Typing tool
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Typing tool
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Complete norovirus genomes
| MW305607 | GII.17 | |
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| GII.P31 |
ORF1: 1..5069
ORF2: 5050..6672
ORF3: 6672..7451
LOCUS MW305607 7507 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate Arg4446 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305607
VERSION MW305607.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7507)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REFERENCE 2 (bases 1 to 7507)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7507
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg4446"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="2005"
/note="genotype: GII.17[GII.P31]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59157.1"
/translation="AAANSNNDIAKSSSDGVFSNMAVTFKRALGARPKQPPPKEIPPR
PPRPPTPELVKNIPPPPPNGEDELVVSYSAKGGVSGLPELTTVRQPEENNTAFSVPPL
NQRESRDAKEPLTGTIIEMWDGEIYHYGLYVEKGLILGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLRRLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANIFLCTLSSLFTRPIKDIIGKLKPLNILNILA
TCDWTFAGIVESLILMAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARELAKKIAASLTGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQPDM
WKNAFSPDFSHIKLSLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEY
ELQGPPLTTFNFDRNKVLAFRQLAAENKYGLMDTMRVGKQLKDVKTMPDLKQALKNVS
IKKCQIVYNGSTYTLEADGKGNVKVDKVQSATVQTNNELTGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTARITKRMNIQNLWSKPQVEDTEETANKEGCPKPKDDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIRDERNGKYSIEEYLQDR
EKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPE
DFKPKGKLWADDDRSVDYNEKLNFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAKEFFGTPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMRIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPRPSVLE
AAKKTIINVLEQTIDPPQKWSFAQACASLDKTTSSGHPHHMRKNDCWNGDSFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYKFHYDADYSRWDSTQQRDVLAAA
LEIMVKFSPEPHLAQVVAEDLLSPSVMDVGDFQISISEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPAFYSKVSKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDHNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6672
/gene="ORF2"
CDS 5050..6672
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59158.1"
/translation="MKMASNDAAPSNDGATGLVPEINNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
VRNTFFHYNNQPANRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTISELTNSRFPVPVDSLFTAQNNNLNVQCQNGRCTLDGELQGTT
QLQPSGICAFRGKITADVHQSHDDRWHMQLTNLNGTPFDPTEDVPAPLGTPDFTGLLY
GVASQRNVQPNPNTTRAHEAVISTTSSQFVPKLGSINFGSTSEDFVVGQPTKFTPVGI
KIETGHDFDQWTLPRYSGHLTLNMNLAPPVAPNFPGEQLLFFRSNVPCAGGVSDGIID
CLLPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRTGYITVAHSGDYPLV
VPSNGYFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6672..7451
/gene="ORF3"
CDS 6672..7451
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59159.1"
/translation="MAGAFIAGLAGDTLTNTVGSLVNAGANAITQKVDFENNKQLQSA
