Typing tool
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Typing tool
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Complete norovirus genomes
| MW305550 | GII.7 | |
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| GII.P7 |
ORF1: 1..5063
ORF2: 5044..6666
ORF3: 6666..7439
LOCUS MW305550 7503 bp RNA linear VRL 06-JUL-2021
DEFINITION Norovirus GII isolate 99HBO nonstructural polyprotein (ORF1) gene,
partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION MW305550
VERSION MW305550.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7503)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses reveal coexistence of
viral populations evolving under recombination constraints
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7503)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7503
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="99HBO"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/country="Paraguay"
/collection_date="17-Jul-2016"
/note="genotype: GII.7[GII.P7]"
gene <1..5063
/gene="ORF1"
CDS <1..5063
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ58986.1"
/translation="FGSQNSVNDSNNATPSNKEEVGAFSNIKVGLKKMLGAVPKGAKA
PSSNQNCPTVKIGPKTLTIPPEPPNGEDTVQFDAKSETIIGLPDLTTVQNEHENTPYT
VPPLSEREHRPATEPLPGTILEMWDGEFYHYSVYVSDGKALGVHKPPAAISLATIELT
PISLYWRPVYTPNYLVSPDTLKGLAGEKFPYTAFSNNCYNFCCWVLELNDTWLNRRCI
SRTTGFFKPYQSWNRKPLPTVDDGKIKKVANAILCALGSLFSKPIKDLLGKLKPLNLL
HLLASCDWTFAGIVETVILMAELFNVFWTPPDVSNFIASLIGDFELQGPEDLAVELVP
VVMGGIGMVLGFTAEKIGRMLSSAASTLRACKDLGNYALDILKLVMKWFFPKKEEKAE
METLRAIEDAVLDMEAIGNNHLTTLLKDKDSLTAFMKTLDLEEEKARKLSTKSSSPDI
VGTINAILARIAAARSLLHKAKEEMFSRIRPVVVMISGRPGIGKTHMARHLAKSIANT
MSGDQRVGLVPRNGVDHWDAYRGERVVLWDDYGMGSPVKDALTLQELADTCPVTLNCD
RIENKGKMFDSDVIIITTNLVNPAPLDYVNFEACSRRVDFLVYAESPEIEKVKRDFPG
QPDMWKDHFRPDFSHIKLTLAPQGGFDKNGNTPHGKGTMRSLTQGSLTARVAGLVHER
RDEFQLQGNDLQTYNFDTNRVSAFRKLAADNKYGIMETMRVGAALKSVKTLEDLKAAL
RDVKFNECEIIYKNSKYRVSSNGKGSVSVDKVEDNASQAVNEVHSALLRLRQARARYY
ISCFQDLVYTLMQVAGASFVVSRISRRFCWERWVKPTETQEVNEPEKEVAQGGWEIEP
KDTEPEGKKGKNKKGRGKKHTAFSSKGLSDEEYDEFKRIREERNGKYSIEEYLQDRDR
YYEEVAVARATEEDFCEEEEAKIRQRIFRPTRKQRKEERGVLGLVTGSDIRKRRPDDF
QPKGNLWADDTRSVDYNERLDFEAPPSVWSRIVPLGTGWGFWVSSNLLITTTHVLPKG
VKELFGVEIKQIQVHKSGEFCRFRFPRPIRPDVTGLVLEEGAPEGTVCSVLVKRPTGE
MIPLAVRMGTHASMKIQGRTVGGQMGMLLTGANAKNMDLGTGPGDCGCPYIYKRGNDI
VVAGVHTAAARGGNTVICATQGQDGEAVLEGNEDLGTYCGAPILGPGKAPKLSTKTKF
WRSSPDALPPGTYEPAYLGGKDPRVEKGPSLQQVMRDQLRPFTEPRGKPPRPAVLEEA
KKTVMNVLEQTIDPAKPWSYSQACASLDKTTSSGSPHHVKKNDHWNGESFTGPLADQA
SKANLMYEQAKHVQPVYTAALKDELVKTDKIYKKIKKRLLWGSDLGTMIRCARAFGGL
MDSMKASCIALPCRVGMNMNEDGPIIFDKHSKYRYHYDADYSRWDSTQQRSILSAAME
