Typing tool

Complete norovirus genomes

MW305607  GII.17
 GII.P31

Length: 7,507 | 3 CDS

ORF1: 1..5069
ORF2: 5050..6672
ORF3: 6672..7451
LOCUS       MW305607                7507 bp    RNA     linear   VRL 06-JUL-2021
DEFINITION  Norovirus GII isolate Arg4446 nonstructural polyprotein (ORF1)
            gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
            cds.
ACCESSION   MW305607
VERSION     MW305607.1
KEYWORDS    .
SOURCE      Norovirus GII
  ORGANISM  Norovirus GII
            Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
            Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE   1  (bases 1 to 7507)
  AUTHORS   Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
            Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
            Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
            Green,K.Y. and Parra,G.I.
  TITLE     Genome-wide analyses of human noroviruses reveal coexistence of
            viral populations evolving under recombination constraints
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7507)
  AUTHORS   Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
            Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
            Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
            Green,K.Y. and Parra,G.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
            Administration, 10903 New Hampshire Avenue, Silver Spring, MD
            20993, USA
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: High-performance Integrated Virtual
                                     Environment (HIVE) v. 2
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..7507
                     /organism="Norovirus GII"
                     /mol_type="genomic RNA"
                     /isolate="Arg4446"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:122929"
                     /country="Argentina"
                     /collection_date="2005"
                     /note="genotype: GII.17[GII.P31]"
     gene            <1..5069
                     /gene="ORF1"
     CDS             <1..5069
                     /gene="ORF1"
                     /codon_start=3
                     /product="nonstructural polyprotein"
                     /protein_id="QPJ59157.1"
                     /translation="AAANSNNDIAKSSSDGVFSNMAVTFKRALGARPKQPPPKEIPPR
                     PPRPPTPELVKNIPPPPPNGEDELVVSYSAKGGVSGLPELTTVRQPEENNTAFSVPPL
                     NQRESRDAKEPLTGTIIEMWDGEIYHYGLYVEKGLILGVHKPPAAISLAKVELTPLSL
                     FWRPVYTPQYLISPDTLRRLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
                     GFFRPYQDWNRKPLPTMDDSKLKKVANIFLCTLSSLFTRPIKDIIGKLKPLNILNILA
                     TCDWTFAGIVESLILMAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
                     GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
                     RAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
                     NALLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARELAKKIAASLTGD
                     QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
                     KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQPDM
                     WKNAFSPDFSHIKLSLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEY
                     ELQGPPLTTFNFDRNKVLAFRQLAAENKYGLMDTMRVGKQLKDVKTMPDLKQALKNVS
