Typing tool
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Typing tool
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Complete norovirus genomes
| MW305561 | GII.6 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6687
ORF3: 6687..7463
LOCUS MW305561 7514 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 291HBO nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305561
VERSION MW305561.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7514)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7514)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7514
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="291HBO"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Paraguay"
/collection_date="29-Aug-2016"
/note="genotype: GII.6[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59019.1"
/translation="FGSQNSVNDSINTAPSNKEEVGAFSNIKVGFKKMLGAVPKGTKA
PSSDQHCPSVKIGTKTLIVPPEPPNGEDTVQFDAKSETVRGLPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSGGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLSRRSI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFGIFWTPPDVSSFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFKQDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGTALKSVKTLEDLKVAL
RDVKFNECEIIYRNSKYRVSSNGKGSVSVDKVEDQISQTANEVGAALLRLRQARARYY
VSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVRPTETQETSESEKEVAQSRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGSDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
INELFGVEIKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMVRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWYGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6687
/gene="ORF2"
CDS 5044..6687
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59020.1"
/translation="MKMASNDAAPSNDGAANLVPEATNEVMALEPVVGASIAAPVVGQ
QNIIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVENISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQENTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAPIDMLYTDPNEAIVVQPQNGRCTLDGTLQGTTQ
LVPTQICSFRGTLISQTSRSADSTDSAPRARNHPLHVQLKNLDGTPYDPTDEVPAVLG
AIDFKGTVFGVASQRNTTGGSIGATRAHEVHIDTTNPRYTPKLGSVLMYSESTDFDDG
QPTRFTPIGMGADDWHQWELPEYSGHLTLNMNLAPAVAPAFPGERILFFRSVVPSAGG
YGSGHIDCLIPQEWVQHFYQEAAPSQSAVALIRYVNPDTGRNIFEAKLHREGFITVAN
SGNNPIVVPPNGYFRFEAWVNQFYTLTPMGTGQGRRRIQ"
gene 6687..7463
/gene="ORF3"
CDS 6687..7463
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59021.1"
/translation="MAGAFLAGLAGDAITSGVGSLINAGANAINQKVEYDFNKQLQLA
SFKHDKEMLQSQVLATKQLQQEMMNIRQGVLSAGGFSPADAARGAVNAPMTKILDWNG
TRYFAPNSMKTTSYSGQFSSNPVHRQPTLPRSEPPKIKVNSDSASVYSSASTVPSQST
HSTVLTAGSSSSRTTSSSTAASTPSRTSDWVRGQNERLSPFMDGALQTTFVTPPSSKA
SSYGSVSTVPKAVLDSWTPMFNTYRQPLFAHVRRRGESQI"
ORIGIN
1 cctttggcag ccaaaactct gtcaatgaca gtatcaacac cgccccttct aataaagaag
61 aggttggtgc attctccaac atcaaagttg gttttaagaa aatgctgggt gccgttccca
121 aggggaccaa agcacccagt agtgatcagc actgcccctc agttaaaatc gggaccaaga
