Typing tool
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Typing tool
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Complete norovirus genomes
| MW305565 | GII.4 Farmington Hills | |
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| GII.P4 Apeldoorn |
ORF1: 1..5062
ORF2: 5043..6665
ORF3: 6665..7471
LOCUS MW305565 7493 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate 735SR nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305565
VERSION MW305565.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7493)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 7493)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7493
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="735SR"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Paraguay"
/collection_date="2004"
/note="genotype: GII.4[GII.P4]"
gene <1..5062
/gene="ORF1"
CDS <1..5062
/gene="ORF1"
/codon_start=2
/product="nonstructural polyprotein"
/protein_id="QPJ59031.1"
/translation="ANSNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPREIPQRPP
RPPTPELVKNIPPPPPNGEDEIVVSYSVKDGVSGLPDLSTVRQPEESNTAFSVPPLNQ
RENRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLARVELTPLSLFW
RPVYIPQYLISPDALKKLHGETFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTTGF
FRPYQDWNRKPLPTTDDSKLKKVANIFLCALSSLFTRPIKDIIGKLRPLNILNILASC
DWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLAVELVPVVMGGI
GLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMVRS
IEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTINA
LLARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKKIAASLTGDQR
VGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIENKG
KVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDMWK
NVFISDFSHIKLTLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEFEL
QGPTLTTFNFDRNKVLAFRQLAAENKYGLMDTMKVGRQLKDVRTMPELKQALKNISIK
KCQIVYSGCTYTLESDGKGNVKVDRVQSASVQTNNELTGALHHLRCARIRYYVRCVQE
ALYSIIQIAGAAFVTTRIVKRMNIQDLWSKPQVENTEETTSEDGCPKPEDDEEFVISS
DDIKTEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDK
YYEEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPDDF
KPKGRLWADDDRSVDYNEKLSFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQG
AKEFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRSTGE
LMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDY
VVIGVHTAAARGGNTVICATQGSEGEAILEGGDNKGTYCGAPILGPGSAPKLSTKTKF
WRSSTAPLPPGTYEPAYLGGKDPRVKGGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAA
KKTIINVLEQTIDPPEKWSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGRLADQA
SKANLMFEEGKNMTPVYTAALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGL
MDELKAHCVTLPIRVGMNMNEDGPIIFERHSRYTYHYDADYSRWDSTQQRAVLAAALE
IMVKFSPEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVPCTSQWNSIAHWLLTL
CALSEVTNLSPDTIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLREYGLKPTRPDKTE
GPLVISEDLNGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGSNHEDPSETMIPHS
QRPIQLMSLLGEAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLST
WEGDRNLAPSFVNEDGVE"
mat_peptide <1..952
/gene="ORF1"
/product="p48"
mat_peptide 953..2050
/gene="ORF1"
/product="NTPase"
mat_peptide 2051..2587
/gene="ORF1"
/product="p22"
mat_peptide 2588..2986
/gene="ORF1"
/product="VPg"
mat_peptide 2987..3529
/gene="ORF1"
/product="Pro"
mat_peptide 3530..5059
/gene="ORF1"
/product="RdRp"
gene 5043..6665
