Typing tool
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Typing tool
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Complete norovirus genomes
| MW305555 | GII.6 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6696
ORF3: 6696..7475
LOCUS MW305555 7528 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 194HBO nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305555
VERSION MW305555.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7528)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7528)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7528
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="194HBO"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Paraguay"
/collection_date="09-Aug-2016"
/note="genotype: GII.6[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59001.1"
/translation="LGSQNSVNDSISTTPSNKEEAGAFSNIKVGFKKMLGAVPKGTKA
PSSDQHCPTVKVGPKTLTVPPEPPNGEDTVQFDVKSETVIGIPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSGGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVCPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLSRRSI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKNIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGNPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRIDFLVYAESPEIEKVKRDFPG
QPDMWKDYFKQDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
KDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKNVKTLEDLKVAL
RDVKFNECEIIYRNSKYRVSSNGKGSVSVDKVEDHTSQTANEVGSALLRLRQARARYY
VSCFQDLVYTLIQVAGASFVVNRISKRFCWERWVKPTETQEASETEKEVAQGRWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTRKQRKEERGVLGLVTGSDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
VKELFGVEIKQIQIHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSILVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNEDLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLKPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWTYSQACASLDKTTSSGSPHHVRKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMVRCARAFGGL
MDSMKASCISLPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRNILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPESVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6696
/gene="ORF2"
CDS 5044..6696
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59002.1"
/translation="MKMASNDAAPSNDGAANLVPEANNEVMALEPVVGASIAAPVVGQ
QNIIDPWIRENFVQAPQGEFTVSPRNSPGEMLLNLELGPELNPYLSHLSRMYNGYAGG
MQVQVVLAGNAFTAGKIIFAAVPPHFPVDNISAAQITMCPHVIVDVRQLEPVLLPLPD
IRNRFFHYNQEDTPRMRLVAMLYTPLRANSGEDVFTVSCRVLTRPAPDFEFTFLVPPT
VESKTKPFTLPILTLGELSNSRFPAAIDMLYTDPNESIVVQPQNGRCTLDGTLQGTTQ
LVPTQICAFRGTLISQNARAADLTDSPQRARNHPLHVQVKNLDGTQYDPTDDIPAVLG
AIDFKGTVFGVASQRDVSGTQEQGHYATRAHEAHIDTTDPKYAPKLGTILIKSESTDF
TTNQPIRFTPVGMGDNNWRQWELPDYSGSLTLNMNLAPAVSPAFPGERILFFRSIVPS
AGGYGSGYIDCLIPQEWVQHFYQEAAPSQSAVALVRYVNPDTGRNIFEAKLHREGFLT
VANSGNNPIVVPPNGYFRFEAWVNQFYTLAPMGSGQGRRRAQ"
gene 6696..7475
/gene="ORF3"
CDS 6696..7475
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59003.1"
/translation="MAGAFFAGLAGDVVSNGIGSLINAGANAVNQKVEYDFNKQLQMA
SFKHDKEMLQSQVLATKQLQQEMMNIKQGMLTAGGFSPADAARGAVNAPMTKILDWNG