181 cattaatagt tccccctgag cccccaaatg gtgaagacac cgtgcagttt gatgcgaagt
241 cggaaactgt gcgcgggtta ccagacttga caacggtgca gaacgaacac gaaaacacac
301 catacactgt ccccccattg agcgaaaggg agcacagacc agctactgaa ccgcttcctg
361 gcacaatact ggagatgtgg gatggtgaat tctaccatta ctctgtgtac gtcagcggtg
421 gcaaagccct aggggttcac aagccccctg cagcgataag cctcgcgacg atagagctca
481 cacccatatc tctttattgg aggcccgttt acacccccaa ctatctggtc tgtccagaca
541 cgttgaaggg ccttgctggt gagaagttcc cctacactgc cttcagcaac aactgttaca
601 acttctgttg ctgggtgctt gagctcaatg acacgtggct tagcaggaga agcatttcta
661 ggaccaccgg cttcttcaaa ccataccagt cttggaatag gaaacccctt ccaacagttg
721 atgatggaaa gatcaaaaag gtggccaacg caattctctg tgcacttgga tcactgtttt
781 caaaaccaat caaggaccta ttgggcaaac ttaaaccatt gaacttgctg cacttgctcg
841 catcatgtga ctggacgttt gcgggtatag tagagacagt catcctaatg gcggaacttt
901 tcggcatctt ttggacaccg ccagatgttt ccagtttcat agcctccctg ataggtgatt
961 ttgaattgca agggccggag gacctggctg tggagcttgt acccgtggtc atgggtggca
1021 taggaatggt tctcggcttc actgctgaaa agataggccg catgctatcg tccgctgcat
1081 caacactacg ggcgtgcaaa gacttgggga attatgctct tgacatattg aaacttgtta
1141 tgaagtggtt cttcccaaag aaagaagaga aagccgagat ggaaacccta agggcgattg
1201 aggatgccgt cctggacatg gaagctatag gaaataacca tctcacaacc ctcctcaagg
1261 acaaggatag cctcacggct ttcatgaaga ctctagatct agaagaagag aaggcgagga
1321 agctgtccac caaatcatcc tcgccggaca ttgtcggcac cattaatgcc atactggcta
1381 gaatagctgc tgccaggtcc ctcttgcaca aggctaaaga agaaatgttc agtaggatca
1441 gacccgtggt tgtcatgatc tcaggtaggc ctggcattgg caaaacccac atggcaagac
1501 acttggctaa gagtatcgcc aacaccatga gcggcgacca gagagtgggg ctcgtcccac
1561 gcaacggggt cgaccattgg gacgcctaca ggggagagag ggtggtttta tgggatgatt
1621 atggcatggg aaaccctgtc aaagatgcct taacactaca agagctggcc gacacctgcc
1681 cagtaactct aaactgtgat aggattgaga acaaggggaa gatgtttgac agtgatgtca
1741 ttataatcac gaccaattta gtcaacccag cgcccctcga ttatgtaaac ttcgaggcgt
1801 gctccagaag ggtcgacttt ctggtctatg cagagtcgcc agaaattgag aaggttaaga
1861 gagacttccc cggccaacct gacatgtgga aggaccattt caagcaagac ttttcccaca
1921 taaaactgac tctagcccca cagggtggat ttgacaagaa tggcaacacc ccgcatggta
1981 agggcaccat gcgatcccta acccaggggt ccctgactgc aagggttgca ggtcttgttc
2041 atgagaggag agacgagttt cagctccagg ggaacgatct tcaaacatat aactttgata
2101 ccaacagagt ctctgcattt aggaagctgg ccgcggacaa caagtatggg atcatggaga
2161 ctatgagagt gggcacagcg cttaagagcg tcaagacctt ggaagatctg aaagttgcac
2221 tgagagatgt gaagttcaac gagtgtgaga taatttacag aaactccaaa taccgagtct
2281 cttccaatgg taaaggttct gtctctgttg acaaagttga ggaccaaata tcccagaccg
2341 caaacgaagt gggtgcagca ctccttagac tcagacaggc aagagccagg tactatgtca
2401 gctgcttcca agacctcgtt tacactctaa tacaggtcgc cggagcatca ttcgttgtca
2461 acaggatctc taaaaggttc tgctgggaga gatgggtcag accaaccgag acccaggaaa
2521 cgagtgaatc cgaaaaggaa gtggcccaaa gcagatggga gattgagccc aaggacacag
2581 aaccagaagg taagaagggt aaaaacaaga aaggaagagg caagaaacac acagctttct