SFQHDKDMLQAQVAATKQLQAEMIAIKQGILTAGGFSPTDAARGAVGAPMTKVLDWSG
TRYWAPNSTRTTGYSGQFTSTPVHMPTKITQPAPAKRTQPPSSSSGSIYSLSTQSTVL
TKPSSGSSSVSSAFTQSTQLSSIPSMDRTANWVNQQRSLSPYMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTHRQPLFAHLRVRGESRV"
ORIGIN
1 ccgctgctgc caacagcaac aacgacatcg caaaatcttc aagtgacgga gtgttttcca
61 acatggctgt cactttcaaa cgagccctcg gggcgcggcc caaacagccg cccccgaagg
121 aaataccacc cagaccccca cgaccaccca caccagaact ggtcaaaaat atccctcctc
181 ccccgcccaa cggggaggat gaactagtgg tttcctacag cgccaaaggt ggcgtttccg
241 gcctgcctga acttaccact gtcagacaac cggaagaaaa caacacggcg ttcagtgttc
301 ccccactcaa ccagagggag agtagggacg ccaaggaacc actaactgga acaattattg
361 aaatgtggga tggagaaata taccattacg gtctgtacgt ggaaaaaggt ctcatacttg
421 gtgtgcataa gccacctgca gccatcagcc ttgccaaggt tgagctaaca ccactttctc
481 tgttctggag acctgtgtac accccccagt atctcatctc tccagacact cttaggagac
541 tgcacggaga atcattcccc tacacagcat ttgacaataa ttgctacgcc ttctgttgtt
601 gggtgttgga cctaaacgat tcatggctaa gtaggaggat gatccagaga acaacaggtt
661 tcttcagacc atatcaagac tggaacagga aacccctccc cactatggat gactccaaat
721 taaagaaggt agccaacata ttcttgtgta ctctgtcttc gctattcacc agacccatca
781 aggacataat agggaagcta aaacctctta acatcctcaa tattttggcc acatgtgatt
841 ggaccttcgc aggcatagtg gaatccctaa tactcatggc agaactcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgatcg cccccttact aggtgattac gagctgcaag
961 gacctgagga cctcgcagta gaactcgtcc cagtagtgat gggggggata ggtttggtgc
1021 taggattcac caaagagaaa attgggaaga tgttgtcatc cgctgcatcc actttgagag
1081 cttgtaaaga ccttggtgca tacggactgg aaattttaaa attggtcatg aaatggttct
1141 tcccaaagaa agaggaagca aatgagttgg ccatggtgag agccatcgag gatgcggtgc
1201 tggacctcga ggcaattgaa aacaaccaca tgaccaccct gcttaaagat aaagacagct
1261 tggcaaccta catgagaacc cttgaccttg aggaggagaa agccagaaaa ctctcaacca
1321 aatctgcttc acccgatatt gtgggcacaa tcaatgctct tctggcaagg atcgctgctg
1381 cacgctccct agtgcatcgg gcgaaagaag agctctccag caggccaaga cctgttgttg
1441 tgatgatatc gggaaaacca ggaataggga aaactcacct tgccagggaa ctggctaaga
1501 agatcgcggc ttccctcaca ggggaccaac gtgtgggtct cataccgcgc aatggtgttg
1561 accattggga cgcatacaag ggagaaaggg tggtcctatg ggatgactac ggaatgagca
1621 accccatcca tgacgccctc aggttgcagg agcttgctga cacttgtccc ctcacgctga
1681 actgtgacag gattgagaac aaaggaaaag tttttgacag tgatgctata attatcacca
1741 ccaatctggc caacccagca ccactagatt atgtcaactt tgaagcgtgt tcgaggcgca
1801 ttgacttcct cgtgtacgca gatgctcctg atgtagagaa ggcaaaacgc gacttcccag
1861 gccagcccga catgtggaag aacgctttca gtcccgactt ctcacacata aaactgtcac
1921 tggccccaca gggtggcttc gataagaacg gaaacacccc acatgggaaa ggcgtcatga
1981 aaaccctcac cactggctcc ctcatcgccc gagcatcagg gttgctccat gagaggctag
2041 atgaatatga gttacagggc ccgcctctca ccactttcaa ctttgaccgc aataaggtcc
2101 ttgctttcag acagcttgct gctgaaaaca agtatgggtt gatggacaca atgagagttg
2161 gaaaacagct caaggatgtc aagaccatgc cagacctcaa gcaagctctc aaaaatgtct
2221 cgatcaagaa gtgtcaaata gtgtacaatg gtagcaccta cacacttgag gccgatggca
2281 agggtaatgt gaaggttgac aaagtacaaa gtgccaccgt gcaaaccaac aatgaactaa
