Typing tool
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Typing tool
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Complete norovirus genomes
| MW305595 | GII.12 | |
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| GII.P29 |
ORF1: 1..5075
ORF2: 5056..6663
ORF3: 6663..7442
LOCUS MW305595 7491 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate 110-2 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305595
VERSION MW305595.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7491)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7491)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7491
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="110-2"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="USA"
/collection_date="16-Nov-1987"
/note="genotype: GII.12[GII.P29]"
gene <1..5075
/gene="ORF1"
CDS <1..5075
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59121.1"
/translation="AAATSNNDNAKSSSDGVLNSMAVTFKRALGARPKQPPPREITQK
QKPPRPPTPELIKKIPPPPPNGEDELVVSYSVKDGVSGLPELSTVSQPGETNTAFSVP
PLNQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISFAKVELTPL
SLYWRPVYTPQYLISPDTLRKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQR
TTGFFRPYQDWNRKPLPTMDDSKLKKVANVVLCALSSLFTRPIKDIIGKLRPLNILNI
LASCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDEVNELA
MVRSIEDAVLDLEAIENNHMTALLKDKDSLATYMNTLDLEEEKARRLSTKSASPDIVG
TINALLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARDLAKKIAATLT
GDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRI
ENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVFADAPDVEKAKRDFPGQP
DMWKDAFRPDFSHIKLMLAPQGGFDKNGNTPHGKGVMKTLTSGSLIARASGLLHERLD
EYELQGPTPTTFNFDQNKVFAFRQLAAENKYGLMDTMRVGSQLKGVKTMSELKQALKN
IAIKKCQIVYGGSTYSLESDGKGNVKVERVQSATVQTNNELTGALHHLRCARIRYYVK
CVQEALYSIIQIAGAAFVTTRIAKRMNIQNLWSRPQVEDTEETINKDGCPKPKDDEEF
VVSSEDIKVEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQ
DRDKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRN
PDDFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHV
IPQGAQEFFGVSIRQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKR
PTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKR
GNDYVVIGVHTAAARGGNTVICATQGSEGEAVLEGGDNKGTYCGAPILGPGSAPKLST
KTKFWRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPNPSV
LEAAKKTIINVLEQTIDPPQKWSFSQACASLDKTTSSGHPHHMRKNECWNGESFTGKL
ADQASKANLMYEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARA
FGGLMDELKAHCVTLPIRVGMNMNEDGPIIFEKHSRYHYHYDADYSRWDSTQQRAVLA
AALEIMVKFSSEPHLAQVVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHW
LLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPGKLTAKLIEYGLKPTRP
DKTEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETM
IPHSQRPIQLMSLLGEAALHGPSFYSRISKLVIAELKEGGMDFYVPRQEPMFRWMRFS
DLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2600
/gene="ORF1"
/product="p22"
mat_peptide 2601..2999
/gene="ORF1"
/product="VPg"
mat_peptide 3000..3542
/gene="ORF1"
/product="Pro"
mat_peptide 3543..5072
/gene="ORF1"
/product="RdRp"
gene 5056..6663
/gene="ORF2"
CDS 5056..6663
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59122.1"
/translation="MKMASNDAAPSNDGAAGLVPEANNETMALEPVVGASIAAPLTGQ
NNIIDPWIRLNFVQAPNGEFTVSPRNSPGEVLLNLELGPELNPYLSHLSRMYNGYAGG
VEVQVLLAGNAFTAGKLVFAAVPPHFPLENISPGQITMFPHVIVDVRTLEPVLLPLPD
VRNNFFHYNQQNEPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFNYLVPP
TVESKTKPFTLPILTMGELTNSRFPVPIDELYTSPNENLVVQPQNGRCTLDGELQGTT
QLLPTAVCSFRGRINTKVAGEDNVWNMQVTNINGTPFDPTEDVPAPLGTPDFSGKIFG
VLSQRNTNNACRAHDAVVATNSPKFTPKLGSLHIGTWEQTDIDTNQPTKFTPVGLHEH
TDYNQWTLPNYSGALTLNMGLAPPVAPTFPGEQILFFRSHVPLKGGVADTVIDCLLPQ
EWVQHLYQESAPSQSDVALIRFTNPDTGRVLFEAKLHRNGYITVSNTGSKPIVVPANG
YFRFDSWVNQFYSLAPMGTGNGRRRVQ"
gene 6663..7442
/gene="ORF3"
CDS 6663..7442
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59123.1"
/translation="MAGAFIAGLAGDIVTNSIGSLVNAGANAINQKVDFENNKQLQQA
SFNHDKEMLQAQIQATKQLQQDMIAIRQGVLTAGGFSPTDAARGAVNAPMTQVLDWNG
TRYWAPGATRTTAFSGGFTSSTHTKTVDLSNKTTAAPIPSKPISRPSSSVSSNSTRST
LVSGSSTSPSVRSLSSVSSQSSSPSSRTSEWVRSQNRALEPYMRGALQTAYVTPPSSR
ASSNGTVSTVPKEILDSWTSAFNTRRQPLFAHLRRRGESQA"
ORIGIN
1 ccgctgctgc taccagcaac aacgacaacg caaaatcttc aagtgacgga gtactaaata
61 gtatggctgt cacttttaaa cgagccctcg gggcccggcc taaacagccg cccccgaggg
121 aaataacaca aaaacaaaaa cccccacgac cgcccacccc agaactgatc aaaaagatcc
181 cgcccccccc gcccaacggg gaggacgagt tggtggtctc ctatagcgta aaagatggcg
241 tttccggttt gcctgagctc tccaccgtca gccagccggg cgagaccaac acggcgttta
301 gtgttccccc actcaaccaa agggaaaaca gagacgctaa ggagccacta actggcacta
361 ttctggaaat gtgggatggg gagatctacc attatggcct gtatgtggaa cggggtttgg
421 tgcttggggt acacaaacca ccagcagcta tcagctttgc caaggttgag ctgacaccat
481 tgtccctgta ctggagacca gtgtacaccc ctcagtacct tatatccccg gacaccctca
541 gaaaactaca cggggagtca ttcccttaca cggcctttga caacaactgt tacgccttct
601 gttgttgggt cctggacctg aacgactctt ggcttagcag gaggatgata cagagaacaa
661 ctggcttttt caggccttac caggactgga acagaaaacc cctccccacc atggatgatt
721 ccaaattaaa gaaggtggcc aatgtagtcc tgtgtgcctt gtcatcattg ttcaccagac
781 ctattaagga cataattgga aaactaagac ccctaaacat cctcaacata ttggcttcct
841 gcgattggac ctttgcaggt atagtagaat ccctaatcct cctggcagaa ctctttggag
901 tattttggac acccccagat gtgtctgcga tgatcgcccc tttactaggt gactatgaac
961 tacaggggcc tgaggacctt gctgtagaac tcgtaccagt ggtaatgggg gggataggtt
1021 tggttctagg tttcaccaaa gagaaaattg gcaagatgct atcatctgcc gcgtccactc
1081 tcagggcttg taaagatctt ggagcttacg ggttagaaat cttgaagctg gtcatgaagt
1141 ggtttttccc gaagaaagac gaggtgaacg aactcgcaat ggtgagatcc atcgaagacg
1201 cagtattgga cctcgaagcg attgaaaaca accacatgac cgctctgctc aaagacaagg
1261 atagtttggc aacctatatg aacactctag atcttgaaga ggagaaagct agaagactgt
1321 ccaccaagtc tgcctcccct gacatcgtgg gtacaataaa cgccctgctg gcacggatcg
1381 cagccgctcg ttccctggtg catcgggcaa aagaggagct ttctagcaga ccaaggcccg
1441 ttgttgtgat gatatcaggt aaaccaggaa tagggaagac tcaccttgct agagacctag
1501 caaagaaaat cgcagccacc ctcacaggag atcagagggt gggtctcatc ccacgaaacg
1561 gcgttgatca ctgggacgca tataaaggtg aaagagttgt cctctgggat gactatggga
1621 tgagcaaccc catccatgac gccctcagat tacaagaact cgccgacacg tgccctctga
1681 cactaaattg tgataggatt gagaacaagg gaaaagtctt tgacagtgat gctataatca
1741 tcacaactaa tctggccaac ccagcaccat tggactatgt caactttgaa gcatgctcaa
1801 ggcgtatcga cttccttgtg ttcgctgatg ctcctgatgt tgagaaggca aagcgtgact
1861 tccctggaca acctgacatg tggaaagatg cctttagacc tgacttctca cacataaagc
1921 tgatgctggc cccccaaggg ggttttgaca agaatggcaa caccccacac gggaaaggcg
1981 tcatgaagac cctcacatct ggctctctca ttgcacgcgc atcagggctc ctccatgaga
