Typing tool
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Typing tool
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Complete norovirus genomes
| MW305606 | GII.7 | |
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| GII.P7 |
ORF1: 1..5034
ORF2: 5015..6637
ORF3: 6637..7410
LOCUS MW305606 7468 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate Arg4416 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305606
VERSION MW305606.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7468)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7468)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7468
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg4416"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="2004"
/note="genotype: GII.7[GII.P7]"
gene <1..5034
/gene="ORF1"
CDS <1..5034
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QPJ59154.1"
/translation="SNDATPSNKEEAGAFSNIKVGFKKMLGAVPKGTKAPSSGQHCPT
VKIGPKTLTIPPEPPNGEDTVQFDAKSETIIGLPDLTTVQNEHENTPYTVPPLSEREH
RPATEPLPGTILEMWDGEFYHYSVYVSDGKALGVHKPPAAISLATIELTPISLYWRPV
YTPNYLVSPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLNRRCISRTTGFFKP
YQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLLHLLASCDWT
FAGIVETVILMAELFNVFWTPPDVSNFVASLIGDFELQGPEDLAVELVPVVMGGIGMV
LGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAEMETLRAIED
AVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDIVGTINAILA
RIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANTMSGDQRVGL
VPRNGVDHWDAYRGERVVLWDDYGMGSPVKDALTLQELADTCPVTLNCDRIENKGKMF
DSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPGQPDMWKDHF
KPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHERRDEFQLQGN
DLQTYNFDTNRVSAFRKLAADNKYGVMETMRVGAALKNVKTLEDLKVALRDVKFNECE
IIYKNSKYRVSSNGKGSVSVDKVEDNASQTVNEVQSALLRLRQARARYYISCFQDLVY
TLIQVAGASFVVNRISRRFCWERWVKPTETQEVNESEKEVVQDRWEIEPKDTGPEGKK
GKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDRYYEEVAVAR
ATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGSDIRKRRPDDFQPKGNLWAD
DTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKGVKELFGVEI
KQIQVHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILIKRPTGEMIPLAVRMG
THASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDIVVAGVHTAA
ARGGNTVICATQGQDGEAVLEGNEDLGTYCGAPILGPGKAPKLSTKTKFWRSSPDALP
PGTYEPAYLGGKDPRVEKGPSLQQVMRDQLRPFTEPRGKPPRPAVLEEAKKTVMNVLE
QTIDPAKPWSYSQACASLDKTTSSGSPHHVKKNDHWNGESFTGPLADQASKANLMYEQ
AKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGLMDSMKASCI
ALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAMEVMVRFSAEP
ELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTLSAMAEVSGL
SPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTEGPLVITEDL
TGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHSQRATQLMAL
LGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLSTWEGDRNLAP
EGVNEDGVE"
mat_peptide <1..942
/gene="ORF1"
/product="p48"
mat_peptide 943..2040
/gene="ORF1"
/product="NTPase"
mat_peptide 2041..2559
/gene="ORF1"
/product="p22"
mat_peptide 2560..2958
/gene="ORF1"
/product="VPg"
mat_peptide 2959..3501
/gene="ORF1"
/product="Pro"
mat_peptide 3502..5031
/gene="ORF1"
/product="RdRp"
gene 5015..6637
/gene="ORF2"
CDS 5015..6637
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59155.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNEVMPLEPVAGASLATPVVGQ
