Typing tool
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Typing tool
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Complete norovirus genomes
| MW305608 | GII.3 | |
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| GII.P21 |
ORF1: 1..5069
ORF2: 5050..6696
ORF3: 6696..7460
LOCUS MW305608 7512 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate Arg4452 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305608
VERSION MW305608.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7512)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7512)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7512
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg4452"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Argentina"
/collection_date="2005"
/note="genotype: GII.3[GII.P21]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59160.1"
/translation="AAANSNNDNVKSSSDGVLSNMAVTFKRALGARPKQPPPRDKPPR
PPRPPTPELVKAIPPPPPNGEDEPTISYNVREGVSGLPELSTVTQPEESSTAFSVPPL
SQRESRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPLSL
YWRPVYTPQYLISPDTLRKLHGETFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTVDDSKVKKVANVVLCALSSLFTRPIKDIIGKLKPLNILNILA
TCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDETNELAMV
RSIEDAVLDLEAIENNHMTALLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLSRIAAARSLVHRAKEELSSRPRPVVVMISGRPGIGKTHLARELAKKIASSLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPEVEKAKRDFPGQPDM
WKDTFKPDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTASSLVARASGLLHERLDEY
ELQGPTPTTFNFDRNKVLAFRQLAAENKYGLVDTMRVGSQLKNVKTMTELKQALKNIS
VKKCQLVYGGGTYTLESDGKGNVHVEKVKNTSVQTNNELSGALHHLRCARIRYYVKCV
QEALYSILQIAGAAFITTRIAKRMNIQNLWSKPQMEDLEETSNEEGCPKPKNDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
HGAQEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYVVIGVHTAAARGGNTVICATQGSEGEAMLEGGDSKGTYCGAPILGPGNAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
AAKKTIINVLEQTIDPPQRWTYAQACASLDKTTSSGHPHHIRKNECWNGETFTGKLAD
QASRANLMYEEGKNMTPVYTGALKDELVKTDKIYGSIKKRLLWGSDLSTMIRCARAFG
GLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRAVLAAA
LEIMVKFSSEPHLAQVVAEDLLSPSVMDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTTKLKEYGLKPTRPDK
TEGPLIISEDLDGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGPNHEDPFETMIP
HSQRPIQLMSLLGEAALHGPSFYSKISKLVISELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6696
/gene="ORF2"
CDS 5050..6696
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59161.1"
/translation="MKMASNDATPSNDGAAGLVPEINNEAMALDPVAGAAIAAPLTGQ
QNIIDPWIMNNFVQAPGGEFTVSPRNSPGEVLLNLELGPEINPYLAHLARMYNGYAGG
FEVQVVLAGNAFTAGKIIFAAIPPNFPIDNLSAAQITMCPHVIVDVRQLEPVNLPMPD
VRNNFFHYNQGSDSRLRLIAMLYTPLRANNSGDDVFTVSCRVLTRPSPDFSFNFLVPP
TVESKTKPFTLPILTISEMSNSRFPVPIDSLHTSPTENIVVQCQNGRVTLDGELMGTT
QLLPSQICAFRGVLTRSTSRASDQADTATPRLFNYYWHIQLDNLNGTPYDPAEDIPGP
LGTPDFRGKVFGVASQRNPDSTTRAHEAKVDTTAGRFTPKLGSLEISTESDDFDQNQP
TRFTPVGIGVDNEADFQQWSLPDYSGQFTHNMNLAPAVSPNFPGEQLLFFRSQLPSSG
GRSNGVLDCLVPQEWVQHFYQESAPAQTQVALVRYVNPDTGRVLFEAKLHKLGFMTIA
KNGDSPITVPPNGYFRFESWVNPFYTLAPMGTGNGRRRIQ"
gene 6696..7460
/gene="ORF3"
CDS 6696..7460
