Typing tool
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Typing tool
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Complete norovirus genomes
| MW305567 | GII.4 Yerseke | |
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| GII.P4 Apeldoorn |
ORF1: 1..5061
ORF2: 5042..6664
ORF3: 6664..7470
LOCUS MW305567 7492 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate 912SR nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305567
VERSION MW305567.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7492)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7492)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7492
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="912SR"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Paraguay"
/collection_date="2005"
/note="genotype: GII.4[GII.P4]"
gene <1..5061
/gene="ORF1"
CDS <1..5061
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="QPJ59037.1"
/translation="ANSNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPREVPQRPP
RPPTPELVKNIPPPPPNGEDEIVVSYSAKDGVSGLPDLSTVRQPEESNTAFSVPPLSQ
RENRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLARVELTPLSLFW
RPVYTPQYLISPDALKKLHGETFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTSGF
FRPYQDWNRKPLPTMDDSKLKKVANIFLCALSSLFTRPIKDIIGKLRPLNILNILASC
DWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMGGI
GLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMVRS
IEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTINA
LLARIAAARSLVHRAKEELSSRPRPVVLMISGKPGIGKTHLAREVAKRIAASLTGDQR
VGLVPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIENKG
KVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDMWK
NAFSSDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEFEL
QGPTLTTFNFDRNKVLAFRRLAAENKYGLMDTMKVGRQLKDVRTMPELKQALNNISIK
KCQIVYSGCTYTLESDGKGNVKVDRVQSASVQTNNELTGALHHLRCARIRYYVMCVQE
ALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVENTEETASKDGCPKPKDDEEFVISS
DDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDK
YYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPDDF
KPKGKLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQG
AREFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRSTGE
LMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDY
VVIGVHTAAARGGNTVICATQGSEGEATLEGGDNKGTYCGAPILGPGSAPKLSTKTKF
WRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAA
KKTIINVLEQTIDPPEKWSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGRLADQA
SKANLMFEEGKNMTPVYTAALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGL
MDELKAHCVTLPIRVGMNMNEDGPIIFERHSRYTYHYDADYSRWDSTQQRAVLAAALE
IMVKFSPEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVPCTSQWNSIAHWLLTL
CALSEVTNLSPDTIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLREYGLKPTRPDKTE
GPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGSNHEDPSETMIPHS
QRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLST
WEGDRNLAPSFVNEDGVE"
mat_peptide <1..951
/gene="ORF1"
/product="p48"
mat_peptide 952..2049
/gene="ORF1"
/product="NTPase"
mat_peptide 2050..2586
/gene="ORF1"
/product="p22"
mat_peptide 2587..2985
/gene="ORF1"
/product="VPg"
mat_peptide 2986..3528
/gene="ORF1"
/product="Pro"
mat_peptide 3529..5058
/gene="ORF1"
/product="RdRp"
gene 5042..6664
/gene="ORF2"
CDS 5042..6664
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59038.1"
/translation="MKMASSDAAPSDGSTANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNSYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDPTIKLIAMLYTPLRANNAGEDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFSVPILTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSPVNICTFRGDVTHIAGTQNYTMNLASQNWNNYDPTEETPAPLGTPDFVGRIQGVL
TQTTRRDGSTRGHKATVSTGSVHFIPKLGSVQFSTDTSNDFETGQNTRFTPVGVVQDG
GTTHQNEPQQWVLPDYSGRDSHNVHLAPAVAPSFPGEQLLFFRSTMPGCSGYPNMNLD
CLLPQEWVQHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRAL"
gene 6664..7470
/gene="ORF3"
CDS 6664..7470
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59039.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSSLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGAVN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGALTGRTNLRATVPARGSSGTPS
NTSTAASVYSNQTASTRLGSTAGSGASVSSLPSTARTRSWVEDQNRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEVLDSWTGAFNTRRQPLFAHIRKRGESRA"
ORIGIN
1 gctaacagca acaacgacac cgcaaaatct tcaagtgacg gagtgctttc tagcatggct
61 gtcactttta aacgagccct cggggcgcgg cctaagcagc ctcccccgag ggaagtacca
121 caaagacccc cacgaccacc tactccagaa ctggtcaaaa atatcccccc tcccccgccc
181 aacggagagg atgaaatagt ggtttcttac agtgccaaag atggtgtttc cggtttgcct
241 gatctttcca ccgtcaggca accagaggaa tctaacacgg ccttcagtgt ccctccactc
301 agtcagaggg agaatagaga tgctaaagag ccactgacag gaacaattct agaaatgtgg
361 gatggagaaa tctaccatta tggcctgtat gtggagcgag gtcttgtact aggtgtgcac
421 aaaccaccag ctgccatcag ccttgctagg gtcgaactaa caccactctc cttgttctgg
481 agacctgtgt atactcctca gtatctcatc tccccagacg ctctcaagaa attacacgga
541 gaaacgttcc cctacacagc ctttgacaac aattgctatg ccttttgttg ttgggtcctg
601 gacctaaacg attcgtggct gagtaggagg atgatccaga gaacgtctgg cttcttcagg
661 ccctaccaag attggaatag gaaacccctc cccactatgg atgactccaa attaaagaag
721 gtagctaaca tattcctgtg tgctctgtct tcgctattca ccaggcccat aaaagatata
781 atagggaagc taaggcctct taacatcctc aatatcttgg cctcatgtga ttggactttt
841 gcaggcatag tggagtcctt aatactcttg gcagaactct ttggagtttt ctggacaccc
901 ccagatgtgt ctgcgatgat tgccccctta ctcggtgatt acgaactaca aggacctgag
961 gaccttgcgg tggagctcgt ccctgtagtg atggggggaa ttggtttggt actaggattc
1021 accaaagaga agattggaaa aatgttatca tctgctgcat ccaccttgag ggcttgtaaa
1081 gatcttggtg catatgggct agagatccta aagttggtca tgaagtggtt cttcccgaag
1141 aaagaggaag caaatgaact ggctatggtg agatccatcg aggatgcagt cctggatctc
1201 gaggcaattg aaaacaacca tatgaccacc ttgctcaaag acaaagacag tctggcaact
1261 tacatgagga cccttgacct tgaggaggag aaagccagga aactctcaac caagtctgct
1321 tcacctgaca tcgtgggcac aatcaacgcc cttctggcga gaatcgctgc tgcacgttct
1381 ctggtgcatc gagcgaagga ggagctttcc agcagaccaa gacctgtagt attgatgata
1441 tcaggtaaac caggaatagg gaagacccac cttgctaggg aagtggctaa gagaatcgca
1501 gcctccctta caggagacca gcgtgtaggc ctcgtcccac gcaatggcgt cgaccattgg
1561 gatgcgtata aaggggagag ggtcgtccta tgggacgact atggaatgag caatcccatc
1621 cacgacgccc tcaggttgca agaactcgct gacacttgcc ccctcactct aaactgtgac
1681 aggattgaga ataaaggaaa ggtctttgac agcgatgtca tcattatcac cactaatctg
1741 gctaacccag caccactgga ctatgtcaac tttgaagcat gctcgaggcg cattgacttc
1801 ctcgtgtatg cagaagctcc tgaagtcgaa aaggcgaagc gtgacttccc aggccaacct
1861 gacatgtgga agaacgcctt cagttctgac ttctcacaca taaaactaac attggctcca
1921 cagggtggct ttgacaagaa cgggaacacc cctcacggaa agggcgtcat gaagactctc
