Typing tool
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Typing tool
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Complete norovirus genomes
| MW305577 | GII.13 | |
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| GII.P41 |
ORF1: 1..5075
ORF2: 5056..6684
ORF3: 6684..7418
LOCUS MW305577 7462 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate KL90 nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305577
VERSION MW305577.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7462)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7462)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7462
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="KL90"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Malaysia"
/collection_date="04-May-1978"
/note="genotype: GII.13[GII.P41]"
gene <1..5075
/gene="ORF1"
CDS <1..5075
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59067.1"
/translation="AAATSNNDNAKSSSDGVLNSMAVTFKRALGARPKQPPPRETTQK
QKPPRPPTPELVKKIPPPPPNGEDELVVSYSVKDGVSGLPELSTVSQPDEANTAFSVP
PLNQRENRDAKEPLPGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELAPL
SLYWRPVYTPQYLMSPDTLKKLHGELFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQR
TTGFFRPYQDWNRKPLPTMDDSKLKKVANIMLCALSSLFTRPIKDIIGKLRPLNILNI
LASCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVV
MGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKDEASELA
MVRSIEDAVLDLEAIENNHMTSLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVG
TINALLARIAAARSLVHRAKEELSSRPRPVVVMISGKPGIGKTHLARELAKKIAATLT
GDQRVGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRI
ENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDVEKAKRDFPGQP
DMWKDAFKPDFSHIKLMLAPQGGFDKNGNTPHGKGVMKTLTSGSLIARASGLLHERLD
EYELQGPTPTTFNFDQNKVFAFRQLAAENKYGLMDTMRVGSQLKGVKTVSELKQTLKN
IAIKKCQIVYNGSTYSLESDGKGNVKVEKVQSATVQTNNELSGALHYLRCARIRYYVK
CVQEALYSIIQIAGAAFVTTRIAKRMNIQNLWSKPQVEDAEETINKDGCPKQKDDEEF
VIASEDIKVEGKKGKNKSGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQ
DRDKYYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRN
PDDFKPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHV
IPQGSQEFFGVSIKQIQIHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVATLLIKR
PTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTIPGDCGCPYIYKR
GNDYVVIGVHTAAARGGNTVICATQGSEGEAMLEGGDNKGTYCGAPILGPGNAPKLST
KTKFWRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPNPSV
LEAAKKTIINVLEQTIDPPQKWSFSQACASLDKTTSSDHPHHMRKNECWNGESFTGKL
ADQASKANLMYEEGKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARA
FGGLMDELKAHCVTLPIRVGMNMNEDGPIIFEKHSRYNYHYDADYSRWDSTQQRAVLA
AALEIMVKFSPEPHLAQIVAEDLLSPSVMDVGDFKISITEGLPSGVPCTSQWNSIAHW
LLTLCALSEVTNLSPDTIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRP
DKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPSETM
IPHSQRPIQLMSLLGEAALHGPSFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFS
DLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..965
/gene="ORF1"
/product="p48"
mat_peptide 966..2063
/gene="ORF1"
/product="NTPase"
mat_peptide 2064..2600
/gene="ORF1"
/product="p22"
mat_peptide 2601..2999
/gene="ORF1"
/product="VPg"
mat_peptide 3000..3542
/gene="ORF1"
/product="Pro"
mat_peptide 3543..5072
/gene="ORF1"
/product="RdRp"
gene 5056..6684
/gene="ORF2"
CDS 5056..6684
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59068.1"
