Typing tool
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Typing tool
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Complete norovirus genomes
| MW305590 | GII.4 US95 | |
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| GII.P4 US95 |
ORF1: 1..5069
ORF2: 5050..6669
ORF3: 6669..7475
LOCUS MW305590 7521 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate 170 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305590
VERSION MW305590.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7521)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7521)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7521
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="170"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Japan"
/collection_date="16-Dec-1995"
/note="genotype: GII.4[GII.P4]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59106.1"
/translation="AVANSNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPREIPQR
PPRPPTPELVKKIPPPPPNGEDEIVVSYSVKDGVSGLPELSTVRQPEEANTAFSVPPL
NQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLILGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLKKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANIFLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKRIAASLTGD
QRVGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDM
WKNAFSSDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEF
ELQGPAITTFNFDRNKVLAFRQLAAENKYGLMDTMKVGRQLKDVRTMPDLKQALKNIS
IKKCQIVYSGCTYTLESDGKGNVKVDRVQSASVQTNNELAGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVEDTGEAINKDGCPKPKDDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAKEFFGIPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKREN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
AAKKTIINVLEQTIDPPEKWSFTQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPIRVGMNMNEDGPIIFERHSRYKYHYDADYSRWDSTQQRAVLAAA
LEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6669
/gene="ORF2"
CDS 5050..6669
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59107.1"
/translation="MKMASNDANPSDGSTANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFTVPILTVEEMSNSRFPIPLEKLYTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSAVNICTFRGDVTHIAGSHDYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTREDGSTRAHKATVSTGSVHFTPKLGSVQYTTDTNNDFQTGQNTKFTPVGVIQDG
NNHQNEPQQWVLPNYSGRTGHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMNLDC
LLPQEWVQHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGPHDLVI
PPNGYFRFDSWVNQFYTLAPMGNGAGRRRAL"
gene 6669..7475
/gene="ORF3"
CDS 6669..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59108.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQGMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRTNLRATVPARGSSSTLS
STPTATSVYSNQTVSTRLGSSAGSGASVSSLPLTARTRSWVEDQNRNLSPFMRGALNT
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKQGESRV"
ORIGIN
1 ccgctgttgc caacagcaac aacgacaccg caaaatcttc aagtgacgga gtgctttcta
