Typing tool
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Typing tool
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Complete norovirus genomes
| MW305579 | GII.2 | |
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| GII.P30 |
ORF1: 1..5069
ORF2: 5050..6678
ORF3: 6678..7457
LOCUS MW305579 7501 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate KL137 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305579
VERSION MW305579.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7501)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7501)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7501
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="KL137"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Malaysia"
/collection_date="14-Jul-1978"
/note="genotype: GII.2[GII.P30]"
gene <1..5069
/gene="ORF1"
CDS <1..5069
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59073.1"
/translation="AAVNSNNDNAKSSSDGVLSSMAVTFKRALGARPKQPPPREIPQR
PPRPPTPELVKKIPPPPPNGEDEPVVHYSAKDGITGLPELTTVRQPEEVATAFSVPPL
DQRENRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPLSL
YWRPVYTPQYLIAPDTLRKLHGELFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTT
GFFRPYQDWNRKPLPTMDDSKLKKVANILLCALSSLFTRPIKDIIGKLRPLNILNILA
SCDWSFASIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMG
GIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMV
RAIEDAVLDLEAIENNHMTALLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTI
NALLARIAAARSLVHRAKEELSSRLRPVVVMISGKPGIGKTHLARELAKKIATTLSGD
QRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPVHDALRLQELADTCPLTLNCDRIEN
KGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQPDM
WKSAYSPDFSHIKLMLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEF
ELQGPNLTTFNFDRNKIQAFRQLAAENKYGLVDTMRVGGQLKSVRTIPELKQALKNIL
IKRCQIVYGGSTYTLESDGKGSVKVEKVQNTNIQINNELAGALHHLRCARIRYYVKCV
QEALYSIIQIAGAAFVTTRIVKRMNIQNLWSRPPVGDAEEVTSQDGCPKPKDDDEFVI
SSSDITPEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDR
DKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPD
DFKPKGKLWADDERVVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIP
QGTQEFFGVPIKQIQIHKSGEFCRLRFPKSIRTDVTGMILEEGAPEGTVVSLLIKRPT
GELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGN
DYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGNAPKLSTKT
KFWRSSTVPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLE
AAKKTIINVLEQTIDPPQKWSFSQACASLDKTTSSGHPHHIRKNDCWNGESFTGKLAD
QASKANLMYEEGKNMTPVYTGALKDELVKTDKIYGQIKKRLLWGSDLATMIRCARAFG
GLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRFSYHYDADYSRWDSTQQRAVLAAA
LEIMVKFSPEPHLAQIVAEDLLAPSVMDVGDFKITINEGLPSGVPCTSQWNSIAHWLL
TLCALSEVTNLAPDIVQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDK
TEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQIYWTRGPNHEDPSETMIP
HSQRPIQLMSLLGEAALHGPTFYTKISKLVITELKEGGMDFYVPRQEPMFRWMRFSDL
STWEGDRNLAPSFVNEDGVE"
mat_peptide <1..959
/gene="ORF1"
/product="p48"
mat_peptide 960..2057
/gene="ORF1"
/product="NTPase"
mat_peptide 2058..2594
/gene="ORF1"
/product="p22"
mat_peptide 2595..2993
/gene="ORF1"
/product="VPg"
mat_peptide 2994..3536
/gene="ORF1"
/product="Pro"
mat_peptide 3537..5066
/gene="ORF1"
/product="RdRp"
gene 5050..6678
/gene="ORF2"
CDS 5050..6678
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59074.1"
/translation="MKMASNDAAPSTDGAAGLVPESNSEVMALEPVAGAALAAPVTGQ
TNIIDPWIRANFVQAPNGEFTVSPRNAPGEVLLNLELGPELNPYLAHLARMYNGYAGG
MEVQVMLAGNAFTAGKLVFAAVPPHFPVENLSPQQITMFPHVIIDVRTLEPVLLPLPD
VRNNFFHYNQKDDPKMRIVAMLYTPLRSNGSGDDVFTVSCRVLTRPSPDFDFTYLVPP
TVESKTKPFTLPILTLGELSNSRFPVSIDQMYTSPNEVISVQCQNGRCTLDGELQGTT
QLQVSGICAFKGEVTAHLQDNDHLYNITITNLNGSPFDPSEDIPAPLGVPDFQGRVFG
VITQRDKQNAAGQSQPANRGHDAVVPTYTAQYTPKLGQVQIGTWQTDDLKVNQPVKFT
PVGLNDTEHFNQWVVPRYAGALNLNTNLAPSVAPVFPGERLLFFRSYLPLRGGYGNPA
IDCLLPQEWVQHFYQEAAPSMSEVALVRYINPDTGRALFEAKLHRAGFMTVSSNTSAP
VVVPANGYFRFDSWVNQFYSLAPMGTGNGRRRIQ"
gene 6678..7457
/gene="ORF3"
CDS 6678..7457
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59075.1"
/translation="MAGAFVAGLAGDVLSNGLSSLINAGANAINQRAEFDFNQRLQQN
SFNHDKEMLQAQIQATKQLQADMMAIKQGVLTAGGFSPTDAARGAVNAPMTQALDWNG
TRYWAPGSMRTTSYSGRFTSTAPARQADFQHTQNRPSSGSSVSSYTTQSSRPTLTTTT
GSSHGTTSSNSTRSTNLSQSTVSRATSRTSEWVRDQNRNLEPYMHGALQTAFVTPPSS
RASDGTVSTVPKGVLDSWTPAFNTRRQPLFAHLRKRGESQA"
ORIGIN
1 ccgctgctgt aaacagcaac aacgacaacg caaaatcttc aagtgacgga gtactatcta
61 gtatggctgt cacttttaaa cgagcccttg gggcccggcc taaacagccg cccccgaggg
121 aaataccaca aaggccccca aggccaccca ctccagaact ggtgaaaaag atcccacctc
181 ccccgcccaa cggggaagat gaaccggtcg ttcattatag tgccaaagat ggcataactg
241 ggctgcccga acttacaaca gtgaggcagc cagaagaggt tgctacagca ttcagcgtcc
301 cacccctcga ccagagagag aatagggacg ctaaggagcc attgaccggc accatcttgg
361 agatgtggga tggcgagatc taccattatg gcctatatgt ggagcgaggg ctggtgcttg
421 gcgtgcacaa accaccagcc gccatcagcc tcgctaaagt tgagttaaca cctctatctt
481 tgtattggag accagtgtac accccccagt acctcatcgc tcctgacacc ctcaggaaac
541 tgcacgggga gttatttcca tacacggcct ttgataacaa ctgctatgcc ttctgctgct
601 gggtgttgga cttaaatgat tcttggttga gcagaaggat gatacagaga acaactggct
661 ttttcaggcc ttaccaagat tggaatagga agcccctccc caccatggat gactccaagt
721 tgaagaaggt ggccaacata cttttgtgtg ccttgtcatc actattcact agacccatca
781 aggacataat tgggaaactc aggcctctca acatccttaa catcctggct tcttgtgatt
841 ggtctttcgc aagtatagtg gaatctctaa ttctcctggc tgaactcttt ggagttttct