VMVRFSAEPELAQVVAEDLLAPSQLDVGDFVISVQEGLPSGVPCTSQWNSIAHWILTL
SAMAEVSGLSPDVVQAHSCFSFYGDDEIVSTDINLDPMKLTQKLREYGLVPTRPDKTE
GPLVITEDLTGLTFLRRSIARDPAGWFGKLDQDSILRQLYWTRGPNHENPYESMVPHS
QRATQLMALLGEASLHGPQFYKKVSKMVINEIKSGGLEFYVPRQEAMFRWMRFSDLST
WEGDRNLAPEGVNEDGVE"
mat_peptide <1..971
/gene="ORF1"
/product="p48"
mat_peptide 972..2069
/gene="ORF1"
/product="NTPase"
mat_peptide 2070..2588
/gene="ORF1"
/product="p22"
mat_peptide 2589..2987
/gene="ORF1"
/product="VPg"
mat_peptide 2988..3530
/gene="ORF1"
/product="Pro"
mat_peptide 3531..5060
/gene="ORF1"
/product="RdRp"
gene 5044..6666
/gene="ORF2"
CDS 5044..6666
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ58987.1"
/translation="MKMASNDAAPSNDGAAGLVPEINNEVMPLEPVAGASLATPVVGQ
QNIIDPWIRNNFVQAPAGEFTVSPRNSPGEILLDLELGPELNPYLAHLARMYNGHAGG
MEVQIVLAGNAFTAGKIIFAAIPPGLPYENLSPSQITMCPHVIIDVRQLEPVLLPMPD
IRNNFFHYNQGNDPKLRLVAMLYTPLRANNSGDDVFTVSCRVLTKPSPDFEFTFLVPP
TVESKTKQFTLPILKISEMTNSRFPVPVEMMYTARNENQVVQPQNGRVTLDGELLGTT
PLLAVNICKFKGEVIAKNGDVRSYRMDMEITNTDGTPIDPTEDTPGPIGSPDFQGILF
GVASQRNKNEQNPATRAHEANINTGGDQYAPKLAQVKFFSESQDFEVHQPTVFTPVGV
AGDTSHPFRQWVLPRYGGHLTNNTHLAPAVAPLFPGEQILFFRSQIPSSGGHELGYMD
CLVPQEWVQHFYQEAATAQSEVALIRFINPDTGRVLFEAKLHKQGFITVAHTGDNPIV
MPPNGYFRFEAWVNQFYSLAPVGTGNGRRRIQ"
gene 6666..7439
/gene="ORF3"
CDS 6666..7439
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ58988.1"
/translation="MASAFFANLAGGVASNGISSLINAGANAINQKVEFDYNKQLQNA
SFSHDKEMLQAQIEATKRLQQEMIDIKQGVLTAAGFSPTDAARGSVGAPMTKLVDWSG
TRYWAPGAMRTTGYSGTFTHLPPMQPTSYVNNQNRQLFKVDPSPSSSSGSSVSSVKTQ
STALSGTSRVDSPSQSTLSTRPSSRTSDWVRSQNERLSPFMNGALQTTYVTPPSSRVS
SVSTVSTVPKEVLDSWTPMFNTHRQPLFAHLRRRGESQI"
ORIGIN
1 cctttggcag tcaaaactct gtcaatgaca gtaataacgc caccccttct aacaaagaag
61 aggttggtgc attctccaac attaaagttg gacttaagaa aatgctgggc gccgtaccca
121 aaggtgccaa agcgcccagc agtaatcaaa attgccccac agttaagatc gggcctaaaa
181 cgttgacaat tccccctgag cccccaaatg gtgaagacac cgtacaattt gatgcaaagt
241 cagaaactat aattgggcta ccagacttga caacggtgca aaacgaacac gaaaacactc
301 catacactgt ccctccatta agtgagaggg agcacaggcc ggccactgaa ccacttcctg
361 gcacaatact ggagatgtgg gatggtgagt tttaccatta ctccgtgtac gtcagtgatg
421 gcaaagctct gggggtccac aaaccaccgg cggctataag cctagcgacg atagagctca
481 cccccatatc actctactgg aggcccgttt acacccccaa ctacttggtc tctccagaca
541 cattaaaggg cctcgctggt gagaagttcc cctacacggc cttcagtaat aactgttaca
601 acttctgttg ttgggtgctt gagctcaacg acacgtggct taatagaaga tgcatttcca
661 gaactaccgg cttcttcaaa ccataccagt cttggaatag aaaacctctc ccaactgttg
721 atgatggaaa gatcaaaaag gtggccaatg cgatcctctg tgcactcggt tcgctgtttt
781 caaaaccaat caaagaccta ttaggtaaac tcaagccctt gaatctactg cacttgctcg
841 cgtcctgtga ttggacgttt gcaggcatag tggagacagt catcttaatg gcggaacttt