                     IKKCQIVYNGSTYTLEADGKGNVKVDKVQSATVQTNNELTGALHHLRCARIRYYVKCV
                     QEALYSIIQIAGAAFVTARITKRMNIQNLWSKPQVEDTEETANKEGCPKPKDDEEFVI
                     SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIRDERNGKYSIEEYLQDR
                     EKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPE
                     DFKPKGKLWADDDRSVDYNEKLNFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
                     QGAKEFFGTPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
                     GELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
                     DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKT
                     KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPSVLE
                     AAKKTIINVLEQTIDPPQKWSFAQACASLDKTTSSGHPHHMRKNDCWNGDSFTGKLAD
                     QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
                     GLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYKFHYDADYSRWDSTQQRDVLAAA
                     LEIMVKFSPEPHLAQVVAEDLLSPSVMDVGDFQISISEGLPSGVPCTSQWNSIAHWLL
                     TLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
                     TEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
                     HSQRPIQLMSLLGEAALHGPAFYSKVSKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
                     STWEGDHNLAPSFVNEDGVE"
     mat_peptide     <1..959
                     /gene="ORF1"
                     /product="p48"
     mat_peptide     960..2057
                     /gene="ORF1"
                     /product="NTPase"
     mat_peptide     2058..2594
                     /gene="ORF1"
                     /product="p22"
     mat_peptide     2595..2993
                     /gene="ORF1"
                     /product="VPg"
     mat_peptide     2994..3536
                     /gene="ORF1"
                     /product="Pro"
     mat_peptide     3537..5066
                     /gene="ORF1"
                     /product="RdRp"
     gene            5050..6672
                     /gene="ORF2"
     CDS             5050..6672
                     /gene="ORF2"
                     /note="major capsid protein"
                     /codon_start=1
                     /product="VP1"
                     /protein_id="QPJ59158.1"
                     /translation="MKMASNDAAPSNDGATGLVPEINNETLPLEPVAGAAIAAPVTGQ
                     NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
                     VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
                     VRNTFFHYNNQPANRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
                     SVESKTKPFSLPILTISELTNSRFPVPVDSLFTAQNNNLNVQCQNGRCTLDGELQGTT
                     QLQPSGICAFRGKITADVHQSHDDRWHMQLTNLNGTPFDPTEDVPAPLGTPDFTGLLY
                     GVASQRNVQPNPNTTRAHEAVISTTSSQFVPKLGSINFGSTSEDFVVGQPTKFTPVGI
                     KIETGHDFDQWTLPRYSGHLTLNMNLAPPVAPNFPGEQLLFFRSNVPCAGGVSDGIID
                     CLLPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRTGYITVAHSGDYPLV
                     VPSNGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
     gene            6672..7451
                     /gene="ORF3"
     CDS             6672..7451
                     /gene="ORF3"
                     /note="minor structural protein; small basic protein"
