Typing tool

Complete norovirus genomes

MW305589  GII.4 US95
 GII.P4 US95

Length: 7,521 | 3 CDS

ORF1: 1..5069
ORF2: 5050..6669
ORF3: 6669..7475
LOCUS       MW305589                7521 bp    RNA     linear   VRL 06-JUL-2021
DEFINITION  Norovirus GII isolate 75 nonstructural polyprotein (ORF1) gene,
            partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION   MW305589
VERSION     MW305589.1
KEYWORDS    .
SOURCE      Norovirus GII
  ORGANISM  Norovirus GII
            Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
            Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE   1  (bases 1 to 7521)
  AUTHORS   Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
            Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
            Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
            Green,K.Y. and Parra,G.I.
  TITLE     Genome-wide analyses of human noroviruses reveal coexistence of
            viral populations evolving under recombination constraints
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7521)
  AUTHORS   Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
            Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
            Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
            Green,K.Y. and Parra,G.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
            Administration, 10903 New Hampshire Avenue, Silver Spring, MD
            20993, USA
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: High-performance Integrated Virtual
                                     Environment (HIVE) v. 2
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..7521
                     /organism="Norovirus GII"
                     /mol_type="genomic RNA"
                     /isolate="75"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /db_xref="taxon:122929"
                     /country="Japan"
                     /collection_date="30-Dec-1995"
                     /note="genotype: GII.4[GII.P4]"
     gene            <1..5069
                     /gene="ORF1"
     CDS             <1..5069
                     /gene="ORF1"
                     /codon_start=3
                     /product="nonstructural polyprotein"
                     /protein_id="QPJ59103.1"
                     /translation="AVANSNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPREIPQR
                     PPRPPTPELIKKIPPPPPNGEDEIVVSYSVRDGVSGLPELSTVRQPEEANTAFSVPPL
                     NQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLILGVHKPPAAISLAKVELTPLSL
                     FWRPVYTPQYLISPDTLKKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
                     GFFRPYQDWNRKPLPTMDDSKLKKVANVFLCALSSLFTRPIKDIIGKLRPLNILNILA
                     SCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
                     GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
                     RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
                     NALLARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKRIAASLTGD
                     QRVGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
                     KGKVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDM
                     WKNAFSSDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEF
                     ELQGPALTTFNFDRNKVLAFRQLAAENKYGLMDTMKVGRQLKDVRTMPDLKQALKNIS