QNIIDPWIRNNFVQAPAGEFTVSPRNSPGEILLDLELGPELNPYLAHLARMYNGHAGG
MEVQIVLAGNAFTAGKIIFAAIPPGFPYENLSPSQITMCPHVIIDVRQLEPVLLPMPD
IRNNFFHYNQGNDPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTKPSPDFEFTFLVPP
TVESKTKQFTLPILKISEMTNSRFPVPVEMMYTARNENQVVQPQNGRVTLDGELLGTT
PLLAVNICKFKGEVIAKNGDVRSYRMDMEITNTDGTPIDPTEDTPGPIGSPDFQGILF
GVASQRNKNEQNPATRAHEANINTGGDQYAPKLAQVKFFSESQDFEVHQPTVFTPVGV
AGDSSHPFRQWVLPRYGGHLTNNTHLAPAVAPLFPGEQILFFRSQIPSSGGHELGYMD
CLVPQEWVQHFYQEAATAQSEVALIRFINPDTGRVLFEAKLHKQGFITVAHTGDNPIV
MPPNGYFRFEAWVNQFYSLAPVGTGNGRRRIQ"
gene 6637..7410
/gene="ORF3"
CDS 6637..7410
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59156.1"
/translation="MASAFFANLAGGVASNGISSLINAGANAINQKVEFDYNKQLQNA
SFSHDKEMLQAQIEATKRLQQEMIDIKQGVLTAAGFSPTDAARGSVGAPMTKLVDWSG
TRYWAPGAMRTTGYSGTFTHLPPMQSAPYVNNQNRQLLKVDPSLPSSSGSSVSSVKTQ
STTLSGTSRVGSSSQSTLSTRPSTRTSDWVRSQNERLSPFMNGALQTTYVTPPSSRAS
SVSTVSTVPKEVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 agtaacgacg ccaccccttc taacaaagaa gaggctggtg cattctccaa catcaaagtt
61 ggattcaaga aaatgctggg tgccgtaccc aagggtacca aagcacccag cagtggtcaa
121 cattgcccca cagttaagat cgggcctaaa acattaacaa tcccccctga gcccccaaat
181 ggtgaagaca ccgtacagtt tgatgcaaag tcagaaacta taattgggct accggacttg
241 acaacggtgc aaaacgaaca cgaaaacacc ccatacactg tccctccatt aagtgagagg
301 gagcacagac cggccactga accacttcct ggcacaatat tggagatgtg ggatggtgag
361 ttttaccatt actccgtgta cgtcagcgac ggtaaagctc tgggggtcca caaaccaccg
421 gcggctataa gcctcgcgac gatagagctc acccccatat cactttattg gaggcccgtt
481 tataccccca attatttggt ctccccggac acattaaagg gcctcgctgg tgagaagttc
541 ccctacacgg ccttcagtaa caactgttat aacttctgct gctgggtgct tgagctcaac
601 gacacgtggc ttaacagaag atgcatttcc agaaccaccg gattcttcaa accataccag
661 tcttggaaca ggaaacctct cccaaccgtt gatgatggaa agatcaaaaa ggtggccaac
721 gcgatcctct gtgcactcgg ctcgctgttt tcaaaaccaa tcaaagatct gttaggcaaa
781 ctcaagccat tgaatctact acacttgctt gcgtcttgtg attggacgtt tgcgggtata
841 gtggagacag tcatcttaat ggcggaactt tttaatgtct tctggacccc gccagatgtc
901 tctaattttg tagcctccct gataggtgat tttgaattgc aagggcctga ggacctggct
961 gtggagctcg ttcccgtggt tatgggtggt ataggaatgg ttctcggttt taccgctgag
1021 aagataggcc gcatgctgtc gtccgctgca tcaacattgc gggcgtgcaa agacctaggg
1081 aactatgccc ttgacatact caaattggtc atgaagtggt tcttcccaaa gaaggaagag
1141 aaagctgaga tggaaacctt gagggcgatt gaagatgccg tcctagatat ggaagctata
1201 gggaataacc acctcacaac ccttctcaag gacaaagaca gcctcacggc ttttatgaag
1261 accctggacc tagaagagga gaaggccagg aaactgtcca ctaaatcatc ttcaccggac
1321 atagtcggca ccatcaatgc catactagct aggatagctg ctgctagatc ccttctacat
1381 aaggccaaag aagagatgtt cagcaggatc agaccagtgg tcgttatgat ctcaggcaga
1441 cctggcattg gaaaaaccca catggcgaga catttggcta agagcatcgc caacaccatg
1501 agtggcgacc agagagtcgg gctcgttccg cgcaacggtg tcgaccactg ggacgcctac
1561 aggggagaga gggtggtcct gtgggacgac tatggtatgg ggagccctgt taaagacgcc
1621 ctaacactac aagagctggc cgacacatgt ccagtcactt taaattgtga taggattgag
1681 aataagggga agatgtttga cagtgatgtc atcataatca cgaccaacct agtcaacccc
1741 gcgcccctcg actatgtgaa cttcgaggcg tgttctagga gagttgactt cctggtctat
1801 gcagagtcac cagaaattga aaaggtcaag agagacttcc ctggccagcc tgacatgtgg
1861 aaagaccatt ttaagccaga cttttcccac atcaagctga ctctagcccc ccagggtggg
1921 tttgacaaaa atggcaacac cccacacggc aagggcacca tgcggtccct aacccagggg
