Typing tool
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Typing tool
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Complete norovirus genomes
| MW305609 | GII.17 | |
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| GII.P13 |
ORF1: 1..5078
ORF2: 5059..6684
ORF3: 6684..7463
LOCUS MW305609 7520 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg4521 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305609
VERSION MW305609.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7520)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7520)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7520
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg4521"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2005"
/note="genotype: GII.17[GII.P13]"
gene <1..5078
/gene="ORF1"
CDS <1..5078
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59163.1"
/translation="VAGKNNNNDNAKSSSDGLFSNMSVTFKKALGARPKQPPPGETKQ
ISKPPRPPTPELVKRIPPPPPNGEDEPKVVYKVGEGVSGLPDLTTVTQPDAQCTAYSV
PPLSQREAGDAKEPLPGSILEMWDGEIYHYGLYVERGHVLGVHKPPAAISLAKIELTP
LSLYWRVVYTPQYLIAPDTLKNLNGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQ
RTTGFFRPYQEWNRKPLPTMDEPKIKKVANAVLCALSSLFTRPIKDIIGKLKPMNILN
ILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDFEMQGPEDLAVELVPV
VMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANEL
AMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIV
GTINSLLARIAAARSLVHKAKEELSSRQRPVVVMISGRPGIGKTHLARELAKKVATTL
AGDQRIGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIQDALRLQELADTCPLTLNCDR
IENKGKVFDSDAIIITTNLSNPAPLDYVNFEACSRRIDFLVYADAPDIEKAKRDFPGQ
PDMWKDHYRPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKSLTVGSLIARASGLLHERM
DEFELQGPGLSTFNFDRNKVAAFRQLAAENKYGMLDTLRVGNQLKGVKTMDELKRAIN
NITIKKCQIVYNGCTYTMESDGRGKVLVDKVQNTTVQTNNELSGALHHLRSARIRYYV
KCFQEAIYSLLQIAGAAFVTSRIVRRMNISNLWSKPPAEDNDESEDKGGCPKPRDEDE
FTVDSKDIKVEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYL
QDRDRYYEELAIAKATEEDFCEEEEAKIRQRIFRPTRKQRKEERATLGLVTGSEIRKR
NPDDFKPRGKLWADDDRSVDYNEKISFEAPPSIWSRIVNFGSGWGFWVSSSLFITSTH
VIPKGITEAFGVPINQIQIHKSGEFCRLRFPKPIRTDVSGMILEEGAPEGTVATILVK
RPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYK
RGNDFVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGNAPKLS
TKTKFWRSSNAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPNPS
VLESAKRTIINVLEQTIDPPQKWTYAQACASLDKTTSSGYPHHVRKNDYWSGETFTGK
LADQASKANLMYEEGKHMTPVYTAALKDELVKTDKIYGNIKKRLLWGSDLSTMIRCAR
AFGGLMDELKAHCITLPVRVGMNMNEDGPIIFEKHSRYNYHYDADYSRWDSTQQRAVL
AAALEIMVRFSAEPQLAQIVAEDLLSPSVVDVGDFKITINEGLPSGVPCTSQWNSISH
WLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTR
PDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQLYWTKGPNHDDPSET
MIPHAQRPVQLMALLGESSLHGPSFYSKVSKLVISELKEGGMDFYVPRQESMFRWMRF
SDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..968
/gene="ORF1"
/product="p48"
mat_peptide 969..2066
/gene="ORF1"
/product="NTPase"
mat_peptide 2067..2603
/gene="ORF1"
/product="p22"
mat_peptide 2604..3002
/gene="ORF1"
/product="VPg"
mat_peptide 3003..3545
/gene="ORF1"
/product="Pro"
mat_peptide 3546..5075
/gene="ORF1"
/product="RdRp"
gene 5059..6684
/gene="ORF2"
CDS 5059..6684
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59164.1"
/translation="MKMASNDAAPSNDGAAGLVPEINTETLPLEPVAGAALAAAVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEVLLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
VRNTFFHYNNRPSERMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTISELTNSRFPAPIDSLFTAQNNNLNVQCQNGRCTLDGELQGTT
QLLPTGICAFRGKISADVQNSHQDRWHMQLTNLNGTPFDPTDDVPAPLGTPDFTGLLF
GVASQRNVGGTGNNTTRAHEVVIATTSTQFVPKLGSINFGSESDDFQVGPPTKFTPVG
IKVETGHPFRQWDLPNYSGALTLNMNLAPPVAPNFPGEQLLFFRSNVPCAGGVSEGVI
DCLLPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRTGYITVAHSGDYPL
VVPSNGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6684..7463
/gene="ORF3"
CDS 6684..7463
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59165.1"
/translation="MAGAFIAGLAGDMLTSAVGSLANAGANAITQKIDFENNKQLQTA
SFQHDKDMLRAQVDATKQLQAEMIAIKQGILTAGGFSPADAARGAVGAPMTKVLDWSG
TRYWAPNSTKTTSYSGQFTSTPVHTPNFNSKPRPPAKTQPSSSSSGSVYSLSTQSTLL
PGPSSSGSSVSSVSTQSTKLSSVSSMSRTADWVNQQRSLSPYMSGALNISHVTPPSSR
TSSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 ccgttgctgg caaaaacaac aacaacgaca acgcaaaatc ttcaagtgac ggattgtttt
61 ctaacatgtc tgtcactttt aagaaagccc tcggggcgcg gcctaaacag ccgcccccgg
121 gagaaacaaa gcaaatctct aaaccgccaa gaccgccgac accggaattg gtgaagagaa
181 tacccccacc cccacccaat ggcgaagacg agccaaaagt ggtgtacaag gtgggagaag
241 gtgtgtctgg gctgcctgac ttaacaactg tcacgcagcc tgatgcacaa tgtacagcct
301 atagcgtccc cccgctcagt caaagagagg cgggtgacgc gaaggaacca ttacctggct
361 ccatcttgga gatgtgggat ggtgagatct atcattatgg gctgtacgtg gagcgtggcc
421 acgtgcttgg ggtacacaaa ccacccgctg cgataagcct cgctaaaatt gagttaacac
481 cattgtctct ttattggagg gtggtttaca ccccccagta cttgatagct ccagacactt
541 tgaagaacct gaatggagaa tcattcccat acacggcttt tgacaacaac tgctatgctt
601 tttgctgctg ggttttggac ctcaatgatt cttggctcag caggagaatg atccaaagga
661 ccactggttt cttcaggcct taccaggagt ggaacagaaa gcccttacca accatggacg
721 agcccaagat caagaaagtt gcaaacgccg tcctatgtgc tctctcttca ctcttcacca
781 gacccattaa agacatcatc ggcaagctaa aaccaatgaa catccttaac atactggcaa
841 cttgtgactg gacctttgca ggcatagtgg aatcccttat tcttcttgct gaactctttg