                     /codon_start=1
                     /product="VP2"
                     /protein_id="QPJ59159.1"
                     /translation="MAGAFIAGLAGDTLTNTVGSLVNAGANAITQKVDFENNKQLQSA
                     SFQHDKDMLQAQVAATKQLQAEMIAIKQGILTAGGFSPTDAARGAVGAPMTKVLDWSG
                     TRYWAPNSTRTTGYSGQFTSTPVHMPTKITQPAPAKRTQPPSSSSGSIYSLSTQSTVL
                     TKPSSGSSSVSSAFTQSTQLSSIPSMDRTANWVNQQRSLSPYMSGALNISHVTPPSSR
                     ASSSGTVSTVPKEVLDSWTSAFNTHRQPLFAHLRVRGESRV"
ORIGIN      
        1 ccgctgctgc caacagcaac aacgacatcg caaaatcttc aagtgacgga gtgttttcca
       61 acatggctgt cactttcaaa cgagccctcg gggcgcggcc caaacagccg cccccgaagg
      121 aaataccacc cagaccccca cgaccaccca caccagaact ggtcaaaaat atccctcctc
      181 ccccgcccaa cggggaggat gaactagtgg tttcctacag cgccaaaggt ggcgtttccg
      241 gcctgcctga acttaccact gtcagacaac cggaagaaaa caacacggcg ttcagtgttc
      301 ccccactcaa ccagagggag agtagggacg ccaaggaacc actaactgga acaattattg
      361 aaatgtggga tggagaaata taccattacg gtctgtacgt ggaaaaaggt ctcatacttg
      421 gtgtgcataa gccacctgca gccatcagcc ttgccaaggt tgagctaaca ccactttctc
      481 tgttctggag acctgtgtac accccccagt atctcatctc tccagacact cttaggagac
      541 tgcacggaga atcattcccc tacacagcat ttgacaataa ttgctacgcc ttctgttgtt
      601 gggtgttgga cctaaacgat tcatggctaa gtaggaggat gatccagaga acaacaggtt
      661 tcttcagacc atatcaagac tggaacagga aacccctccc cactatggat gactccaaat
      721 taaagaaggt agccaacata ttcttgtgta ctctgtcttc gctattcacc agacccatca
      781 aggacataat agggaagcta aaacctctta acatcctcaa tattttggcc acatgtgatt
      841 ggaccttcgc aggcatagtg gaatccctaa tactcatggc agaactcttt ggagttttct
      901 ggacaccccc agatgtgtct gcgatgatcg cccccttact aggtgattac gagctgcaag
      961 gacctgagga cctcgcagta gaactcgtcc cagtagtgat gggggggata ggtttggtgc
     1021 taggattcac caaagagaaa attgggaaga tgttgtcatc cgctgcatcc actttgagag
     1081 cttgtaaaga ccttggtgca tacggactgg aaattttaaa attggtcatg aaatggttct
     1141 tcccaaagaa agaggaagca aatgagttgg ccatggtgag agccatcgag gatgcggtgc
     1201 tggacctcga ggcaattgaa aacaaccaca tgaccaccct gcttaaagat aaagacagct
     1261 tggcaaccta catgagaacc cttgaccttg aggaggagaa agccagaaaa ctctcaacca
     1321 aatctgcttc acccgatatt gtgggcacaa tcaatgctct tctggcaagg atcgctgctg
     1381 cacgctccct agtgcatcgg gcgaaagaag agctctccag caggccaaga cctgttgttg
     1441 tgatgatatc gggaaaacca ggaataggga aaactcacct tgccagggaa ctggctaaga
     1501 agatcgcggc ttccctcaca ggggaccaac gtgtgggtct cataccgcgc aatggtgttg
     1561 accattggga cgcatacaag ggagaaaggg tggtcctatg ggatgactac ggaatgagca
     1621 accccatcca tgacgccctc aggttgcagg agcttgctga cacttgtccc ctcacgctga
     1681 actgtgacag gattgagaac aaaggaaaag tttttgacag tgatgctata attatcacca
     1741 ccaatctggc caacccagca ccactagatt atgtcaactt tgaagcgtgt tcgaggcgca
     1801 ttgacttcct cgtgtacgca gatgctcctg atgtagagaa ggcaaaacgc gacttcccag
     1861 gccagcccga catgtggaag aacgctttca gtcccgactt ctcacacata aaactgtcac
     1921 tggccccaca gggtggcttc gataagaacg gaaacacccc acatgggaaa ggcgtcatga
     1981 aaaccctcac cactggctcc ctcatcgccc gagcatcagg gttgctccat gagaggctag
     2041 atgaatatga gttacagggc ccgcctctca ccactttcaa ctttgaccgc aataaggtcc
     2101 ttgctttcag acagcttgct gctgaaaaca agtatgggtt gatggacaca atgagagttg
     2161 gaaaacagct caaggatgtc aagaccatgc cagacctcaa gcaagctctc aaaaatgtct