                     IKKCQIVYSGCTYTLESDGKGNVKVDRVQSASVQTNNELAGALHHLRCARIRYYVKCV
                     QEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVEDTGEAINKDGCSKPKDDEEFVI
                     SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
                     DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
                     DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
                     QGAKEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
                     GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKREN
                     DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKT
                     KFWRSSTTPLPPGTYEPAYLGGRDPRVKDGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
                     AAKKTIINVLEQTIDPPEKWSFTQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
                     QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
                     GLMDELKAHCVTLPIRVGMNMNEDGPIIFERHSRYKYHYDADYSRWDSTQQRAVLAAA
                     LEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
                     TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
                     TEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
                     HSQRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
                     STWEGDRNLAPSFVNEDGVE"
     mat_peptide     <1..959
                     /gene="ORF1"
                     /product="p48"
     mat_peptide     960..2057
                     /gene="ORF1"
                     /product="NTPase"
     mat_peptide     2058..2594
                     /gene="ORF1"
                     /product="p22"
     mat_peptide     2595..2993
                     /gene="ORF1"
                     /product="VPg"
     mat_peptide     2994..3536
                     /gene="ORF1"
                     /product="Pro"
     mat_peptide     3537..5066
                     /gene="ORF1"
                     /product="RdRp"
     gene            5050..6669
                     /gene="ORF2"
     CDS             5050..6669
                     /gene="ORF2"
                     /note="major capsid protein"
                     /codon_start=1
                     /product="VP1"
                     /protein_id="QPJ59104.1"
                     /translation="MKMASNDANPSDGSTANLVPEVNNEVMALEPVVGAAIAAPVAGQ
                     QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
                     FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
                     VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
                     TVESRTKPFTVPILTVEEMSNSRFPIPLEKLYTGPSSAFVVQPQNGRCTTDGVLLGTT
                     QLSAVNICTFRGDVTHIAGSHDYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
                     TQTTREDGSTRAHKATVSTGSVHFTPKLGSVQYTTDTNNDFQTGQNTKFTPVGVIQDG
                     NNHQNEPQQWVLPNYSGRTGHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMNLDC
                     LLPQEWVQHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGPHDLVI
                     PPNGYFRFDSWVNQFYTLAPMGNGAGRRRAL"
     gene            6669..7475
                     /gene="ORF3"
     CDS             6669..7475
                     /gene="ORF3"
                     /note="minor structural protein; small basic protein"
                     /codon_start=1