901 gggtgttctg gacgccccca gatgtgtctg cgatgatcgc tcccttgctc ggtgattttg
961 aaatgcaggg ccctgaggat cttgccgtgg agctcgtgcc cgtggtaatg ggagggatag
1021 gtctggtgtt gggattcacc aaggaaaaga tcggcaagat gctttcatca gctgcatcca
1081 cactcagggc ttgcaaagat ctaggggctt atggattgga aatactcaaa ttagttatga
1141 aatggttctt tcctaagaaa gaagaggcca acgagctggc catggtaagg gccattgagg
1201 atgctgtgtt agacctggag gcaatagaaa acaaccatat gaccactctc ctcaaggaca
1261 aagacagtct tgccacatac atgagaaccc tcgacttgga ggaagagaaa gcaagaaagc
1321 tctccaccaa atctgcatca ccagacatcg tgggcacaat aaactcactg ttggcaagga
1381 ttgcagcagc tcggtcacta gtccacaaag caaaagaaga gctgtcaagc agacaaaggc
1441 ctgttgtcgt tatgatatct ggcaggccgg gcatagggaa aactcacctt gccagagagc
1501 tggccaagaa agttgcaaca acactggcag gtgaccaaag gattggcctg gtgcccagga
1561 atggtgtgga ccattgggac gcctacaaag gagaaagagt ggtgctgtgg gacgactatg
1621 gcatgagcaa ccccatacag gatgccctaa gactccaaga actggctgac acctgtcctc
1681 taacacttaa ctgtgacaga attgaaaaca agggaaaggt gtttgatagc gatgccataa
1741 taataacaac caacctctca aatccagcac ccttagacta tgttaacttt gaggcctgct
1801 ccaggcgcat agacttctta gtgtatgcag atgcaccaga tattgagaag gccaagcgag
1861 atttccctgg ccagccagac atgtggaaag accattacag accagacttc tcacacatca
1921 agctccaact ggccccacag ggcggttttg acaagaacgg caacacccca cacggtaagg
1981 gtgtgatgaa gtccttgact gttgggtcac tgatcgccag agcctctggc ctgctccatg
2041 aaagaatgga tgaatttgag ctacagggtc ctggtctgtc aactttcaac tttgaccgta
2101 acaaggtcgc tgcctttaga caactggcag ctgaaaataa gtatggcatg ttggacacac
2161 tgagagtggg aaaccagcta aagggtgtca aaaccatgga tgagttgaaa cgagccatca
2221 ataacatcac catcaaaaag tgccagatag tatataatgg atgcacctac actatggaat
2281 ctgatggacg tggcaaagtg ttagttgaca aagtgcaaaa cacaacagtt caaaccaaca
2341 atgagctctc gggggccctg caccacctca ggtctgcaag aataagatac tatgtcaagt
2401 gcttccaaga ggcaatctac tccctactcc aaattgctgg tgcagctttt gtcacctcac
2461 gcatagtgag gcgaatgaac atctcaaacc tatggtcgaa gccacctgct gaagacaatg
2521 atgaatcaga ggacaaagga gggtgtccca aacccagaga tgaggatgag ttcaccgttg
2581 attccaaaga catcaaagtg gaaggaaaga aaggcaagaa caaatctggg agaggaaaga
2641 aacacacagc tttctccagc aagggcctca gtgatgaaga atatgatgag tacaaaagaa
2701 tcagagaaga aagaaatggc aagtactcga tagaagagta cctccaagat agggacaggt
2761 attatgagga acttgccatt gctaaagcca ctgaggaaga cttttgtgaa gaggaggagg
2821 ccaaaatccg ccagaggatc ttccgtccta ccaggaaaca acggaaggag gagagagcca
2881 ctctcggact cgtcacgggg tcagaaatca ggaagaggaa cccggatgac ttcaaaccaa
2941 gaggaaaact gtgggctgat gacgacagga gtgtggatta taatgagaaa ataagttttg
3001 aagcaccacc aagcatctgg tcaagaatag ttaattttgg ttcaggctgg gggttctggg
3061 tgtcctcaag cctttttata acctcaaccc acgtgatacc gaaggggatc acggaggctt