901 tcaacgtatt ctggaccccg ccagatgtct ctaattttat agcctccctg ataggtgatt
961 ttgaactaca agggcctgaa gacctggctg tagaactcgt ccccgtggtt atgggtggca
1021 tagggatggt tctcggcttc accgccgaga agataggccg catgctgtcg tccgctgcat
1081 caacactgcg ggcgtgcaaa gacctaggga actacgccct tgacatactc aaattggtca
1141 tgaaatggtt cttcccaaag aaggaagaga aggctgagat ggaaaccttg agggcgattg
1201 aagatgccgt ccttgatatg gaagctatag ggaataacca cctcacgacc cttctcaagg
1261 acaaagacag cctcacagct ttcatgaaga ccttggatct agaagaggag aaggcgagaa
1321 aactgtccac taaatcatct tcaccggaca tagtcggcac catcaacgcc atattagcta
1381 ggatagctgc tgctagatcc cttctacata aggccaaaga ggagatgttc agtagaatca
1441 gaccagtggt cgtcatgatc tcaggcagac ctggcattgg aaaaacccac atggcgaggc
1501 acttggctaa gagcatcgcc aacaccatga gtggcgatca gagagtcgga ctcgttccac
1561 gcaacggtgt cgatcactgg gacgcctaca ggggagagag ggtggtcttg tgggatgact
1621 acggcatggg gagccctgtt aaagacgccc taacactgca agagttggcc gacacatgtc
1681 cagtcacttt gaattgtgat aggattgaga ataagggaaa gatgtttgat agcgatgtca
1741 tcataatcac gaccaaccta gtcaaccccg cacccctcga ttatgtgaac ttcgaggcgt
1801 gttctaggag agttgacttc ctggtctatg cagagtcacc agaaattgaa aaggtcaaga
1861 gagacttccc tggccagcct gacatgtgga aagaccattt tagaccagat ttttcccata
1921 ttaagttgac tctagccccc cagggtgggt ttgacaaaaa tggcaatacc ccacatggca
1981 agggtaccat gcggtcctta acccaggggt ccctgactgc gagagttgca ggccttgtcc
2041 atgagaggag ggacgagttc cagctccaag gaaatgacct ccaaacatac aactttgaca
2101 ccaacagagt ctccgcattt agaaaattgg ctgcagataa caagtatggg atcatggaga
2161 cgatgagagt tggtgcagcg ctcaagagtg tgaagacctt ggaagatctt aaagctgcat
2221 tgagggatgt gaaattcaat gagtgtgaaa taatttacaa gaactctaag taccgagtct
2281 cttccaacgg caaaggctcg gtttctgttg acaaagttga agacaatgcc tcccaggctg
2341 tgaacgaggt gcattcagca cttcttagac tcaggcaggc aagggccaga tactacatca
2401 gctgcttcca agacctcgtt tacactctca tgcaggttgc cggggcatca ttcgtcgtca
2461 gtaggatctc cagaagattc tgctgggaaa ggtgggtcaa accgaccgag acccaggaag
2521 tgaatgagcc cgaaaaggaa gtggcccaag gtggatggga aattgagccc aaggacacag
2581 aaccggaagg taagaagggt aagaacaaga aaggaagggg caagaaacac acagccttct
2641 ctagcaaagg cctgagtgat gaagagtacg atgagttcaa gagaatcagg gaagaaagga
2701 acggaaagta ctccattgag gaatacctgc aggaccgaga ccgctattat gaagaggtgg
2761 cagttgctcg ggcgacagag gaggacttct gtgaagagga agaagccaaa ataagacaaa
2821 gaattttccg cccgacaagg aaacagagga aggaggaaag gggcgtgctt ggcttggtca
2881 ctggctcaga catcagaaag aggagacccg acgacttcca accaaagggc aacctatggg
2941 cagatgacac cagaagtgtg gactacaacg agaggcttga ttttgaagca cccccgagtg
3001 tttggtcaag aatagtccca ttaggcactg gttgggggtt ttgggtttca tccaaccttc