2341 ctggtgccct acaccatcta aggtgcgcca gaattaggta ctatgtcaag tgtgtccagg
2401 aggcactgta ttccatcatc caaattgctg gggctgcgtt cgtcaccgcg cgcatcacta
2461 agcgcatgaa tatacagaat ctctggtcca agccacaggt agaagacaca gaggagacgg
2521 ccaacaaaga aggttgccca aaacccaaag atgatgaaga gtttgtcatt tcatccgacg
2581 atataaaaac tgagggtaag aaagggaaga acaagactgg ccgtggtaag aagcacacag
2641 ccttttcaag taaagggctc agtgatgagg agtacgatga gtacaaaagg atcagagatg
2701 aaaggaatgg taagtattcc atagaagagt accttcagga cagagaaaag tactatgagg
2761 aggtggccat tgccagggca accgaagagg acttctgtga agaagaagaa gccaaaatcc
2821 ggcagaggat tttcaggcca acaaggaaac aacgcaaaga agagagggcc tctcttggtt
2881 tagtcacagg atctgagatc aggaaaagaa acccagaaga cttcaaaccc aagggaaaac
2941 tgtgggctga tgatgacaga agtgttgact acaatgagaa acttaatttt gaagctccac
3001 caagcatctg gtcgcggata gtcaattttg gctcgggttg gggtttttgg gtttccccca
3061 gcctgttcat aacatcaact catgtcatac cccaaggtgc aaaagagttc ttcggaaccc
3121 ccatcaaaca aattcagata cacaaatcag gcgaattctg ccgattgagg ttcccaaaac
3181 caatcaggac tgatgtgacg ggcatgatcc tagaagaggg tgcacccgaa gggaccgtgg
3241 tcacactact aatcaagagg ccaactggag aactcatgcc tctggcagct agaatgggga
3301 cccatgcaac catgaggatt caagggcgca cagttggggg gcaaatgggc atgcttctga
3361 cagggtccaa cgccaaaagt atggacctag gcacaacacc gggtgactgt ggctgtccct
3421 acatctacaa aaggggaaat gactacgtgg tcattggagt ccatacggct gctgcccgtg
3481 gaggaaacac tgtcatatgt gccacccagg ggagtgaggg agaagccaca cttgaaggtg
3541 gtgacaacaa gggaacctac tgtggtgcgc caatcttggg tccaggaagt gccccaaaac
3601 tcagtaccaa gaccaagttt tggagatcat ccacaacacc actcccacct ggcacctatg
3661 aaccagccta cctcggtggt aaggacccca gagtcaaagg tggcccttca ttgcaacaag
3721 ttatgaggga ccagctaaaa ccatttacag aacccagggg caagccgcca agaccaagtg
3781 tgttggaagc tgccaagaag accatcatca atgttcttga gcaaacaatt gacccacccc
3841 agaaatggtc attcgcacag gcttgcgcgt cccttgacaa gaccacctcc agtggccacc
3901 cgcaccacat gcggaaaaac gactgctgga acggggactc ctttacaggc aaattggcag
3961 atcaggcttc caaggccaac ctgatgtttg aagaggggaa gaacatgacc ccagtctaca
4021 caggtgcact taaggatgaa ttggtcaaaa ctgataaaat ttatggcaag atcaagaaga
4081 ggctcctgtg gggctcagac ctggcgacca tgatccggtg cgctcgagcc tttggaggcc
4141 ttatggatga acttaaggca cactgtgtta cgcttcctgt tagagttggt atgaacatga
4201 atgaggatgg ccctatcatc tttgagaagc actccagata taaatttcac tatgatgctg
4261 attattcccg gtgggactca acacaacaaa gagatgtgct agcggcagcc ctagaaatca
4321 tggtcaaatt ctctccagaa ccacacctgg cccaggtagt tgcagaagac ctcctctccc
4381 ccagtgtaat ggatgtgggt gattttcaaa tctcaataag tgaggggctc ccctccgggg
4441 tgccttgcac ctcccaatgg aattccattg cccattggct cctcactctt tgcgcactct
4501 ctgaagtcac ggacctgtcc cctgacatca ttcaggccaa ttcccttttc tccttttatg
4561 gtgatgatga gattgtgagc acagacataa agttggaccc agagaaactg acagcaaaac
4621 tcaaagagta cgggctgaaa ccaacccgcc ccgacaaaac tgaaggaccc cttgttatct
4681 ctgaagatct ggatggcctg acattcttac ggagaactgt gacccgtgac ccagctggct
4741 ggtttggaaa actggagcag agctcaattc tcaggcaaat gtactggacc aggggcccca
4801 accatgaaga tccatctgaa acaatgatac cacactccca aagacccata caactgatgt
4861 ccttgctggg cgaggctgca ctccacggcc cggcgtttta tagcaaagtt agcaagttag
