Typing tool
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Typing tool
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Complete norovirus genomes
| MW305589 | GII.4 US95 | |
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| GII.P4 US95 |
ORF1: 1..5069
ORF2: 5050..6669
ORF3: 6669..7475
LOCUS MW305589 7521 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate 75 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305589
VERSION MW305589.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7521)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7521)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7521
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="75"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Japan"
/collection_date="30-Dec-1995"
/note="genotype: GII.4[GII.P4]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59103.1"
/translation="AVANSNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPREIPQR
PPRPPTPELIKKIPPPPPNGEDEIVVSYSVRDGVSGLPELSTVRQPEEANTAFSVPPL
NQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLILGVHKPPAAISLAKVELTPLSL
FWRPVYTPQYLISPDTLKKLHGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANVFLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKRIAASLTGD
QRVGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDM
WKNAFSSDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEF
ELQGPALTTFNFDRNKVLAFRQLAAENKYGLMDTMKVGRQLKDVRTMPDLKQALKNIS
IKKCQIVYSGCTYTLESDGKGNVKVDRVQSASVQTNNELAGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVEDTGEAINKDGCSKPKDDEEFVI
SSDDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGAKEFFGVPIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKREN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKT
KFWRSSTTPLPPGTYEPAYLGGRDPRVKDGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
AAKKTIINVLEQTIDPPEKWSFTQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLAD
QASKANLMFEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPIRVGMNMNEDGPIIFERHSRYKYHYDADYSRWDSTQQRAVLAAA
LEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFKISINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6669
/gene="ORF2"
CDS 5050..6669
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59104.1"
/translation="MKMASNDANPSDGSTANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFTVPILTVEEMSNSRFPIPLEKLYTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSAVNICTFRGDVTHIAGSHDYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTREDGSTRAHKATVSTGSVHFTPKLGSVQYTTDTNNDFQTGQNTKFTPVGVIQDG
NNHQNEPQQWVLPNYSGRTGHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMNLDC
LLPQEWVQHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGPHDLVI
PPNGYFRFDSWVNQFYTLAPMGNGAGRRRAL"
gene 6669..7475
/gene="ORF3"
CDS 6669..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59105.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQGMMKVKQAMLLEGGFSETDAARGAIN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRTNLRATVPARGSSSALS
STPTATSVYSNQTVSTRLGSSAGSGTSVSSLPSTARTRSWVEDQNRNLSPFMRGALNT
