Typing tool
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Typing tool
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Complete norovirus genomes
| MW305556 | GII.6 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6687
ORF3: 6687..7463
LOCUS MW305556 7515 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 203HBO nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305556
VERSION MW305556.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7515)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7515)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7515
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="203HBO"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Paraguay"
/collection_date="04-Aug-2016"
/note="genotype: GII.6[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59004.1"
/translation="FGSQNSVNDSINTAPSNKEEVGAFSNIKVGFKKMLGAVPKGTKA
PSSDQHCPSVKIGTKTLTVPPEPPNGEDTVQFDAKSETVRGLPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSGGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLSRKSI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFGIFWTPPDVSSFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFKPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGTALKSVKTLEDLKVAL
RDVKFNECEIIYRNSKYRVSSNGKGSVSVDKVEDQTSQTANEVGAALLRLRQARARYY
VSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQEASESEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTKKQRKEERGVLGLVTGSDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
INELFGVEIKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNENLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWYGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6687
/gene="ORF2"
CDS 5044..6687
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59005.1"
/translation="MKMASNDAAPSNDGAANLVPEATNEVMALEPVVGASIAAPVVGQ
QNIIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVENISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQENTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAPIDMLYTDPNEAIVVQPQNGRCTLDGTLQGTTQ
LVPTQICSFRGTLISQTSRSADSTDSAPRARNHPLHVQLKNLDGTPYDPTDEVPAVLG
AIDFKGTVFGVASQRNTTGSSIGATRAHEVHIDTTNPRYTPKLGSVLMYSESTDFDDG
QPTRFTPIGMGADDWHQWELPEYSGHLTLNMNLAPAVAPAFPGERILFFRSAVPSAGG
YGSGHIDCLIPQEWVQHFYQEAAPSQSAVALIRYVNPDTGRNIFEAKLHREGFITVAN
SGNNPIVVPPNGYFRFEAWVNQFYTLTPMGTGQGRRRIQ"
gene 6687..7463
/gene="ORF3"
CDS 6687..7463
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59006.1"
/translation="MAGAFLAGLAGDAITSGVGSLINAGANAINQRVEYDFNKQLQLA
SFKHDKEMLQSQVLATKQLQQEMMNIRQGVLSAGGFSPADAARGAVNAPMTKILDWNG
TRYFAPNSMKTTSYSGQFSSNPVHRQPTLPRSEPPKTKVNSDSASVYSSASTVPSQST
QSTVLTAGSSSSRTTSSSAAASTLSRTSDWVRGQNERLSPFMDGALQTTFVTPPSSKA
SSHGSVSTVPKAVLDSWTPMFNTHRQPLFAHVRRRGESQI"
ORIGIN
1 cctttggcag ccaaaactct gtcaatgaca gtatcaacac cgccccttct aataaagaag
61 aggttggtgc attctccaac atcaaagttg gttttaagaa gatgctgggt gccgttccca
121 aggggaccaa agcacccagt agtgatcagc actgcccctc agttaagatc gggaccaaga