/translation="MKMASNDAAPSNDGAASLVPEGINETMPLEPVAGASIAAPVAGQ
TNIIDPWIRTNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAIPPNFPVDMISPAQITMLPHLIVDVRTLEPIMIPLPD
VRNVFYHFNNQPQPRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFIYLVPP
SVESKTKPFTLPILTISELTNSRFPIPIEQLYTAPNENNVVQCQNGRCTLDGELQGTT
QLLSSAICSYRGRTVANNGDNWDQNLLQLTYPSGASYDPTDEVPAPLGTQDFSGMLYG
VLTQDNTNVSAGEAKNAKGIYISTTSGKFTPKIGSIGLHSITEHVHPNQQSRFTPVGV
AVNENTPFQQWVLPHYAGSLALNTNLAPAVAPTFPGEQLLFFRSRVPCVQGQQGQDVF
MDCLLPQEWVNHFYQEAAPSQADVALIRYVNPDTGRTLFEAKLHRSGFITVSHTGAYP
LVVPPNGHFRFDSWVNQFYSLAPMGTGNGRRRIQ"
gene 6684..7418
/gene="ORF3"
CDS 6684..7418
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59069.1"
/translation="MAGAFIAGLAGDMLTSAVGSLTSAGANAINQKLNFDYNKQLQSA
SFQHDKEMLQAQIDATKKLQSEMIAIKHGVLTAGGFSPADAARGAVNAPMTRVLDWSG
TRYYAPNSAQTTSYSGQFTPSPVHRVQVKPSSSSTQRTAAPSSVRSLSTQSTSVTGSA
SLGGSSTISSSSRTADWVQQQRALSPYMHGALQTAYVTPPSSRASNVSSVSTEPKGVL
DSWTPVFNTRRQPLFAHLRKRGESQA"
ORIGIN
1 ccgctgctgc taccagcaac aacgacaacg caaaatcttc aagtgacgga gtactaaata
61 gtatggctgt cacttttaaa cgagccctcg gggcccggcc taagcaaccg cccccgaggg
121 aaacaacaca aaaacaaaaa cccccacgac cgcccactcc agagttggtc aagaagatcc
181 cgcctccccc gcctaacggg gaggacgaat tagtggtctc ctatagtgtg aaagatggcg
241 tctccggttt gcctgagctc tctaccgtca gtcaaccaga cgaggccaac acagcattta
301 gtgtcccccc actaaaccag agggagaaca gggatgctaa ggaaccactg cctggcacca
361 tactggagat gtgggatgga gagatctacc attatggcct gtacgtggaa cggggtctgg
421 tgcttggagt acacaagcca ccagcggcta tcagtcttgc caaggttgag ttggcaccat
481 tgtctctata ttggagacca gtgtacaccc cccagtatct tatgtccccg gacactctca
541 aaaagctaca tggagaatta ttcccttaca cggcctttga caataactgt tacgccttct
601 gttgttgggt cttagatcta aacgattctt ggcttagcag gagaatgata cagagaacaa
661 ctggcttttt ccgtccctac caggactgga acagaaagcc ccttcccacc atggatgatt
721 ccaaattgaa aaaggtggcc aatataatgc tgtgtgcttt gtcatcacta ttcaccaggc
781 ccattaagga cataattgga aagttgagac cactaaacat cctcaacata ttggcttcct
841 gcgattggac ttttgcaggt atagtagaat ccctaatcct cctggcagag ctctttggag
901 ttttctggac acccccagat gtgtctgcga tgatcgcccc cttactaggt gactacgagc
961 tacagggacc tgaagacctt gctgtggaac tcgtaccagt agtaatgggg gggataggtt
1021 tggttctagg tttcaccaaa gaaaagattg gcaaaatgct atcatctgct gcatccactc
1081 ttagggcttg taaagacctt ggagcatacg gattggaaat cttaaaatta gtcatgaaat
1141 ggttcttccc aaagaaagat gaggcaagcg agctcgcaat ggtgagatcc attgaggacg
1201 cagtattgga tcttgaagca attgaaaaca accacatgac ctctttgctc aaagacaagg
1261 acagtttggc aacctacatg agaactctag atcttgaaga ggaaaaggct agaaaactct
1321 ccaccaagtc tgcctctcct gacattgtgg gcacaattaa tgccctattg gcgcggatcg
1381 cagccgcccg ctccctggtg catcgtgcaa aagaagagct ttctagcagg ccaaggcccg
1441 ttgttgtgat gatatcaggc aaaccgggaa taggaaagac tcacctcgct agagagttag
1501 caaagaaaat tgcagccacc ctcacagggg atcagagggt gggtcttgtc ccacggaacg
1561 gcgttgacca ttgggacgca tacaaaggtg agagagtcgt cctttgggat gactatggga
1621 tgagcaaccc cattcatgac gccctcagac tgcaagaact tgctgacacg tgccccctga
1681 cactaaattg tgacagaatt gagaacaagg gaaaagtctt tgacagtgat gctataatca
1741 ttacaactaa tctggccaac ccagcaccac tggattatgt taactttgaa gcatgctcaa
1801 ggcgcattga cttcctcgtg tatgctgatg cccctgatgt tgagaaggca aagcgtgact
1861 ttccaggaca acctgacatg tggaaggacg ctttcaaacc cgacttctca catataaagt
1921 taatgctggc ccctcaaggt gggtttgata agaacggcaa caccccacac ggaaagggcg