1981 accaccggct cccttattgc ccgggcatca ggactactcc atgagagact agatgaattt
2041 gaactacagg gcccaactct caccaccttc aactttgatc gcaacaaagt gcttgccttc
2101 aggcgacttg ctgctgaaaa caaatatggg ttgatggaca caatgaaagt tgggaggcag
2161 ctcaaggatg tcagaaccat gccagagctt aaacaagcac tcaataatat ctcaatcaag
2221 aagtgccaga tagtgtatag tggttgcacc tacacacttg agtctgatgg caagggcaat
2281 gtgaaagttg acagagttca gagcgcctct gtgcagacca acaatgagct gactggcgcc
2341 ctgcaccatc taaggtgcgc cagaatcaga tactatgtca tgtgtgtcca ggaggccctg
2401 tattccatca tccagattgc tggggctgca tttgttacca cgcgcatcgt caagcgcatg
2461 aacatacaag atctatggtc caagccacaa gtggaaaaca cagaggagac tgccagcaag
2521 gacgggtgcc caaaacccaa agatgatgaa gagttcgtca tttcatccga cgacatcaaa
2581 actgagggca agaaagggaa gaacaagact ggccgcggca agaagcacac agccttctca
2641 agcaaaggcc tcagtgatga agagtatgat gagtacaaga ggattagaga agagaggaat
2701 ggcaagtact ccatagaaga gtaccttcag gacagggaca aatactatga ggaggtagcc
2761 attgccaggg cgaccgagga agacttctgt gaagaggagg aggccaagat ccggcaaagg
2821 atcttcaggc caacaagaaa acaacgcaag gaggaaagag cttctctcgg tttagttaca
2881 ggttctgaaa ttaggaaaag aaacccagat gatttcaaac ccaaggggaa actgtgggct
2941 gacgatgata gaagtgtgga ctacaatgag aaactcagtt ttgaggcccc accaagcatc
3001 tggtcgagaa tagtcaactt tggttcaggt tggggattct gggtctcccc cagcctgttc
3061 ataacgtcaa cccatgtcat accccagggc gcaagggagt tctttggagt ccctatcaaa
3121 cagattcagg tgcacaagtc aggcgaattc tgtcgcttga gattcccaaa accaatcagg
3181 actgatgtga caggcatgat cttagaagaa ggtgcacccg agggcaccgt ggtcacgcta
3241 ctcatcaaaa ggtctactgg agaactcatg cccctagcag ctaggatggg gacccatgcg
3301 accatgaaaa tccaaggacg cactgttgga ggtcaaatgg gcatgcttct gacaggatcc
3361 aacgccaaaa gcatggatct gggcaccaca ccaggtgatt gtggctgtcc ctacatttac
3421 aagagaggaa atgactatgt ggtcattgga gtccacacgg ctgccgctcg tgggggaaac
3481 actgtcatat gtgccaccca agggagtgag ggagaggcta cactcgaagg tggtgacaat
3541 aaggggacat actgtggtgc accaattcta ggcccaggga gtgccccaaa actcagcacc
3601 aagaccaaat tctggagatc gtccacagca ccactcccac ctggcaccta tgaaccagcc
3661 tatcttggtg gcaaggatcc cagagtcaag ggtggccctt cactgcagca agtcatgagg
3721 gatcagttga agccatttac agagcccagg ggcaagccac caaagccaag tgtgctagaa
3781 gctgccaaga aaaccatcat caatgtcctt gagcaaacaa ttgatccacc tgagaaatgg
3841 tcattcgcac aagcttgcgc gtcccttgat aagaccactt ccagtggcca cccgcaccac
3901 atgcggaaaa acgactgctg gaacggggag tccttcacag gcagactggc agaccaggct
3961 tccaaggcca acctgatgtt tgaagaaggg aagaacatga ccccagtcta cacagctgcg
4021 cttaaggatg aattagttaa aactgacaaa atttacggta agatcaagaa gaggcttctc
4081 tggggctcgg atttagcgac catgatccgg tgtgctcgag cattcggagg cctaatggat
4141 gaactcaaag cacactgtgt cacacttccc attagagttg gtatgaatat gaatgaggat
4201 ggccccatca tcttcgagag gcattccagg tacacatatc actatgatgc tgattactcc
4261 cggtgggatt caacacaaca gagagccgtg ttggcagcag ctctagaaat catggttaaa
4321 ttctccccag aaccacattt ggctcaggta gtcgcagaag accttctttc tcccagcgtg
4381 gtggacgtgg gtgacttcac aatatcaatc aacgagggtc ttccctctgg ggtgccctgc
4441 acctcccaat ggaactccat cgcccactgg cttctcactc tctgtgcgct ctctgaagtt
4501 acaaacttgt cccctgacac catacaggct aattccctct tctctttcta tggtgatgat
4561 gagattgtta gcacagacat aaagttggac ccagagaagt tgacagcaaa gctcagggaa
4621 tatgggttaa agccaacccg ccctgacaaa actgaaggac ccctcgtcat ctctgaagac
4681 ttgaatggcc tgactttcct gcggagaact gtgacccgcg acccagctgg ttggtttgga