/gene="ORF2"
CDS 5043..6665
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59032.1"
/translation="MKMASNDATPSDGSTANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFSAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDPTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFSVPILTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSPVNICTFRGDVTHIAGTQNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGVL
TQTTRRDGSTRGHKATVSTGSVHFTPKLGSVQFSTDTSNDFETGQNTRFTPVGVVQDG
STTHQNEPQQWVLPNYSGRDGHNVHLAPAVAPSFPGEQLLFFRSTMPGCSGYPNMNLD
CLLPQEWVQHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGAGRRRAL"
gene 6665..7471
/gene="ORF3"
CDS 6665..7471
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59033.1"
/translation="MAGAFFAGLASDVLGSGLGSLISAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGAVN
APMTKALDWSGTRYWAPDARTTTYNAGRFSTPQPSGTPPGRTNLRATAPARGSSSTPS
STSTAASVYSNQTASTRLGSTAGSGTSVSSLPSTARTRSWVEDQNRNLSPFMRGAHNI
SFVTPPSSRSSSQGTVSTVPKEVLDSWTGAFNTRRQPLFAHIRNRGESRV"
ORIGIN
1 tgctaacagc aacaacgaca ccgcaaaatc ttcaagtgac ggagtgcttt ctagcatggc
61 tgtcactttt aaacgagccc tcggggcgcg gcctaagcag cctcccccga gggaaatacc
121 acaaagaccc ccacgaccac ctaccccaga actggtcaaa aacatccccc cccccccgcc
181 caacggagag gatgaaatag tggtctctta tagtgtcaaa gatggcgttt ccggtttgcc
241 tgatctttcc accgtcaggc aaccggaaga gtctaacacg gccttcagtg tccctccact
301 caaccagagg gagaatagag atgctaagga gccactgact ggaacaattc tggaaatgtg
361 ggatggagaa atctaccatt atggcctgta tgtggagcga ggtcttgtac taggtgtgca
421 caaaccacca gctgccatta gcctcgctag ggtcgaatta acaccactct ccttgttctg
481 gagacctgtg tatattcctc agtacctcat ctctccagac gctctcaaga aattacacgg
541 agaaacgttc ccctacacag cctttgacaa caattgctat gccttttgtt gctgggtcct
601 ggacctaaac gactcgtggc tgagtaggag aatgatccag agaacaactg gcttcttcag
661 gccctaccaa gattggaata ggaaacccct ccccactacg gatgactcca aactaaagaa
721 ggtagctaac atattcctgt gtgctctgtc ttcgctattc accaggccca taaaagatat
781 aatagggaaa ctaaggcctc ttaacatcct caacatcttg gcctcatgtg attggacttt
841 tgcaggcata gtggagtcct tgatactctt ggcagaactc tttggagttt tctggacacc
901 cccagatgtg tctgcgatga ttgccccctt actcggtgat tacgagctgc aaggacctga
961 ggaccttgca gtggagctcg tccctgtagt gatgggggga attggtttgg tgctaggatt
1021 caccaaagag aagattggaa aaatgttgtc atctgctgca tccactttga gagcttgtaa
1081 agatcttggt gcatatgggc tagagatcct aaagttggtc atgaagtggt tcttcccgaa
1141 gaaagaggaa gcaaatgaac tggctatggt gagatccatc gaggatgcag tcctggatct
1201 cgaggcaatt gaaaacaacc atatgaccac cttactcaaa gacaaagaca gcctggcaac
1261 ctatatgaga acccttgacc ttgaggagga gaaagccaga aaactctcaa ccaagtctgc
1321 ttcacctgac atcgtgggca caatcaacgc ccttctggcg agaatcgctg ctgcacgttc
1381 tctggtgcat cgagcgaagg aggaactttc cagcagacca agacctgtag tattgatgat
1441 atcaggtaga ccaggaatag ggaaaaccca ccttgctagg gaagtggcta agaaaatcgc
1501 agcctccctt acaggagacc agcgtgtagg tctcatccca cgcaatggcg tcgaccattg
1561 ggatgcgtac aagggggaga gggtcgtcct atgggacgac tatggaatga gcaatcccat
1621 ccacgatgcc ctcaggttgc aagaacttgc tgacacttgc cccctcaccc taaactgtga
1681 caggattgag aataaaggaa aggtctttga cagcgatgtc atcattatca ccactaatct
1741 ggctaaccca gcaccactgg actatgtcaa ctttgaagca tgctcgaggc gcatcgactt
1801 cctcgtgtat gcagaagccc ctgaagtcga aaaggcaaag cgtgacttcc caggccaacc
1861 tgacatgtgg aagaacgttt tcatttctga tttctcacac ataaaactaa cattggcccc
1921 acagggtggc ttcgacaaga acgggaacac cccacacgga aagggtgtca tgaagactct