61 gcatggctgt cacttttaaa cgagccctcg gggcgcggcc taaacagccc cccccgaggg
121 aaataccaca aagaccccca cgaccaccca ccccagaact ggtcaaaaag atcccccctc
181 ccccgcccaa cggggaggat gaaatagtgg tttcttatag tgtcaaagat ggcgtttccg
241 gtctgcctga gctttccacc gtcaggcaac cggaagaagc caatacggcc ttcagtgtcc
301 ccccactcaa ccagagggaa aatagggatg ctaaggagcc actgactgga acaattctgg
361 aaatgtggga tggggagatc taccattacg gcctatatgt ggagcgaggt cttatacttg
421 gtgtgcacaa accaccagct gccattagcc tcgccaaggt cgagctaaca ccactctcct
481 tgttctggag acctgtgtat actccccagt atctcatctc tccagacact ctcaagaaat
541 tacacggaga atcgtttccc tatacagcct ttgacaacaa ttgctatgcc ttctgttgct
601 gggtcttgga cctaaacgac tcgtggctga gtaggagaat gatccagaga acaactggtt
661 tcttcagacc ctaccaagat tggaatagga aacccctccc cactatggat gattccaaat
721 taaagaaggt agctaatata ttcctgtgtg ctctatcttc actattcacc aggcccataa
781 aagacataat agggaagcta aggcctctta acatccttaa catcttggcc tcatgtgatt
841 ggactttcgc aggcatagtg gaatccttga tactcttggc agagctcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgattg cccccttact cggtgattac gagttacaag
961 ggcctgagga ccttgcagtg gaactcgttc ctgtagtgat ggggggaatt ggtttggtgc
1021 taggatttac caaagagaag attggaaaaa tgttgtcatc tgctgcatcc accttaagag
1081 cttgtaaaga tcttggtgca tacgggctgg aaatcctaaa gttagtcatg aagtggttct
1141 tcccaaagaa agaggaagca aatgaactgg ctatggtgag atccatcgag gatgcagtgc
1201 tggacctcga ggcaattgaa aacaaccata tgaccaccct gctcaaagac aaagacagtc
1261 tggcaaccta catgaggacc cttgaccttg aggaggagaa agccaggaag ctctcaacca
1321 agtccgcttc acctgacatc gtgggcacaa tcaacgccct tctggcgagg atcgctgctg
1381 cacgttccct ggtgcatcga gcgaaggagg agctttccag cagaccaaga cctgttgtct
1441 tgatgatatc aggcagacca ggaataggga agacccacct tgctagggaa gtggccaaga
1501 gaatcgcagc ctccctcaca ggagaccagc gtgtaggcct cgtcccacgc aatggcgtcg
1561 accactggga tgcatacaag ggggagaggg tcgtcctatg ggacgactat gggatgagca
1621 atcccatcca cgatgccctc aggttgcaag aactcgctga cacttgcccc ctcactctaa
1681 actgtgacag gattgagaac aaaggaaagg tctttgacag tgatgtcata attatcacca
1741 ctaatctggc caacccagca ccactggact atgtcaactt tgaagcatgc tcgaggcgca
1801 tcgatttcct cgtgtatgca gaagcccctg aagtcgaaaa ggcgaaacgt gacttcccag
1861 gccaacctga catgtggaag aacgctttca gttctgattt ctcacacata aaactaacac
1921 tggctccaca gggtggcttc gataagaacg ggaacacccc acacgggaag ggcgtcatga
1981 agactctcac cactggctcc cttattgccc gggcatcagg gctactccat gagaggctag
2041 atgagtttga actacagggc ccagctatca ccaccttcaa ctttgatcgc aacaaagtgc
2101 ttgcctttag gcagcttgct gctgaaaaca aatacgggtt gatggacaca atgaaagttg
2161 gaaggcagct caaggatgtc agaaccatgc cagatcttaa acaagcactc aagaatatct
2221 caatcaagaa gtgccagata gtgtacagtg gttgcaccta tacacttgag tctgatggca
2281 agggcaatgt gaaagttgac agagttcaga gcgcctccgt gcagaccaac aacgagctgg
2341 ccggcgccct acaccatcta aggtgcgcca gaatcaggta ttatgtcaag tgtgtccagg
2401 aggccctgta ttccatcatc caaattgctg gagctgcatt tgtcaccacg cgcatcgtca
2461 agcgcatgaa catacaagac ctctggtcca agccacaagt ggaagacaca ggggaggcta