3121 ttggtgtgcc catcaatcaa atacaaattc acaagtcagg agagttctgt cgcctgaggt
3181 tcccaaaacc catcaggacg gatgtgagtg ggatgatctt ggaggaaggt gcccctgagg
3241 gaaccgtcgc aaccatcctt gtcaaacggc cgacagggga gttgatgccc ttggctgcta
3301 gaatgggaac ccatgccaca atgaagatcc aagggagaat ggtgggtggc cagatgggca
3361 tgttgctcac cggctcaaac gccaagagca tggacctcgg cacaacacca ggtgattgtg
3421 ggtgccctta catatacaag agaggcaacg actttgtggt catcggcgta cacaccgcag
3481 cagcacgcgg aggcaacaca gtcatatgtg ccacacaagg aagtgaaggt gaagccactc
3541 ttgaaggagg agacaacaag ggtacttact gtggagcccc tatcctgggt cctggcaacg
3601 caccaaaatt gagcaccaaa acaaaattct ggagatcttc caatgcacca ctcccaccag
3661 gtacctatga gccagcatac ctaggtggaa aagacccacg agtgaaggga ggtccgtcct
3721 tgcaacaagt catgagagac cagctcaagc ctttcactga acccagaggg aaaccaccaa
3781 acccaagtgt tctggaatcg gcaaagagaa ccatcatcaa cgttttggaa caaactattg
3841 acccacccca aaagtggaca tatgcccagg catgtgcatc tcttgacaaa acaacttcca
3901 gcggttaccc acatcatgtt cgcaagaatg actactggag tggtgagaca ttcacaggca
3961 aactggcaga tcaagcttca aaggcaaatc ttatgtatga ggaaggaaaa cacatgacac
4021 cggtgtacac cgcggccctc aaggatgaac tggttaaaac tgacaaaatc tatggtaata
4081 tcaagaagag gctactgtgg ggttctgacc tttccaccat gatccgatgt gctagggcat
4141 tcggtggcct catggatgaa ctcaaggcac actgcatcac ccttcctgtc agagttggca
4201 tgaacatgaa tgaagatgga ccaataatat ttgagaaaca ctccagatac aactaccatt
4261 atgatgcaga ctactcccgt tgggattcta cacaacaacg ggcggtgctt gcagcagcac
4321 ttgaaattat ggtgagattt tctgctgagc cacaattggc gcagatagtg gctgaggacc
4381 tgctttcacc aagtgtggtt gatgtgggtg atttcaaaat tacaatcaat gagggccttc
4441 catccggcgt gccttgcacg tcccagtgga actcaatctc ccactggttg ctcacattgt
4501 gtgccttatc tgaagtgaca ggactaggtc ctgacatcat acaggccaac tccatgtact
4561 ctttctatgg tgatgatgaa attgtgagca ctgacataaa attggaccca gaaaaattaa
4621 ctgcaaaact caaagaatat ggcctcaagc ccactcgtcc tgacaaaact gagggaccat
4681 tggtgattag tgaagacttg aacgggttga cattccttcg ccgcactgtg acccgtgatc
4741 cagcaggctg gtttggaaaa ctagatcaaa gctctatcct caggcaattg tattggacaa
4801 aaggacccaa ccatgacgac cccagtgaaa ccatgatacc acatgcacag aggcccgtac
4861 aactcatggc actactggga gaatcctccc tacacggacc ctcattttac agcaaagtta
4921 gtaaattggt tatatctgaa cttaaggagg gaggaatgga tttttatgtg cccagacaag
4981 agtcaatgtt cagatggatg aggttctcag atctaagcac atgggagggc gatcgcaatc
5041 tggctcccag ttttgtgaat gaagatggcg tcgaatgacg ctgctccatc taatgatggt
5101 gctgcgggcc tcgtcccaga gatcaacacc gagacccttc ccctggaacc agtggctggt
5161 gcagctcttg ctgcggctgt cactggtcaa aataatataa ttgatccctg gattagaaca
5221 aattttgtac aagcacccaa tggggagttc actgtttcac ctagaaattc cccaggagaa
5281 gtcctcctaa atttagaatt aggtcctgat ttaaatcctt atttggcaca cttatctaga