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59162.1"
/translation="MAGAFIAGLAGDIFTNTVGSLVNAGANAINQKVDFENNKYLQNA
SFNHDKEMLNAQIEATKRLQADMIAIKQGVLTAGGFSPTDAARGAINAPMTKVLDWNG
TRYWAPNATSTTSMSGGFTNQAAHRTTPNFKTYQAPKSTPSSGSSVRSNSTQITSLSS
HSSGSSRSSGFTVVSSLPSSNRTRDWVNQQNFNLEPHMPGSLRTAFVTPPSSTASSSG
TVSTVPKNVLDSWTSAFNTRRQPLFAHLRRRGESNV"
ORIGIN
1 ccgctgctgc caacagcaac aacgacaacg taaaatcttc aagtgacgga gtattatcta
61 atatggctgt cacttttaaa cgagccctcg gggcgcggcc taaacaaccg cccccgaggg
121 acaagccacc aagaccccca agaccaccca caccagagtt ggttaaggca atcccccctc
181 ccccacccaa cggggaggac gagccaacca tttcttacaa cgtcagagag ggtgtctctg
241 gtttgcctga actctcaacg gtcacccaac cggaagagag ttctacggca ttcagtgtcc
301 cccctcttag tcagagggag agcagagatg caaaggaacc cttgactgga accatcctgg
361 agatgtggga cggggagatc taccattacg gcttgtacgt ggaacgagga ctagtgctcg
421 gtgtacacaa accaccagca gccatcagcc ttgctaaggt tgagctgacc cccttgtctt
481 tgtattggag accagtgtac accccacagt acctcatttc ccctgacact ctcaggaagt
541 tgcatgggga gacgttccct tacacagcct ttgacaacaa ctgttatgcc ttctgctgct
601 gggttcttga cttgaacgat tcatggctga gcagaaggat gatacagagg acaacaggct
661 tctttcgacc ctaccaggac tggaacagaa aacccctccc cacggtggat gactccaaag
721 tgaagaaggt ggccaatgtt gtcctctgtg ctctctcctc attgtttact agaccaatta
781 aggatattat tggaaagttg aaacccctaa acatcctcaa catcctagcc acatgtgatt
841 ggacttttgc aggcatagta gaatcactga tcctcttggc tgagttgttt ggagttttct
901 ggacaccccc agatgtgtct gcaatgatcg ctcccttact gggtgattat gagctacagg
961 ggcccgagga cctcgctgtg gaactcgtac ccgtagtaat gggagggata ggtttggtgc
1021 tgggattcac caaagagaaa atcggtaaaa tgctttcatc tgctgcttca accctgaggg
1081 catgtaaaga tcttggtgca tatgggctgg agatcctcaa gttggtcatg aaatggtttt
1141 tcccaaagaa agacgagaca aacgaattgg ctatggtgag atccatcgag gatgcagtat
1201 tagacctcga ggccattgag aacaaccata tgacagctct actcaaggat aaggatagcc
1261 ttgcaaccta catgaggact cttgacttgg aagaggagaa ggcgaggaag ttgtccacca
1321 agtctgcctc accggacatc gtgggcacga tcaacgccct gctgtcaagg attgcagctg
1381 cccggtctct agtacacagg gctaaggagg aactgtcaag caggccccga ccggttgttg
1441 tgatgatttc agggagacca ggtataggga aaacccatct agctagagag ttggcaaaga
1501 agatcgcctc ctcactcaca ggtgaccaga gggtgggcct tatcccacgc aacggagttg
1561 accactggga tgcgtacaaa ggtgaaagag tcgttctctg ggacgactac gggatgagca
1621 accctatcca cgacgccctt agactccagg agctcgctga tacctgtccc ctcacactta
1681 actgtgacag gattgagaac aaaggcaaag tctttgacag tgacgccata ataataacta
1741 ccaatttagc taacccagcg ccactggatt atgtcaactt tgaagcttgc tcaagacgca
1801 tagacttcct cgtctatgct gatgcccctg aagttgagaa ggctaaacgg gacttcccag
1861 gccagccaga tatgtggaaa gacaccttca aacctgactt ctcacacata aaactgacac
1921 tagccccaca aggaggtttt gacaagaatg gcaacacccc tcatgggaag ggtgtcatga
1981 agaccctcac tgctagttct ctcgttgccc gagcatcagg gctcctccac gagagactag
2041 acgagtatga gctgcaaggc ccaactccca caacattcaa cttcgaccgt aacaaggtgc
2101 ttgcttttag gcaacttgct gctgagaaca agtacggtct tgttgacaca atgagggtcg
2161 gatcacagct caagaatgtc aaaaccatga cagaactcaa acaggctctc aagaacatct
2221 cagtcaagaa atgccagctt gtgtatggcg ggggcacgta cacacttgaa tctgatggta
2281 aaggcaatgt gcatgtcgag aaggtgaaga acaccagtgt gcaaactaat aacgagctct