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRV"
ORIGIN
1 ccgctgttgc caacagcaac aacgacaccg caaaatcttc aagtgacgga gtgctttcta
61 gcatggctgt cacttttaaa cgagccctcg gggcgcggcc taaacagccc cccccgaggg
121 aaataccaca aagaccccca cgaccaccca ccccagaact gatcaaaaag atcccccctc
181 ccccgcccaa cggggaggat gaaatagtgg tttcttatag tgtcagagat ggcgtttccg
241 gtctgcctga gctttccacc gtcaggcaac cggaagaagc caatacggcc ttcagtgtcc
301 ccccactcaa ccagagggag aatagggatg ctaaggagcc actgactgga acaattctgg
361 aaatgtggga tggagagatc taccattacg gcctatatgt ggagcgaggt cttatacttg
421 gtgtgcacaa accaccagct gccattagcc tcgccaaggt cgagctaaca ccactctcct
481 tgttctggag acctgtgtat actccccagt atctcatctc tccagacact ctcaagaaat
541 tacacggaga atcgtttccc tacacagcct ttgacaacaa ttgctatgcc ttctgttgct
601 gggtcttgga cctaaacgac tcgtggctga gtaggagaat gatccagaga acaactggtt
661 tcttcagacc ctaccaagat tggaatagga aacccctccc cactatggat gattccaaat
721 taaagaaggt agctaatgta ttcctgtgtg ctctatcttc actattcacc aggcccataa
781 aagacataat agggaagcta aggcctctta acatcctcaa catcttggcc tcatgtgatt
841 ggactttcgc aggcatagtg gaatccttga tactcttggc agagctcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgattg cccccttact cggtgattac gagttacaag
961 gacctgagga ccttgcagtg gaactcgttc ctgtagtgat ggggggaatt ggtttggtgc
1021 taggatttac caaagagaag attggaaaaa tgttgtcatc tgctgcatcc accttaagag
1081 cttgtaaaga tcttggtgca tacgggctgg aaatcctaaa gttagtcatg aagtggttct
1141 tcccaaagaa agaggaagca aatgaactgg ctatggtgag atccatcgag gatgcagtgc
1201 tggaccttga ggcaattgaa aacaaccata tgaccacctt gctcaaagac aaagacagtc
1261 tggcaaccta catgagaacc cttgaccttg aggaggagaa agccagaaag ctctcaacca
1321 agtccgcttc acctgacatc gtgggcacaa tcaacgccct tctggcgaga atcgctgctg
1381 cacgttccct ggtgcatcga gcgaaggagg agctttccag cagaccaaga cctgttgtct
1441 tgatgatatc aggcagacca ggaataggga agacccacct tgccagggaa gtggccaaga
1501 gaatcgcagc ctccctcaca ggagaccagc gtgtaggcct cgtcccacgc aatggcgtcg
1561 accactggga tgcatacaag ggggagaggg tcgtcctatg ggacgactat gggatgagca
1621 atcccatcca cgatgccctc aggttgcaag aactcgctga cacttgcccc ctcactctaa
1681 actgtgacag gattgagaac aaaggaaagg tctttgacag cgatgtcata attatcacca
1741 ccaatctggc caacccagca ccactggact atgtcaactt tgaagcatgc tcgaggcgca
1801 ttgatttcct cgtgtatgca gaagcccctg aagtcgaaaa ggcgaaacgt gacttcccag
1861 gccaacctga catgtggaag aacgctttca gttctgattt ctcacacata aaactaacac
1921 tggctccaca gggtggcttt gataagaacg ggaacacccc acacggaaag ggcgtcatga
1981 agactctcac cactggctcc cttattgccc gggcatcagg gctactccat gagaggctag
2041 atgagtttga actacagggc ccagctctca ccaccttcaa ctttgatcgc aacaaagtgc
2101 ttgcctttag gcagcttgct gctgaaaaca aatacgggtt gatggacaca atgaaagttg
2161 gaaggcagct caaggatgtc agaaccatgc cagaccttaa acaagcactc aagaacatct
2221 caatcaagaa gtgccagata gtgtacagtg gttgcaccta tacacttgag tctgatggca
2281 agggcaatgt gaaagttgac agagttcaga gcgcctccgt gcaaaccaac aacgagctgg
2341 ccggcgccct acaccatcta aggtgcgcca gaatcaggta ctatgtcaag tgtgtccagg
2401 aagccctgta ttccatcatc caaattgctg gagctgcatt tgtcaccacg cgcatcgtca