5341 atgtacaatg ggtatgctgg tggagtggag gtccaggttc tcctagcggg gaacgcgttc
5401 accgctggaa agatcctctt cgctgccgta ccgccaaatt tcccagttga attcttaagt
5461 cctgcccaaa tcactatgct cccacatttg atagttgacg tcaggaccct tgagccaatt
5521 atgatacccc tccccgacgt gagaaacacc ttcttccatt acaacaatag gccctctgag
5581 cgtatgcgtt tggtggccat gttgtacaca cccctgagat ccaacggttc aggtgatgat
5641 gtcttcacag tctcatgcag ggtgctaact agacccactc cagattttga atttacctac
5701 ctagttccac cctcagtaga gtctaagaca aagcctttct ctcttcccat cttaaccatt
5761 tctgaattga ctaattcaag gtttccagca cccattgatt cattgtttac tgcccaaaat
5821 aacaatctta atgtccaatg tcagaatggt cggtgcacac tagatggtga gttgcaggga
5881 accacccagc tgctcccaac tggaatatgt gccttcagag ggaaaatatc agcagatgtg
5941 caaaacagtc accaagacag gtggcacatg cagttgacaa atctcaatgg aaccccattt
6001 gacccaacag atgatgtccc agctccgctt ggcacccctg acttcacagg tctactgttt
6061 ggagttgcaa gtcaaagaaa cgttggtgga acaggtaaca acactaccag ggcccacgag
6121 gtagtgatag caacaactag cacacaattt gtaccaaaat tgggttctat taattttggg
6181 agtgaaagtg atgatttcca agtgggccca ccaaccaaat tcacaccagt tggaatcaaa
6241 gttgagaccg ggcatccttt cagacaatgg gacctaccta actattctgg agcactgacc
6301 ctcaacatga accttgcccc acctgttgcc ccaaacttcc caggtgagca gctgctcttc
6361 tttagatcaa atgttccttg tgctggtggt gtcagtgagg gtgtcattga ctgcctactg
6421 cctcaagagt ggatacaaca tttctaccag gaatccgctc catctcaatc agatgtggca
6481 ctgatcagat atgtcaaccc tgacacgggc cgcactctct ttgaggcaaa actccacagg
6541 actggttaca ttactgttgc tcactctggt gactatcctc ttgttgttcc ttccaatggc
6601 tacttcagat ttgattcttg ggtaaatcaa ttttactcac tcgcccccat gggaactggg
6661 aatgggcgca ggagagtgca gtaatggcag gagcttttat agcaggtctt gcaggtgaca
6721 tgctcacctc tgctgtaggc tcactggcga atgccggagc aaatgccata acacagaaaa
6781 ttgactttga aaacaacaaa caacttcaaa cagcctcctt tcaacatgac aaagatatgc
6841 tccgcgcaca agtggatgca accaagcagc tgcaggcaga aatgattgcc atcaaacagg
6901 ggatcttgac cgctggcggc ttctcccctg ctgacgcagc aagaggggct gtaggggcac
6961 ccatgaccaa ggtgcttgac tggtctggca cacgctattg ggcaccaaat tctaccaaaa
7021 caacaagtta ttccgggcag ttcacatcaa cgcctgtgca cacaccaaat ttcaacagca
7081 aacccaggcc tcctgccaaa acccagcctt cttcttcttc ttctggtagt gtttatagtc
7141 tttcaactca atcaacttta ctccctggac cctcttcttc gggttcatct gtttcttctg
7201 tctcaacaca atcaacaaaa ttgagttcag tttcttctat gagtagaaca gcagattggg
7261 ttaatcaaca aaggagcctc agcccttaca tgagcggggc ccttaatatt tctcatgtga
7321 cacctccatc aagcaggact tcaagttcgg gaacagtctc aactgtgccc aaagaagttt
7381 tggactcctg gacatctgca ttcaatacac gcagacagcc gctcttcgca cacctcagag
7441 tgagggggga gtcacgtgtt tagtgaaaag aatcaattag ttttaattag gttaaatttt
7501 aaattttaat tggatctttt
//