2521 tcaacaagga cgggtgccca aaacccaaag atgatgagga gttcgtcatt tcatccgacg
2581 atatcaaaac tgagggcaag aaagggaaga ataagactgg ccgcggcaag aagcacacag
2641 ccttctcaag caaaggtctc agtgatgaag agtacgacga gtacaagagg attagagaag
2701 aaagaaatgg caagtactcc atagaagagt accttcagga cagggacaaa tactatgagg
2761 aggtggccat tgccagggcg accgaggaag acttctgtga agaggaggag gccaagattc
2821 ggcaaaggat tttcaggcca acaaggaaac aacgcaagga ggaaagggcc tctctcggtt
2881 tagtcacagg ttctgaaatc aggaaaagga acccagatga tttcaagccc aaggggaaac
2941 tgtgggctga tgatgacaga agtgtggact acaatgagaa actcagtttt gaggccccac
3001 caagcatctg gtcgaggata gtcaactttg gttcaggttg gggcttttgg gtctctccca
3061 gtctgttcat aacatcaacc catgtcatac cccagggcgc aaaggagttc tttggaatcc
3121 ccatcaagca aattcagata cacaaatcag gcgaattctg tcgcttgagg ttcccaaaac
3181 caatcaggac tgatgtgacg ggtatgatct tagaagaagg tgcgcccgaa ggcaccgtgg
3241 tcacactact catcaagagg cctactggag aacttatgcc cctagcagct agaatgggga
3301 cccatgcaac catgaaaatt caagggcgta ctgttggagg tcagatgggc atgcttctga
3361 caggatccaa cgccaaaagc atggacctgg gcaccacacc aggtgactgc ggctgcccct
3421 acatctacaa gagggaaaat gactatgtgg ttattggagt ccacacggct gccgctcgtg
3481 ggggaaacac tgtcatatgt gccacccagg ggagtgaggg ggaggctaca cttgaaggtg
3541 gtgacagtaa gggaacatac tgtggtgcac caatcctagg cccagggagt gccccaaaac
3601 tcagcaccaa gaccaaattc tggagatcgt ccacaacacc actcccacct ggcacctatg
3661 aaccagccta tcttggtggt aaggacccca gagtcaaggg tggcccttca ttgcaacaag
3721 ttatgaggga tcagttgaaa ccatttacag agcccagggg caaaccacca aagccaagtg
3781 tgttggaagc tgccaagaaa accatcatca atgtccttga acaaacaatc gatccacccg
3841 agaaatggtc attcacgcaa gcttgcgcgt cccttgacaa gactacttcc agtggccatc
3901 cgcaccacat gcggaaaaac gactgctgga acggggagtc cttcacaggc aagctggcag
3961 accaggcttc caaggccaac ctgatgttcg aagaggggaa gaacatgacc ccagtctaca
4021 caggtgcact taaggatgag ttagttaaaa ctgacaaaat ttatggtaag atcaagaaga
4081 ggcttctctg gggctcggac ttagcgacca tgatccggtg cgctcgagca ttcggaggct
4141 taatggatga actcaaagca cactgcgtta cacttcctat cagagttggt atgaatatga
4201 atgaggacgg ccccatcatc ttcgagaggc attccagata caaatatcac tatgatgctg
4261 attactctcg gtgggattca acacaacaga gagccgtgtt ggcagcagcc ctagaaatca
4321 tggttaaatt ctcctcagaa ccacatttgg ctcaggtggt cgcagaagac cttctttctc
4381 ctagcgtggt ggatgtgggt gacttcaaaa tatcaatcaa tgagggtctc ccctctgggg
4441 tgccctgcac ctcccaatgg aactccatcg cccactggct tctcactctc tgtgcgctct
4501 ctgaagttac aaacttgtcc cctgacatca tacaggctaa ttccctcttc tccttttatg
4561 gtgatgatga aattgttagt acagatataa agttggaccc agagaaattg acagcaaaac
4621 tcaaggaata cgggttgaaa ccaacccgcc ctgacaaaac tgaagggccc cttgttattt
4681 ctgaagactt aaatggtctg accttcctgc ggagaactgt gacccgcgac ccagctggtt
4741 ggtttggaaa attggagcag agttcaatac tcagacaaat gtactggact aggggcccca
4801 accatgaaga cccatctgaa acaatgattc cacattccca aagacccata caattgatgt
4861 ccctactggg agaggccgca ctccacggcc cagcattcta cagcaaaatt agcaagttag
4921 ttattgcaga gctaaaagaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccaacccat ctgatgggtc cacagccaac