181 cattaacagt tccccctgag cccccaaatg gtgaagacac cgtgcagttt gatgcgaagt
241 cggaaactgt gcgcgggtta ccagacttga caacggtgca gaacgaacac gaaaacacac
301 catacactgt ccccccattg agcgaaaggg agcacagacc agctactgaa ccgcttcctg
361 gcacaatact ggagatgtgg gatggtgaat tctaccatta ctctgtgtac gtcagcggtg
421 gcaaagccct aggggttcac aagccccctg cagcgataag cctcgcgacg atagagctca
481 cacccatatc cctttattgg aggcccgttt acacccccaa ctatctggtc tgtccagaca
541 cgttgaaggg ccttgctggt gagaagttcc cctacacggc cttcagcaac aactgttaca
601 acttctgttg ctgggtgctt gagctcaatg acacgtggct tagcaggaaa agcatttcta
661 ggaccaccgg cttcttcaaa ccataccagt cttggaatag gaaacccctt ccaacagttg
721 atgatggaaa gatcaaaaag gtggccaacg caattctctg tgcacttgga tcactgtttt
781 caaaaccaat caaggaccta ttgggcaaac ttaaaccatt gaacttgctg cacttgctcg
841 catcatgtga ctggacgttt gcgggtatag tagagacagt catcctaatg gcggaactct
901 tcggcatctt ttggacaccg ccagatgttt ccagtttcat agcctccctg ataggtgatt
961 ttgaattgca agggccggag gacctggctg tggagcttgt acccgtggtc atgggtggca
1021 taggaatggt tctcggcttc actgctgaga agataggccg catgctatcg tccgctgcat
1081 caacactacg ggcgtgcaaa gacttgggga attatgctct tgacatattg aaactggtta
1141 tgaagtggtt cttcccaaag aaggaagaga aagccgagat ggaaacccta agggcgattg
1201 aggatgccgt cctggacatg gaagctatag gaaataacca tctcacaacc ctcctcaagg
1261 acaaggatag cctcacggct ttcatgaaga ctctagatct agaagaagag aaggcgagga
1321 agctgtccac caaatcatcc tcgccggaca ttgtcggcac cattaatgcc atactggcta
1381 gaatagctgc tgccaggtcc ctcttgcaca aggctaaaga agaaatgttc agtaggatca
1441 gacccgtggt tgtcatgatc tcgggtaggc ctggcattgg caaaacccac atggcaagac
1501 acttggctaa gagtatcgcc aacaccatga gcggcgacca gagagtgggg ctcgtcccac
1561 gcaacggggt cgatcattgg gacgcctaca ggggagagag ggtggtttta tgggatgatt
1621 atggcatggg aaaccctgtc aaagatgcct taacactaca agagctggcc gacacctgcc
1681 cagtaactct aaactgtgat aggattgaga acaaggggaa gatgtttgac agtgatgtca
1741 ttataatcac gaccaattta gtcaacccag cgcccctcga ttatgtaaac ttcgaggcgt
1801 gctccagaag ggtcgacttt ctggtctatg cagagtcgcc agaaattgag aaggttaaga
1861 gagacttccc cggccaacct gacatgtgga aagaccattt caagccagac ttttcccaca
1921 taaaactgac tctagcccca cagggtggat ttgacaagaa tggcaacacc ccgcatggta
1981 agggcaccat gcgatcccta acacaggggt ccctgactgc aagggttgca ggtcttgttc
2041 atgagaggag agacgagttt cagctccagg ggaacgacct tcaaacatat aactttgata
2101 ccaacagagt ctctgcattt aggaagctgg ccgcagacaa caagtatggg atcatggaga
2161 ctatgagagt gggcacagcg cttaagagcg tcaagacctt ggaagatctg aaagttgcac
2221 tgagagatgt gaagttcaac gagtgtgaga taatttacag aaactccaaa taccgagtct
2281 cttccaatgg taaaggttct gtctctgttg acaaagttga ggaccaaaca tcccagaccg
2341 caaacgaagt gggtgcagca ctccttagac tcagacaggc aagagccagg tactatgtca
2401 gctgcttcca agacctcgtt tacactctaa tacaggtcgc cggagcatca ttcgttgtca
2461 acaggatctc taaaaggttc tgctgggaga gatgggtcaa accaaccgag acccaggaag
2521 cgagtgaatc cgaaaaggaa gtggcccaag gcagatggga gattgagccc aaggacacag
2581 aaccagaagg taagaagggt aagaacaaga aaggaagagg caagaaacac acagctttct