                     /product="VP2"
                     /protein_id="QPJ59105.1"
                     /translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
                     SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQGMMKVKQAMLLEGGFSETDAARGAIN
                     APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRTNLRATVPARGSSSALS
                     STPTATSVYSNQTVSTRLGSSAGSGTSVSSLPSTARTRSWVEDQNRNLSPFMRGALNT
                     SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRV"
ORIGIN      
        1 ccgctgttgc caacagcaac aacgacaccg caaaatcttc aagtgacgga gtgctttcta
       61 gcatggctgt cacttttaaa cgagccctcg gggcgcggcc taaacagccc cccccgaggg
      121 aaataccaca aagaccccca cgaccaccca ccccagaact gatcaaaaag atcccccctc
      181 ccccgcccaa cggggaggat gaaatagtgg tttcttatag tgtcagagat ggcgtttccg
      241 gtctgcctga gctttccacc gtcaggcaac cggaagaagc caatacggcc ttcagtgtcc
      301 ccccactcaa ccagagggag aatagggatg ctaaggagcc actgactgga acaattctgg
      361 aaatgtggga tggagagatc taccattacg gcctatatgt ggagcgaggt cttatacttg
      421 gtgtgcacaa accaccagct gccattagcc tcgccaaggt cgagctaaca ccactctcct
      481 tgttctggag acctgtgtat actccccagt atctcatctc tccagacact ctcaagaaat
      541 tacacggaga atcgtttccc tacacagcct ttgacaacaa ttgctatgcc ttctgttgct
      601 gggtcttgga cctaaacgac tcgtggctga gtaggagaat gatccagaga acaactggtt
      661 tcttcagacc ctaccaagat tggaatagga aacccctccc cactatggat gattccaaat
      721 taaagaaggt agctaatgta ttcctgtgtg ctctatcttc actattcacc aggcccataa
      781 aagacataat agggaagcta aggcctctta acatcctcaa catcttggcc tcatgtgatt
      841 ggactttcgc aggcatagtg gaatccttga tactcttggc agagctcttt ggagttttct
      901 ggacaccccc agatgtgtct gcgatgattg cccccttact cggtgattac gagttacaag
      961 gacctgagga ccttgcagtg gaactcgttc ctgtagtgat ggggggaatt ggtttggtgc
     1021 taggatttac caaagagaag attggaaaaa tgttgtcatc tgctgcatcc accttaagag
     1081 cttgtaaaga tcttggtgca tacgggctgg aaatcctaaa gttagtcatg aagtggttct
     1141 tcccaaagaa agaggaagca aatgaactgg ctatggtgag atccatcgag gatgcagtgc
     1201 tggaccttga ggcaattgaa aacaaccata tgaccacctt gctcaaagac aaagacagtc
     1261 tggcaaccta catgagaacc cttgaccttg aggaggagaa agccagaaag ctctcaacca
     1321 agtccgcttc acctgacatc gtgggcacaa tcaacgccct tctggcgaga atcgctgctg
     1381 cacgttccct ggtgcatcga gcgaaggagg agctttccag cagaccaaga cctgttgtct
     1441 tgatgatatc aggcagacca ggaataggga agacccacct tgccagggaa gtggccaaga
     1501 gaatcgcagc ctccctcaca ggagaccagc gtgtaggcct cgtcccacgc aatggcgtcg
     1561 accactggga tgcatacaag ggggagaggg tcgtcctatg ggacgactat gggatgagca
     1621 atcccatcca cgatgccctc aggttgcaag aactcgctga cacttgcccc ctcactctaa
     1681 actgtgacag gattgagaac aaaggaaagg tctttgacag cgatgtcata attatcacca
     1741 ccaatctggc caacccagca ccactggact atgtcaactt tgaagcatgc tcgaggcgca
     1801 ttgatttcct cgtgtatgca gaagcccctg aagtcgaaaa ggcgaaacgt gacttcccag
     1861 gccaacctga catgtggaag aacgctttca gttctgattt ctcacacata aaactaacac
     1921 tggctccaca gggtggcttt gataagaacg ggaacacccc acacggaaag ggcgtcatga
     1981 agactctcac cactggctcc cttattgccc gggcatcagg gctactccat gagaggctag
     2041 atgagtttga actacagggc ccagctctca ccaccttcaa ctttgatcgc aacaaagtgc
     2101 ttgcctttag gcagcttgct gctgaaaaca aatacgggtt gatggacaca atgaaagttg
     2161 gaaggcagct caaggatgtc agaaccatgc cagaccttaa acaagcactc aagaacatct