2461 agcgcatgaa catacaagac ctctggtcca agccacaagt ggaagacaca ggggaggcta
2521 tcaacaagga cgggtgctca aaacccaaag atgatgagga gttcgtcatt tcatccgatg
2581 atatcaaaac tgagggcaag aaagggaaga acaagactgg ccgcggcaag aagcacacag
2641 ccttctcaag caaaggtctc agtgatgaag agtacgacga gtacaagagg attagagaag
2701 aaagaaatgg caagtactcc atagaagagt accttcagga cagggacaaa tactatgagg
2761 aggtggccat tgccagggcg accgaggaag acttctgtga agaggaggag gccaagattc
2821 ggcaaaggat cttcaggcca acaaggaaac aacgcaagga ggaaagggcc tctctcggtc
2881 tagtcacagg ttctgaaatc aggaaaagga acccagatga tttcaagccc aaggggaaac
2941 tgtgggctga tgatgataga agtgtggact acaatgagaa actcagtttt gaggccccac
3001 caagcatctg gtcgaggata gtcaactttg gttcaggttg gggcttttgg gtttctccca
3061 gtctgttcat aacatcaacc catgtcatac cccagggcgc aaaggagttc tttggagtcc
3121 ccatcaagca aattcagata cacaaatcag gcgaattctg tcgcttgagg ttcccaaaac
3181 caatcaggac tgatgtgacg ggcatgatct tagaagaagg tgcgcccgaa ggcaccgtgg
3241 tcacactact catcaagagg cctactggag aacttatgcc cttagcagct agaatgggga
3301 cccatgcaac catgaaaatt caagggcgca ctgttggagg tcagatgggc atgcttctga
3361 caggatccaa cgccaaaagc atggacctag gtaccacacc aggtgactgc ggctgcccct
3421 acatctacaa gagggaaaat gactatgtgg ttattggagt ccacacggct gccgctcgtg
3481 ggggaaacac tgtcatatgt gccacccagg ggagtgaggg ggaggctaca cttgaaggtg
3541 gtgacagtaa gggaacatac tgtggtgcac caatcctagg cccagggagt gccccaaaac
3601 tcagcaccaa gaccaaattc tggagatcgt ccacaacacc actcccacct ggcacctatg
3661 aaccagccta tcttggtggt agggacccca gagtcaagga tggcccttca ttgcaacaag
3721 ttatgaggga tcagttgaaa ccatttacag agcccagggg caaaccacca aagccaagtg
3781 tgttggaagc tgccaagaaa accatcatca atgtccttga acaaacaatt gatccacctg
3841 agaaatggtc attcacgcaa gcttgcgcgt cccttgacaa gactacttcc agtggccatc
3901 cgcaccacat gcggaaaaac gactgctgga acggggagtc cttcacaggc aagctggcag
3961 accaggcttc caaggccaac ctgatgttcg aagaggggaa gaacatgacc ccagtctaca
4021 caggtgcgct taaggatgaa ttagttaaaa ctgacaaaat ttatggtaag atcaagaaga
4081 ggcttctctg gggctcggac ttagcgacca tgattcggtg cgctcgagca ttcggaggct
4141 taatggatga actcaaagca cactgtgtta cacttcctat cagagttggt atgaatatga
4201 atgaggatgg ccccatcatc ttcgagaggc attccaggta caaatatcac tatgatgctg
4261 attactctcg gtgggattca acacaacaga gagccgtatt ggcagcagcc ctagaaatca
4321 tggttaaatt ctcctcagaa ccacatttgg ctcaggtagt cgcagaagac cttctttctc
4381 ccagcgtggt ggatgtgggt gacttcaaaa tatcaatcaa tgagggtctc ccctctgggg
4441 tgccctgcac ctcccaatgg aactccatcg cccactggct tctcactctc tgtgcgctct
4501 ctgaagttac aaacttgtcc cctgacatca tacaggctaa ttccctcttc tccttttatg
4561 gcgatgatga aattgttagt acagatataa agttggaccc agagaaattg acagcaaaac
4621 tcaaggaata cgggttgaaa ccaacccgcc ctgacaaaac tgaagggccc cttgttattt
4681 ctgaagactt aaatggtctg accttcctgc ggagaactgt gacccgcgac ccagctggtt
4741 ggtttggaaa attggagcag agttcaatac tcagacaaat gtactggact aggggcccca
4801 accatgaaga cccatctgaa acaatgattc cacattccca aagacccata caattgatgt
4861 ccctactggg agaggccgca ctccacggcc cagcattcta cagcaaaatt agcaagttag
4921 ttattgcaga gctaaaagaa ggtggcatgg atttttacgt gcccagacaa gagccaatgt