TRYWAPNSMKTTSYSGQFSSSPVHRSPAPLQHTAPPKSKLQSDSASMYSSPSTVSSQS
THSTVLSAGTGTSRSTPTSTATSTLSRTSDWVRGQNERLGPFMDGALQTTFVTPPSSK
ASSNGTVSTVPKAVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 cccttggcag tcaaaactct gtcaatgaca gtatcagcac caccccttca aacaaagaag
61 aggctggtgc attctccaac attaaagttg gatttaagaa aatgctgggt gccgtaccta
121 agggcactaa agcacccagc agtgaccagc actgtccaac agttaaggtc gggcccaaaa
181 cactgacagt cccccctgaa cccccaaatg gtgaagacac tgtacagttt gatgtaaaat
241 cggaaactgt gattgggata ccggacttga caacagtgca aaatgaacat gaaaataccc
301 catacactgt ccctccactg agtgagaggg aacacagacc agccactgag ccacttcctg
361 gcacaatatt ggagatgtgg gatggtgaat tttaccacta ctccgtgtac gtcagcggcg
421 gcaaagctct gggggttcac aaacctccgg cagctataag tctcgcgacg atagagctca
481 cccccatatc tctatactgg aggcccgttt acacccccaa ctatctggtc tgcccagaca
541 cactaaaagg tctcgctggt gaaaagttcc cctacacggc cttcagcaac aattgctaca
601 acttctgttg ctgggtgctt gaactcaatg acacgtggct tagcagaaga agcatttcta
661 gaaccaccgg cttcttcaaa ccgtaccagt cttggaacag gaagcctctc ccaaccgtag
721 atgatggaaa gatcaaaaag gtggccaacg cgatcctttg tgcactcggt tcgctgttct
781 caaaaccaat caaggaccta ctaggcaagc tcaaaccatt gaacttacta cacctgctcg
841 cgtcgtgtga ttggacgttt gcaggtatag tggagacagt catcttaatg gcagaactct
901 tcaacgtctt ttggaccccg ccagacgtct ctaatttcat agcctccctg ataggtgatt
961 ttgaattgca ggggcctgag gacttggcgg tagagcttgt tcctgtggtt atgggtggta
1021 taggaatggt tctcggcttc acagctgaga agataggtcg catgctgtcg tccgctgcat
1081 caacactgcg ggcgtgtaaa gacttaggga actatgccct tgacatactt aaattggtca
1141 tgaaatggtt cttcccaaag aaagaggaga aagccgagat ggaaacctta agggcaattg
1201 aggatgccgt cctagatatg gaggccatag gcaacaacca cctcacaacc ctcctcaagg
1261 ataaagacag tctcacggcc tttatgaaga ccttggatct ggaagaagag aaagcaagga
1321 agctatccac caaatcatcc tcaccggata tcgttggcac tatcaatgcc atactggcta
1381 ggatagctgc cgctagatcc ctcctgcaca aagccaaaga agaaatgttc agcaggatta
1441 gaccagtggt tgttatgatc tcaggcagac ctggcattgg aaaaactcat atggcgagac
1501 atctggctaa aaacatcgcc aacaccatga gtggtgacca aagagtcggg ctcgttccgc
1561 gcaacggggt tgaccactgg gacgcttaca gaggagagag agtggtcttg tgggatgatt
1621 atggaatggg gaaccctgtc aaagatgctt taacactaca agagctagct gacacatgcc
1681 cagtcactct aaactgtgac aggatcgaga acaagggaaa aatgttcgac agtgatgtca
1741 tcataatcac gaccaatcta gtcaaccctg cacctctcga ttatgtgaac ttcgaggcat
1801 gttctagaag gattgatttc ttggtctatg cagaatcacc agagattgag aaggttaaga
1861 gagatttccc tggccaacct gacatgtgga aagactattt caaacaagac ttttcccata
1921 taaagctaac cctagccccc caaggcgggt ttgacaagaa tggtaacacc ccgcatggta
1981 agggtaccat gcgatccctc acccaggggt ccctgaccgc aagggtcgca ggccttgttc
2041 acgagagaaa ggatgagttc cagttacaag ggaatgacct ccagacatat aactttgaca
2101 ccaacagggt ctctgcgttc agaaaactgg ctgcagacaa caagtacgga atcatggaaa
2161 caatgagagt gggtgcagcg ctcaaaaatg tcaaaacttt ggaagatctg aaggtcgcct
2221 tgagagatgt aaagttcaat gagtgtgaaa taatttacag gaactccaag taccgggtct
2281 cttccaacgg caagggctct gtttctgttg acaaagttga ggaccacacg tctcagactg
2341 caaatgaagt gggctcagca ctcctcagac ttaggcaagc aagggctaga tattatgtta