2341 ccggggcttt gcaccatctc aggtgtgcca ggatcaggta ctatgtcaag tgtgtccagg
2401 aagctctcta ctccatcttg caaattgccg gggctgcatt cattaccacg cgcattgcaa
2461 agcgcatgaa catacaaaac ctctggtcca aaccacaaat ggaagatctg gaggagacta
2521 gcaacgagga gggttgtcca aaacctaaaa atgatgagga atttgttatc tcctctgatg
2581 acatcaaaac cgagggcaag aaaggaaaga acaaaactgg ccgtggtaag aagcacacag
2641 ccttttccag caaaggcctc agcgatgagg agtacgatga gtataagaga atcagggaag
2701 agagaaatgg caagtactcc atagaggaat acctacagga cagagacaag tactatgagg
2761 aggtggccat agccagggca accgaggaag atttctgtga agaagaggag gctaaaatcc
2821 ggcaaaggat attcagacca acaaggaaac aacgcaaaga ggaaagggcc tctctcggtt
2881 tggtcacagg ctctgagatc aggaagagaa acccagatga ttttaagccc aaagggaaac
2941 tatgggccga tgatgacagg agtgttgact acaatgagaa actcagcttt gaggctccac
3001 caagcatttg gtcacgaata gtcaactttg gttcagggtg gggcttttgg gtctcgccta
3061 gcctcttcat aacatcaacc catgtcattc cccacggcgc acaggagttc tttggagtac
3121 ccatcaaaca gatacaaatt cacaaatcag gtgagttctg ccggcttagg ttcccaaaac
3181 caatcaggac agatgtcacg ggcatgatcc tggaggaagg tgctccagaa ggcaccgttg
3241 ccacacttct catcaagaga ccaactgggg aactcatgcc cttggcagcc agaatgggca
3301 cccatgcgac catgaaaatt cagggtcgca ctgttggtgg acagatgggc atgctactca
3361 cagggtctaa cgccaagagc atggatttgg gcacaactcc tggcgattgt ggttgtccct
3421 acatatacaa aagagggaac gactacgtgg tcattggagt tcacactgcc gccgctcgtg
3481 gaggaaacac cgtaatctgt gcaacccagg gaagcgaggg tgaggccatg ctcgaaggtg
3541 gtgatagcaa aggaacttac tgtggagcac caatattagg ccctggaaat gcccccaaac
3601 tcagcaccaa aaccaaattc tggaggtctt ccaccacccc cctaccaccc ggaacctatg
3661 aaccagctta tctgggtggc aaggacccta gagtgaaagg tggtccctca ctgcaacagg
3721 ttatgaggga tcaactaaaa ccattcactg agcccagagg caagccaccc aaaccaagtg
3781 tactagaagc tgccaagaag actataatca atgtgcttga acagacaata gacccacctc
3841 aaagatggac atacgcgcag gcgtgtgcat cactagacaa aaccacttcc agcggacacc
3901 ctcaccacat acggaagaac gagtgctgga acggggagac tttcacagga aaactggcag
3961 accaagcatc aagggctaac ctaatgtatg aggaaggaaa gaacatgacc ccagtataca
4021 caggagcttt gaaggatgag ctagtcaaga ctgataagat ctatgggagt atcaaaaaga
4081 gactcctgtg ggggtcagac ctatcaacca tgatacggtg tgcacgagcc ttcggtgggc
4141 taatggacga gctcaaggcc cattgcgtca cactaccagt cagggttggc atgaacatga
4201 atgaggatgg acccataata tttgagaaac attccagata cagatatcat tatgatgcag
4261 attactcccg ctgggattca acacaacaaa gagcagtgct ggctgcagct ttggaaataa
4321 tggtcaaatt ctcatcagag cctcatctgg ctcaagtggt tgcagaagac ctcttgtccc
4381 caagtgtgat ggatgtgggt gatttcaaga tatcaatcaa cgaggggttg ccctctggtg
4441 taccttgcac ctcacaatgg aactccattg cccactggct cctgacacta tgtgcgctgt
4501 ctgaagtcac agatctgtcc cctgacatca tccaggcaaa ctccctattc tccttttatg
4561 gtgatgatga aatagtgagc acagacatca aattggaccc agaaaaattg acaacgaaat
4621 tgaaggaata cgggctaaaa ccaacccgtc ctgataaaac agaaggaccc ttaattatct
4681 ctgaagattt ggatggcctg accttcttac ggagaacggt gacccgtgat ccggctgggt
4741 ggtttggcaa actggaccaa agttcaatac tcaggcagat gtactggacc aggggaccaa
4801 accatgagga cccctttgaa acaatgatac cacactccca aagacccata caactgatgt
4861 cactactggg tgaagctgca ttgcatggcc catcattcta cagtaaaatt agcaagctgg