2641 ccagtaaagg cctgagtgac gaggagtatg acgagttcaa gagaatcaga gaagaaagga
2701 acggaaaata ctccattgag gaatacctgc aagaccggga tcgctactat gaggaagtgg
2761 cagttgcccg ggcgacagag gaggacttct gtgaagagga agaggccaag ataagacaaa
2821 gaatctttcg ccccacaaag aaacagagga aggaagaaag gggggtgctt ggtttggtca
2881 ctggctcaga catcagaaag agaagaccag acgattttca accgaagggc aacctgtggg
2941 cagacgacac caggagtgtg gactacaacg agagacttga tttcgaggcc cccccgagtg
3001 tctggtcaag aatagtccca ttgggcactg gctggggctt ctgggtctca tcaaacctcc
3061 tgatcacaac aacgcacgtc ctacctaagg ggattaatga actctttgga gttgagatca
3121 aacagattca gattcataag tctggagagt tctgcaggtt cagattccca agaccaatta
3181 gaccggatgt cacagggctc gtgttggagg aaggcgctcc agaaggcact gtctgctcca
3241 tactcgtaaa gagacctaca ggtgagatga tccccctggc agtgaggatg ggtacgcatg
3301 catccatgaa gatacagggt aggaccgtcg gtggccagat ggggatgctc ctcacagggg
3361 caaatgcgaa gaacatggat cttggcaccg gtcctggtga ctgcggttgc ccttacatct
3421 acaaacgtgg caatgatata gttgtcgcgg gtgtccacac cgcagcagcc cggggaggca
3481 acactgttat atgtgccact caagggcaag atggggaagc agtccttgag ggaaatgaga
3541 accttggcac ttactgtggt gctccaatct tgggtccagg caaggcgccc aaacttagca
3601 cgaagaccaa gttctggcgt tcatcaccag acgccttgcc gccaggcact tatgagcctg
3661 cctacttggg aggtaaggac cctagagtgg aaaaagggcc atccctgcag caagtcatga
3721 gggaccagtt aaaacctttc acagaaccca ggggcaagcc acctaggcct gcagtcttag
3781 aagaggccaa aaagacagtg atgaatgttc tagagcaaac cattgaccct gctaaaccat
3841 ggacctattc ccaagcatgt gcctcactgg acaagaccac ttccagtggt agcccccatc
3901 atgtcaggaa aaatgaccat tggaatgggg aatccttcac tggccccctc gcagaccaag
3961 catccaaagc caacctcatg tacgagcagg ccaagcatgt gcagcccgtg tacacggccg
4021 cacttaaaga tgaactagtc aaaaccgata agatctacaa gaagataaag aaaaggctct
4081 tgtgggggtc ggatcttggt acaatgatca ggtgtgccag ggcctttggc ggtctcatgg
4141 atagcatgaa ggcaagctgc atagccctcc catgtagggt aggaatgaac atgaatgaag
4201 atggccccat catatttgac aagcattcta agtataggta ccattatgat gctgactatt
4261 ccaggtggga ctcaacccag caaaggagca ttctctcggc cgctatggaa gtgatggtgc
4321 ggttctctgc tgaaccagag ctggcacaag tggttgcaga ggacctcctg gcacccagcc
4381 aactagatgt tggcgacttc gtcatctcag tccaggaggg tctgccatca ggggtcccat
4441 gcacatcaca atggaattca atagcacact ggatcctaac cttgagtgca atggcagaag
4501 tatcgggtct ctcaccagac gttgttcaag cccactcctg tttctcattc tacggtgatg
4561 atgagatcgt cagcactgac atcaaccttg accccatgaa gttgacacag aagctcagag
4621 agtatggcct ggtccccacc cgacctgaca aaactgaggg tcccctcgta ataactgaag
4681 atctcaccgg cctaacgttc ctgcgtaggt caattgcacg ggacccagct gggtggtatg
4741 gaaaattgga ccaagactca atcctcagac agttgtactg gacaaggggc cccaaccatg
4801 agaacccata cgagagcatg gtccctcatt cccagcgggc cacacaactt atggcccttc
4861 tcggtgaggc ttcactgcac ggccctcaat tttacaagaa agttagcaag atggttatta
4921 atgagatcaa aagtggtggt ctggaattct atgtgcccag acaagaggcc atgttcagat
4981 ggatgagatt ttctgacctc agcacatggg agggcgatcg caatcttgct cccgagggtg
5041 tgaatgaaga tggcgtcgaa tgacgctgct ccatcgaatg atggtgctgc caacctcgta