901 ggacaccccc agatgtgtct gcgatgatcg cccccttact gggtgactac gagctgcaag
961 gacctgaaga tcttgctgtg gaacttgtac cggtagtaat gggggggata ggattggtgt
1021 tggggttcac caaggaaaag attgggaaga tgctatcatc tgccgcctcc accctgaggg
1081 cctgcaaaga ccttggcgcc tatgggctgg aaattctgaa actggtcatg aaatggtttt
1141 tcccaaagaa agaggaggca aacgagcttg cgatggtgag ggctattgag gacgcagtcc
1201 tagatctcga ggctattgag aacaaccata tgacagctct actcaaagat aaagatagcc
1261 tcgcgacata catgaggact cttgatttgg aggaagaaaa ggccagaaag ctctccacta
1321 agtccgcttc acctgatata gtgggcacga tcaacgccct actggctaga attgccgctg
1381 ctcgttccct tgtacacagg gccaaggaag aactgtccag cagactaagg ccagttgtcg
1441 tgatgatatc tggcaaacct ggcatcggga agacccatct ggctagagaa ttggcaaaga
1501 agattgctac aaccctctca ggagaccaga gggtaggcct catcccccgc aacggagtcg
1561 accactggga tgcttacaag ggtgagagag tcgttctctg ggacgactat ggaatgagta
1621 accctgtcca cgatgcccta agactccaag aacttgctga cacctgcccc ctgaccctaa
1681 actgtgacag aattgagaac aagggcaagg tttttgacag tgatgccata atcatcacaa
1741 ccaacctggc taacccagct ccacttgatt atgtcaactt tgaagcttgc tccagacgca
1801 ttgatttcct cgtgtatgcc gatgcacctg acgttgagaa ggcgaagcgc gacttcccgg
1861 gacaacctga catgtggaag agcgcttaca gtcccgactt ctcacacatc aagctaatgc
1921 tggctcccca gggtggtttt gacaaaaatg gcaacacccc acacgggaaa ggtgtcatga
1981 agaccctcac aacaggctcc ctcattgccc gtgcttcagg gctcctccat gaaagactgg
2041 atgaattcga actacaagga cccaacctca caactttcaa ctttgaccgt aataaaatac
2101 aggcttttag gcagcttgct gccgaaaaca aatatggctt ggtagacaca atgagagtgg
2161 gtggacaact caagagtgtc agaactatac cagaactcaa gcaggccctc aagaacatac
2221 taatcaaaag gtgccagata gtgtacggtg gcagcaccta cacacttgaa tctgatggca
2281 aagggagtgt gaaagtggaa aaagtgcaaa ataccaacat ccaaatcaac aacgagctag
2341 ctggtgctct acaccacctc cgatgcgcca ggatcaggta ttatgttaaa tgtgttcagg
2401 aggctcttta ctccattatc caaattgctg gggccgcgtt tgtaaccacg cgcattgtga
2461 agcgcatgaa catacagaac ttgtggtcaa ggcctccagt aggagatgcg gaggaggtca
2521 ctagccagga tggttgccca aagcccaaag atgatgatga gttcgttatc tcgtctagtg
2581 acatcacgcc tgaaggcaag aaaggaaaga acaagactgg ccgcggtaag aaacacacag
2641 ccttctcgag caagggtctc agtgatgagg agtacgatga gtacaaaaga attagggaag
2701 aaaggaatgg taagtactcc atagaagaat accttcagga cagagacaag tattatgagg
2761 aagtggccat agccagggca actgaggaag acttctgtga ggaagaagaa gccaagatcc
2821 gacagaggat atttaggcca acgaggaagc aacgcaagga ggagagggct tcccttggcc
2881 ttgtcaccgg ctcagagatc agaaagagaa acccagacga cttcaaacct aaaggaaagc
2941 tgtgggctga tgatgaaagg gttgttgact ataatgagaa actcagtttc gaggcccccc
3001 cgagcatctg gtcaaggata gtcaactttg ggtcaggatg ggggttttgg gtgtccccta
3061 gcctgttcat tacatcaacc catgttatac cccaaggcac tcaggaattc tttggtgtac