4981 tcagatggat gagattctca gatctgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccaacccat ctgatgggtc cacagccaac
5101 ctcgtcccag aggtcaacaa tgaggttatg gctttggagc ccgttgttgg tgccgctatt
5161 gcggcacctg tagcgggcca acaaaatgta attgacccct ggattagaaa taattttgta
5221 caagcccctg gtggagagtt tacagtatcc cctagaaacg ctccgggtga gatactatgg
5281 agcgcgccct tgggccctga tttgaacccc tacctttctc atttggccag aatgtacaat
5341 ggttatgcag gtggttttga agtgcaggta atcctcgcgg ggaacgcgtt caccgccggg
5401 aaaatcatat ttgcagcagt cccaccaaat tttccaactg aaggcttgag ccccagccag
5461 gttactatgt tcccccatat aatagtagat gttaggcaat tggaacctgt gttgatcccc
5521 ttacctgatg ttaggaacaa tttctatcat tacaatcaat caaatgattc taccattaaa
5581 ttgatagcaa tgctgtatac accacttagg gctaataatg ctggggatga tgtcttcaca
5641 gtctcttgtc gagtcctcac gaggccatcc cccgattttg atttcatatt cttggtgcca
5701 cccacagttg aatcaagaac taaaccattc accgtcccaa tcttaactgt tgaggaaatg
5761 tccaattcaa gattccccat tcctttggaa aagttgtaca cgggtcccag cagtgctttt
5821 gttgtccaac cacaaaatgg caggtgcacg actgatggcg tgctcttagg cactacccag
5881 ctgtctgctg tcaacatctg caccttcaga ggggatgtca cccacattgc gggcagtcat
5941 gattatacaa tgaatttggc ttctcaaaat tggaacaatt atgacccaac agaagaaatc
6001 ccagcccctc tgggaactcc agatttcgtg ggaaagatcc aaggcatgct cacccaaacc
6061 acgagagagg atggctcgac ccgcgcccac aaagctacag tgagcactgg aagtgtccac
6121 tttactccaa agctgggcag tgtccaatac accactgaca caaacaatga ttttcaaact
6181 ggccaaaaca cgaaattcac cccagtcggc gtcatccagg acggtaataa ccatcaaaat
6241 gaaccccaac aatgggtact cccaaattac tcaggtagaa ctggtcataa tgtgcaccta
6301 gctcctgccg ttgcccccac ttttccgggt gagcaacttc ttttctttag gtccactatg
6361 cccggatgta gcgggtatcc caacatgaat ctggattgcc tactcccaca ggaatgggtg
6421 cagcacttct accaagaagc agctccagca caatctgatg tggctctgct gagatttgtg
6481 aatccagaca caggtagggt tctgtttgag tgcaagctcc ataaatcagg ctatgtcaca
6541 gtggctcaca ccggcccgca tgatttggtt atccccccca atggttactt tagatttgat
6601 tcctgggtca accagttcta cacacttgcc cccatgggaa atggagcggg gcgtagacgt
6661 gcattataat ggctggagcc ttctttgctg ggttggcatc tgatgtcctt ggctctggac
6721 ttggttccct aatcaatgct ggggctgggg ccatcaacca aaaagttgaa tttgaaaata
6781 acagaaaatt gcaacaagct tccttccaat ttagtagcaa cctacaacag gcttccttcc
6841 aacatgataa agagatgctc caagcacaga ttgaggccac taaaaaattg caacagggta
6901 tgatgaaggt taaacaggcg atgctcctag agggtggatt ctctgaaaca gatgcagccc
6961 gtggggcaat caacgccccc atgacaaagg ctctggactg gagcggaaca aggtactggg
7021 ctcctgacgc caggaccaca acatacaatg caggccgctt ttccacccct caaccttcgg
7081 gggcattgcc aggaagaact aatcttaggg ctactgtccc cgctcggggc tcctctagtg
7141 cactttctag tactcccact gctacttctg tgtattcaaa tcaaactgtt tcaacgagac
7201 ttggttcttc agctggttct ggtaccagtg tctcgagtct cccgtcaact gcaaggacta
7261 ggagctgggt tgaggatcaa aacagaaatt tgtcaccttt tatgaggggg gctctcaaca
7321 catcattcgt caccccacca tctagtagat cctctagcca aggcacagtc tcaaccgtgc
7381 ctaaagaaat tttggactcc tggactggcg ctttcaacac gcgcaggcag cctctcttcg
7441 ctcacattcg taagcgaggg gagtcacggg tgtaatgtga aaagacaaaa ttgattatct
7501 ttcctttctt tagtgtcttt t
//