1981 tcatgaaaac cctcacatct ggttctctca ttgcacgtgc atcagggctc ctccatgaaa
2041 gattggacga atacgagttg caaggcccaa cgcctacaac cttcaacttc gaccagaaca
2101 aagtctttgc tttcaggcaa ctcgctgctg aaaacaaata cgggttgatg gataccatga
2161 gagtgggaag tcagctcaag ggagtcaaaa ctgtgtcaga gcttaagcag acgcttaaga
2221 acattgcaat taaaaagtgc cagatagtct acaatggttc tacatactca cttgaatctg
2281 atggcaaagg taatgtaaaa gttgaaaagg tacagagtgc aactgtgcaa accaataacg
2341 agctatctgg tgcactacac tatctcagat gcgccaggat caggtattat gttaagtgtg
2401 tccaggaggc cctttattcc atcatccaaa ttgctggggc cgcgtttgtc accacgcgca
2461 ttgcaaaacg catgaacata caaaatcttt ggtctaagcc acaggtggag gatgcagaag
2521 aaaccatcaa taaagatggg tgtccaaaac aaaaagatga tgaggagttt gtcatcgcgt
2581 ctgaagacat caaagttgag ggcaagaagg gaaagaacaa gtctggccga ggcaagaagc
2641 acacagcctt ttcaagcaaa ggtctcagtg atgaggagta cgatgaatac aaaagaatta
2701 gagaagaaag aaatggtaag tactccatag aagaatacct tcaggacagg gacaaatact
2761 atgaagaggt ggccatagcc agggctactg aagaggactt ctgtgaggaa gaggaagcca
2821 aaatccgaca gaggattttc aggccaacga ggaaacaacg caaagaggag agagcttctc
2881 ttggcctggt tacaggctct gaaatcagga agaggaaccc agatgacttc aaacccaagg
2941 gaaaattgtg ggctgatgac gacagaagtg tcgattacaa tgagaagctc agtttcgaag
3001 ctcccccaag catctggtca agaatagtca actttggttc aggttggggt ttctgggttt
3061 caccaagttt gtttataaca tccacccatg ttatacctca gggatcacag gagttcttcg
3121 gggtttccat taaacagatt caaatccata aatcgggtga gttctgccga ctaaggtttc
3181 caaagccaat cagaactgat gtgacgggta tgatcctgga ggaaggggcc cctgaaggaa
3241 cagtggccac actactcata aagagaccaa ctggggaact catgccactg gcagctagga
3301 tgggtaccca tgcaactatg aagatccagg gtcgcactgt tgggggccaa atgggaatgc
3361 tcctgacagg atccaacgcc aagagcatgg acctgggtac tataccaggt gactgtgggt
3421 gtccatatat ctacaaaaga ggaaatgact acgtggtcat tggagtccac actgccgccg
3481 ctcgcggagg gaacaccgtc atctgtgcaa cccagggaag cgagggtgag gccatgcttg
3541 aaggtggtga caacaaaggc acctattgcg gtgcaccaat cctaggtcca gggaatgccc
3601 ccaaactcag tactaagacc aaattttgga ggtcctcaac agccccactc ccgcctggca
3661 catacgaacc agcctacctc ggaggtaagg accccagagt taagggtggc ccctcattac
3721 aacaagtcat gagagaccaa ttaaagccat tcacggaacc caggggcaag ccaccaaacc
3781 caagtgtgct agaagctgcc aaaaagacca tcattaacgt tcttgaacaa acaatagacc
3841 caccacagaa atggtcgttt tcacaagcat gcgcatcgct tgacaaaacc acctccagtg
3901 accacccgca ccacatgcgg aagaatgaat gttggaatgg agagtccttc acaggaaaat
3961 tggcagatca agcttcaaaa gctaacctaa tgtatgagga agggaaaaac atgaccccag
4021 tctacacagg tgcccttaag gatgagctag tcaaaactga caaaatatat ggcaagatca
4081 agaagaggct cctctggggg tcagatctgg caaccatgat tcggtgtgct cgagcattcg
4141 gaggactaat ggatgaactc aaggcccact gcgtcacact tcctattaga gttgggatga
4201 acatgaatga ggatggtccc atcatctttg aaaagcactc caggtacaac taccattatg
4261 atgcagatta ctctcggtgg gattcaacac aacagagggc tgtgttagct gcagctctag
4321 aaatcatggt aaagttttcc ccagaaccac acctcgccca gatagtcgca gaagaccttc
4381 tgtcccctag tgtgatggac gtgggcgatt ttaaaatatc aatcactgaa gggctcccct
4441 ctggggtgcc ttgcacctca caatggaact ctattgccca ttggctcctc acactctgtg
4501 cactctctga ggtaacaaat ttgtcccccg acaccatcca agcaaattct cttttctctt
4561 tctatggtga tgatgaaatt gtgagtacag atattaaatt ggatccagaa aagttgacag
4621 ctaaactgaa agagtatggg ctgaagccaa ctcgccctga taagactgaa ggacctctgg
4681 tcatctctga ggacttgaat ggcctgacct tcctgcggag aactgtgacc cgcgacccag