     2221 cgatcaagaa gtgtcaaata gtgtacaatg gtagcaccta cacacttgag gccgatggca
     2281 agggtaatgt gaaggttgac aaagtacaaa gtgccaccgt gcaaaccaac aatgaactaa
     2341 ctggtgccct acaccatcta aggtgcgcca gaattaggta ctatgtcaag tgtgtccagg
     2401 aggcactgta ttccatcatc caaattgctg gggctgcgtt cgtcaccgcg cgcatcacta
     2461 agcgcatgaa tatacagaat ctctggtcca agccacaggt agaagacaca gaggagacgg
     2521 ccaacaaaga aggttgccca aaacccaaag atgatgaaga gtttgtcatt tcatccgacg
     2581 atataaaaac tgagggtaag aaagggaaga acaagactgg ccgtggtaag aagcacacag
     2641 ccttttcaag taaagggctc agtgatgagg agtacgatga gtacaaaagg atcagagatg
     2701 aaaggaatgg taagtattcc atagaagagt accttcagga cagagaaaag tactatgagg
     2761 aggtggccat tgccagggca accgaagagg acttctgtga agaagaagaa gccaaaatcc
     2821 ggcagaggat tttcaggcca acaaggaaac aacgcaaaga agagagggcc tctcttggtt
     2881 tagtcacagg atctgagatc aggaaaagaa acccagaaga cttcaaaccc aagggaaaac
     2941 tgtgggctga tgatgacaga agtgttgact acaatgagaa acttaatttt gaagctccac
     3001 caagcatctg gtcgcggata gtcaattttg gctcgggttg gggtttttgg gtttccccca
     3061 gcctgttcat aacatcaact catgtcatac cccaaggtgc aaaagagttc ttcggaaccc
     3121 ccatcaaaca aattcagata cacaaatcag gcgaattctg ccgattgagg ttcccaaaac
     3181 caatcaggac tgatgtgacg ggcatgatcc tagaagaggg tgcacccgaa gggaccgtgg
     3241 tcacactact aatcaagagg ccaactggag aactcatgcc tctggcagct agaatgggga
     3301 cccatgcaac catgaggatt caagggcgca cagttggggg gcaaatgggc atgcttctga
     3361 cagggtccaa cgccaaaagt atggacctag gcacaacacc gggtgactgt ggctgtccct
     3421 acatctacaa aaggggaaat gactacgtgg tcattggagt ccatacggct gctgcccgtg
     3481 gaggaaacac tgtcatatgt gccacccagg ggagtgaggg agaagccaca cttgaaggtg
     3541 gtgacaacaa gggaacctac tgtggtgcgc caatcttggg tccaggaagt gccccaaaac
     3601 tcagtaccaa gaccaagttt tggagatcat ccacaacacc actcccacct ggcacctatg
     3661 aaccagccta cctcggtggt aaggacccca gagtcaaagg tggcccttca ttgcaacaag
     3721 ttatgaggga ccagctaaaa ccatttacag aacccagggg caagccgcca agaccaagtg
     3781 tgttggaagc tgccaagaag accatcatca atgttcttga gcaaacaatt gacccacccc
     3841 agaaatggtc attcgcacag gcttgcgcgt cccttgacaa gaccacctcc agtggccacc
     3901 cgcaccacat gcggaaaaac gactgctgga acggggactc ctttacaggc aaattggcag
     3961 atcaggcttc caaggccaac ctgatgtttg aagaggggaa gaacatgacc ccagtctaca
     4021 caggtgcact taaggatgaa ttggtcaaaa ctgataaaat ttatggcaag atcaagaaga
     4081 ggctcctgtg gggctcagac ctggcgacca tgatccggtg cgctcgagcc tttggaggcc
     4141 ttatggatga acttaaggca cactgtgtta cgcttcctgt tagagttggt atgaacatga
     4201 atgaggatgg ccctatcatc tttgagaagc actccagata taaatttcac tatgatgctg
     4261 attattcccg gtgggactca acacaacaaa gagatgtgct agcggcagcc ctagaaatca
     4321 tggtcaaatt ctctccagaa ccacacctgg cccaggtagt tgcagaagac ctcctctccc
     4381 ccagtgtaat ggatgtgggt gattttcaaa tctcaataag tgaggggctc ccctccgggg
     4441 tgccttgcac ctcccaatgg aattccattg cccattggct cctcactctt tgcgcactct
     4501 ctgaagtcac ggacctgtcc cctgacatca ttcaggccaa ttcccttttc tccttttatg
     4561 gtgatgatga gattgtgagc acagacataa agttggaccc agagaaactg acagcaaaac
     4621 tcaaagagta cgggctgaaa ccaacccgcc ccgacaaaac tgaaggaccc cttgttatct
     4681 ctgaagatct ggatggcctg acattcttac ggagaactgt gacccgtgac ccagctggct
     4741 ggtttggaaa actggagcag agctcaattc tcaggcaaat gtactggacc aggggcccca
     4801 accatgaaga tccatctgaa acaatgatac cacactccca aagacccata caactgatgt