3121 ccatcaagca gattcaaatt cacaaatcag gggagttctg ccgcctgaga ttccctaaat
3181 caatcagaac tgatgtaaca ggcatgatcc tagaagaggg agccccagaa ggaaccgtgg
3241 tctcactact catcaagaga ccaaccggtg agctcatgcc cctggcagcc agaatgggca
3301 cccatgcgac tatgaagatc caaggtcgca cggttggggg tcagatgggc atgttgctaa
3361 cagggtccaa tgctaaaagc atggatttgg gcacgacgcc tggtgactgt ggctgcccct
3421 acatttataa gagaggcaat gactacgtgg tcatcggcgt gcacacagcc gcggctcgcg
3481 gaggtaacac tgtcatctgt gcaacccagg gtagtgaagg tgaggccacg ctcgaaggcg
3541 gtgataacaa aggtacctac tgtggagctc caatattggg tcctggtaac gcacccaaac
3601 tcagtaccaa gactaagttc tggaggtcct ccacagtgcc actcccaccc gggacctatg
3661 aaccagccta cttaggtggc aaggatccca gggtgaaggg tggaccttca ctacaacaag
3721 tcatgagaga ccagctaaaa ccattcactg agcctagggg caaaccaccc aagccaagtg
3781 tgctggaagc cgccaagaag accattatca atgtgttgga gcaaacaata gatccccccc
3841 aaaaatggtc attttcacaa gcatgtgcgt cgcttgataa aaccacctcc agcggccacc
3901 cccaccacat acggaagaac gattgctgga atggagagtc ttttacagga aaattggcag
3961 atcaagcatc aaaagctaac ctaatgtatg aggaaggaaa gaacatgacc ccagtctata
4021 caggggccct caaggatgag ctggtcaaga ctgacaagat ttatgggcag atcaagaaaa
4081 ggcttctttg gggctcggac ttggcaacaa tgatccgttg tgcgcgggcg tttggagggt
4141 tgatggatga gcttaaggcc cattgtgtaa cacttcctgt cagggttgga atgaacatga
4201 atgaggatgg acccataatc tttgaaaagc actccaggtt ctcataccac tatgatgcag
4261 actactcacg atgggactca acccaacaga gggcagtgct agctgcagcc ttggaaatca
4321 tggtaaaatt ctcaccagaa ccacatttgg cccaaattgt tgcagaggat ctcctagccc
4381 ccagtgtgat ggatgtaggt gatttcaaaa taacaattaa cgagggtctg ccctcgggag
4441 taccctgcac atcacagtgg aattccatcg cccactggct cctcacactc tgtgcactat
4501 ctgaagtcac aaacctggct cctgacatcg tacaagctaa ctccttgttc tctttctatg
4561 gtgatgatga aattgtgagc actgacataa aattagaccc agagaaactc acagcaaaac
4621 tcaaagaata cggactcaaa ccaacccgcc cggacaaaac tgaaggaccc ctgatcatat
4681 ccgaggactt gaatggtttg acctttctgc ggcggaccgt gacccgtgat ccagctgggt
4741 ggtttggcaa gttggaccag agttcaattc tcaggcagat atactggact aggggcccca
4801 accatgagga cccgtccgaa acaatgatac cacactccca gaggcctata cagctgatgt
4861 ctcttttggg tgaagcagcc ttgcatggtc caacatttta caccaaaatc agtaaattgg
4921 tcatcacaga gctgaaggaa ggtggcatgg atttttacgt gcccagacag gaacccatgt
4981 tcaggtggat gaggttctcg gatttgagca cgtgggaggg cgatcgcaat ctggctccca
5041 gttttgtgaa tgaagatggc gtcgaatgac gccgctccat ctactgatgg cgcagccggc
5101 ctcgtgccag aaagtaatag tgaggtcatg gctcttgagc ctgtggctgg tgctgccttg
5161 gcagccccgg ttaccggtca aacaaatatt atagaccctt ggattagagc aaattttgtc
5221 caggccccta atggtgaatt cacagtttct ccccgcaatg cccctggtga agtgctattg