     2221 caatcaagaa gtgccagata gtgtacagtg gttgcaccta tacacttgag tctgatggca
     2281 agggcaatgt gaaagttgac agagttcaga gcgcctccgt gcaaaccaac aacgagctgg
     2341 ccggcgccct acaccatcta aggtgcgcca gaatcaggta ctatgtcaag tgtgtccagg
     2401 aagccctgta ttccatcatc caaattgctg gagctgcatt tgtcaccacg cgcatcgtca
     2461 agcgcatgaa catacaagac ctctggtcca agccacaagt ggaagacaca ggggaggcta
     2521 tcaacaagga cgggtgctca aaacccaaag atgatgagga gttcgtcatt tcatccgatg
     2581 atatcaaaac tgagggcaag aaagggaaga acaagactgg ccgcggcaag aagcacacag
     2641 ccttctcaag caaaggtctc agtgatgaag agtacgacga gtacaagagg attagagaag
     2701 aaagaaatgg caagtactcc atagaagagt accttcagga cagggacaaa tactatgagg
     2761 aggtggccat tgccagggcg accgaggaag acttctgtga agaggaggag gccaagattc
     2821 ggcaaaggat cttcaggcca acaaggaaac aacgcaagga ggaaagggcc tctctcggtc
     2881 tagtcacagg ttctgaaatc aggaaaagga acccagatga tttcaagccc aaggggaaac
     2941 tgtgggctga tgatgataga agtgtggact acaatgagaa actcagtttt gaggccccac
     3001 caagcatctg gtcgaggata gtcaactttg gttcaggttg gggcttttgg gtttctccca
     3061 gtctgttcat aacatcaacc catgtcatac cccagggcgc aaaggagttc tttggagtcc
     3121 ccatcaagca aattcagata cacaaatcag gcgaattctg tcgcttgagg ttcccaaaac
     3181 caatcaggac tgatgtgacg ggcatgatct tagaagaagg tgcgcccgaa ggcaccgtgg
     3241 tcacactact catcaagagg cctactggag aacttatgcc cttagcagct agaatgggga
     3301 cccatgcaac catgaaaatt caagggcgca ctgttggagg tcagatgggc atgcttctga
     3361 caggatccaa cgccaaaagc atggacctag gtaccacacc aggtgactgc ggctgcccct
     3421 acatctacaa gagggaaaat gactatgtgg ttattggagt ccacacggct gccgctcgtg
     3481 ggggaaacac tgtcatatgt gccacccagg ggagtgaggg ggaggctaca cttgaaggtg
     3541 gtgacagtaa gggaacatac tgtggtgcac caatcctagg cccagggagt gccccaaaac
     3601 tcagcaccaa gaccaaattc tggagatcgt ccacaacacc actcccacct ggcacctatg
     3661 aaccagccta tcttggtggt agggacccca gagtcaagga tggcccttca ttgcaacaag
     3721 ttatgaggga tcagttgaaa ccatttacag agcccagggg caaaccacca aagccaagtg
     3781 tgttggaagc tgccaagaaa accatcatca atgtccttga acaaacaatt gatccacctg
     3841 agaaatggtc attcacgcaa gcttgcgcgt cccttgacaa gactacttcc agtggccatc
     3901 cgcaccacat gcggaaaaac gactgctgga acggggagtc cttcacaggc aagctggcag
     3961 accaggcttc caaggccaac ctgatgttcg aagaggggaa gaacatgacc ccagtctaca
     4021 caggtgcgct taaggatgaa ttagttaaaa ctgacaaaat ttatggtaag atcaagaaga
     4081 ggcttctctg gggctcggac ttagcgacca tgattcggtg cgctcgagca ttcggaggct
     4141 taatggatga actcaaagca cactgtgtta cacttcctat cagagttggt atgaatatga
     4201 atgaggatgg ccccatcatc ttcgagaggc attccaggta caaatatcac tatgatgctg
     4261 attactctcg gtgggattca acacaacaga gagccgtatt ggcagcagcc ctagaaatca
     4321 tggttaaatt ctcctcagaa ccacatttgg ctcaggtagt cgcagaagac cttctttctc
     4381 ccagcgtggt ggatgtgggt gacttcaaaa tatcaatcaa tgagggtctc ccctctgggg
     4441 tgccctgcac ctcccaatgg aactccatcg cccactggct tctcactctc tgtgcgctct
     4501 ctgaagttac aaacttgtcc cctgacatca tacaggctaa ttccctcttc tccttttatg
     4561 gcgatgatga aattgttagt acagatataa agttggaccc agagaaattg acagcaaaac
     4621 tcaaggaata cgggttgaaa ccaacccgcc ctgacaaaac tgaagggccc cttgttattt
     4681 ctgaagactt aaatggtctg accttcctgc ggagaactgt gacccgcgac ccagctggtt
     4741 ggtttggaaa attggagcag agttcaatac tcagacaaat gtactggact aggggcccca
     4801 accatgaaga cccatctgaa acaatgattc cacattccca aagacccata caattgatgt