1981 tccctgactg cgagagttgc aggccttgtc catgagagga gagatgagtt ccagctccaa
2041 ggaaatgacc tccaaacata caactttgac accaacagag tctccgcatt caggaaattg
2101 gctgcagata acaagtatgg ggtcatggag acgatgagag tgggtgcggc actcaagaat
2161 gtgaagacct tggaagatct caaagttgca ttgagggatg tgaaattcaa tgagtgtgaa
2221 ataatttata agaactctaa gtatcgagtc tcttccaacg gtaaaggctc agtttctgtt
2281 gacaaagttg aggacaatgc atcccagact gtaaacgagg tacaatcagc acttctcagg
2341 ctcaggcaag cgagggccag gtattacatc agctgcttcc aagacctcgt ctacactctc
2401 atacaggttg ccggagcatc attcgttgtc aacaggatct ccagaaggtt ctgctgggaa
2461 aggtgggtca aaccaaccga gacccaggag gtgaatgagt ccgaaaagga agtggttcaa
2521 gatagatggg aaattgagcc caaggataca ggaccagaag gcaagaaggg taagaacaag
2581 aaaggaaggg gtaagaaaca cacagctttc tctagcaaag gcctgagtga tgaagagtat
2641 gacgagttca agagaatcag ggaagaaagg aacggaaagt actccattga ggaatacctg
2701 caagaccgag accgctatta tgaagaagtg gcagttgccc gggcgacaga ggaggacttc
2761 tgtgaagagg aagaggccaa aataagacaa aggattttcc gcccgacaaa gaaacagagg
2821 aaggaggaaa ggggtgtgct tggcttagtc accggttcag acatcagaaa gaggagacca
2881 gacgattttc aaccaaaagg caacctatgg gcagatgaca ccagaagtgt ggactacaat
2941 gagaggcttg attttgaagc gcccccaagt gtttggtcaa gaatagtccc attaggcact
3001 ggttggggat tctgggtttc atccaacctt ctgatcacaa caacacacgt cctgcctaaa
3061 ggggttaagg aactctttgg agttgaaatc aagcaaattc aagttcataa gtctggagag
3121 ttttgcaggt ttaggttccc aagacctatc aggccagatg tcacaggact cgtgctggag
3181 gaaggcgccc cagagggcac tgtttgttct atactcataa aaaggcccac aggtgagatg
3241 attcccttgg cagtgaggat gggcacacat gcatccatga aaatacaggg caggaccgtt
3301 ggtggccaga tggggatgct tctcacagga gcaaacgcga agaacatgga tctcggcacc
3361 ggtcctggtg actgcggttg tccctacatc tacaaacgtg gcaatgacat tgttgtcgcg
3421 ggtgtccata ccgcagcagc ccggggaggc aacactgtca tatgcgccac ccaagggcaa
3481 gatggggaag cagtccttga gggaaatgag gaccttggta cctactgtgg cgccccaatt
3541 ctgggccctg gcaaggcgcc taaactcagc acgaagacca agttttggcg ctcatcacca
3601 gatgccttgc cacctggcac atatgagcct gcttacctag gaggcaaaga ccccagagtg
3661 gaaaaagggc cctccctgca gcaagtcatg agagaccagt tgagaccctt cacagaaccc
3721 aggggcaaac cacctagacc tgcagtctta gaagaagcca aaaagacagt gatgaatgtt
3781 ctagaacaaa ccattgaccc cgccaagcca tggtcctatt cgcaggcatg tgcctcactg
3841 gacaaaacca cctctagtgg tagtccccat cacgttaaga aaaatgacca ctggaatggg
3901 gagtccttca ctggtcccct tgcagatcag gcatctaaag ccaacctcat gtatgagcag
3961 gctaagcatg tgcagcccgt gtacacggcc gcgcttaaag atgagcttgt taagactgac
4021 aagatctaca aaaagataaa gaagaggctc ctatgggggt cggaccttgg cacaatgatc
4081 aggtgcgcca gggcttttgg tggtctcatg gacagcatga aggctagttg tatagctctt
4141 ccatgcaggg tgggaatgaa catgaatgaa gatggcccca tcatatttga caaacattct
4201 aagtacaggt accactatga tgctgactat tctaggtggg actcaaccca acaaaggagc
4261 attctttctg ccgccatgga agtgatggtg cggttttctg ctgaaccaga attggcacaa
4321 gtggttgcgg aagacctttt ggcacctagc cagcttgatg ttggcgattt tgtcatctca
4381 gtccaggagg gtctgccatc aggagtccca tgtacatcac aatggaattc aatagcacac
4441 tggatcctaa ctttgagtgc aatggcagaa gtgtcaggtc tctcaccaga tgttgtccaa
4501 gctcactctt gtttttcatt ttatggggac gatgagatcg tcagtactga tatcaacctt
4561 gaccccatga agttgacaca gaaactcagg gagtacggtc tggtccccac ccggcctgat
4621 aaaactgaag gtcccctcgt cataactgaa gacctcaccg gcctgacgtt ccttcgcagg
4681 tcgattgctc gggacccagc tggttggttt ggaaaattgg accaagattc aatcctcagg
