
3181 ccatcaggac agatgtgtca ggtatgatac tggaggaggg agcgcctgaa ggcactgttg
3241 ccaccatact catcaaaaga accactggag agctgatgcc tcttgcagca agaatgggca
3301 cccacgcgac catgaggata caaggacgca cggtgggcgg ccagatggga atgctgctca
3361 ctgggtccaa tgcaaagagc atggatcttg gcaccacgcc tggtgactgc gggtgtccct
3421 acatttacaa aaggggcaat gattacatag tcattggagt tcacacagca gccgctcgtg
3481 gcggaaacac tgtcatctgc gccacacaag gtagtgaggg tgaggccaca ctcgagggtg
3541 gtgacaacaa aggaacatac tgtggggcac caatcctagg acctgggaat gccccgaaac
3601 taagcaccaa aaccaagttc tggaggtcct ctacaacacc actcccaccc ggcacatacg
3661 aaccggcata tctgggggga aaagaccccc gagtcaaagg tggaccgtct ctgcaacaag
3721 tcatgcgaga ccaactgaag ccattcaccg aaccccgtgg taagccacca aaaccaagtg
3781 tccttgaagc tgccaaaaag acaatcatca atgtgctaga gcaaacaata gatcccccac
3841 agaagtggac gtacgcgcag gcgtgcgcgt ctctcgacaa aaccacatct agtgggtatc
3901 cccaccacgt gcgcaaaaac gagcactgga atggggaatc tttcacagga aaattggctg
3961 atcaggcatc aaaagcaaac ctaatgtttg aagaggggaa gcacatgacc ccagtttaca
4021 cagctgccct taaggatgag ttggtcaaaa ctgagaaagt gtatgggagg ataaagaaga
4081 ggttgctttg gggttctgac ctggccacca tggtgcggtg cgcgcgctct tttggcggtt
4141 tgatggacga actcaaggcc cactgtgtga cacttccgat aagggttggc atgaatatga
4201 atgaagatgg accaatagtc tttgagaaac actccagata caggtatcac tatgatgcag
4261 actattccag gtgggattca acacagcaga gagacgttct ggctgcggcc atggagatta
4321 tggttaaatt ctcagcagaa ccacaactag cccaaatagt tgcagaggat ctattgtcgc
4381 ctagtgtagt tgacgtaggc gacttcagaa tttccattaa tgaaggatta ccatcaggtg
4441 tcccttgcac ctctcaatgg aactccatcg cacattggct cctcaccttg tgcgcccttt
4501 ctgaagttac agacctctct cctgacattg tgcaagccaa ctctctcttc tccttctatg
4561 gtgatgatga aattgtgagt acagacatta aattagaccc agaaaaattg acggggaagt
4621 tgagagaata cggcctcaaa cccactcgtc ctgacaaaac tgagggcccc ctgaccatta
4681 gcgaggatct gaacggcctg accttcttga ggagaaccgt cacccgtgac cctgcagggt
4741 ggtttggcaa actggaccaa agctctatac tcaggcaatt gtattggacc aaaggcccta
4801 atcatgaaga cccctctgag tcaatgattc cacactccca gaggcctata caactcatgt
4861 cacttttggg cgaggcagca ctgcatgaac catcgtttta cagcaagatc agcaagcttg
4921 tgatatctga gttgaaagaa ggtggaatgg atttttacgt gcccaggcaa gaacccatgt
4981 tcaggtggat gagattctcg gatttgagca cgtgggaggg cgatcgcaat cttgctccca
5041 gtcttgtgaa tgaagatggc gtcgaatgac gccgctccat ctactgatgg tgcagccggc
5101 ctcgtgccag aaagtaacaa tgaggtcatg gctcttgaac ccgtggctgg tgccgccttg
5161 gcagccccgg tcaccggtca aacaaatatt atagatcctt ggattagagc aaattttgtc
5221 caggccccta atggtgaatt tacagtctct ccccgtaatg cccctggtga agtgctactg
5281 aatctagagt tgggtccaga attaaatcct tatctggcac atttagcaag aatgtacaac