2041 gattggatga atacgagctg cagggcccaa cacccacaac cttcaacttt gaccagaata
2101 aggtttttgc tttcaggcaa ctcgctgctg agaacaagta tgggttaatg gacaccatga
2161 gagtgggaag ccagctcaag ggtgtcaaaa ccatgtcaga gcttaaacag gcactcaaga
2221 acatcgcaat caaaaagtgt caaatagtct atggaggttc aacatattca cttgaatctg
2281 atggcaaagg caatgtaaag gtcgagagag tgcagagcgc aactgtgcag accaacaacg
2341 aactgacagg tgctctgcac catctcagat gcgccaggat caggtattac gttaagtgtg
2401 tccaggaggc cctgtactct atcatccaaa ttgctggggc cgcgtttgtc accacgcgca
2461 ttgcaaaacg catgaacata caaaaccttt ggtccaggcc acaagtggag gacacagaag
2521 agaccatcaa caaagatggg tgcccaaagc ccaaagatga tgaggagttt gtcgtatcgt
2581 ctgaggacat aaaagttgag ggcaagaagg gaaagaacaa gtctggtcgt ggtaagaaac
2641 acacagcctt ctcaagcaag ggtctcagtg atgaggagta cgatgaatat aaaagaatta
2701 gggaagaaag aaatggcaag tactccatag aagaatacct tcaggacaga gacaagtatt
2761 atgaggaggt ggccatagct agggctactg aggaggactt ctgtgaggaa gaggaggcca
2821 agatccgaca gaggatcttc agaccaacga ggaaacaacg caaagaggag agggcctctc
2881 ttggactggt cacaggctca gaaatcagaa agagaaaccc agatgacttc aaacctaagg
2941 gaaaattgtg ggctgatgac gacaggagtg ttgactacaa tgagaaactc agttttgaag
3001 ctcccccaag tatctggtca agaatagtca actttggttc aggttggggc ttctgggtct
3061 caccaagcct gttcataaca tccactcatg ttatacctca gggagcacag gagttcttcg
3121 gggtttccat taggcagatt caaatccaca aatcaggtga attctgtcga ctaagattcc
3181 caaaaccaat taggactgat gtgacgggca tgatcttaga ggagggggcc cctgaaggaa
3241 cagtggccac actgctcata aagagaccaa ctggggaact catgccattg gcggctagga
3301 tgggcaccca cgcaaccatg aagatccaag gccgcaccgt cgggggtcaa atggggatgc
3361 ttttgacagg atccaatgcc aagagcatgg acttgggcac cacaccaggt gactgtggat
3421 gtccatacat ctacaagaga ggaaatgact atgtagtcat tggggtccac acagccgctg
3481 ctcgcggagg aaacactgtc atctgtgcaa cccaaggaag cgaaggtgag gccgtacttg
3541 agggtggtga taacaagggc acctattgcg gtgccccgat cctaggtcca gggagcgccc
3601 caaagctcag caccaagacc aaattctgga ggtcatcaac agcaccactc ccacccggca
3661 catacgaacc agcctaccta ggaggtaagg atcccagggt caagggtggc ccctcattac
3721 agcaagtcat gagagaccaa ttgaaaccat tcacagaacc caggggaaag ccaccaaacc
3781 caagtgtgct ggaagctgcc aagaagacca tcatcaatgt ccttgaacaa acaatagacc
3841 caccccaaaa atggtcattt tcacaggcat gtgcatccct tgataaaacc acctccagtg
3901 gtcatccgca ccacatgcgg aagaatgaat gctggaacgg agagtccttc acaggaaaat
3961 tggcagatca agcttcaaaa gctaacctga tgtatgagga ggggaagaat atgaccccag
4021 tctacacagg tgcactcaag gatgagctag tcaaaactga taaaatatat ggaaaaatta
4081 agaagagact tctctgggga tcagacctgg caaccatgat ccgttgtgct cgagcattcg
4141 gaggactaat ggatgaactc aaggcccact gtgtcacact ccctattaga gttgggatga
4201 acatgaatga agatggcccc attatctttg agaaacattc taggtaccac taccattatg
4261 atgcagacta ctcccggtgg gattcgacac aacagagagc tgtgctagct gcagccctag
4321 aaatcatggt aaaattctct tcagaaccac atctagccca ggtagtcgca gaagaccttt
4381 tgtctcccag tgtgatggac gtgggcgatt tcaagatatc aattactgaa gggcttcctt
4441 ctggggtgcc ttgcacttca cagtggaatt ccatcgccca ttggctcctg acactctgtg
4501 cactctctga ggtaacaaat ttgtcccctg acatcatcca agcaaattcc ctcttctcct
4561 tctatggtga tgatgaaatc gtgagcacag atatcaaatt agacccggga aagcttacag
4621 ccaagttaat agagtatggg ctaaaaccaa ctcgccctga caagactgaa gggcctctgg
4681 tcatctctga ggacctagat ggtctgacct tcttgcggag aactgtgacc cgcgacccag
4741 ctggttggtt tggaaagttg gagcaaagtt caatacttag acaaatgtat tggaccaggg