4741 caactgtact ggacaagggg gcctaaccat gagaacccgt acgagagcat ggttcctcat
4801 tctcagcggg ccacacagct catggccctt cttggtgagg cctcactgca tggtccccag
4861 ttttacaaga aagttagcaa gatggtcatc aatgagatta agagtggtgg tctggagttt
4921 tatgtgccca gacaagaggc catgttcagg tggatgagat tctctgacct cagcacatgg
4981 gagggcgatc gcaatctagc tcccgaaggt gtgaatgaag atggcgtcga atgacgcagc
5041 tccatctaat gatggtgcag caggcctcgt accagagatc aacaatgagg tcatgcccct
5101 tgagcccgtg gctggtgcat cgctggcgac accagttgtc ggacaacaaa atataattga
5161 tccctggata agaaataatt ttgtacaagc tcctgcaggt gagtttacag tctcccctag
5221 aaattctcct ggtgaaattt tgcttgattt ggagttggga ccagaattga acccctacct
5281 tgctcatctg gcccgtatgt acaatgggca cgctggtggt atggaagtgc aaattgtgtt
5341 ggctgggaat gcgttcacag ctggcaagat catatttgct gccatccctc cagggttccc
5401 atatgaaaat ttgtcacctt cacaaattac aatgtgccct catgttataa ttgatgttag
5461 acaattagaa ccagtcctac tacctatgcc agatatcaga aataacttct tccattacaa
5521 tcagggcaat gatccaaaat tgagattggt agctatgctc tacacccctt taagggctaa
5581 taattctggt gatgatgtgt tcacagtttc ttgtagggtc ctcactaaac cgtcacctga
5641 ttttgaattc acatttctag ttccccccac ggttgaatcc aagaccaagc agtttacatt
5701 gcccatcctc aagatatcag agatgaccaa ctcaagattc ccagtgccag tggaaatgat
5761 gtacacagcc aggaatgaga accaagttgt ccagccacag aatggtaggg tcacacttga
5821 tggcgaacta ttaggcacca cacccttatt ggctgtcaac atctgcaaat tcaagggaga
5881 ggttatagct aagaatggag atgtgagatc ctataggatg gacatggaaa tcaccaacac
5941 tgatggcacc ccaattgacc ccacagaaga cacacctggt cccattggtt cacctgattt
6001 tcaaggtata ctttttggcg ttgccagcca acgcaacaag aatgagcaaa accccgccac
6061 gagagcccat gaagccaaca ttaacactgg tggggaccaa tacgccccca aattggccca
6121 agtgaaattc ttctcagagt cccaggattt cgaggtgcac cagcccacag ttttcacccc
6181 agttggtgtg gcaggcgact cttcccaccc tttcagacag tgggtcctgc ctcgatacgg
6241 tggacatctc accaataaca cccacttggc tccagcagtg gcccctctat tcccaggtga
6301 gcagattcta ttctttagat cacaaatacc tagctcaggc ggccatgaat tgggttacat
6361 ggactgcctt gtcccacaag aatgggtcca acacttctat caagaagctg ccacagctca
6421 gtctgaggtg gcactcataa ggtttatcaa cccagacact ggcagagtcc tctttgaggc
6481 caaactgcac aagcaaggct ttataactgt ggctcacact ggtgataacc caattgtcat
6541 gccaccaaat gggtacttta gatttgaagc ctgggttaat cagttttact cactcgcccc
6601 cgtgggaact gggaatgggc gcaggaggat ccaataatgg ctagtgcttt ctttgcaaat
6661 ttggcaggag gcgttgcctc caatggaatt agttcactca taaatgctgg ggctaatgct
6721 attaatcaaa aggttgagtt tgattataat aaacaactcc aaaatgcatc cttctcccat
6781 gataaggaaa tgctccaagc ccaaattgaa gccactaaac gtctgcaaca agagatgatt
6841 gacataaaac aaggggtgtt gacagccgcg ggattctctc ctacggatgc cgcgaggggt
6901 tctgtcggcg cgccaatgac aaaattagtt gattggagtg gcactagata ttgggcacct
6961 ggcgccatga ggacaacagg ttattcaggg acttttactc acttaccccc tatgcagtct
7021 gctccatatg ttaataatca aaacagacaa cttcttaaag tagatccttc tcttccctct
7081 tcgagtggtt cttctgtttc ttctgtcaaa acacaatcaa ctaccctctc gggcacttca
7141 agggtgggct cctcatctca gtcaaccctg tcgaccaggc cgagcacaag gacatctgat
7201 tgggtgcgta gccaaaatga aaggttgagc cccttcatga atggagcgtt gcaaacaacg
7261 tatgtaacgc caccatccag tagggcatca agtgtcagca cagtctcgac cgtgccgaaa
7321 gaggttttgg actcctggac gcctatgttt aacactcaca ggcagccact cttcgcccac
7381 ttgcgtaggc gaggggagtc acagatttag tgaaaagatt ggttgggaaa gtttgattag
7441 tttgttcttc ttttctacta tcccttta
//