1981 caccactggc tcccttattg cccgggcatc agggctactc cacgagaggc tagatgaatt
2041 tgagctacag ggcccaactc tcaccacctt caactttgat cgtaataaag tgcttgcctt
2101 tagacaactt gctgctgaaa acaaatatgg gttgatggac acaatgaaag ttgggaggca
2161 gctcaaggat gtcagaacca tgccagagct taaacaagca ctcaagaata tctcaatcaa
2221 gaagtgccag atagtgtata gtggttgcac ctacacactt gagtctgatg gcaagggcaa
2281 tgtgaaagtt gacagagttc aaagcgcctc cgtacagacc aacaatgagc tgactggcgc
2341 cctgcaccac ctaaggtgcg ccagaatcag atactatgtc aggtgtgtcc aggaggccct
2401 gtattccatc atccagattg ctggggctgc atttgtcacc acgcgcatcg tcaagcgcat
2461 gaacatacaa gacctatggt ccaagccaca agtggaaaac acagaggaga ctaccagcga
2521 ggacgggtgc ccaaaacccg aagatgatga ggagtttgtc atttcatccg acgacatcaa
2581 aactgagggt aagaaaggga agaacaaaac tggccgtggc aagaagcaca cagccttctc
2641 aagcaaaggt ctcagtgatg aagagtacga tgagtacaag aggattagag aagaaagaaa
2701 tggcaagtac tccatagaag agtaccttca ggacagggac aaatactatg aagaggtggc
2761 cattgccagg gcgaccgagg aagacttctg tgaagaggag gaggccaaga tccggcaaag
2821 gatcttcagg ccaacaagga aacaacgcaa ggaggaaaga gcttctctcg gtttagttac
2881 aggttctgaa attaggaaaa gaaacccaga tgatttcaaa cccaagggga gactgtgggc
2941 tgacgatgac agaagtgtgg actacaatga gaaactcagt tttgaagccc caccaagcat
3001 ctggtcgagg atagtcaatt ttggttcagg ttggggattc tgggtctccc ccagtctgtt
3061 cataacatca acccacgtca taccccaggg cgcaaaagag ttctttggag tccccatcaa
3121 acaaattcag gtacacaagt caggcgaatt ctgtcgcttg agattcccaa aaccaatcag
3181 gactgatgtg acgggcatga tcttagaaga aggtgcaccc gagggcaccg tggtcacatt
3241 actcatcaaa aggtctactg gagaactcat gcccctagca gctaggatgg ggacccatgc
3301 aaccatgaaa atccaaggac gcactgttgg aggccaaatg ggcatgcttc tgacaggatc
3361 caacgccaaa agcatggatc tgggcaccac accaggtgat tgtggctgtc cctacatcta
3421 caagagagga aatgactatg tggtcattgg agtccacacg gctgccgctc gtgggggaaa
3481 cactgtcata tgtgccaccc aggggagtga gggagaggct atacttgaag gtggtgacaa
3541 taaggggaca tattgtggtg caccaatcct aggcccaggg agtgccccaa aacttagcac
3601 caagaccaaa ttctggagat cgtccacagc accactccca cccggtacct atgaaccagc
3661 ctatcttggt ggcaaggacc ccagagtcaa gggtggccct tcactgcagc aagtcatgag
3721 agatcagttg aagccattta cagagcccag gggcaagcca ccaaagccaa gtgtgttaga
3781 agctgccaag aaaaccatca tcaatgtcct tgagcaaaca attgacccac ctgagaaatg
3841 gtcattcgca caagcgtgcg catcccttga caagactact tccagtggcc atccccatca
3901 catgcggaaa aacgactgct ggaacgggga gtccttcaca ggcaggctgg cagaccaggc
3961 ttccaaggcc aacctgatgt ttgaagaagg gaagaacatg accccagtct acacagctgc
4021 gcttaaggat gaattagtta aaactgataa aatttatggt aagatcaaga agaggcttct
4081 ctggggctcg gatttggcga ccatgatccg gtgtgctcga gcattcggag gcctaatgga
4141 tgaactcaaa gcgcactgtg tcacacttcc cattagagtt ggtatgaata tgaatgagga
4201 tggccccatt atcttcgaga ggcattccag gtacacatat cactatgatg ctgactactc
4261 tcgatgggat tcaacacagc agagagccgt gttggcagca gctctagaaa tcatggttaa
4321 attctcccca gaaccacatt tggctcaggt agtcgcagaa gaccttcttt ctcctagcgt
4381 ggtggatgtg ggtgacttca caatatcaat caacgagggt cttccctctg gggtgccctg
4441 cacctcccaa tggaactcca tcgcccactg gcttctcact ctttgtgcgc tctctgaagt
4501 cacaaatttg tcccctgata ccatacaggc taattccctc ttctcttttt atggtgatga
4561 tgaaattgtt agcacagaca taaaattgga cccagagaag ttgacagcaa agctcaggga
4621 gtatgggttg aaaccaaccc gccctgacaa aactgaagga ccccttgtca tctctgaaga
4681 cttgaatggc ctgactttcc tgcggagaac tgtgacccgc gacccagctg gttggtttgg