     4861 ccctactggg agaggccgca ctccacggcc cagcattcta cagcaaaatt agcaagttag
     4921 ttattgcaga gctaaaagaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
     4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcgcaat ctggctccca
     5041 gttttgtgaa tgaagatggc gtcgaatgac gccaacccat ctgatgggtc cacagccaac
     5101 ctcgtcccag aggtcaacaa tgaggttatg gctttggagc ccgttgttgg tgccgctatt
     5161 gcggcacctg tagcgggcca acaaaatgta attgacccct ggattagaaa taattttgta
     5221 caagcccctg gtggagagtt tacagtatcc cctagaaacg ctccgggtga gatactatgg
     5281 agcgcgccct tgggccctga tttgaacccc tacctttctc atttggccag aatgtacaat
     5341 ggttatgcag gtggttttga agtgcaggta atcctcgcgg ggaacgcgtt caccgccggg
     5401 aaaatcatat ttgcagcagt cccaccaaat tttccaactg aaggcttgag ccccagccag
     5461 gttactatgt tcccccatat aatagtagat gttaggcaat tggaacctgt gttgatcccc
     5521 ttacctgatg ttaggaacaa tttctatcat tacaatcaat caaatgattc taccattaaa
     5581 ttgatagcaa tgctgtatac accacttagg gctaataatg ctggggatga tgtcttcaca
     5641 gtctcttgtc gagtcctcac gaggccatcc cccgattttg atttcatatt cttggtgcca
     5701 cccacagttg aatcaagaac taaaccattc accgtcccaa tcttaactgt tgaggaaatg
     5761 tccaattcaa gattccccat tcctttggaa aagttgtaca cgggtcccag cagtgctttt
     5821 gttgtccaac cacaaaatgg caggtgcacg actgatggcg tgctcttagg cactacccag
     5881 ctgtctgctg tcaacatctg caccttcaga ggggatgtca cccacattgc gggcagtcat
     5941 gattatacaa tgaatttggc ttctcaaaat tggaacaatt atgacccaac agaagaaatc
     6001 ccagcccctc tgggaactcc agatttcgtg ggaaagatcc aaggcatgct cacccaaacc
     6061 acgagagagg atggctcgac ccgcgcccac aaagctacag tgagcactgg aagtgtccac
     6121 tttactccaa agctgggcag tgtccaatac accactgaca caaacaatga ttttcaaact
     6181 ggccaaaaca cgaaattcac cccagtcggc gtcatccagg acggtaataa ccatcaaaat
     6241 gaaccccaac aatgggtact cccaaattac tcaggtagaa ctggtcataa tgtgcaccta
     6301 gctcctgccg ttgcccccac ttttccgggt gagcaacttc ttttctttag gtccactatg
     6361 cccggatgta gcgggtatcc caacatgaat ctggattgcc tactcccaca ggaatgggtg
     6421 cagcacttct accaagaagc agctccagca caatctgatg tggctctgct gagatttgtg
     6481 aatccagaca caggtagggt tctgtttgag tgcaagctcc ataaatcagg ctatgtcaca
     6541 gtggctcaca ccggcccgca tgatttggtt atccccccca atggttactt tagatttgat
     6601 tcctgggtca accagttcta cacacttgcc cccatgggaa atggagcggg gcgtagacgt
     6661 gcattataat ggctggagcc ttctttgctg ggttggcatc tgatgtcctt ggctctggac
     6721 ttggttccct aatcaatgct ggggctgggg ccatcaacca aaaagttgaa tttgaaaata
     6781 acagaaaatt gcaacaagct tccttccaat ttagtagcaa cctacaacag gcttccttcc
     6841 aacatgataa agagatgctc caagcacaga ttgaggccac taaaaaattg caacagggta
     6901 tgatgaaggt taaacaggcg atgctcctag agggtggatt ctctgaaaca gatgcagccc
     6961 gtggggcaat caacgccccc atgacaaagg ctctggactg gagcggaaca aggtactggg
     7021 ctcctgacgc caggaccaca acatacaatg caggccgctt ttccacccct caaccttcgg
     7081 gggcattgcc aggaagaact aatcttaggg ctactgtccc cgctcggggc tcctctagtg
     7141 cactttctag tactcccact gctacttctg tgtattcaaa tcaaactgtt tcaacgagac
     7201 ttggttcttc agctggttct ggtaccagtg tctcgagtct cccgtcaact gcaaggacta
     7261 ggagctgggt tgaggatcaa aacagaaatt tgtcaccttt tatgaggggg gctctcaaca
     7321 catcattcgt caccccacca tctagtagat cctctagcca aggcacagtc tcaaccgtgc
     7381 ctaaagaaat tttggactcc tggactggcg ctttcaacac gcgcaggcag cctctcttcg
     7441 ctcacattcg taagcgaggg gagtcacggg tgtaatgtga aaagacaaaa ttgattatct
     7501 ttcctttctt tagtgtcttt t
//