2641 ccagtaaagg cctgagtgat gaggagtatg acgagttcaa gagaatcaga gaagaaagga
2701 acggaaaata ctccattgag gaatacctgc aagaccggga tcgctactat gaggaagtgg
2761 cagttgcccg ggcgacagag gaggacttct gtgaagagga agaggccaag ataagacaaa
2821 gaatctttcg ccccacaaag aaacagagga aggaagaaag gggggtgctt ggtttggtta
2881 ctggctcaga catcaggaag agaagaccag acgattttca accgaagggc aacctgtggg
2941 cagacgacac caggagtgtg gactacaacg agagacttga tttcgaggcc cccccgagtg
3001 tctggtcaag aatagtccca ttgggcactg gctggggctt ctgggtttca tcaaacctcc
3061 tgatcacaac aacgcacgtc ctacctaagg ggattaatga actctttgga gttgagatca
3121 aacagattca gattcataag tctggagagt tctgcaggtt cagattccca agaccaatta
3181 gaccggatgt cacagggctc gtgttggagg aaggcgctcc agaaggcact gtctgctcca
3241 tactcgtgaa gagacctaca ggtgagatga tccccctggc agtgaggatg ggtacgcatg
3301 catccatgaa gatacagggt aggaccgtcg gtggccagat ggggatgctc ctcacagggg
3361 caaatgcgaa gaacatggat cttggcaccg gtcctggtga ctgcggttgc ccttacatct
3421 acaaacgtgg caatgacata gttgtcgcgg gtgtccacac cgcagcagcc cggggaggca
3481 acactgttat atgtgccact caagggcaag atggggaagc agtccttgag ggaaatgaga
3541 accttggcac ttactgtggt gctccaatct tgggtccagg caaggcgccc aaacttagca
3601 cgaagactaa gttctggcgt tcatcaccag acgccttgcc gccaggcact tatgagcctg
3661 cctacttggg aggtaaggac cctagagtgg aaaaaggacc atccctgcag caagtcatga
3721 gggaccagct aaaacctttc acagaaccca ggggcaagcc acctaggcct gcagtcttag
3781 aagaggccaa aaagacagtg atgaatgttc tagagcaaac cattgaccct gctaaaccat
3841 ggacctattc ccaagcatgt gcctcactgg acaagaccac ttccagtggt agcccccatc
3901 atgtcaggaa aaatgaccat tggaatgggg aatccttcac tggccccctc gcagaccaag
3961 catccaaagc caacctcatg tacgaacagg ccaagcatgt gcagcccgtg tacacggccg
4021 cacttaaaga tgaactagtc aaaaccgata agatctacaa gaagataaag aaaaggctct
4081 tgtgggggtc ggatcttggt acaatggtca ggtgtgccag ggcctttggc ggtctcatgg
4141 atagcatgaa ggcaagctgc atagccctcc catgtagggt aggaatgaac atgaatgaag
4201 atggccccat catatttgac aagcattcta agtataggta ccattatgat gctgactatt
4261 ccaggtggga ctcaacccag caaaggagca ttctctcggc cgctatggaa gtgatggtgc
4321 ggttctctgc tgaaccagag ctggcacaag tggttgcaga ggacctcctg gcacccagcc
4381 aactagatgt tggcgatttc gtcatctcag tccaggaggg tctgccatca ggggtcccat
4441 gcacatcaca atggaattca atagcacact ggatcctaac cttgagtgca atggcagaag
4501 tatcgggtct ctcaccagat gttgttcaag cccactcctg tttctcattc tacggtgatg
4561 atgagatcgt cagcactgac atcaaccttg accccatgaa gttgacacag aagctcagag
4621 agtatggcct ggtccccacc cgacctgaca aaactgaggg tcccctcgta ataactgaag
4681 atctcaccgg cctaacgttc ctgcgtaggt caattgcacg ggacccagct gggtggtatg
4741 gaaaattgga ccaagactca atcctcagac agttgtactg gacaaggggc cccaaccatg
4801 agaacccata tgagagcatg gtccctcatt cccagcgggc cacacaactc atggcccttc
4861 tcggtgaggc ttcactgcat ggtcctcagt tttacaagaa agttagcaaa atggttatta
4921 atgagatcaa aagtggtggt ctggaattct atgtgcccag acaagaggcc atgttcagat
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgagggtg
5041 tgaatgaaga tggcgtcgaa tgacgctgct ccatcgaatg atggtgctgc caacctcgta