4741 aaaactggag cagagttcaa tactcaggca aatgtactgg actaggggct ccaaccatga
4801 agacccatct gaaacaatga ttccacactc ccaaagaccc atacaattga tgtccctact
4861 gggggaggcc gcactccacg gcccagcatt ctacagcaaa atcagcaagt tagtcattgc
4921 agagctaaaa gaaggtggca tggattttta cgtgcccaga caagagccaa tgttcagatg
4981 gatgagattc tcagatctga gcacgtggga gggcgatcgc aatctggctc ccagttttgt
5041 gaatgaagat ggcgtcgaat gacgccaccc catctgatgg gtccacagcc aacctcgtcc
5101 cagaggtcaa caatgaggtt atggctttgg agcccgttgt tggtgccgct attgcggcac
5161 ctgtagcggg ccaacaaaat gtaattgacc cctggattag aaataatttt gtacaagccc
5221 ctggtggaga gtttacagta tcccctagaa acgctccagg tgaaatacta tggagcgcgc
5281 ccttgggccc tgatctgaat ccctaccttt cccatttggc tagaatgtac aatggttatg
5341 caggtggttt tgaagtgcaa gtgatcctcg cggggaacgc gttcaccgcc ggaaaaatca
5401 tattttcagc agtcccacca aatttcccaa ccgaaggctt gagccccagc caggtcacta
5461 tgttccccca tataatagta gatgttaggc aactggaacc tgtgttgatc cccttacctg
5521 atgttaggaa taatttctac cattataatc aatcaaatga tcccaccatc aaattgatag
5581 caatgctgta tacaccactt agggctaata atgctgggga tgatgtcttc acagtctctt
5641 gtcgagtcct cacgagacca tcccccgact ttgatttcat atttttggtg ccacccacag
5701 ttgagtcaag aactaaacca ttctctgtcc caattttaac tgttgaagag atgaccaatt
5761 caagattccc tattcctttg gaaaagttgt tcacgggccc cagcagtgcc tttgttgttc
5821 aaccacaaaa tggcagatgc acgactgatg gcgtgctctt aggtactacc cagctgtctc
5881 ctgtcaacat ctgcaccttc agaggggatg tcacccacat tgcaggtact caaaattaca
5941 caatgaatct ggcctcccaa aattggaaca attatgaccc aacagaagaa atcccagccc
6001 ccctgggaac tccagatttc gtgggaaaga tccaaggcgt gctcacccaa accacaagga
6061 gggatggctc gactcgcggc cacaaagcca cagtgagcac tggaagtgtc cactttaccc
6121 caaagctggg cagtgttcaa ttctccactg atacaagcaa tgactttgaa actggccaga
6181 acacgagatt caccccagtc ggtgtcgtcc aggatggcag taccacccac caaaatgaac
6241 cccaacaatg ggtgcttcca aattattcag gtagagatgg tcacaatgta cacctagccc
6301 ctgccgtggc cccctctttt ccgggtgagc aacttctttt cttcaggtcc actatgcccg
6361 gatgcagcgg gtatcccaac atgaatttgg attgcctact cccccaggag tgggtgcagc
6421 acttctacca agaggcagcc ccagcacaat ctgatgtggc tctgctaaga tttgtgaatc
6481 cagacacagg tagggttttg tttgagtgca agcttcataa atcaggctat gtcacagtgg
6541 ctcacactgg ccaacatgat ttggttatcc ctcccaatgg ctattttaga ttcgattcct
6601 gggtcaacca attctacaca cttgccccca tgggaaatgg agcggggcgt agacgtgcat
6661 tataatggct ggagctttct ttgctggatt ggcatctgat gtccttggct ctggacttgg
6721 ttccctaatc agtgctgggg ctggggccat caaccaaaaa gttgaatttg aaaacaacag
6781 aaagttgcaa caagcttcct tccaatttag cagcaaccta caacaggctt cctttcaaca
6841 tgataaagag atgctccaag cacaaattga ggccaccaaa aagttacaac aggaaatgat
6901 gaaagttaaa caggcaatgc tcctagaggg tgggttctct gaaacggatg cagcccgtgg
6961 ggcagtcaac gcccccatga caaaggcttt ggactggagc ggaacaaggt actgggctcc
7021 tgatgctagg accacaacat acaatgcagg ccgcttttct acccctcaac cctcggggac
7081 accgccagga agaaccaatc tcagggctac tgcccccgct cggggctcct ccagcacacc
7141 ttctagcact tctactgctg cttctgtgta ctcaaatcaa actgcttcaa cgagacttgg
7201 ttctacagct ggttctggta ccagtgtctc gagcctcccg tcaactgcaa ggactaggag
7261 ctgggttgag gatcaaaaca ggaatttgtc acctttcatg aggggggccc acaacatatc
7321 gtttgtcacc ccaccatcta gcagatcctc tagccaaggc acagtctcaa ccgtgcctaa
7381 agaagttttg gactcctgga ctggcgcttt caacacgcgc aggcagcctc tcttcgctca
7441 cattcgtaat cgaggggagt cacgggtgta atgtgaaaag acaaaattga tta
//