5341 gggtatgccg gtgggatgga ggtgcaggtc atgttggctg ggaacgcgtt cacagccggc
5401 aagttggtct tcgccgctgt accacctcac ttcccggttg aaaaccttag cccacagcaa
5461 atcaccatgt ttcctcatgt gattatagat gtaagaacct tggaacctgt tttattacca
5521 ctccctgatg ttaggaacaa tttcttccat tataatcaga aagatgatcc taaaatgaga
5581 attgtggcta tgctttatac cccccttagg tctaatggtt caggtgatga tgtgtttaca
5641 gtctcctgca gggtgttgac tagaccctcc cctgactttg attttacata tctggtgcca
5701 ccaacagtgg aatctaaaac aaaaccattc actctcccaa tcctcacact tggggaactt
5761 tccaattcta gattcccagt gtccatagac cagatgtaca ccagtcccaa tgaggttata
5821 tcagtgcagt gtcaaaatgg taggtgcaca ttggacgggg agcttcaggg gacaacacaa
5881 ctccaagtca gtggcatttg tgctttcaag ggagaagtga ccgcccattt gcatgacaac
5941 gatcacctat acaatgtcac catcacaaac ctgaatgggt ccccttttga cccctccgag
6001 gacatccctg cccctctggg catgcctgat ttccagggaa gggtctttgg tatcatctcc
6061 caaagagata aacataatag ccctgggtat aatgaaccag caaacagggg acacgacgct
6121 gtggtcccta cttacacagc acagtacacc ccaaaattgg gtcagattca aattggcact
6181 tggcagaccg acgacctcac agtcaatcaa ccagtcaaat tcaccccagt cggactcaat
6241 gacactgaac attttaacca atgggtggtc cccagatacg ctggtgcctt aaacctcaac
6301 acaaaccttg ccccctctgt cgctccagta tttccaggag agcgcctgct tttctttaga
6361 tcatatatcc ctcttaaggg tggttatgga aatccagcca ttgattgcct attaccacaa
6421 gagtgggtgc aacacttcta tcaggaggct gccccatcaa tgagtgaggt ggcccttgtc
6481 agatacatca acccggatac tggtcgagca ctgtttgagg ccaagctcca cagagctggt
6541 ttcatgacag tctcgagcaa caccagtgcc ccggtggttg tgcctgccaa tggatacttc
6601 aggtttgatt cttgggtgaa tcaattctat tctctcgccc ccatgggaac tggaaatggg
6661 cgtagaaggg tacaataatg gctggagctt ttgtagctgg tcttgcaggg gacgtgctca
6721 gcaatgggct cagttcatta attaatgcag gtgctaatgc aataaatcag agggcagaat
6781 ttgattttaa tcagaaatta cagcaaaatt cttttaatca tgataaggag atgttgcagg
6841 ctcagattca ggcaactaag cagctgcagg cagacatgat ggctattaaa cagggggtcc
6901 tgaccgctgg cggcttttcc cctgctgacg cggccagagg cgctgtgaat gcgcccatga
6961 cacaggcgct ggattggaac ggcacaaggt attgggcacc aggctctatg aggaccacat
7021 cttactctgg aaaattcaca tcaaccgccc cagtgaggca ggccgacttc catcacaccc
7081 aaagccggcc atcgagtggc tcttctgtgt cctcctttgc cactcattct tcaaggccaa
7141 ctttgaccac aaccactggg tcctcacatg gcacaacctc atcaaattca actcgtagca
7201 caagcctctc ccaatcaacg gtctctagag ctacatctag gactggtgag tgggttagag
7261 atcaaaatag aaatttggaa ccctacatgc atggtgcctt acagacagcc tttgtcaccc
7321 caccctccag cagggcgtct gacgggacag tctcaaccgt cccaaaaggt gttttggact
7381 cctggacacc tgcgttcaac acccgcaggc agccgctctt tgcacacctc cgtaagaggg
7441 gggagtcaca agcttagtga aaaggtgaaa atttgtttag aataaattga ttttaccttt
7501 t
//