5101 ccagaggcca ccaatgaggt tatggcactt gagccggtgg taggagcctc aattgctgct
5161 cctgtcgtcg gccaacaaaa tataattgac ccctggatta gagaaaattt tgttcaggca
5221 ccacagggtg agtttactgt atcaccaagg aactcacctg gtgagatgct tctaaatctt
5281 gaattaggcc ctgagctcaa cccttatttg agtcacttgt cccgcatgta taatggctat
5341 gctggtggta tgcaggttca ggtggtccta gctgggaatg cgttcacagc tggtaaaatc
5401 atctttgccg ccgttccacc acatttccct gttgagaaca ttagtgcagc ccaaatcaca
5461 atgtgccccc atgtaattgt tgatgtaaga cagcttgagc cagtgctttt gcccctccct
5521 gacataagga atagattctt tcattataat caggaaaata ccccccggat gagacttgtg
5581 gctatgttgt atacacccct tagagcaaat tctggtgagg atgtgtttac ggtgtcttgc
5641 agagtcctga cccgccctgc ccccgacttt gagttcacgt ttttggtgcc accgactgtg
5701 gagtcaaaga ccaagccctt tacactccct attctgactc ttggagagct gtccaactcc
5761 agattccccg ctccgataga catgttgtac actgacccca atgaggcaat tgtggtgcaa
5821 ccacaaaatg gcaggtgcac tctagatgga acacttcaag ggaccaccca actggtaccc
5881 acccaaattt gctccttcag gggcacgcta attagccaga cgtcgaggtc tgcagattca
5941 acagattcag ccccacgggc gaggaaccac cctctccacg ttcagctgaa gaacctcgat
6001 gggacaccat atgacccaac agatgaggtg ccagcagttt tgggtgccat agatttcaaa
6061 ggaactgtgt ttggggtcgc tagccaaaga aacaccacag ggggctctat aggagcaacc
6121 cgcgcccatg aagtgcacat agacaccaca aaccctagat acaccccaaa gcttggctcc
6181 gtgttgatgt attctgaatc tactgatttt gatgatggac aacccacccg cttcaccccc
6241 attggtatgg gagccgatga ttggcaccaa tgggaattgc ccgaatattc tggtcacctt
6301 actcttaaca tgaatttggc ccctgcagtt gcccctgctt tccctggtga gcgcattctc
6361 ttcttcagat cagtggtgcc gtctgctggt ggctatggat caggtcacat agattgcctc
6421 atcccacagg agtgggttca gcatttctac caggaggccg ctccatcaca gtctgcggtg
6481 gctcttatca gatatgtcaa ccctgacact ggaaggaaca tctttgaggc aaaactgcat
6541 agagaagggt tcatcactgt ggcaaattct ggaaacaacc ccatagttgt gcccccaaac
6601 ggttacttca ggtttgaggc ctgggtcaat caattctata cactcacccc catgggaact
6661 ggacaggggc gcagaagaat tcaataatgg caggagcttt cttagctgga ttggcaggtg
6721 acgccataac aagtggtgtc gggtccctaa tcaatgctgg ggccaatgca attaaccaaa
6781 aggtagaata tgactttaat aaacagctcc aattggcatc cttcaaacat gacaaagaga
6841 tgttgcaatc acaagtactg gccactaaac agctccagca ggagatgatg aacataaggc
6901 aaggggtctt gtccgctggc ggcttctccc ctgcagatgc cgcgagaggt gctgtgaacg
6961 cgccgatgac aaaaattttg gattggaatg gaacaaggta ctttgcccca aatagtatga
7021 agacaaccag ttattcgggc cagttttcca gcaaccctgt gcataggcag cccactttgc
7081 cccgttctga acccccaaaa attaaggtta atagtgattc tgctagtgtg tatagttctg
7141 catctactgt tccttcacaa tcaactcact caacggtttt gactgcgggg tctagctcat
7201 ctaggacaac atcttcttct acagcagctt ccaccccatc caggactagt gactgggtga
7261 gaggacaaaa tgaaaggctt agcccgttta tggatggtgc tctccaaaca acttttgtca
7321 caccaccatc gagcaaagct tcatcatatg ggtcggtctc aaccgttccc aaagctgttt
7381 tggactcctg gactcctatg ttcaatacct ataggcagcc tctcttcgcc catgtgcgca
7441 ggcgagggga gtcacagatt tagtgaaaag attgattagg ttttctttct ttcttctttt
7501 ccttttcttt cttt
//