2401 gctgtttcca agatctcgtc tataccctca tacaggttgc tggggcatca ttcgttgtca
2461 acaggatctc aaaaaggttc tgctgggaaa ggtgggttaa accaaccgaa acccaagaag
2521 cgagtgagac cgaaaaggaa gtggctcaag gtagatggga gatagagccc aaagacacag
2581 aacccgaagg caagaagggt aagaacaaga aagggagagg caagaaacac acagccttct
2641 ccagcaaagg cctaagtgat gaagagtatg atgagttcaa gagaatcaga gaagagagga
2701 acggaaaata ttccattgag gaatacctgc aagaccggga ccgctactat gaagaagtgg
2761 cagttgcccg ggcaacagaa gaggactttt gtgaagaaga agaagccaaa ataagacaaa
2821 gaatcttccg cccgacaagg aagcaaagga aagaggaaag gggggtactt ggcttagtca
2881 ctggttcaga tatcaggaag aggagaccag acgattttca accaaaaggc aacctgtggg
2941 cagatgacac taggagtgtg gactacaatg agagacttga ctttgaggct ccaccaagcg
3001 tctggtcaag aatagtccca ttgggcactg gttggggctt ctgggtttca tcaaacctcc
3061 tgatcacaac aacacacgtc ctgcccaagg gggtcaagga actctttggg gtcgaaatca
3121 aacaaattca aatccacaag tctggagaat tctgcaggtt taggttccca agaccgatca
3181 ggccagatgt cacaggactc gtgttggagg aaggtgctcc tgaaggtact gtctgttcta
3241 tactcgtcaa gaggcctaca ggtgagatga tccccctagc agtgaggatg ggcacgcatg
3301 cgtctatgaa aatacagggt aggaccgtcg gtggtcagat gggaatgctc ctcacagggg
3361 caaatgcaaa gaacatggat cttggcaccg gtcctggtga ctgcggttgt ccttacatct
3421 ataagcgtgg caacgacata gttgtcgcgg gtgtccacac cgcagcagct cgggggggca
3481 acactgtcat ttgtgccact caaggacaag acggagaggc agtccttgag ggaaatgaag
3541 accttggcac ctactgtggt gctccaattc tgggccctgg taaagcgcct aaactcagca
3601 caaaaactaa attttggcgc tcgtcaccag atgctctacc tcctggcacg tatgagcctg
3661 cttatctggg gggtaaggac cccagagtgg aaaaggggcc ctccctacaa caagttatga
3721 gagaccagct gaaaccattt acagagccca ggggcaaacc acctagacca gcagttttag
3781 aagaggctaa aaagacagtg atgaacgttc tagaacagac cattgaccct gctaaaccat
3841 ggacttactc acaagcatgt gcttcactgg acaagaccac ctctagtgga agcccccacc
3901 atgtcaggaa aaatgaccac tggaatgggg agtcttttac tggtcccctc gcggaccaag
3961 catctaaagc caacctcatg tatgaacagg caaagcatgt gcagcccgtg tacacggccg
4021 cgctcaaaga tgaacttgtt aagactgata agatctacaa gaaaataaag aagagacttc
4081 tatgggggtc agaccttggc acgatggtca ggtgtgccag ggcttttggt ggccttatgg
4141 acagtatgaa agcaagttgt atatcccttc catgcagggt ggggatgaac atgaatgagg
4201 atggccctat catatttgac aaacactcca agtataggta ccactatgat gctgactact
4261 ctaggtggga ctcaacccag caaaggaaca ttctttccgc cgccatggag gtgatggtga
4321 ggttctctgc tgagccagaa ctggcacaag tggtcgcaga ggacctttta gcgcctagcc
4381 agctagatgt tggcgacttt gtcatctcag tccaggaggg cctgccatca ggagtcccat
4441 gtacgtcgca atggaattca atagcgcact ggattctaac tctgagcgca atggcagaag
4501 tgtcaggtct ctcaccagat gttgtccaag cccactcctg tttctcattt tatggcgacg
4561 atgagatcgt cagcactgat atcaaccttg atcccatgaa actgacacaa aaactcaggg
4621 agtatggtct ggttcccacc cggcctgata agactgaagg ccccctcgtt ataactgaag
4681 acctcaccgg cctgacattc ctgcgcagat cgattgcacg ggacccagct ggatggtttg
4741 gaaaattgga ccaagactca atcctcaggc aattatactg gacaaggggg cccaaccatg
4801 aaaacccata cgagagcatg gttccccact cccagcgagc cactcagctc atggcccttc
4861 ttggtgaggc ttcattgcat ggtccccagt tttacaagaa agttagcaag atggtcatca
4921 atgaaattaa gagtggtggt ctggagtttt atgtgcccag acaagaggcc atgtttaggt