5281 aatctagaat tgggtccaga attaaatcct tatctggcac atttggcaag aatgtacaac
5341 gggtatgccg gtgggatgga ggtgcaggtc atgctagctg ggaacgcgtt cacagctggc
5401 aaattggtct tcgctgctgt accacctcat tttccggttg aaaaccttag cccacagcaa
5461 attaccatgt tcccccatgt gattatagat gttaggactt tggaacctgt tttgttgcca
5521 ctccccgatg ttagaaataa tttctttcat tataatcaaa aagatgatcc taagatgaga
5581 attgtggcta tgctttatac tcccctcagg tccaatggtt ctggtgatga tgtgtttaca
5641 gtctcttgca gggtgttgac tagaccctcc cctgattttg attttacata cctggtgcca
5701 ccaacagtgg aatccaaaac aaaaccattc actcttccaa ttcttacact tggggagctt
5761 tccaattcta gatttccagt gtccatagat cagatgtaca ctagccccaa tgaagtcata
5821 tctgtgcagt gccagaatgg aaggtgcaca ctggatgggg agctccaagg aacaacacag
5881 ctccaagtta gtggcatttg tgcattcaaa ggagaagtga ccgcccactt gcaggacaat
5941 gatcacctat acaacatcac catcacaaac ttgaatgggt ccccttttga tccctctgag
6001 gacatccccg cccccctggg tgtgcccgac tttcagggaa gagtctttgg tgtcatcact
6061 caaagagaca aacagaatgc cgctggacaa agccagccgg caaacagggg acacgatgct
6121 gtagttccca cttacacagc ccagtacacc ccaaaattgg gtcaggttca aattggcaca
6181 tggcagaccg acgatcttaa agtcaaccaa ccagtaaaat tcaccccagt cggtctcaat
6241 gatacagaac atttcaatca gtgggtggtt cctaggtacg ctggtgcttt aaatctaaat
6301 acaaatcttg ccccctctgt tgctccagtg tttccagggg agcgtttgct cttctttaga
6361 tcatacctcc cccttagggg tggttatgga aacccagcta ttgattgcct gctaccacaa
6421 gagtgggtgc agcattttta tcaggaagca gccccctcaa tgagtgaggt agcccttgtc
6481 agatacatca atccggacac tggccgggcg ctgtttgagg ccaaactcca cagagctggt
6541 ttcatgacag tctcgagtaa caccagtgct ccggtggttg tgcctgccaa cggatacttc
6601 agatttgact cttgggtgaa ccaattttat tctcttgccc ccatgggaac tggaaatggg
6661 cgtagaagga ttcagtaatg gctggagctt tcgtagctgg tctcgcgggg gatgtgctca
6721 gcaatgggct cagttcacta attaatgcag gtgctaatgc aataaatcag agagcagaat
6781 ttgattttaa ccagagatta cagcaaaatt cttttaatca tgataaggag atgttgcagg
6841 ctcagattca ggcaactaag cagctgcagg cagacatgat ggctataaag cagggggttc
6901 tgaccgctgg cggcttttcc cctactgatg cagccagagg cgctgtgaac gcgcccatga
6961 cacaggcgct ggattggaat ggcacaaggt attgggcacc aggctccatg aggactacat
7021 cctactctgg caggttcaca tcgaccgccc cggcaaggca ggccgacttt caacacactc
7081 aaaatcggcc ttcgagtggc tcttctgtgt cctcttatac cactcaatct tcaagaccaa
7141 ctctaaccac aaccacaggg tcctcacacg gtacaacctc atccaattcg acccgtagca
7201 caaacctttc ccagtcgacg gtctctaggg ctacctctag gactagtgag tgggttagag
7261 atcaaaatag gaatttggaa ccctacatgc atggtgcctt acagacagcc tttgtcaccc
7321 caccttccag cagggcatct gacgggacag tctcaaccgt ccccaaaggt gttttggact
7381 cctggacacc tgcgttcaac acccgcaggc agccgctttt tgcacacctc cgtaagaggg
7441 gggagtcaca agcttagtga aaaggtgaaa acttatctta agttaattga ttctaccttt
7501 t
//