4801 gccctaacca tgaggacccc tctgaaacaa tgataccaca ctcccagaga cccatacagc
4861 taatgtcact gctaggtgaa gcagcactgc atggaccatc attctacagc aggatcagta
4921 agctggtcat tgcagagttg aaggaaggtg gcatggactt ttacgtgcct agacaggagc
4981 caatgttccg atggatgagg ttctcagact tgagcacgtg ggagggcgat cgcaatctgg
5041 ctcccagttt tgtgaatgaa gatggcgtcg aatgacgccg ctccatctaa tgatggtgca
5101 gccggtctcg taccagaggc taacaatgag accatggcac ttgagccagt ggttggggct
5161 tcaatagcgg ctccactcac tggtcaaaat aatattatag acccctggat tagattaaat
5221 tttgtacagg cccccaatgg agagttcact gtctcaccac ggaactcacc tggagaagtc
5281 ttgctaaact tagaattagg ccctgaacta aatccttatt tgtcacatct atctagaatg
5341 tataatggtt atgcaggagg agtggaggtg caagtgttgc tggccgggaa tgcgttcaca
5401 gctggaaaat tggtgtttgc tgcagtccct ccccactttc cattagaaaa tattagccct
5461 ggacaaataa ctatgttccc ccatgtgatt gttgatgtta gaactttaga accagttttg
5521 ttgcccctcc cagatgttag gaataatttc tttcattata atcagcaaaa tgaacccaga
5581 atgagacttg tggctatgct ctacaccccc ctcaggtcca atggttctgg tgatgatgtc
5641 ttcactgtct cctgcagggt gctcactcgc ccctctcctg attttgattt taattatctg
5701 gttcccccca cagttgaatc aaagacaaaa ccattcacat tgcctatcct aactatgggt
5761 gagctgacca attctaggtt tcctgtacct atagatgaac tttacaccag ccccaatgag
5821 aacctggttg tgcaacccca gaatggtagg tgtacgctag atggggagtt gcaggggaca
5881 acccagcttc ttcccacggc agtctgctcg ttccgtggcc gcataaacac aaaggtggcc
5941 ggggaagata atgtttggaa catgcaagtc actaatatca atggaacacc ctttgaccca
6001 actgaggatg tcccagcacc attgggcacc cccgactttt cagggaaaat cttcggcgta
6061 ctcagccaaa gaaatacaaa caatgcctgc agagcccatg atgcagtggt ggcaaccaac
6121 agccccaaat ttaccccaaa attgggttct ctccatattg gaacttggga acaaactgat
6181 attgacacca accagcccac taaattcacc ccagtcgggc tacatgaaca cacagattat
6241 aaccagtgga ctttgcctaa ttattctggt gcattaaccc tcaatatggg attggcccct
6301 cctgttgctc ccactttccc tggtgaacag attctcttct ttagatctca tgtccctctt
6361 aaaggaggag tagcagacac agtcattgat tgcctcctgc cacaggagtg ggtccaacac
6421 ctttaccagg aatctgcccc ctcacagtca gatgtggccc taatcagatt cacaaaccca
6481 gacacagggc gtgtcttatt tgaggcaaaa ttacacagaa atggctacat cactgtgtcc
6541 aatactggaa gcaaaccaat tgttgtgcca gctaatggtt actttagatt tgactcctgg
6601 gtcaaccaat tttattctct tgcccccatg ggaactggga acgggcgtag aagggtgcag
6661 taatggctgg agcttttata gcagggcttg caggtgacat agtcactaac agcattggct
6721 cacttgtgaa cgctggggcc aacgcaataa accagaaagt agactttgaa aacaataaac
6781 aacttcaaca ggcctccttc aatcatgaca aagagatgct acaagcccaa atccaagcca
6841 caaaacagtt gcagcaagat atgattgcaa tcaggcaggg ggttttgacc gcaggcggct
6901 tttcccccac tgatgcagcg agaggtgcag tcaacgcacc gatgactcaa gtcttggact
6961 ggaatggtac taggtactgg gctcctgggg ctacaaggac aactgccttt tcaggaggat
7021 tcaccagctc cacccatacc aagactgttg atttatccaa taaaacaaca gctgcaccaa
7081 tcccctcaaa gcccatatct aggcctagtt cttctgtttc ttcaaattca acccgctcaa
7141 ctctagttag tgggtcttct acctctcctt ctgtgaggag tctgtctagt gtttcttccc
7201 agtcttcctc tccttcttcc cgaaccagtg agtgggtgcg gagtcagaat agagcactgg
7261 aaccatacat gaggggggcg ttgcaaacag cttacgttac gcctccctct agtagggctt
7321 ccagcaatgg cacagtctca accgtgccaa aggaaatttt ggactcctgg acatctgcgt
7381 ttaacacccg cagacagccg cttttcgctc atctccgtcg gagaggggag tcacaagctt
7441 agtgaaaaga tagaatttct ctttttacct cttcttttat ttctgtcttt t
//