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgagagtg
5041 tgaatgaaga tggcgtcgaa tgacgccgct ccatcaaatg atggtgctgc caacctcgta
5101 ccagaggcca ataatgaggt tatggcactt gaaccggtgg tgggagcttc aatcgcagct
5161 cctgttgtcg gtcagcagaa tataattgac ccctggatta gagaaaattt tgttcaagca
5221 ccacagggcg agtttactgt ttcaccaagg aactcgcccg gtgagatgct tcttaatctt
5281 gaattgggcc cggaacttaa cccctatttg agtcacttgt cccgcatgta caatgggtat
5341 gctggtggca tgcaggttca ggtggtccta gctgggaatg cgttcacagc tgggaagatc
5401 atctttgccg ctgtgccacc acacttccct gtggataata ttagtgcagc ccagataact
5461 atgtgtcccc atgtgattgt tgatgtgaga cagcttgaac cagtgcttct acccctcccc
5521 gatataagga acaggttctt ccattacaac caggaagaca ccccccggat gaggcttgtg
5581 gctatgctct acacgcctct aagggctaat tcaggagagg atgtgttcac tgtgtcttgt
5641 agggttttga ctcgccccgc tccagatttt gaatttacat tcttggttcc accaactgtt
5701 gaatcaaaaa caaaaccctt tactctacct attctaaccc ttggtgagtt gtctaattcc
5761 cgttttcctg ctgctataga tatgctttac actgacccca atgaatcaat agtcgttcag
5821 ccccaaaatg gtagatgcac ccttgatggc acgctgcagg gcacaacaca actggtccca
5881 acacagattt gtgcctttag aggtactctg atcagtcaga atgcgagagc ggccgattta
5941 acagattccc cccagagagc ccgtaatcat ccgttgcacg tccaggtcaa gaacctagat
6001 ggcacacagt atgacccaac agatgacatc cctgcagtcc tgggggctat tgacttcaaa
6061 ggtacagtgt tcggagtggc aagccagagg gatgtctctg ggacacaaga acagggccat
6121 tatgccaccc gggctcatga agcacacatt gacacaactg atccaaagta tgcacctaaa
6181 ttaggcacaa ttctcatcaa atctgaatct actgatttca ccacaaatca acccattagg
6241 ttcactccag tgggcatggg tgataacaat tggagacagt gggaattgcc tgactattct
6301 ggtagtttga ctctgaacat gaaccttgcc cctgctgttt ccccagcttt ccctggtgag
6361 cgaatccttt tctttcggtc tatagtgcca tcagctggag gctacgggtc tggctatata
6421 gactgtctca taccccagga atgggtgcaa catttctacc aggaggcagc accttcacaa
6481 tctgctgttg cactggttag gtatgtcaac cccgacactg ggcgtaacat ctttgaggcc
6541 aagttgcata gagaagggtt cctcaccgtg gctaattctg gaaataatcc tattgtggtt
6601 ccccctaatg gttattttag atttgaggct tgggttaatc aattctatac acttgccccc
6661 atgggatctg gacaggggcg tagaagagct cagtaatggc tggagccttc ttcgcagggt
6721 tagcaggtga tgtcgtgtcg aacggcatcg gttccctcat caatgcaggt gctaatgcag
6781 tcaatcaaaa ggttgagtat gattttaata agcaacttca gatggcatca tttaaacatg
6841 ataaggagat gttacaatca caggtgttgg caaccaaaca actgcagcaa gagatgatga
6901 acataaagca ggggatgttg accgctggcg gcttttctcc tgcggacgct gctagagggg
6961 ctgttaacgc cccaatgaca aaaatattgg actggaatgg cacaagatat tgggcaccta
7021 acagcatgaa aaccacaagt tactcaggac aattctctag tagccctgtc cacaggtctc
7081 ctgctcccct ccagcacact gccccaccaa aaagtaagtt gcaaagtgat tctgctagta
7141 tgtatagctc cccttccact gtttcttcac aatcaactca ttcaacagtg ttgtctgcag
7201 gaactgggac gtctagatcc acccccacgt ccacagcaac ctccaccctg tctaggacca
7261 gcgactgggt tagaggacag aatgaaaggc ttggcccgtt tatggatggt gctctccaaa
7321 ctacttttgt cacaccacca tcgagcaaag cttcatcaaa tgggacagtc tcgaccgtgc
7381 ccaaagctgt tttggactcc tggactccta tgttcaatac gcataggcag cctctcttcg
7441 cccacttgcg taggcgaggg gagtcacaga tttagtgaaa agagtgatta ggctttcttt
7501 cccttcttct ttcccttttc tctctttt
//