4741 ctggttggtt tggaaaattg gaacagagtt caatacttag acaaatgtat tggaccaggg
4801 gtcccaatca tgaggacccc tccgaaacaa tgataccaca ttcccaaaga cccatacagc
4861 taatgtccct attaggtgaa gctgcactgc atggcccatc attctacagc aagatcagca
4921 agctagtcat tgcagagttg aaggaaggtg gcatggattt ttacgtgcct agacaagagc
4981 caatgtttcg atggatgagg ttctcagact tgagcacgtg ggagggcgat cgcaatctgg
5041 ctcccagttt tgtgaatgaa gatggcgtcg aatgacgccg ctccatctaa tgatggtgca
5101 gctagtctcg taccagaggg catcaatgag actatgccat tggaacccgt tgctggcgca
5161 tctattgctg ccccagtagc gggacaaact aatataattg acccctggat aagaacaaac
5221 tttgtgcaag cccccaatgg agaattcaca gtgtcgccaa gaaattcccc tggtgagatt
5281 ttgttaaatt tagaattagg accagatcta aatccttatt tggcccatct atcaagaatg
5341 tataatggtt atgctggagg tgttgaggtg caagtactcc ttgctgggaa tgcgttcaca
5401 gcaggtaaga tactgtttgc agcaatcccc cctaactttc ctgtagacat gattagtcca
5461 gcccagatca ctatgcttcc ccacttgatt gtagatgtta ggaccttgga acctatcatg
5521 atacctttgc ctgatgttag aaatgtgttc tatcacttca acaaccaacc ccaacctaga
5581 atgaggctag tagctatgct ttacacccca ttgaggtcta atggttcagg agatgatgtt
5641 ttcactgtgt cttgtagagt gctaactagg ccaactcctg attttgagtt tatttatttg
5701 gtaccccctt ctgtggaatc taaaaccaaa ccattcacat taccaatact gaccatttct
5761 gaattgacca actctcgatt ccctattcca attgagcaat tgtacacggc cccaaatgag
5821 aacaatgttg tccagtgcca aaatggcagg tgcaccttgg atggtgagct ccaaggcacg
5881 acccaactgc tgtcaagtgc gatatgctct tataggggca ggactgtggc caacaatggg
5941 gataattggg accagaatct gctccagctg acctatccaa gtggtgcaag ttatgacccc
6001 accgatgaag tgccagcacc attgggcact caggatttta gtgggatgtt gtatggagtg
6061 ctgacccagg acaatacaaa tgtgagtgca ggggaggcca aaaatgctaa gggaatatat
6121 atatctacca ccagtgggaa attcacccca aaaattgggt caattggatt gcattcaata
6181 actgagcatg tgcaccctaa ccaacagtcg cggtttactc ctgttggagt tgccgtgaat
6241 gagaataccc ccttccaaca atgggttcta ccacactatg caggtagcct tgctctcaac
6301 accaatttgg cacccgctgt tgccccaacc ttccctggtg agcaattgtt attcttcagg
6361 tcccgtgttc catgtgttca aggccagcag gggcaagatg tgttcatgga ttgtctccta
6421 ccccaagagt gggtaaatca tttttatcaa gaagcagctc cttctcaagc agacgttgcc
6481 ctcatcaggt atgtcaaccc tgacactggc cgtacgctgt ttgaagccaa attgcataga
6541 tcaggtttca tcactgtgtc acatactggt gcttaccctc ttgtggtccc cccaaatggt
6601 cactttaggt ttgattcttg ggttaatcaa ttttattcac tcgcccccat gggaactggc
6661 aatgggcgca ggagaattca ataatggcag gagcatttat agctggttta gccggtgaca
6721 tgttgacttc tgctgttggg tcactgacct ctgcaggagc caatgccatc aaccaaaaat
6781 taaattttga ttacaacaaa caactccaaa gcgcatcctt ccagcatgac aaggaaatgt
6841 tgcaggctca aattgacgcc acaaagaagc tccaatcaga gatgattgca atcaagcatg
6901 gggttttgac cgcgggcggc ttttccccag ctgatgcagc cagaggggca gtcaacgccc
6961 caatgacaag agtgttggat tggtcaggaa cacgctacta tgccccaaat tctgcacaaa
7021 ccactagtta ctctgggcaa ttcaccccct cgccagttca tcgggtgcag gtgaagcctt
7081 cctctagctc aactcagcgg actgcagctc caagcagtgt ccgcagtctg tcaactcaat
7141 caacctctgt gactggctca gcttccctgg gggggtcttc tacaatctct tccagctcta
7201 ggacagcaga ttgggtgcaa cagcaaaggg ctcttagccc atacatgcat ggagccctgc
7261 agacggcgta tgtcacaccg ccgtcaagta gggcctccaa tgtgagctct gtctcaacag
7321 agcccaaagg ggttttggac tcctggacac ctgtgtttaa cacacgcagg cagccgctgt
7381 ttgcacacct caggaagagg ggggagtcac aggcttagtg aaaaggataa tcaatgatta
7441 aatgtgattt tgttctcctt tt
//