5101 ctcgtcccag aggtcaacaa tgaggttatg gctttggagc ccgttgttgg tgccgctatt
5161 gcggcacctg tagcgggcca acaaaatgta attgacccct ggattagaaa caattttgta
5221 caagcccctg gtggagagtt tacagtatcc cctagaaacg ctccgggtga gatattatgg
5281 agcgcgccct tgggccctga tttgaacccc tacctttctc atttggccag aatgtacaat
5341 ggttatgcag gtggttttga agtgcaggta atcctcgcgg ggaacgcgtt caccgccggg
5401 aaaatcatat ttgcagcagt cccaccaaat tttccaactg aaggcttgag ccccagccag
5461 gttactatgt tcccccatat aatagtagat gttaggcaat tggaacctgt gttgatcccc
5521 ttacctgatg ttaggaataa cttctatcat tacaatcaat caaatgattc taccattaaa
5581 ttgatagcaa tgctgtatac accacttagg gctaataatg ctggggatga tgtcttcaca
5641 gtctcttgtc gagtcctcac gaggccatcc cccgattttg atttcatatt cttggtgcca
5701 cccacagttg aatcaagaac taaaccattc accgtcccaa tcttaactgt tgaggaaatg
5761 tccaactcaa gattccccat tcctttggaa aagttgtaca cgggtcccag cagtgctttt
5821 gttgtccaac cacaaaatgg caggtgcacg actgatggcg tgctcttagg cactacccag
5881 ctgtctgctg tcaacatctg caccttcaga ggggatgtca cccacattgc aggcagtcat
5941 gactatacaa tgaatttggc ttctcaaaat tggaacaatt atgacccaac agaagaaatc
6001 ccagcccctc tgggaactcc agatttcgtg ggaaagatcc aaggcatgct cacccaaacc
6061 acaagagagg atggctcgac ccgcgcccac aaagctacag tgagcactgg gagtgtccac
6121 tttactccaa agctgggcag tgttcaatac accactgaca caaacaatga ttttcaaact
6181 ggccaaaaca cgaaattcac cccagtcggc gtcatccagg acggtaataa tcatcaaaat
6241 gaaccccaac aatgggtgct cccaaattac tcaggtagaa ctggtcataa tgtgcaccta
6301 gctcctgccg ttgcccccac tttcccgggt gagcaacttc ttttctttag gtccactatg
6361 cccggatgta gcgggtatcc caacatgaat ctggattgcc tactccccca ggaatgggtg
6421 cagcacttct accaagaagc agctccagca caatctgatg tggctctgct gagatttgtg
6481 aatccagaca caggtagggt tctgtttgag tgcaagctcc ataaatcagg ctatgtcaca
6541 gtggctcaca ctggcccgca tgatttggtt atccccccca atggttactt tagatttgat
6601 tcctgggtca accagttcta cacacttgcc cccatgggaa atggagcggg gcgcagacgt
6661 gcattataat ggctggagct ttctttgctg gattggcatc tgatgtcctt ggctctggac
6721 ttggttccct aatcaatgct ggggctgggg ccatcaacca aaaagttgaa tttgaaaata
6781 acagaaaatt gcaacaagct tccttccaat ttagtagcaa cctgcaacag gcttccttcc
6841 aacatgataa ggagatgctc caagcacaaa ttgaggccac taagaaattg caacagggta
6901 tgatgaaggt taaacaggcg atgctcctag agggtggatt ctctgaaaca gatgcagccc
6961 gtggggcaat caacgccccc atgacaaagg ctctggactg gagcggaaca aggtactggg
7021 ctcctgatgc caggaccaca acatacaatg caggccgctt ttccacccct caaccttcgg
7081 gggcattgcc aggaagaact aatcttaggg ctactgtccc cgctcggggc tcctctagta
7141 cactttctag tactcccact gctacttctg tgtattcaaa tcaaactgtt tcaacgagac
7201 ttggttcttc agctggttct ggtgccagtg tctcgagtct cccgttaact gcaaggacta
7261 ggagctgggt tgaggatcaa aacagaaatt tgtcaccttt tatgaggggg gctctcaaca
7321 catcattcgt caccccacca tctagtagat cctctagcca aggcacagtc tcaaccgtgc
7381 ctaaagaaat tttggactcc tggactggcg ctttcaacac gcgcaggcag cctctcttcg
7441 ctcacattcg taagcaaggg gagtcacggg tgtaatgtga aaagacaaaa ctgattatct
7501 ttcctttctt tagtgtcttt t
//