3061 tgatcacaac aacacacgtc ctgcctaaag gggtcaagga actctttgga gttgaaatca
3121 aacaaatcca agttcataag tctggagagt tttgcaggtt taggtttcca agacccatca
3181 ggccagatgt cacaggactc gtgctggagg aaggagcccc agagggcact gtctgttctg
3241 tacttgtaaa aagacccaca ggtgaaatga tcccccttgc agtgaggatg ggcacgcacg
3301 catccatgaa aatacagggc aggaccgttg gtggccaaat ggggatgctc ctcacaggag
3361 caaacgcgaa gaacatggac ctcggtactg gtcctggtga ctgcggttgc ccctacatct
3421 acaaacgtgg caacgacata gttgtcgcgg gtgttcacac cgcagcagcc cgggggggca
3481 acactgtcat atgcgccacc caagggcaag acggggaagc agtccttgag ggaaatgagg
3541 accttggcac ctactgtggc gccccaattc tgggtcctgg caaggcgccc aaactcagca
3601 cgaagaccaa gttttggcgc tcatcaccag atgccttgcc acctggcaca tatgaacctg
3661 cttacctagg aggcaaagac cccagggtgg aaaaaggtcc ctccctgcag caagtcatga
3721 gagaccagtt gagacccttc acagaaccca ggggcaaacc gcccagacct gcagtcctgg
3781 aggaagcaaa gaagacagtg atgaatgttt tagaacaaac cattgacccc gccaagccat
3841 ggtcctactc ccaggcatgt gcctcacttg acaaaaccac ctctagtggt agtcctcacc
3901 acgttaagaa aaatgaccac tggaatgggg agtccttcac tggtccactt gcagatcagg
3961 catctaaagc caatctcatg tatgaacagg ccaaacatgt gcagcccgtg tacacggcag
4021 cgcttaaaga tgagcttgtt aagactgaca agatctacaa gaagataaag aagaggctcc
4081 tatgggggtc ggaccttggc acaatgatca ggtgcgccag ggcttttggt ggtctcatgg
4141 acagcatgaa ggcgagttgt atagctcttc cttgcagggt aggaatgaac atgaatgaag
4201 atggccccat catatttgac aaacactcta agtacaggta ccactatgat gctgactatt
4261 ctaggtggga ctcaacccaa cagaggagca ttctctctgc cgctatggaa gtaatggtgc
4321 ggttttctgc tgaaccagaa ctggcacaag tggttgcaga ggaccttttg gctcctagcc
4381 agcttgacgt tggcgacttt gtcatctcag tccaggaggg tctaccatca ggagtcccat
4441 gcacatcaca atggaattca atagcacact ggatcctgac tttgagtgca atggcagaag
4501 tgtcaggtct ctcaccagat gttgtccaag ctcactcctg tttttcattt tacggggacg
4561 atgagatcgt cagtactgat atcaatcttg accccatgaa gttgacacag aaactcaggg
4621 agtatggtct ggtccccacc cggcctgata aaactgaagg ccccctcgtt ataactgaag
4681 acctcaccgg cctgacattc ctccgtaggt cgattgctcg ggacccagct ggttggtttg
4741 ggaaactgga ccaagactca attctcaggc agctatactg gacaaggggg cctaaccatg
4801 agaacccgta tgagagcatg gtccctcatt ctcagcgggc cacacagctc atggcccttc
4861 ttggtgaggc ctcgctgcat ggtccccagt tttacaagaa agttagcaag atggtcatca
4921 acgagattaa gagtggtggt ctggagtttt atgtgcccag acaagaggcc atgttcaggt
4981 ggatgagatt ctctgacctc agcacatggg agggcgatcg caatcttgct cccgaaggtg
5041 tgaatgaaga tggcgtcgaa tgacgcagct ccatctaatg atggtgcagc aggcctcgtg
5101 ccagagatca acaatgaggt catgcccctt gagcccgtgg ctggtgcatc gctggcgaca
5161 ccagttgtcg ggcaacaaaa tataattgat ccctggataa gaaataattt tgtacaagct
5221 cctgcaggtg agtttacagt ttcccctaga aattcccctg gtgaaatttt acttgatttg