4741 aaactagagc agagttcaat actcaggcaa atgtactgga ctaggggctc caaccatgaa
4801 gacccatctg aaacaatgat tccacactcc caaagaccca tacaattgat gtccctactg
4861 ggggaggccg cactccacgg cccagcattc tacagtaaaa tcagcaagtt agtcattgca
4921 gagctaaaag aaggtggcat ggatttttac gtgcccagac aagagccaat gttcagatgg
4981 atgagattct cagatctgag cacgtgggag ggcgatcgca atctggctcc cagttttgtg
5041 aatgaagatg gcgtcgagtg acgccgcccc atctgatggg tctacagcca acctcgtccc
5101 agaggtcaat aatgaggtta tggctttgga gcccgttgtt ggtgccgcta ttgcggcacc
5161 tgtagcgggc caacaaaatg taattgaccc ctggattaga aataattttg tacaagcccc
5221 tggtggagaa ttcacagtat cccctagaaa cgctccaggt gaaatactat ggagcgcgcc
5281 tttgggccct gatttgaatc cctacctttc ccatttggcc agaatgtaca atagttatgc
5341 aggtggtttt gaagtgcagg taatcctcgc ggggaacgcg ttcaccgccg gaaaaatcat
5401 atttgcagca gtcccaccaa atttcccaac tgaaggcttg agccccagcc aggtcactat
5461 gttcccccat ataatagtag atgttaggca actagaacct gtgttgatcc ccttacctga
5521 tgttaggaat aatttctatc attacaatca atcaaatgac cccaccatca aactgatagc
5581 aatgctgtat acaccactta gggctaataa tgctggggaa gatgtcttca cagtctcttg
5641 tcgagttctc acgaggccat cccccgattt tgatttcata tttttggtgc cacccacagt
5701 tgagtcaaga accaaaccat tctctgtccc aattctaact gttgaggaga tgaccaattc
5761 aagattcccc attcctttgg aaaagttgtt cacgggcccc agcagtgctt ttgttgttca
5821 accacaaaat ggcaggtgca cgactgatgg cgtactctta ggtaccaccc aactgtctcc
5881 tgtcaacatc tgcaccttca gaggggatgt cacccacatt gcaggtactc aaaattacac
5941 aatgaatctg gcctcccaaa attggaacaa ttatgaccca acagaagaaa ccccagcccc
6001 tctgggaact ccagatttcg tgggaaggat ccaaggcgtg ctcacccaaa ccacaaggag
6061 ggatggctcg acccgcggcc acaaagccac agtgagcact ggaagtgtcc actttatccc
6121 aaagctgggc agtgtccaat tctccactga tacaagcaat gactttgaaa ctggtcaaaa
6181 cacgagattc accccagtcg gtgttgtcca ggatggtggc accacccatc agaatgaacc
6241 ccaacaatgg gtgcttccag attattcagg cagagatagc cataatgtac acctagcccc
6301 tgccgtggcc ccctcttttc cgggtgaaca acttcttttc tttaggtcca ctatgcccgg
6361 atgcagcggg tatcctaaca tgaatctgga ttgcctactc ccccaagagt gggtgcagca
6421 cttctaccaa gaggcagccc cagcacaatc tgatgtggct ctgctaagat ttgtgaatcc
6481 agacacaggt agggttctgt ttgagtgcaa gcttcataaa tcaggctatg tcacagtggc
6541 tcacactggc caacatgatt tggttatccc ccccaatggt tattttagat ttgattcctg
6601 ggtcaaccaa ttctatacac ttgcccccat gggaaatgga acggggcgta gacgtgcact
6661 ataatggctg gagctttctt tgctggattg gcatctgatg tccttggctc tggacttggt
6721 tccctaatca atgctggggc tggggccatc aaccaaaaag ttgaatttga aaacaacaga
6781 aaattacaac aagcttcctt ccaatttagc agcagcctac aacaggcttc ctttcaacat
6841 gataaagaga tgctccaagc acaaattgag gccaccaaaa agttgcaaca ggaaatgatg
6901 aaagttaaac aggcaatgct cctagagggt gggttctctg agacagatgc agcccgtggg
6961 gcagtcaacg cccccatgac aaaggctttg gactggagcg gaacaaggta ctgggctccc
7021 gatgctagga ctacaacata caatgcaggc cgcttttcca cccctcaacc ctcgggggca
7081 ctgacaggaa gaactaatct cagggctact gtccccgctc ggggctcctc tggcacacct
7141 tctaatactt ctactgctgc ttctgtgtac tcaaatcaaa ctgcttcaac gagacttggt
7201 tctacagctg gttctggtgc cagtgtctcg agcctcccgt caactgcaag gactaggagc
7261 tgggttgagg atcaaaacag gaatttgtca ccttttatga ggggggccca caacatatcg
7321 tttgtcaccc caccatctag tagatcctct agccaaggca cagtctcaac cgtgcctaaa
7381 gaagttttgg actcctggac tggcgctttc aacacgcgca ggcagcctct cttcgctcac
7441 attcgtaagc gaggggagtc acgggcataa tgtgaaaaga caaaattgat ta
//