4921 tcattgcaga gctgaaggaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcacaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccgctccat ctaatgatgg tgctacgggc
5101 ctcgtcccag agatcaacaa cgagaccctt cctctggaac cagtggcggg tgcagctatt
5161 gccgcgcctg ttactggcca aaataatata attgatccct ggattagaac aaattttgta
5221 caagcaccca atggggagtt tacagtctca cccagaaact ctcctggaga aattctctta
5281 aatctggaat tgggtcctga tttgaatccg tatttggcac atctatctag aatgtataat
5341 gggtatgctg gtggcgtaga agttcaagtc ctcctagcag ggaatgcgtt cactgcagga
5401 aagattctct tcgctgccgt tccaccaaat ttcccagttg aattcttgag tcctgcacaa
5461 atcaccatgt tgccacattt aatagttgat gttagaaccc ttgaacctat catgatacca
5521 ctcccagatg tcaggaacac cttcttccat tacaacaatc aacctgccaa tcgcatgcga
5581 ttggtggcca tgctgtatac ccccttgaga tctaatggtt ctggtgatga tgtcttcaca
5641 gtgtcatgta gagtgctaac taggcccacc ccagattttg agtttacata tttggtcccc
5701 ccttcggtag agtccaagac caagcccttt tctctgccca tattgaccat ttctgaattg
5761 accaactcaa gattccctgt accggtggat tcattgttca cagcccaaaa caacaatctc
5821 aatgtccagt gtcaaaatgg tcgttgcaca ctggatggtg agttgcaggg aaccactcag
5881 ttacaaccat caggcatctg cgcctttaga ggcaaaataa cggcagatgt gcaccagagc
5941 cacgatgaca gatggcacat gcaactgaca aatctcaatg gaaccccctt cgatccaaca
6001 gaggatgtgc cagctccact gggcactcca gacttcacag gccttctcta cggagttgcg
6061 agccaaagga atgttcaacc caacccaaac accaccaggg cacatgaagc tgtgatctcc
6121 acaaccagtt cgcagttcgt gccaaagtta gggtcaatca actttggtag cacaagtgaa
6181 gacttcgtcg tgggccaacc caccaaattc acaccagttg gtattaagat tgagactgga
6241 catgatttcg atcaatggac cctacctaga tattcaggcc atttgacact caatatgaac
6301 cttgccccac ccgttgctcc aaatttccct ggtgaacagt tacttttctt cagatcaaac
6361 gtcccctgtg ccggtggcgt cagtgatggc atcatcgact gcctgttgcc tcaggagtgg
6421 atacagcact tctaccagga gtctgctccc tcccaatctg atgtggccct gatcagatat
6481 gtcaaccctg acacgggtcg cacactcttt gaggcgaaac tccacagaac gggctacatc
6541 actgttgctc attcaggtga ctatcccctt gttgtcccct ccaatggata tttcagattt
6601 gattcttggg tgaaccagtt ttactcactc gcccccatgg gaactgggaa tgggcgcagg
6661 cgggtgcagt aatggcagga gctttcatag caggtctagc aggtgacacg ctcaccaaca
6721 cagttggttc actggtgaac gccggggcca atgctatcac ccaaaaggtg gactttgaaa
6781 ataacaaaca gctccaatct gcctccttcc aacatgacaa agacatgctc caagcacaag
6841 tggctgccac caagcagtta caggctgaaa tgatcgccat caagcagggg atattgaccg
6901 caggcggctt ttcccccact gacgcggcga gaggagcagt gggtgcaccc atgaccaaag
6961 tccttgattg gtccggtact cgttactggg ctccaaattc cacgcggaca actggctatt
7021 cagggcagtt cacatcaaca cccgtgcata tgcccacaaa gataactcag cctgctcctg
7081 caaaaaggac tcaaccccct tcttcctctt caggtagcat ttatagtctt tcaacacaga
7141 gtactgtttt gaccaagcct tcttcaggct cctcttctgt ttcttctgct tttacacaat
7201 ctacacaatt gagttcaatt ccttcaatgg atagaacagc aaattgggta aatcagcaaa
7261 gaagcctcag cccctacatg agtggtgcac ttaacatatc tcatgtaaca cctccatcga
7321 gcagggcttc gagttcagga acagtctcaa ctgtacccaa agaagttttg gactcctgga
7381 catctgcatt caacacacac agacagccgc tcttcgcaca cctcagagtg aggggggagt
7441 cacgtgttta gtgaaaagaa ccaattaatt ttaattagtt gtgattgaat tcaaaattgg
7501 atctttt
//