4921 tcatctcaga attgaaagag ggtggaatgg atttttacgt gcccagacaa gaaccaatgt
4981 ttaggtggat gagattctcg gatttgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccactccat ctaatgatgg tgccgccggc
5101 ctcgtcccag agatcaacaa tgaggcaatg gcgctagacc cagtggcggg tgcagcgata
5161 gcagcacccc tcactggtca gcaaaatata attgatccct ggattatgaa taattttgtg
5221 caagcacctg gtggtgagtt tacagtatcc cctaggaatt cccctggtga agtgcttctt
5281 aatttggaat tgggcccaga aataaatccc tatttggccc atcttgccag aatgtataat
5341 ggttatgcag gtggatttga agtgcaggta gtcctagctg gaaatgcgtt tacagcagga
5401 aagataatct ttgcagctat accccctaat tttccaattg ataatctaag cgcagcacag
5461 atcacaatgt gcccacatgt gattgtggat gtcagacagt tggaaccggt caacctcccg
5521 atgcctgacg ttcgcaacaa cttcttccat tacaatcaag ggtctgattc gagattgcgc
5581 ttaattgcaa tgctgtatac acctcttagg gcaaataatt ctggtgatga tgtttttact
5641 gtgtcttgta gagtattgac taggcctagc cctgatttct catttaattt ccttgtgcca
5701 cctactgtgg agtcaaagac aaaacccttc actctcccta ttctgactat ctctgaaatg
5761 tccaattcta ggtttccagt gccgattgat tctctgcata ccagcccaac tgagaatatt
5821 gttgtccagt gccaaaatgg gcgcgtcact cttgatggtg agttgatggg caccacccaa
5881 ctcttaccca gtcaaatctg tgctttcagg ggcgtgctca ccagatcaac aagcagggcc
5941 agtgatcagg ccgacacggc aacccctagg ttgtttaatt attattggca catacaattg
6001 gataatctaa atgggactcc ctatgatcct gcagaagaca taccaggccc cctaggaacg
6061 ccagatttcc ggggcaaagt ctttggcgtg gccagccaga gaaaccccga cagcacaact
6121 agagcacatg aagcaaaggt ggacacaaca gctggtcgtt tcaccccaaa actaggctca
6181 ttagagatat ccactgagtc tgatgacttt gaccaaaacc aaccaacaag attcacccca
6241 gttggcattg gagttgacaa tgaagcggac ttccaacaat ggtctttgcc cgactattct
6301 ggtcagttca cccataacat gaacttagcc ccagctgttt ctcctaactt ccctggtgag
6361 cagctcctct tcttccgctc acagttacca tcctctggtg ggcgatccaa cggagttcta
6421 gactgcctgg tccctcaaga gtgggttcag cacttctacc aagaatcggc ccccgctcaa
6481 actcaagtgg ccctggttag gtatgtcaac cctgacactg gtagagtatt atttgaggcc
6541 aagctgcaca aattaggttt catgactata gctaagaatg gtgattctcc aataactgtc
6601 cctccaaatg gatattttag gtttgaatct tgggtgaacc cattttacac acttgccccc
6661 atgggaactg ggaatgggcg tagaaggatt caataatggc tggagctttt atagcaggat
6721 tagctggtga tatatttaca aatactgtag gatctttagt taatgcaggg gctaatgcca
6781 ttaatcaaaa agttgatttc gagaacaata aatatttaca aaatgcttcc tttaatcatg
6841 ataaggaaat gttaaatgca caaattgagg caacaaagag gttacaggct gacatgattg
6901 ctatcaaaca aggggttttg accgctggcg gcttctcccc cactgatgca gcccgcgggg
6961 caattaatgc ccccatgaca aaagtcctag attggaatgg gacgaggtac tgggcaccaa
7021 atgccacctc cacaacctcg atgtcgggtg gcttcacaaa tcaggcagcg cacagaacca
7081 cgccaaattt taaaacgtac caggctccca aatccacacc cagcagtggg tcttcagtga
7141 ggtcaaactc aacccaaatt actagcctga gctcacactc gtccgggtcg tctcgatcca
7201 gcgggtttac agtagttagc tcattaccat cctctaacag gactagggac tgggtcaacc
7261 aacaaaattt caatttggaa ccacacatgc ctgggtctct tagaacagct tttgtcactc
7321 caccatctag cacagcctct agttcaggta cggtctcgac cgtgcccaaa aatgttttgg
7381 actcctggac atctgcgttc aatacgcgca gacagccgct attcgcacac cttcgcagaa
7441 ggggggagtc aaatgtttag tgaaaagatt attttaaatt tgatttaaat tggatttgat
7501 ttggaatctt tt
//