5281 gagttgggac cagagttgaa cccttatctc gctcatctgg cccgtatgta caatgggcac
5341 gctggtggca tggaagtgca aattgtgttg gctgggaacg cgttcacagc tggcaagatc
5401 atatttgctg ccatccctcc agggctccca tacgaaaatt tgtcaccttc acaaattaca
5461 atgtgccccc acgttataat tgatgttaga caattagaac cagtcctatt acctatgcca
5521 gatattagaa ataatttctt ccattacaat cagggtaatg atccaaaatt gaggttggta
5581 gctatgctct acactccttt aagggctaac aattctggtg atgatgtgtt tacagtttct
5641 tgtagggtcc tcactaaacc gtcacctgat tttgaattca catttttggt tccccccaca
5701 gttgaatcca agaccaagca attcacattg cccatcctca aaatatcaga gatgaccaat
5761 tcaagattcc cagtgccggt ggaaatgatg tacacagcaa ggaatgaaaa tcaagttgtc
5821 cagccacaaa atggtagggt cacactcgat ggcgagctat tgggcaccac acccttgttg
5881 gctgtcaaca tctgcaaatt caagggagag gtcatagcta agaatggaga tgtgagatcc
5941 tataggatgg acatggaaat caccaacact gatggcaccc caattgaccc cactgaagat
6001 acacctggtc ccattggatc acctgatttt caaggtatac tctttggtgt tgccagtcaa
6061 cgcaacaaga atgagcagaa ccctgccacg agagcccatg aagccaacat caatactggt
6121 ggggaccaat acgcccccaa attggcccaa gtgaaattct tctcagagtc ccaggatttc
6181 gaggtgcatc agcccacagt tttcacccca gttggtgtgg caggtgacac ttcccaccct
6241 ttcagacagt gggtcctgcc tcgatatggt ggacatctca ccaacaacac ccacttggct
6301 ccagcagtgg cccctttatt cccaggtgag cagattctgt tctttagatc acaaataccc
6361 agttcaggcg gccatgaatt gggttacatg gactgccttg tcccacaaga gtgggtccaa
6421 cacttctatc aagaagctgc cacagctcag tctgaggtgg cactcataag gttcatcaac
6481 ccagacactg gtagagtcct ctttgaggcc aagctacaca agcaaggctt tataactgtg
6541 gctcacactg gtgataaccc aattgttatg ccaccaaatg ggtatttcag atttgaagcc
6601 tgggtcaatc agttttactc actcgccccc gtgggaactg ggaatgggcg taggaggatc
6661 caataatggc tagtgctttc tttgcaaatt tggcaggagg cgttgcctcc aatggaatta
6721 gttcactcat aaatgctggg gctaatgcta ttaaccaaaa ggttgaattt gattacaata
6781 aacaactcca aaatgcatcc ttctcccacg ataaagaaat gctccaagcc caaattgaag
6841 ccactaaacg tttgcaacaa gagatgattg acataaaaca aggggtgctg acggctgcgg
6901 gattctctcc cacggatgcc gcgaggggct ctgtcggcgc gccaatgaca aaattagttg
6961 attggagtgg cactagatat tgggctcctg gtgccatgag gacaacaggc tattcaggga
7021 ctttcactca cttgccccct atgcagccta cttcatatgt taataatcag aatagacaac
7081 tttttaaagt agatccttct ccttcttctt caagtggttc ttctgtttct tctgttaaaa
7141 cacaatcaac tgctctctcg ggcacttcaa gggtggactc tccatcccag tcaaccctgt
7201 cgaccagacc gagctcaagg acatctgatt gggtgcgtag ccaaaatgaa aggttgagcc
7261 ccttcatgaa tggagcgttg caaacaacgt atgtaacgcc accatctagc agggtatcaa
7321 gtgtcagcac agtctcgacc gtgccgaaag aggttttgga ctcctggacg cctatgttta
7381 acactcacag gcagccgctc ttcgcccacc tgcgtaggcg aggggagtca cagatttagt
7441 gaaaagatta attaggaaag cttgattagt ttccttttct attattcctt taatttttct
7501 ttt
//