     4861 ccttgctggg cgaggctgca ctccacggcc cggcgtttta tagcaaagtt agcaagttag
     4921 tcattgcaga gctgaaggaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
     4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcacaat ctggctccca
     5041 gttttgtgaa tgaagatggc gtcgaatgac gccgctccat ctaatgatgg tgctacgggc
     5101 ctcgtcccag agatcaacaa cgagaccctt cctctggaac cagtggcggg tgcagctatt
     5161 gccgcgcctg ttactggcca aaataatata attgatccct ggattagaac aaattttgta
     5221 caagcaccca atggggagtt tacagtctca cccagaaact ctcctggaga aattctctta
     5281 aatctggaat tgggtcctga tttgaatccg tatttggcac atctatctag aatgtataat
     5341 gggtatgctg gtggcgtaga agttcaagtc ctcctagcag ggaatgcgtt cactgcagga
     5401 aagattctct tcgctgccgt tccaccaaat ttcccagttg aattcttgag tcctgcacaa
     5461 atcaccatgt tgccacattt aatagttgat gttagaaccc ttgaacctat catgatacca
     5521 ctcccagatg tcaggaacac cttcttccat tacaacaatc aacctgccaa tcgcatgcga
     5581 ttggtggcca tgctgtatac ccccttgaga tctaatggtt ctggtgatga tgtcttcaca
     5641 gtgtcatgta gagtgctaac taggcccacc ccagattttg agtttacata tttggtcccc
     5701 ccttcggtag agtccaagac caagcccttt tctctgccca tattgaccat ttctgaattg
     5761 accaactcaa gattccctgt accggtggat tcattgttca cagcccaaaa caacaatctc
     5821 aatgtccagt gtcaaaatgg tcgttgcaca ctggatggtg agttgcaggg aaccactcag
     5881 ttacaaccat caggcatctg cgcctttaga ggcaaaataa cggcagatgt gcaccagagc
     5941 cacgatgaca gatggcacat gcaactgaca aatctcaatg gaaccccctt cgatccaaca
     6001 gaggatgtgc cagctccact gggcactcca gacttcacag gccttctcta cggagttgcg
     6061 agccaaagga atgttcaacc caacccaaac accaccaggg cacatgaagc tgtgatctcc
     6121 acaaccagtt cgcagttcgt gccaaagtta gggtcaatca actttggtag cacaagtgaa
     6181 gacttcgtcg tgggccaacc caccaaattc acaccagttg gtattaagat tgagactgga
     6241 catgatttcg atcaatggac cctacctaga tattcaggcc atttgacact caatatgaac
     6301 cttgccccac ccgttgctcc aaatttccct ggtgaacagt tacttttctt cagatcaaac
     6361 gtcccctgtg ccggtggcgt cagtgatggc atcatcgact gcctgttgcc tcaggagtgg
     6421 atacagcact tctaccagga gtctgctccc tcccaatctg atgtggccct gatcagatat
     6481 gtcaaccctg acacgggtcg cacactcttt gaggcgaaac tccacagaac gggctacatc
     6541 actgttgctc attcaggtga ctatcccctt gttgtcccct ccaatggata tttcagattt
     6601 gattcttggg tgaaccagtt ttactcactc gcccccatgg gaactgggaa tgggcgcagg
     6661 cgggtgcagt aatggcagga gctttcatag caggtctagc aggtgacacg ctcaccaaca
     6721 cagttggttc actggtgaac gccggggcca atgctatcac ccaaaaggtg gactttgaaa
     6781 ataacaaaca gctccaatct gcctccttcc aacatgacaa agacatgctc caagcacaag
     6841 tggctgccac caagcagtta caggctgaaa tgatcgccat caagcagggg atattgaccg
     6901 caggcggctt ttcccccact gacgcggcga gaggagcagt gggtgcaccc atgaccaaag
     6961 tccttgattg gtccggtact cgttactggg ctccaaattc cacgcggaca actggctatt
     7021 cagggcagtt cacatcaaca cccgtgcata tgcccacaaa gataactcag cctgctcctg
     7081 caaaaaggac tcaaccccct tcttcctctt caggtagcat ttatagtctt tcaacacaga
     7141 gtactgtttt gaccaagcct tcttcaggct cctcttctgt ttcttctgct tttacacaat
     7201 ctacacaatt gagttcaatt ccttcaatgg atagaacagc aaattgggta aatcagcaaa
     7261 gaagcctcag cccctacatg agtggtgcac ttaacatatc tcatgtaaca cctccatcga
     7321 gcagggcttc gagttcagga acagtctcaa ctgtacccaa agaagttttg gactcctgga
     7381 catctgcatt caacacacac agacagccgc tcttcgcaca cctcagagtg aggggggagt
     7441 cacgtgttta gtgaaaagaa ccaattaatt ttaattagtt gtgattgaat tcaaaattgg
     7501 atctttt
//