5101 ccagaggcca ccaatgaggt tatggcactt gagccggtgg tgggagcctc aattgctgct
5161 cctgtcgtcg gccaacaaaa tataattgac ccctggatta gagaaaattt tgttcaagca
5221 ccacagggtg agtttactgt atcaccaagg aactcacctg gtgagatgct tctaaatctt
5281 gaattaggcc ctgagctcaa cccttatctg agtcacttgt cccgcatgta taatggctat
5341 gctggtggta tgcaggttca ggtggtccta gctgggaatg cgttcacagc tggtaaaatc
5401 atctttgccg ccgtcccacc acatttccct gttgagaaca ttagtgcagc ccaaatcaca
5461 atgtgccccc atgtaattgt tgatgtaaga cagcttgagc cagtgctttt gcccctccct
5521 gacataagga atagattctt tcattataat caggaaaata ccccccggat gagacttgtg
5581 gctatgttgt atacacccct tagagcaaat tctggtgagg atgtgttcac ggtgtcttgc
5641 agagtcctga cccgccctgc ccccgacttt gagttcacgt ttttggtgcc accgactgtg
5701 gagtcaaaga ccaagccctt tacactccct attctgactc ttggagagct gtccaactcc
5761 agattccccg ctccgataga catgttgtac actgacccca atgaggcaat tgtggtgcaa
5821 ccacaaaatg gcaggtgcac tctagatgga acacttcaag ggaccaccca actggtaccc
5881 acccaaattt gctccttcag gggcacgcta attagccaga cgtcgaggtc tgcagattca
5941 acagattcag ccccacgggc gaggaaccac cctctccacg ttcagctgaa gaacctcgat
6001 gggacaccat atgacccaac agatgaggtg ccagcagttt tgggtgccat agatttcaaa
6061 ggaactgtgt ttggggtcgc tagccaaaga aacaccacag ggagctctat aggagcaacc
6121 cgcgcccatg aagtgcacat agacaccaca aaccctagat acaccccaaa gcttggctct
6181 gtgttgatgt attctgaatc tactgatttt gatgatggac aacccacccg cttcaccccc
6241 attggtatgg gagccgatga ttggcaccaa tgggaattgc ccgaatattc tggtcacctc
6301 actcttaata tgaatttggc ccctgcagtt gcccctgctt tccctggtga gcgcattctc
6361 ttcttcagat cagcggtgcc gtctgctggt ggctatggat caggtcacat agattgcctc
6421 atcccacagg agtgggttca gcatttctac caggaggccg ctccatcaca gtctgcggtg
6481 gctcttatca gatatgtcaa ccctgacact ggaaggaaca tctttgaggc aaaactgcat
6541 agagaagggt tcatcactgt ggcaaattct ggaaacaacc ccatagttgt gcccccaaac
6601 ggttacttca ggtttgaggc ctgggtcaat caattctata cactcacccc catgggaact
6661 ggacaggggc gcagaagaat tcaataatgg caggagcttt cttagctgga ttggcaggtg
6721 acgccataac aagtggtgtc gggtccctaa tcaatgctgg ggccaatgca attaaccaaa
6781 gggtagaata tgactttaat aaacagctcc aattggcatc cttcaaacat gacaaagaga
6841 tgttgcaatc acaagtactg gccactaaac agctccagca ggagatgatg aacataaggc
6901 aaggggtttt gtccgctggc ggcttctccc ctgcagatgc cgcgagaggt gctgtgaacg
6961 cgccgatgac aaaaattttg gattggaatg gaacaaggta ctttgcccca aatagtatga
7021 agacaaccag ttattcgggc cagttttcca gcaaccctgt gcataggcag cctactttgc
7081 cccgttctga acccccaaaa actaaggtta atagtgattc tgctagtgtg tatagttctg
7141 catctactgt tccttcacaa tcaactcaat caacggtttt gactgcgggg tctagctcat
7201 ccaggacaac atcttcttct gcagcagctt ctaccctatc taggactagt gactgggtga
7261 gaggacaaaa tgaaaggctt agcccgttta tggatggtgc tctccaaaca acttttgtca
7321 caccaccatc gagcaaagct tcatcacatg ggtcggtctc aaccgttccc aaagctgttt
7381 tggactcctg gactcctatg ttcaataccc ataggcagcc tctcttcgcc catgtgcgca
7441 ggcgagggga gtcacagatt tagtgaaaag attgattagg ttttctttct ttcttctttt
7501 ccttttcttt ctttt
//